Background: Vitamin D is crucial for a wide variety of organ systems; nevertheless, evidence has demonstrated that vitamin D deficiency may place subjects at risk for not only low mineral bone density /osteoporosis and osteopenia but also infectious and chronic inflammatory diseases Vitamin D also has anti-inflammatory effects by suppressing pro-inflammatory cytokines through its effect on bone and mineral metabolism, innate immunity and several VDR gene polymorphisms, vitamin D has been reported to be associated with periodontal disease. Objectives: To assess anti-inflammatory effect of vitamin D3, when administered as monotherapy in generalised chronic periodontitis. Methods: This study comprises of 56 patients of generalised chronic periodontitis who were screened for their serum vitamin D3 levels. Out of which 30 patients who were vitamin D3 deficient (<20ng /><0.002)><0.000). Conclusion: Vitamin D deficiency may place subjects at risk for not only low bone mineral density/osteoporosis and osteopenia, but also infectious and chronic inflammatory diseases like periodontitis.
Evaluation of Oxidative Stress and Stress Induced Serum Protein Changes in Ps...Premier Publishers
Psoriasis is a non-infectious, chronic inflammatory disease of the skin. This study aimed to explore the oxidative stress and stress induced protein changes in psoriasis and to analyse the possible interrelationship between these factors among psoriasis patients. This was a hospital-based case control study which included 50 cases of psoriasis and 50 healthy controls. Serum malondialdehyde was measured by thiobarbituric acid reactivity assay method. Protein carbonyl (PC) was measured by Levine’s method. Protein bound sialic acid (PBSA) was measured using modified Aminoff’s method using a spectrophotometer. Data analysis was done using SPSS software version 16.0. Our results showed significant elevation in the oxidant status (MDA, PC and PBSA) among the psoriasis cases compared to the controls. Multiple linear regression analysis showed a linear relationship between MDA, PBSA and duration of psoriasis. Our study provides evidence to increased ROS production, indicated by increased lipid peroxidation in serum and stress induced protein changes in psoriasis. The findings of our study also suggest that as the duration of psoriasis increases the level of oxidative stress also increases which is indicated by the increase in MDA and PBSA levels.
The efficacy of supplementation with the novel medical food, Souvenaid, in pa...Nutricia
The efficacy of supplementation with the novel medical food, Souvenaid, in patients with Alzheimer’s disease: A systematic review and meta-analysis of randomized clinical trials
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Selected Psychological and Social Factors Contributing to Relapse among Relap...inventionjournals
Drug abuse is a major global problem and in Kenya there has been increasing drug and alcohol abuse with serious negative effects. Treatment and rehabilitation of alcoholism is expensive and non-conclusive due to consequent relapse. This study sought to find out selected psychological and social factors contributing to relapse among recovering alcoholics of Asumbi and Jorgs Ark rehabilitation centres in Kenya. This study adopted the descriptive survey design. The population of the study comprised of all relapsed alcoholics and rehabilitation counsellors in Asumbi and Jorgs Ark rehabilitation centres in Kenya. A sample of 67 recovering alcoholics and 13 counsellors was drawn from the two purposively selected rehabilitation centres and used in the study. The study used two sets of questionnaires, one for relapsed alcoholics and another for rehabilitation counsellors. The questionnaires were piloted to validate and establish its reliability before the actual data collection. Data was collected through administration of two sets of questionnaires to the selected respondents. The data was then processed and analyzed using descriptive statistics including frequencies and percentages with the aid of Statistical Package for Social Sciences (SPSS) version 20.0 for windows. The key findings of this study indicated that the selected psychological factor that mostly contributed to relapse was dwelling on resentment that causes anger and frustration due to unresolved conflict. The social factor that mostly contributed to relapse was hanging around old drinking friends. The key conclusion was that in view of selected factors dwelling on resentment that causes anger and frustration due to unresolved conflict was the major contributor to relapse. The research findings may benefit NACADA, Ministry of Public Health, mental health agencies, psychologists, counsellors, Non-Governmental organizations, policy makers, researchers, drug abusers and alcoholics in Kenya to better understand factors contributing to relapse and devise ways and means of reducing relapse. Based on the major findings of this study, it is recommended that all stakeholders undertake measures aimed at providing a solution to continued relapse of alcoholics by improvement of rehabilitation and follow-up programmes.
Никита Семенов, руководитель отдела по работе с ключевыми клиентами CoMagic
Генерация лидов: как выйти из каменного века
- Анализ работы с лидами на среднем сайте
- Новые инструменты, о которых говорят, но не используют
- Кейсы использования персонализированных лидогенераторов.
Modeling Truck Movements: A Comparison between the Quick Response Freight Man...inventionjournals
In recent years, with a growing realization of the important impacts of truck traffic on the economy as well as urban congestion and pollution levels, there is a keen interest in modeling truck movements with greater accuracy, robustness, and detail. This paper examines two different approaches for explicitly including truck trips into travel demand forecasting models. The approaches considered are (a) the truck modeling methodology published in the Quick Response Freight Manual (QRFM) and (b) an emerging truck tour-based approach. In this paper, the two approaches are demonstrated and compared using the Birmingham, AL region as a case study and statistical analyses are conducted to evaluate the level of accuracy of both approaches. The results demonstrate that the model using tour-based approach performs better than the one based on the QRFM approach with respect to model accuracy, when compared to field data from the study area. However, the tourbased approach requires a comprehensive data collection and processing effort, whereas the QRFM approach uses the publicly available data such as household and employment data. The decision on the best approach for adoption should be made on a case-by-case basis after considering the tradeoffs between accuracy and data availability and processing requirements. Overall, the findings from this study can be used to support the development of efficient freight truck modeling applications for the Birmingham region. Moreover, lessons learned from the Birmingham case study provide valuable insights that can guide freight modeling efforts of planning agencies in other medium sized communities in the future
Evaluation of Oxidative Stress and Stress Induced Serum Protein Changes in Ps...Premier Publishers
Psoriasis is a non-infectious, chronic inflammatory disease of the skin. This study aimed to explore the oxidative stress and stress induced protein changes in psoriasis and to analyse the possible interrelationship between these factors among psoriasis patients. This was a hospital-based case control study which included 50 cases of psoriasis and 50 healthy controls. Serum malondialdehyde was measured by thiobarbituric acid reactivity assay method. Protein carbonyl (PC) was measured by Levine’s method. Protein bound sialic acid (PBSA) was measured using modified Aminoff’s method using a spectrophotometer. Data analysis was done using SPSS software version 16.0. Our results showed significant elevation in the oxidant status (MDA, PC and PBSA) among the psoriasis cases compared to the controls. Multiple linear regression analysis showed a linear relationship between MDA, PBSA and duration of psoriasis. Our study provides evidence to increased ROS production, indicated by increased lipid peroxidation in serum and stress induced protein changes in psoriasis. The findings of our study also suggest that as the duration of psoriasis increases the level of oxidative stress also increases which is indicated by the increase in MDA and PBSA levels.
