Vue.js is a progressive framework for building user interfaces that is designed to be incrementally adoptable. It follows a Model-View-ViewModel (MVVM) pattern, with the view layer as its core focus. A Vue application starts with a view instance created with the Vue function, which manages the view and two-way binding between the model data and DOM. Components can be used to build reusable UI elements and communicate between each other using events and a central event bus. Vue Router allows building single-page applications with multiple views and nested routing.