High-fructose corn syrup (HFCS) is a sweetener derived from corn that is commonly used in processed foods and beverages. There are several misconceptions about HFCS and how it impacts health compared to ordinary sugar. HFCS is made up of fructose and glucose, like sugar, but in slightly different ratios. Research shows the body processes HFCS and sugar similarly, and the small differences in their compositions are unlikely to meaningfully affect health. While excessive consumption of either can contribute to weight gain and related issues, moderation is more important than the source of simple sugars in one's diet. The facts suggest HFCS does not deserve its poor reputation if sugar would be consumed in its place.