The efficacy of supplementation with the novel medical food, Souvenaid, in pa...Nutricia
The efficacy of supplementation with the novel medical food, Souvenaid, in patients with Alzheimer’s disease: A systematic review and meta-analysis of randomized clinical trials
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Selected Psychological and Social Factors Contributing to Relapse among Relap...inventionjournals
Drug abuse is a major global problem and in Kenya there has been increasing drug and alcohol abuse with serious negative effects. Treatment and rehabilitation of alcoholism is expensive and non-conclusive due to consequent relapse. This study sought to find out selected psychological and social factors contributing to relapse among recovering alcoholics of Asumbi and Jorgs Ark rehabilitation centres in Kenya. This study adopted the descriptive survey design. The population of the study comprised of all relapsed alcoholics and rehabilitation counsellors in Asumbi and Jorgs Ark rehabilitation centres in Kenya. A sample of 67 recovering alcoholics and 13 counsellors was drawn from the two purposively selected rehabilitation centres and used in the study. The study used two sets of questionnaires, one for relapsed alcoholics and another for rehabilitation counsellors. The questionnaires were piloted to validate and establish its reliability before the actual data collection. Data was collected through administration of two sets of questionnaires to the selected respondents. The data was then processed and analyzed using descriptive statistics including frequencies and percentages with the aid of Statistical Package for Social Sciences (SPSS) version 20.0 for windows. The key findings of this study indicated that the selected psychological factor that mostly contributed to relapse was dwelling on resentment that causes anger and frustration due to unresolved conflict. The social factor that mostly contributed to relapse was hanging around old drinking friends. The key conclusion was that in view of selected factors dwelling on resentment that causes anger and frustration due to unresolved conflict was the major contributor to relapse. The research findings may benefit NACADA, Ministry of Public Health, mental health agencies, psychologists, counsellors, Non-Governmental organizations, policy makers, researchers, drug abusers and alcoholics in Kenya to better understand factors contributing to relapse and devise ways and means of reducing relapse. Based on the major findings of this study, it is recommended that all stakeholders undertake measures aimed at providing a solution to continued relapse of alcoholics by improvement of rehabilitation and follow-up programmes.
Никита Семенов, руководитель отдела по работе с ключевыми клиентами CoMagic
Генерация лидов: как выйти из каменного века
- Анализ работы с лидами на среднем сайте
- Новые инструменты, о которых говорят, но не используют
- Кейсы использования персонализированных лидогенераторов.
Modeling Truck Movements: A Comparison between the Quick Response Freight Man...inventionjournals
In recent years, with a growing realization of the important impacts of truck traffic on the economy as well as urban congestion and pollution levels, there is a keen interest in modeling truck movements with greater accuracy, robustness, and detail. This paper examines two different approaches for explicitly including truck trips into travel demand forecasting models. The approaches considered are (a) the truck modeling methodology published in the Quick Response Freight Manual (QRFM) and (b) an emerging truck tour-based approach. In this paper, the two approaches are demonstrated and compared using the Birmingham, AL region as a case study and statistical analyses are conducted to evaluate the level of accuracy of both approaches. The results demonstrate that the model using tour-based approach performs better than the one based on the QRFM approach with respect to model accuracy, when compared to field data from the study area. However, the tourbased approach requires a comprehensive data collection and processing effort, whereas the QRFM approach uses the publicly available data such as household and employment data. The decision on the best approach for adoption should be made on a case-by-case basis after considering the tradeoffs between accuracy and data availability and processing requirements. Overall, the findings from this study can be used to support the development of efficient freight truck modeling applications for the Birmingham region. Moreover, lessons learned from the Birmingham case study provide valuable insights that can guide freight modeling efforts of planning agencies in other medium sized communities in the future
Solving Poisson’s Equation Using Preconditioned Nine-Point Group SOR Iterativ...inventionjournals
A well-designed preconditioning of the partial differential equations problems reduces the number of iterations to reach convergence. Dramatic improvements are possible, but the difficulty is to construct the suitable preconditioner.The construction of a specific splitting-type preconditioner in block formulation for a class of group relaxation iterative methods derived from the finite difference approximations have been shown to improve the convergence rates of these methods. This paper is concerned with the application of suitable preconditioning techniques to the Nine-Point Group SOR (N-P SOR) iterative method for solving Poisson’s Equation. Preconditioning strategies which improve the rate of convergence of these iterative methods are investigated. The results reveal the improvements on the convergence rate and the efficiency of the proposed preconditioned Group iterative method.
Vesicular Arbuscular Mycorrhizal Fungal status on some medicinal plants of Go...inventionjournals
Medicinal plants are important for our existence that supplies us many components for drug formulation. In nature the plant of particular kind invades with so many microorganisms. Among them one beneficial one is Va-mycorrhizal fungi. It helps in various ways to promote growth and yield of biomass better in natural habitats. So, to promote growth in garden or manmade environment application of VA-fungi as biofertilizer is beneficial. In this study 41 medicinal plants have been studied and application of VAM fungi inocula on Catharanthus roseus (L.) G. Don. have been done. Monsoon showed highest colonization percentage followed by winter and summer where as spore density showed highest during winter followed by summer and monsoon.
