Why is nucleotide synthesis an important pathway for medical interve.pdf

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Why do you need to use aprotic solvents (THF, diethyl ether) in a Grignard Reaction? Solution RMgX is general representation of grignard reagent it exist as R- and MgX+ R- is very strong base. if we use any protic solvents like H2O and ROH R- abstracts proton from solvent becomes neutral R- + H2O -------------> RH so there will be reaction between grignard reagent and protoc solvent. so we must use aprotic solvent to avoid above mentioned problem..

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Why is nucleotide synthesis an important pathway for medical intervention and what types of
disease could be treated using this information?
Solution
NUCLEOTIDES(PURINES AND PYRIMIDINES) PLAYS AN IMPORTANT ROLE IN
REPLICATING AND QUIESCENT CELLS. NUCLEOTIDES HELP IN PREVENTION OF
NEURODEGENERATION. THEY CAN BE MAINTAINED BY DE NOVO SYNTHESIS OR
SALVAGE PATHWAYS. THE NUCLEOTIDE SYNTHESIS IS IMPORTANT PATHWAY
FOR MEDICAL INTERVENTION AS IT HELP TO DEVELOP DRUG THAT CAN PLAY AS
ANALGOUE IN TREATMENT OF NUCLEOTIDE DISEASES.SALVAGE PATHWAYS
ARE IMPOTANT SOURCES OF NUCLEOTIDES FOR DNA, RNA AND ENZYME CO
FACTORS. DEGREDATION OF NUCLEOTIDES HELPS IN MAINTENANCE OF
NUCLEOIDE POOL. DISEASES DUE TO ENZYMES OF NUCLEOTIDE SYNTHESIS
COULD BE TREATED SUCH AS LESCH-NYHAN DISEASE, ATAXIA TELANGIETASIA,
OROTIC ACIDURIA, GUT,SCID,VON GIERKE DISEASE AND MANY SUCH.

Case study Initial history 27-year-old female comlaining of symptoms of urgency to urinate, frequent urination, and urethral burning during urination persisting for 48 hours Patient awoke from sleep with urgency and suprapubic discomfort 2 nights ago Urine now has strong odor and cloudy appearance Additional history Recurring urinary tract infections since she married at age 22 years Prior UTI associated with similar symptoms Denies history of febrile or hemorrhagic UTI Three episodes over past 2 years May be associated with strenuous physical exertion and sexual intercourse No other medical history She reports an allergy to penicillin which causes a “rush” and “trouble breathing” Physical examination Well-nourished female experiencing mild discomfort Tenderness on palpation of abdominal pelvic area; physical examination otherwise unremarkable T=98.6°C orally; BP=114/64 mmHg; P=68; RR=12 Laboratory results Dipstick urinalysis: Color: Dark yellow, specific gravity=1.030, pH=6.5 Protein: Negative, glucose: negative, Ketone: negative, bilirubin: negative Trace occult blood Leukocytes:large amount Nitrates: positive, urobilinogen:negative Microscopic examination: WBC: too numerous to count (TNTC)/HPF (high power field) Bacteria: TNTC RBC: 3 or 4/HPF Casts: negative Urine culture: E.Coli:> 104 CFU/mL Organism sensitive to ampicillin, nitrofutantoin, trimethoprim-sulfamethoxazole (TMP-SMX), ciprofloxacin, cephalexin What is the history of this patient? Solution The organism is sensitive to antibiotics like ampicillin, nitrofutantoin, trimethoprim- sulfamethoxazole (TMP-SMX), ciprofloxacin, cephalexin. The urine culture shows high number of E.coli present in the urine with 3-4 RBC. Also the WBC is too numerous to count . An initial increase in WBC is indicative of an infection and with such high amount of bacteria in urine , is indicative of a bacterial infection , specifically caused by E.Coli. Although, the urine analysis do not show anymore anomalies, except presence of nitrates. Nitrates in urine occur are also indicative of an urinary tract infection. The initial patient history is also suggestive of an Urinary tract infection, due to cloudy appearance of urine. The indication is of a Cystitis, which is generally caused by an E.coli in the urine . One of the reasons of the recurring urinary infections might be due to sexual intercourse or strenuous activities..

I appreciate any help with the following questions.(1) What typ.pdf

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Hypothesize a set of at least three arguments as to why innovation is important to the competitiveness of nations, companies, leaders, and individual employees. Solution One of the main reasons why innovation is important is the fact that it creates development on nations and business, it opens opportunities to new projects that on the past have not being taken in consideration. Innovation sometimes is the only way an organization has to stay alive on business because of the hard and globalize competition, it creates the unique value for your brand our country, and it is an added value. For example recently Nicaragua offer new investors that they will not need to pay taxes for 10 years as long as they start a business there and offer job to the people in Nicaragua. Innovation makes the organization better every day, it is a constant improvement on the processes on a positive manner, and this increases creativity. You don’t need to create something new that no one has ever think you can take a product and add it qualities that your competition does not have and making your target market to prefer your brand..

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