The document discusses World Spine Day 2023. The theme emphasizes the importance of movement in addressing spinal pain and disability. An estimated 1 billion people worldwide suffer from spinal pain, which is the leading cause of disability globally. This year's World Spine Day campaign calls for greater commitment to tackling spinal pain and lack of access to spine care. It encourages people to stay mobile and avoid inactivity to help their spines.
Scientific Link between viscero-somatic and somato-viseceral diseases and chiropractic adjustments as the earliest indicator and the most appropriate treatment.
Scientific Link between viscero-somatic and somato-viseceral diseases and chiropractic adjustments as the earliest indicator and the most appropriate treatment.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
4. The theme emphasizes the importance of movement in addressing spinal pain
and disability as part of the global burden of disease and addresses the need for
movement education to all regions, cultures, backgrounds, and across the life
course worldwide.
5. An estimated one billion people worldwide suffer from spinal pain. It is the
most significant single cause of disability. Low and middle-income countries
often have limited access to healthcare resources or spinal health professionals.
Effective management and prevention are vital, and this year’s World Spine
Day will encourage people to be kind to their spines.
6. This World Spine Day, we are calling for action to focus on the global burden
of spinal disorders while emphasizing how to #MOVEYOURSPINE;
prioritizing a condition that is more prevalent than cancer, stroke, heart disease,
diabetes, and Alzheimer’s Disease combined.
7. The campaign calls for greater global commitment to tackling spinal pain
and disability by governments, communities, and public health bodies.
8. World Spine Day also recognizes the lack of access to quality spine care and
rehabilitation in under-served communities, which results in chronicity and
permanent deformity. For many populations, spinal pain and disability is not just
a minor inconvenience – it can mean not being able to work and provide food
and sustenance.
9. #MOVEYOURSPINE will focus on highlighting ways in which all
people can help their spines by staying mobile, avoiding physical
inactivity, not overloading their spines, and adopting healthy
habits such as weight loss and smoking cessation.
10. Believed to be the largest global public health event dedicated to promoting
spinal health and well-being, World Spine Day is observed by health
professions and public organizations concerned with spine care throughout the
world.
11. First stage: Formation of notochord.
Second stage:( Blastemal stage) =Mesodermal condensations.
Formation of mesenchymal vertebral column. Sclerotomes
surround notochord and neural tube.
Third stage: (Chondrification) of mesenchymal vertebral column.
Fourth stage:( ossification) of the vertebrae.
Development of Vertebral Column: 4 stages
Notochord contribute to formation of nucleus pulposus where it
surrounded by mesenchymal tissue which form annulus fibrosus. Together
they form intervertebral disc
12. Once the neural tube closes, neuroepithelial cells begin to give rise to another cell type
characterized by a large round nucleus with pale nucleoplasm and a dark-staining nucleolus. These
are the primitive nerve cells, or neuroblasts). They form the mantle layer, a zone around the
neuroepithelial layer. The mantle layer later forms the gray matter of the spinal cord.
The outermost layer of the spinal cord, the marginal layer, contains nerve fibers emerging from
neuroblasts in the mantle layer. As a result of myelination of nerve fibers, this layer takes on a white
appearance and therefore is called the white matter of the spinal cord
Development of Spinal Cord
13. A spina bifida can also be subtyped as:
1. Open: (80-90%) especially if detected antenatally 4
a. Myeloschisis
b. Myelomeningocele (mostly open, associated with Chiari ii malformation)
2. Closed: if covering skin present
a. Meningocele (may be open)
b. Lipomyelomeningocele
c. Myelocystocele
d. Tethered cord
e. Diastematomyelia
f. Syringomyelia
Spina Bifida Occulta
14.
15. Common Spine Disease
Mechanical Back pain
Inflammatory back pain
Mechanical Neck pain
Compressive/Non-compressive myelopathy
Traumatic spinal cord disease
Infection- TB
Tumour of Spine
Vascular Disease of spine
16. Common Investigation Of Spine Disease
X-ray
MRI
Inflammatory marker: CBC, CRP, RF, ACPA, ANA etc.
CT scan
17. Modification of life style
Drugs
Physiotherapy
Surgery
Mode Of Treatment In Spine Disease
19. Excellent
Most of spine problem need conservative management
Accurate diagnosis is vital
Surgical spine condition – treated urgently with surgery, delay
can cause disability.
Outcome Of Treatment In Spine Disease
20. Lower Back Pain From Sitting
As we move towards occupations that require us to sit longer and move less,
back pain and other musculoskeletal pain seem to be on the rise.
In one study office workers were asked to sit for 2 hours at a computer as their
discomfort level was measured throughout this time. The results showed that
discomfort increased significantly over time across the entire body – but low
back pain was reported to have increased the most.
21.
22. 1. Excessive Sitting (Longer than 30 Min)
2. Sitting with Hunched Posture (Kyphosis)
3. Sitting in a Static Position
4. Sitting with Flattened Low Back
5. Sitting with Excessively Arched Low Back
5 Possible Causes For Low Back Pain From Sitting
23. 1. Stand Up/Walk Around/Exercise Every 30 min
2. Vary Your Posture/Move While Sitting
3. Use a Sit-Stand Desk
4. Get Lumbar cushion support
5. Raise your laptop to eye level
What can you do about it?