Cleft lip and palate - The culprit gene- Identified yet? : A reviewinventionjournals
: Various genetic approaches, including genome-wide and candidate gene association studies as well as linkage analysis, have been undertaken to identify aetiologic factors, but results have often been inconclusive or contradictory. These results may support the presence of aetiologic heterogeneity among populations and the presence of multiple genes involved in the aetiology of CL/P. Despite these difficulties, several different genes have been implicated in harbouring genes that contribute to the aetiology of CL/P. Even though the environmental factors have been understood and can be avoided to stop the formation of this facial anomaly, the genetic pathways still show the whirlphool effect and need to be understood and refined in their expression so that the genes and their actions could be identified and the probably existing single gene or family could be identified and reparative measures to stop its expression could be learned.
Analysis of Cr and Cu in Soils around Selected Automobile Workshops of Kaduna...inventionjournals
In this research, speciation analysis of soil samples from selected automobile workshops of Kaduna Metropolis, Nigeria was carried out. A modified Tessier extraction procedure was employed for the analysis. The concentrations of Cr and Cu in the samples were determined using flame atomic absorption spectrometry (FAAS). The soil samples were digested and extracted using different digestion and extraction media. The results revealed that the concentrations of Cr and Cu in the soils varied from one automobile workshop to another. The result also showed that Cr concentration was minimal in the various extraction media and followed the trend; HNO₃ > MgCl₂ > EDTA > Oxalic acid. Similarly, Cu concentration was found to be highest in the oxide phase, followed by that bound to the exchangeable phase. The distribution followed the trend oxalic acid > MgCl₂ > HNO₃: H₂O₂
Analysis of Cabin Mounting Bracket of Truck Using ANSYSinventionjournals
In an automobile industry while designing the components, the most critical aspect considered is the compactness and the weight of the component. The mounting brackets are meant for supporting the structural component and electronic components such as batteries, seats, cabin, chassis, rear body and also it should support the external load such as passenger’s weight. In the initial stage the bracket is designed according to the specifications of the mountings without considering any other factors. Analysis is performed for Existing and New modified designs. The design structure is optimized for its topology and topography. In the present work an attempt has been made to produce optimized design of a mounting bracket. The modeling is carried out in CATIA and meshing with quality is ensured through Hyper Mesh. The analysis is carried out using ANSYS by the objective function as shape and topology and the weighting function as weight, and constraints are on deflection and stresses induced.
Effects of Citalopram in Cognition and Memory in Experimental Animalsinventionjournals
Citalopram is an SSRI which enhances serotonin reuptake, a neurotransmitter involved closely in cognition and memory. With ever increasing cases of dementia and Alzeihmer’s disease and lack of definitive treatment, research into other treatment options are necessary. This study aims to evaluate the cognition and memory enhancing effects of citalopram in experimental animals
Brain Derived Neurotrophic Factor increases during recovery from psychologica...inventionjournals
Objective: To study the levels of plasma BDNF during recovering from psychological stress. Methods: Blood samples from thirty eight participants in a stress treatment project were analyzed for BDNF in plasma before and after 3 months treatment. Symptom levels were assessed by SCL92, work ability index and a question on stress. Physiological and behavioral measures were collected, all at baseline and after treatment. Results: BDNF increased significantly during the follow up, but the levels of BDNF were not correlated to blood pressure, se-cholesterol, HbA1C, se-fibrinogen or salivary cortisol even if the two latter decreased significantly. BDNF increase was inversely associated with improvement in depression symptoms contrary to the expected. Conclusion: Plasma BDNF increased during treatment for psychological stress, but was not associated with physiological stressmarkers or improvement of stress symptoms.
Palestra realizada na Colégio Estadual para alunos do ensino médio. Conceitos biomiméticos e analogia com as flores, permitiram que os alunos refletissem sobre o seu próprio comportamento
Common Fixed Point Theorem in Menger Space through weak Compatibilityinventionjournals
In the present paper, a common fixed point theorem for five self mappings has been proved under more general -norm ( -type norm) in Menger space through weak compatibility. A corollary is also derived from the obtained result. The theorem is supported by providing a suitable example.
Evaluation Study of National Examination and Student New Admission in Efforts...inventionjournals
This study aims to determine: the implementation of the new admissions system at schools in the city of Medan, to determine the level of preparedness of students in national exams and examine the relationship of learning achievement in Junior High School (SMP/MTsN) with student achievement in Senior High School (SMA/MA). The research data collected by the survey directly to schools selected as sample through observation, documentation and depth interview. Collecting data using a set of questionnaire. Research data analysis using SPSS. The results of this study are: new admissions system at the level of SMA/MAin the city of Medan done through the national exam results and a test track. Readiness of students in national exams conducted by the students tend to choose a tutoring to prepare for the National Exam. Apart from that, tutoring is also the place for high school students to learn in preparation for the National Examination, and there is a strong relationship between the results of national examinations in SMP/MTs with academic achievement in SMA/ MA. This indicates that the national exam results can be an indicator for the success of students in further education.
losses of both vitamin D binding protein and 25(OH)D in the urine
The urinary losses of vitamin D binding protein may be secondary to proteinuria.
Deficiency in 25(OH)D may lead to hypocalcemia, hyperparathyroidism, and diminished bone mineral density/content.
Vitamin D deficiency has also been associated with multiple systemic effects including elevated blood pressure ,metabolic syndrome, cardiovascular disease ,anemia and impaired immune system regulation .
This trial aimed to evaluate the efficacy and safety of vitamin D supplementation on the residual moderate and deep pockets following nonsurgical periodontal therapy.
