There are several key differences between American and British English, including vocabulary, spelling, pronunciation, and grammar. Vocabulary differs in terms like automobile and railway terms, idioms, and slang words. Spelling variations were introduced by Noah Webster and include words like "color" and "center" in American English. Pronunciation places stress on different syllables in some words between the two dialects. Grammar also shows differences in verb usage, tenses, and punctuation conventions. American English has influenced British English through globalization and media as well.