Recommended
More Related Content
Similar to Vitamin D.ppt
Similar to Vitamin D.ppt (20)
Recently uploaded
Recently uploaded (20)
Vitamin D.ppt
- 1. Curr Opin Endocrinol Diabetes Obes. 2008;15:489–494. What is Vitamin D? Fat-soluble vitamin and serves as a hormone in the body.1 The only vitamin human body makes itself. Vitamin D is naturally present in few selective foods, such as oily fish & in very low amount in cow's milk.
- 2. Types of Vitamin D Vitamin D3 (Cholecalciferol) Preferred form of supplementation Produced in skin with direct sunlight Vitamin D2 (Ergocalciferol) Found in plants Made by UVB radiation of ergosterol
- 3. Vitamin D Metabolism (Animals, Supplements) (Plants) (Calcitriol: Active form of Vit D)
- 4. J Am Coll Cardiol. 2008;52:1949–1956. Osteoporos Int. 2010 Jul;21(7):1151-4. Vitamin D Status Vitamin D insufficiency, 25(OH)D levels <30ng/ml is prevalent, worldwide, especially in Middle East and South Asia.2
- 5. Vitamin D Deficiency is Common Even in Sunny India More than 80 % of adult Indians not getting Enough Vitamin D INDIA Latitude of 22 ° 00' N Longitude of 77 ° 00‘ W
- 6. 1. Am J Clin Nutr. 2000;72: 472-75 2. Data on file 25(OH) D status of Normal Indians All Indians suffer from Vitamin D Deficiency Soldiers Depigmented subjects Physicians & Nurses Pregnant women Newborns Sales Team Office staff Doctors 0 5 10 15 20 25 30 Vitamin D Levels (ng/ml)
- 7. Signs and symptoms of Vitamin D deficiency Musculoskeletal disorders • Low back pain, joint pain Fatigue and Muscular Weakness Increased susceptibility to infections It thus adversely effects Quality of Life
- 8. Immediate Quality of Life Future Quality of Life Vitamin D Deficiency Affects Quality of Life -Muscle pain and weakness - Osteomalacia (Adults) - Rickets (Children) -Osteoporosis & Fractures -Other Chronic Disorders • Diabetes • Recurrent infections • Hypertension • Heart Disease
- 9. Recommended Vitamin D Intake by Endo. Society Guidelines, 2011 Vitamin D by Michael H. Holick, II Ed. 2010. Reasonable Daily Allowance (IU/Day) Reasonable Allowance (IU/month) 0-6 months 400-1000 12000-30000 6-12 months 400-1000 12000-30000 Children (1-18 Yr) 1000-2000 30,000-60,0000 Adults (19-50 Yr) 1500-2000 45,000-60,000 Elderly (51-70 Yr) 1500-2000 45,000-60,000 Elderly (> 71 Yr) 1500-2000 45,000-60,000 Pregnancy 1500-2000 45,000-60,000 Lactation 1500-2000 45,000-60,000
- 10. Major action of Vitamin D on Various Organs Organ Actions Bone Promotes osteoblastic activity (improves bone mineralization) Regulates osteoclastic activity. (reduces bone resorption) Parathyroid glands Inhibits parathyroid hormone secretion (Improves bone mineralization) Kidneys Enhances Ca reabsorption Intestine Enhances Ca and phosphate transport (absorption) Muscles Strengthens muscles (Increases De Novo Protein Synthesis) Boosts immunity Decreases risk of recurrent infections. Immune system
- 11. Osteoblast & Osteoclast Osteoblasts Cells responsible for synthesis & mineralization of bone. Osteoclasts Cells responsible for dissolution of bone. Cause bone resorption.
- 12. Vitamin D deficiency Syndrome Vitamin D Deficiency Syndrome (VDDS) Musculoskeletal disorders Autoimmune Diseases Muscle Weakness Chronic pain & fatigue Osteomalacia Osteoporosis Hypertension
- 13. Osteomalacia Osteoporosis Physiology Abnormal bone building Degeneration of built bone Occurrence Adults Elderly Symptoms Muscle Weakness Bone Weakness & Pain Frequent fractures Loss on height (due to compression of spine Complications Bone softening Bone bending Results in bone fragility & fractures Prognosis Can be prevented by Ca & Vitamin D supplements Cannot be prevented. Can only be treated Outcome Osteoporosis Fractures Osteomalacia Vs. Osteoporosis
- 14. Osteomalacia Softening of bones due to insufficient vitamin D, or problems with metabolism of this vitamin. Osteomalacia in children is known as Rickets Signs & Symptoms • Bone Weakness • Bone Pain • Muscle Weakness
- 15. Rickets
- 16. Prevalence of Vitamin D Induced Osteomalcia & Rickets in India Osteomalacia & Rickets are the most common disorders due to Vitamin D Deficiency in India Osteomalacia present in 35.3% adults with Vitamin D deficiency1 Rickets present in 30.3 % Indian infants with 25(OH)D <10ng/ml.2 1. Indian J Med Res. 2008;127:219-228. 2. Indian J Med Res. 2011;133:267-273
- 17. Osteoporosis Weakening of Bones In osteoporosis, bones become weak, fragile and brittle due to loss of minerals like calcium They get fractured more easily than normal bone. 1 out of 8 males & 1 out of 3 females in India suffer from Osteoporosis Osteoporosis Normal Bone Osteoporosis Society of India New Delhi Osteoporosis Osteomalacia
- 18. 93 % of all patients With Musculoskeletal Disorders, suffering from persistence pain, were Vit D deficient Low back pain 83% patients < 22.5ng/ml Osteoarthritis knee 48% patients < 30 ng/ml Spondolysis Joint Pain 94% patients with vit D <15 ng/ml Muscle Weakness 94% patients with Vit D < 15ng/ml Vitamin D deficiency also affects Musculoskeletal health…
- 19. Over 90% of Fractures occur after fall and fall rate increases due to poor muscle strength and function.1 Adequate dose of Vitamin D found to be useful in reduction of persistent non specific pain & Fractures Ca & Vitamin D Deficiency Causes Fractures Osteoporosis Increases risk & Rate of Fall Increases risk of Fracture Muscle Weakness Osteomalacia Medicographia. 2010;32(4):384-390
- 20. Vitamin D Status and Hip Fracture Stroke 2001;32:1673-7
- 21. Vitamin D Deficiency : Summary ↓ Calcium in the serum ↑ PTH Osteoblastic activity Osteoclastic activity ↑ calcium efflux from bone OSTEOPOROSIS Vitamin D deficiency ↑ Risk of Fracture Muscle weakness ↑ Risk of falls Osteomalacia
- 22. Vitamin D supplementation in vitamin D deficient Indians ↑ Calcium in the serum ↓ PTH Osteoblastic activity Osteoclastic activity ↓ calcium efflux from bone OSTEOPOROSIS ↑ Vitamin D ↓ Risk of Fracture Muscle Strengthens ↓ Risk of falls Osteomalacia
Editor's Notes
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 16
- 17
- 18
- 19
- 20
- 21
- 22