Vitamin D deficiency is of concern now a days, it has important role in skeletal and non skeletal functions of the body. Good sunlight exposure, consumption of vitamin D rich foods, chemotherapy with vitamin D and supplements of vitamin D has shown positive effect on various non skeletal diseases like cancer, diabetes, diarrhoea, tuberculosis etc. Although Indians are blessed with ample sunlight, still 70 to 100% population is suffering from the vitamin D deficiency. Vitamin D deficiency is likely to play an important role in the very high prevalence of rickets, osteoporosis, cardiovascular diseases, diabetes, cancer and infections such as tuberculosis in India. Fortification of staple foods with vitamin D is the most viable population based strategy to achieve vitamin D sufficiency. Unfortunately, even in advanced countries like USA and Canada, food fortification strategies with vitamin D have been only partially effective and have largely failed to attain vitamin D sufficiency
This talk discusses the physiology of vitamin D and the consequences of vitamin D deficiency. It also presents the evidence for the effects of Vitamin D therapy on Bone density, It also presents the evidence of the effects of vitamin D supplementation on the development of cancer and cardiovascular events
—Chronic patients of spinal cord injury has been detected severe reduction of bone density. Patients with SCI show mostly osteopenia or osteoporosis of the hip and spine. Vitamin D deficiency may contribute to development of osteoporosis in SCI. So a study was conducted on 100 chronic SCI patients to find out status of correlation of Vitamine D and bone mineral density (BMD). Blood samples were collected and investigated routine biochemistry with serum 25(OH)D. DXA scan of hip and spine was also done. This study observed that 55% patients had suboptimal vitamin D. Positive correlation was found between vitamin D & bone mineral density. It is concluded from this study that monitoring of Serum 25(OH)D levels and annual surveillance of bone mineral density is crucial among persons with chronic SCI to reduce progression of osteoporosis and minimize the risk for further fractures. Keywords: 25(OH)D: 25 Hydroxy Vitamin D, DXA: Dual Energy X-Ray Absorptiometry, BMD: Bone Mineral Density.
Vitamin D deficiency is recognized as a global public health problem, with deficiency states reported from various countries. Acting as a Pro- Hormone; this is a unique endogenously synthesized vitamin. Besides its pivotal role in calcium homeostasis and bone mineral metabolism, the vitamin-D endocrine system is now recognized to sub-serve a wide range of fundamental biological functions in cell differentiation, inhibition of cell growth, and immunomodulation. Vitamin-D deficiency affects not only musculoskeletal health but also a wide range of acute and chronic disease. The metabolic product of vitamin-D is a potent, pleiotropic, repair and maintenance; secosteroid hormone that targets more than 200 human genes in a wide variety of tissues, meaning it has as many mechanisms of action on genes it targets. Two related sterol compounds viz. Cholecalciferol [Vitamin-D3] and Ergocalciferol [Vitamin-D2] are grouped as ‘Vitamin-D’. Cholecalciferol is of animal origin and the other Ergocalciferol [Vitamin-D2] is plant based. Interestingly, antirachitic properties of Vitamin-D2 and D3 are identical. After oral administration; Vitamin-D3 is absorbed better than D2 in small intestine; and bile is essential for absorption.
Hybrid optimization of pumped hydro system and solar- Engr. Abdul-Azeez.pdffxintegritypublishin
Advancements in technology unveil a myriad of electrical and electronic breakthroughs geared towards efficiently harnessing limited resources to meet human energy demands. The optimization of hybrid solar PV panels and pumped hydro energy supply systems plays a pivotal role in utilizing natural resources effectively. This initiative not only benefits humanity but also fosters environmental sustainability. The study investigated the design optimization of these hybrid systems, focusing on understanding solar radiation patterns, identifying geographical influences on solar radiation, formulating a mathematical model for system optimization, and determining the optimal configuration of PV panels and pumped hydro storage. Through a comparative analysis approach and eight weeks of data collection, the study addressed key research questions related to solar radiation patterns and optimal system design. The findings highlighted regions with heightened solar radiation levels, showcasing substantial potential for power generation and emphasizing the system's efficiency. Optimizing system design significantly boosted power generation, promoted renewable energy utilization, and enhanced energy storage capacity. The study underscored the benefits of optimizing hybrid solar PV panels and pumped hydro energy supply systems for sustainable energy usage. Optimizing the design of solar PV panels and pumped hydro energy supply systems as examined across diverse climatic conditions in a developing country, not only enhances power generation but also improves the integration of renewable energy sources and boosts energy storage capacities, particularly beneficial for less economically prosperous regions. Additionally, the study provides valuable insights for advancing energy research in economically viable areas. Recommendations included conducting site-specific assessments, utilizing advanced modeling tools, implementing regular maintenance protocols, and enhancing communication among system components.
CFD Simulation of By-pass Flow in a HRSG module by R&R Consult.pptxR&R Consult
CFD analysis is incredibly effective at solving mysteries and improving the performance of complex systems!
Here's a great example: At a large natural gas-fired power plant, where they use waste heat to generate steam and energy, they were puzzled that their boiler wasn't producing as much steam as expected.
R&R and Tetra Engineering Group Inc. were asked to solve the issue with reduced steam production.
An inspection had shown that a significant amount of hot flue gas was bypassing the boiler tubes, where the heat was supposed to be transferred.
R&R Consult conducted a CFD analysis, which revealed that 6.3% of the flue gas was bypassing the boiler tubes without transferring heat. The analysis also showed that the flue gas was instead being directed along the sides of the boiler and between the modules that were supposed to capture the heat. This was the cause of the reduced performance.
Based on our results, Tetra Engineering installed covering plates to reduce the bypass flow. This improved the boiler's performance and increased electricity production.
It is always satisfying when we can help solve complex challenges like this. Do your systems also need a check-up or optimization? Give us a call!
Work done in cooperation with James Malloy and David Moelling from Tetra Engineering.
More examples of our work https://www.r-r-consult.dk/en/cases-en/
Final project report on grocery store management system..pdfKamal Acharya
In today’s fast-changing business environment, it’s extremely important to be able to respond to client needs in the most effective and timely manner. If your customers wish to see your business online and have instant access to your products or services.
Online Grocery Store is an e-commerce website, which retails various grocery products. This project allows viewing various products available enables registered users to purchase desired products instantly using Paytm, UPI payment processor (Instant Pay) and also can place order by using Cash on Delivery (Pay Later) option. This project provides an easy access to Administrators and Managers to view orders placed using Pay Later and Instant Pay options.
In order to develop an e-commerce website, a number of Technologies must be studied and understood. These include multi-tiered architecture, server and client-side scripting techniques, implementation technologies, programming language (such as PHP, HTML, CSS, JavaScript) and MySQL relational databases. This is a project with the objective to develop a basic website where a consumer is provided with a shopping cart website and also to know about the technologies used to develop such a website.
