Non-communicable diseases (NCDs) such as heart disease, cancer, diabetes and respiratory diseases are a major global health challenge, responsible for over 70% of deaths worldwide. NCDs disproportionately impact low and middle-income countries and account for more than 60% of deaths in countries like India. To address this growing epidemic, the document calls for strengthening health systems, adopting a holistic approach to well-being that includes social and environmental factors, and fostering public-private partnerships to develop sustainable solutions and leverage new technologies. A multi-sectoral response is needed to combat NCDs through prevention, management, treatment and national policy measures.