This document will discuss each of the underlying technologies to create and implement an e- commerce website.
Cosmetic shop management system project report.pdfKamal Acharya
Buying new cosmetic products is difficult. It can even be scary for those who have sensitive skin and are prone to skin trouble. The information needed to alleviate this problem is on the back of each product, but it's thought to interpret those ingredient lists unless you have a background in chemistry.
Instead of buying and hoping for the best, we can use data science to help us predict which products may be good fits for us. It includes various function programs to do the above mentioned tasks.
Data file handling has been effectively used in the program.
The automated cosmetic shop management system should deal with the automation of general workflow and administration process of the shop. The main processes of the system focus on customer's request where the system is able to search the most appropriate products and deliver it to the customers. It should help the employees to quickly identify the list of cosmetic product that have reached the minimum quantity and also keep a track of expired date for each cosmetic product. It should help the employees to find the rack number in which the product is placed.It is also Faster and more efficient way.
Overview of the fundamental roles in Hydropower generation and the components involved in wider Electrical Engineering.
This paper presents the design and construction of hydroelectric dams from the hydrologist’s survey of the valley before construction, all aspects and involved disciplines, fluid dynamics, structural engineering, generation and mains frequency regulation to the very transmission of power through the network in the United Kingdom.
Author: Robbie Edward Sayers
Collaborators and co editors: Charlie Sims and Connor Healey.
(C) 2024 Robbie E. Sayers
Immunizing Image Classifiers Against Localized Adversary Attacksgerogepatton
This paper addresses the vulnerability of deep learning models, particularly convolutional neural networks
(CNN)s, to adversarial attacks and presents a proactive training technique designed to counter them. We
introduce a novel volumization algorithm, which transforms 2D images into 3D volumetric representations.
When combined with 3D convolution and deep curriculum learning optimization (CLO), itsignificantly improves
the immunity of models against localized universal attacks by up to 40%. We evaluate our proposed approach
using contemporary CNN architectures and the modified Canadian Institute for Advanced Research (CIFAR-10
and CIFAR-100) and ImageNet Large Scale Visual Recognition Challenge (ILSVRC12) datasets, showcasing
accuracy improvements over previous techniques. The results indicate that the combination of the volumetric
input and curriculum learning holds significant promise for mitigating adversarial attacks without necessitating
adversary training.
Industrial Training at Shahjalal Fertilizer Company Limited (SFCL)MdTanvirMahtab2
This presentation is about the working procedure of Shahjalal Fertilizer Company Limited (SFCL). A Govt. owned Company of Bangladesh Chemical Industries Corporation under Ministry of Industries.
NO1 Uk best vashikaran specialist in delhi vashikaran baba near me online vas...Amil Baba Dawood bangali
Contact with Dawood Bhai Just call on +92322-6382012 and we'll help you. We'll solve all your problems within 12 to 24 hours and with 101% guarantee and with astrology systematic. If you want to take any personal or professional advice then also you can call us on +92322-6382012 , ONLINE LOVE PROBLEM & Other all types of Daily Life Problem's.Then CALL or WHATSAPP us on +92322-6382012 and Get all these problems solutions here by Amil Baba DAWOOD BANGALI
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Student information management system project report ii.pdfKamal Acharya
Our project explains about the student management. This project mainly explains the various actions related to student details. This project shows some ease in adding, editing and deleting the student details. It also provides a less time consuming process for viewing, adding, editing and deleting the marks of the students.
Student information management system project report ii.pdf
Vitamin D And Chronic Periodontitis – A Randomised Double Blinded Placebo Controlled Parallel Clinical Trial
1. International Journal of Pharmaceutical Science Invention
ISSN (Online): 2319 – 6718, ISSN (Print): 2319 – 670X
www.ijpsi.org Volume 5 Issue 7 ‖ November 2016 ‖ PP. 12-15
www.ijpsi.org 12 | P a g e
Vitamin D And Chronic Periodontitis – A Randomised Double
Blinded Placebo Controlled Parallel Clinical Trial.
Nilofer Farjana H - Post graduate1
, Nithya Anand –Professor2
, Chandrasekaran
S -Professor and H.O.D3
Dept.of Periodontics Sree Balaji Dental College and Hospital, Pallikaranai,Chennai
Abstract:
Background: Vitamin D is crucial for a wide variety of organ systems; nevertheless, evidence has demonstrated
that vitamin D deficiency may place subjects at risk for not only low mineral bone density /osteoporosis and
osteopenia but also infectious and chronic inflammatory diseases Vitamin D also has anti-inflammatory effects
by suppressing pro-inflammatory cytokines through its effect on bone and mineral metabolism, innate immunity
and several VDR gene polymorphisms, vitamin D has been reported to be associated with periodontal disease.
Objectives: To assess anti-inflammatory effect of vitamin D3, when administered as monotherapy in generalised
chronic periodontitis.
Methods: This study comprises of 56 patients of generalised chronic periodontitis who were screened for their
serum vitamin D3 levels. Out of which 30 patients who were vitamin D3 deficient (<20ng/ml) formed the study
group. They were randomly given either vitamin D3 supplement or placebo. The Periodontal parameters and
RVG were taken before treatment and post treatment after 2 months.
Results: The results of this study indicate a probing pocket depth reduction in the vitamin D
supplement group. The post-treatment pocket depth is 5.3472 compared to 5.7661 in the pre-
treatment group. A correlation of 0.667 and statistically significant (p<0.002) reduction in
pocket depth is noted. Clinical attachment gain in the post-treatment group was 35.61 compared
to the pre-treatment mean value 33.72 indicating a statistically significant gain in the clinical
attachment (p<0.000).
Conclusion: Vitamin D deficiency may place subjects at risk for not only low bone mineral density/osteoporosis
and osteopenia, but also infectious and chronic inflammatory diseases like periodontitis.
Keywords: periodontitis, proinflammatory cytokines, vitamin D receptor.
I. Introduction
Traditionally, vitamin D has been associated with bone health, and it is well understood that vitamin D
deficiency leads to rickets in children and osteomalacia, osteoporosis in adults. However, it is now known that
adequate vitamin D status is important for optimal functioning of many organs and tissues throughout the body,
including the cardiovascular (CV) system. Vitamin D deficiency in addition to playing an important role in the
genesis of coronary risk factors and Cardio vascular diseases also predisposes to hypertension, diabetes, the
metabolic syndrome, left ventricular hypertrophy, congestive heart failure, and chronic vascular inflammation.
Vitamin D also has anti-inflammatory effects by suppressing pro-inflammatory cytokines, IFN-, TNF-, and
IL-12. Through its effect on bone and mineral metabolism, innate immunity, and several vitamin D receptor
gene polymorphisms, vitamin D has been reported to be associated with the periodontal diseases. The aim of
this randomised double-blinded placebo controlled parallel clinical trial was, to evaluate the serum level of
vitamin D3 among chronic periodontitis patients and to assess the outcome of vitamin D3 monotherapy on
periodontal status in chronic periodontitis patients who were deficient in vitamin D3 levels.
II. Materials and Methods
This study comprises of 56 patients of generalised chronic periodontitis who were screened for their
vitamin D3 levels by serum. Out of which 30 patients who were vitamin D3 deficient (<20ng/ml) formed the
study group. They were randomly given either vitamin D3 supplement or placebo. The periodontal parameters,
questionnaires and RVG were taken before treatment and post treatment of after 2 months.The inclusion
criteriacomprised individuals between the age group of 25-55 years with generalised chronic
periodontitis (probing depth of ≥5 mm and clinical attachment loss ≥ 3mm).The exclusion criteria
were individuals who had undergone periodontal therapy in the last 6 months with history of any
systemic illness such as diabetes, cardiovascular disease, gastrointestinal disturbances or
malabsorption syndrome, renal disorder and disorders in bone metabolism. Individuals who are
Pregnant, steroid therapy and bisphosphonate therapy were also excluded. Institutional ethical
2. Vitamin D And Chronic Periodontitis – A Randomised Double Blinded Placebo Controlled Parallel
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committee approval was obtained and registration of clinical trial was done.Patients were divided
into two groups vitamin D group and placebo group randomly by shuffle of cards method.
Vitamin D3 supplement- Commercially available D-rise vitamin D sachets (8 sachets, each
containing 1 gram Cholecalciferol- 60,000 IU, given in 8 small boxes for each patient) .The
Placebo was - Cellulose powder (8 small boxes for each patient).
Randomisation
III. Results
54 Patients who came to the Department of Periodontology, Sree Balaji Dental College
and Hospital and fulfilled the inclusion criteria were analysed for serum 25(OH) 2vitamin D3.
Individuals <20ng/ml were included in the study. They were randomly allocated to either vitamin
D supplement group or placebo group. Periodontal parameters were assessed. The data were
analysed using statistical package for social sciences (SPSS), version 17.0 statistical tools used
for analysis include paired t-test. The results indicate a probing pocket depth reduction in the
vitamin D supplement group; a post-treatment is 5.3472 compared to 5.7661 in the pre-treatment
group. The correlation is 0.667 and the reduction in probing depth is statistically significant
(p<0.002) [Table I]. Probing pocket depth is greater in the post-treatment, mean value of 7.8033
than in the pre-treatment mean value 5.8033, correlation is 0.813 [Table II]. Statistically
significant increase is seen in the post-treatment probing depth (p<0.001) [Table III]. Clinical
attachment gain in the post-treatment group of mean value 35.61 compared to the pre-treatment
mean value 33.72, correlation is 0.858. There is statistically significant gain in the clinical
attachment (p<0.000) [Table IV]. There is a significant loss of attachment in the placebo group
greater in the post-treatment value (mean=44.17) than in the pre-treatment value (mean=
39.67).Association between skin color and vitamin D deficiency indicate that 66.7% of dark skin
individuals are vitamin D deficient, showing more deficiency in the dark skin individual which is
not statistically significant [Table V] is. A combined intake of fish, diary and egg has less
vitamin D deficiency and elimination of diary intake indicates more vitamin D deficiency.[Table
VI]. It was noted that more females (73%) are vitamin D deficient compared to males (26.7%).
Table No.1: Table Shows Probing Pocket Depth in Vitamin D Supplement Group
Mean N Std. Deviation
Std. Error
Mean
Correlation
s
Sig.
p-value
Pre-treatment
5.7661 18 1.11314 .26237
.667 .002
Post-treatment
5.3472 18 1.69175 .39875
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INFERENCE:
This table shows probing pocket depth reduction in the vitamin D supplement group, post-treatment is 5.3472
compared to 5.7661 in the pre-treatment group. The correlation is 0.667 and the reduction in probing depth is
statistically significant (p>0.002).
Graph No 1: Graph showing comparison between pre-treatment and post-treatment probing pocket depth in
vitamin D supplement group.
Table No2: Table Shows Probing Pocket Depth in Placebo Group.
Mean N
Std.
Deviation
Std. Error
Mean
Correlati
ons
Sig.
Pre-treatment 5.8033 12 1.74464 .5017
.813 .001
Post-treatment 7.8033 12 1.74067 .50249
INFERENCE:
This table shows probing pocket depth is greater in the post-treatment, mean value of 7.8033 than in the pre-
treatment mean value 5.8033. Correlation is 0.813. Statistically significant increase is seen in the post-treatment
probing depth (p>0.001).
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Graph No 2: Graph showing comparison between pre-treatment and post-treatment probing pocket depth in
vitamin D supplement group.
Table No 3: Table Shows Clinical Attachment Level in Vitamin D Supplement Group
INFERENCE:
This table shows clinical attachment gain in the post-treatment group of mean value 35.61 compared to the pre-
treatment mean value 33.72. Correlation is 0.858. There is statistically significant gain in the clinical attachment
(p>0.000).
Mean N Std. Deviation Std. Error Mean
Correlations Sig.
Pre-treatment 35.61 18 9.983 2.353
.858 .000
Post-treatment 33.72 18 8.532 2.011
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Graph No 3: Graph showing comparison between pre-treatment and post-treatment clinical attachment level in
vitamin D supplement group.
Table No 4: Table Shows Clinical Attachment Level in the Placebo Group
INFERENCE:
This table shows loss of attachment in the placebo group greater in the post-treatment of mean value 44.17 than
in the pre-treatment mean value 39.67. The loss of clinical attachment is statistically significant (p>0.000).
Mean N Std. Deviation Std. Error Mean
Correlations Sig.
Pre-treatment 39.67 12 10.731 3.098
.901 .000
Post-treatment 44.17 12 9.183 2.651
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Graph No 4: Graph showing comparison between pre-treatment and post-treatment clinical attachment level in
placebo group.
Table No 5: Table Depicting Skin Color and its association with vitamin D deficiency
INFERENCE:
This table shows association between skin color and vitamin D deficiency by Pearson Chi-square test. Skin
color ranges from dark to fair. 66.7% of dark skin individuals are vitamin D deficient, showing more deficiency
in the dark skin individuals. The association is not statistically significant.
Vitamin D
deficient
Value P-Value
SKIN COLOR Dark Count 20
% of Total 66.7% 3.403 .182
Medium Count 6 3.555
% of Total 20.0% .169
Fair Count 4 .510 .475
% of Total 13.3%
Total Count 30
% of Total 100.0%
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Graph No 5: Graph Depicting Association between Skin Color and Vitamin D deficiency
Table No 6: Table Depicting Association Between Foods Taken with vitamin D deficiency
SUPPLEMENT GIVEN vitamin
D/Placebo
TotalCases Controls
FOODS
TAKEN
Nil Count 1 1 2
% of Total 3.3% 3.3% 6.7%
COD, Fish &
Egg
Count 1 1 2
% of Total 3.3% 3.3% 6.7%
Egg Only Count 2 1 3
% of Total 6.7% 3.3% 10.0%
Fish & Egg Count 13 7 20
% of Total 43.3% 23.3% 66.7%
Fish Only Count 1 1 2
% of Total 3.3% 3.3% 6.7%
Fish, Diary &
Egg
Count 0 1 1
% of Total .0% 3.3% 3.3%
Total Count 18 12 30
% of Total 60.0% 40.0% 100.0%
Chi-Square Tests
Value df p Value
Pearson Chi-Square 1.250a
2 .535
Likelihood Ratio 1.243 2 .537
Linear-by-Linear Association .242 1 .623
N of Valid Cases 30
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INFERENCE:
This table shows that a commonest intake fish, diary and egg of less have vitamin D deficiency. Elimination of
diary intake indicates more vitamin D deficiency. The association is not statistically significant.
Graph No 6: Graph Depicting Association Between foods taken and vitamin D deficiency
Table No 7: Table depicting association between vitamin D deficiency and gender.
SUPPLEMENT GIVEN
vitamin D/Placebo
TotalCases Controls
SEX Male Count 5 3 8
% of
Total
16.7% 10.0% 26.7%
Female Count 13 9 22
% of
Total
43.3% 30.0% 73.3%
Total Count 18 12 30
% of
Total
60.0% 40.0% 100.0%
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Chi-Square Tests
Value df p Value
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
Pearson Chi-Square .028 1 .866
Continuity Correction .000 1 1.000
Likelihood Ratio .029 1 .866
Fisher's Exact Test 1.000 .604
Linear-by-Linear
Association
.027 1 .868
N of Valid Cases 30
INFERENCE:
This table shows more females are vitamin D deficient. 73.3% of females are deficient compared to 26.7% of
males. Correlation is not statistically significant.
Graph No 7: Graph depicting association between vitamin D deficiency and gender.
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IV. Discussion
Most epidemiological data suggest that alveolar bone loss is greater in individuals with
low bone mass or osteoporosis Hilde bolt CF et al 19978
, although such an association is not
universally accepted (Phipps KR et al 2007). It is likely that low intake of vitamin D and calcium
may lead to negative calcium balance, thus causing a secondary increase in calcium removal from
bone, including alveolar bone. Such bone loss may contribute to weakening of tooth-attachment
apparatus.In addition to its action on skeletal homeostasis, vitamin D and in particular its
hormonally active form, 1 , 25 dihydroxyvitamin D, has anti-inflammatory and anti-microbial
effects via modulation of inflammatory cytokine production by immune cells and stimulated
secretion of peptides with anti-bacterial action by cells of monocyte-macrophage lineage, Walters
MR 199216
. These multiple actions of vitamin D are potentially appealing for the mana gement of
patients with periodontal disease, whose pathogenesis is based on chronic bacterial driven
inflammation. The inflammatory response leads to tissue destruction by direct action of bacterial
products or by activation of host defence cells and secretion of inflammatory mediators. These
locally produced factors eventually result in connective tissue breakdown and bone loss via
activation of osteoclast mediated bone resorption, Page RC 199714
.
Average vitamin D and calcium intakes in the general population are below current
recommendations of 400-600IU and 1,000 to 1,200mg daily, Moore C 200411
. Although there is
growing consensus that such daily targets are inadequate, and higher vitamin D intakes (800 -
1,000IU daily) are now recommended by professional organization(National Osteoporosis
foundation 2009). It was estimated that 1 billion people worldwide have vitamin D deficiency or
insufficiency, Holick MF 20067
, their potential role in periodontal disease has not been fully
determined. A number of studies, Dietrich T 20053
suggest that vitamin D and/or calcium intake
result in alveolar bone loss, gingival inflammation and/or attachment loss. Most relevant are data
on subjects (1,200) enrolled in the Third National Health and Survey (NHANES III), sugges ting
that lower dietary intake of calcium increased attachment loss in a dose -dependent fashion,
Nishida M 200013
. In another cohort (6,700 subjects), an association between serum
concentrations of 25-hydroxyvitamin D and gingival inflammation was found, possibly linked to
vitamin D’s anti-inflammatory effect, Dietrich T 20053
.
A potential role of vitamin D in periodontal health is supported by findings that
polymorphisms of the vitamin D receptor gene are associated with periodontitis, alveolar bone,
clinical attachment, and/or tooth loss Koji Inagaki I 200310
. Thus there is evidence pointing to a
potential role of vitamin D and calcium intake on dental health; however, the possible effects of
such dietary supplements on periodontal disease parameters and outcomes have not been
addressed.
Garcia et al 20115
stated that the role of biologically active form of vitamin D in bone and
calcium homeostasis demonstrated to function as an immunomodulatory because of its anti-
inflammatory effect through inhibition of cytokine production by immune cells and stimulation of
monocytes and macrophages to secrete peptides with potent antibiotic activity. This effect of
vitamin D has been linked to bacterial-mediated infections, with low levels of vitamin D being
associated with increased risk of infectious disease. Therefore vitamin D may be beneficial for
the treatment of periodontal disease, an inflammatory condition involving activation of host -
defense cells by bacterial release of inflammatory mediators, which results in the destruction of
supporting periodontal tissues, including connective tissue and alveolar bone.
In the study done by Al-Zahrani 20061
, showed an inverse association between the intake
of dairy products and prevalence of periodontitis. Controversially, in our study the prevalence of
periodontitis was found 3.3% higher in the non-takers of dairy products.Ever since the
publication of Hodgkin and colleagues on uncommon prevalence of vitamin D deficient
rickets/osteomalacia among Punjabis in India, no studies appeared assessing the vitamin D status
of subjects living in tropical and sub-tropical latitude of the India till 1995. Also there has been a
prevailing impression among medical professionals that abundance of sunlight prevents vitamin D
deficiency in India. However between 1995 and 2000. Kochupillai N 20089
showed evidence to
show that even doctors and nurses from northern latitude of India have vitamin D deficiency.
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These observations are confirmed by other authors for Southern part of the country, Harinarayan
CV 20076
. These reports thus scientifically establish evidence for prevalence of vitamin D
deficiency in the sub-continent, despite abundant light. In our study, 53% of individuals are
deficient in spite of living in tropical region. Country-wide preventive intervention, in the form
of milk and edible oil fortification with vitamin D would further enhance bone mineral metabolic
health in India.
Thomas K. Pilgram 199915
studied the relationship between the studies evaluating the
relationship between longitudinal changes in radiographic alveolar bone height in relation to
periodontal disease. They found weak correlations between changes in alveolar bone height. This
is similar to our study, where we evaluated the changes in the alveolar crestal bon e height before
and after treatment. It showed a positive correlation of increase in the crestal height of alveolar
bone.In the study done by, Garcia 20115
showed clinical parameters improvement on vitamin D
and calcium supplements for one year. In addition to its well-known activity in preventing rickets
and osteomalacia, 1, 25 (OH) 2D3 has been shown to have important anticancer, immune
modulatory and innate immune effects, through VDR activation. The 1 , 25 (OH) 2D3-VDR system
plays a role in oral homeostasis and its dysfunction may lead to periodontal disease. Vitamin D
research should make important contribution to oral medicine.
The results of this study indicate a probing pocket depth reduction in the vitamin D
supplement group. The post-treatment pocket depth is 5.3472 compared to 5.7661 in the pre-
treatment group. A correlation of 0.667 and statistically significant (p<0.002) reduction in pocket
depth is noted. Clinical attachment gain in the post-treatment group was 35.61 compared to the
pre-treatment mean value 33.72 indicating a statistically significant gain in the clinical
attachment (p<0.000).This was in accordance with the study done by
Garcia in 2011, where they concluded that improvement in the periodontal parameters (probing
pocket depth, clinical attachment, gingival index, bleeding sites) was found significant
(p<0.0001) in the vitamin D and calcium supplement takers than in the non-takers. This study
also recorded an increase in probing depth and loss of attachment post treatment in the pl acebo
group compared to pre-treatment values indicative of a progression of periodontitis as vitamin d
deficiency persisted. Radiographic findings reveal a gain in crestal bone height in the vitamin D
supplement group compared to the placebo where there were no changes. This was found in
accordance with the study done by D Douglas Miley in 20094
, where they concluded that vitamin
D supplement and calcium in takers showed a borderline significance improvement in the crestal
alveolar bone height.
Skin color has many reviews regarding its influence on cutaneous vitamin D synthesis.
Takiwaki H in 1998, Webb AR in 200617
proved that the cutaneous vitamin D synthesis decreases
with age. Skin color can be estimated subjectively by the observers using color scale. In our study
the association between skin color and vitamin D deficiency shows that as the skin color ranges
from dark to fair percentage of vitamin D deficiency decrease from 66.7% to 3.3% although the
association is not statistically significant. This is reinforced by the study done by Catherine A Mc
Carty in 20082
, where they found that sunlight exposure and vitamin D concentration was not
particularly high due to various factors affecting cutaneous vitamin D synthesis.The combined
intake of fish, diary and egg resulted in lesser deficiency values compared to individuals
consuming only eggs/fish. Elimination of diary intake indicates more vitamin D deficiency. In our
study the association found is not statistically significant. This is in accordance wi th the study
done by Al-Zahrani1
in 2006, in which he found an inverse association between intake of dairy
products and prevalence of periodontitis.
Another notable finding was that females were more vitamin D deficient (73.3%)
compared to males (26.7%). The association was not statistically significant. The probable
explanation could be that in a conservative society like ours women tend to stay more indoors
with less exposure to sunlight. In our study there was no prevalence of vitamin D deficiency
between the months of March and June.Similar facts was emphasized by Levis S in 2005 that
vitamin D deficiency exist for those who avoid sunlight, living indoors and residin g in the sub-
tropical lattitude. The patients who were takers of vitamin D supplements general showed good
compliance and improved in their general health status.
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V. Summary and conclusion
Vitamin D deficiency is endemic and associated with numerous serious diseases.
Understanding the physiology of vitamin D and having a high index of suspicion are keys to
making effective diagnosis. Periodontal disease results in the production of proinflammatory
cytokines, which also result in osteoclastogenesis. It follows that alveolar bone in patients with
periodontal disease and low levels of vitamin D and calcium should be under a heavier
osteoclastic load. Periodontal disease’s unique microbial aetiology, hard tissue environment, it
may be that the effect of vitamin D and calcium on alveolar bone is more pronounced. Perhaps a
new era in medicine, the vitamin D era is on the rise. Although the existence, depth and breadth
of any vitamin D era remain to be seen, a burgeoning literature points to horizons beyond our
vision.
References
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