Biomedical

1. Vitamin B6 deficiency
Rithikha Sri 114
Rohankumar 115

3. Source:
• Plants contain Vitamin B6 in pyridoxine form.
• Animals contain in form of PLP and Pyridoxamine
phosphate.
• Rich sources are:
Legumes
Nuts
Wheat bran
Meat, Fish
Fruits and Vegetables.

4. RDA(recommended daily
allowance):
• Adult: 2mg/day
• Children: 0.5 - 1 mg/day.

5. Biochemical functions:
PLP is the co-factor for more than 100 enzymes involved in
metabolism of amino acids.
Nutrient metabolism: Gluconeogenesis, Glycogenolysis
Carbohydrate, Homocysteine, lipid
Metabolism.
Hemoglobin synthesis: Synthesis of porphyrin
Neurological Functioning: Neurotransmitter synthesis
Immune function: Interleukin - 2 production.

6. • Vitamin B6 :
Absorption occurs in small
Intestine(jejunum)
⬇️
Metabolized to active form
In Liver
⬇️
Excreted in Urine.

7. Deficiency:
Vitamin B6 deficiency is rare but can be influenced
by certain drugs like isoniazid
penicillamine,cycloserine and L-dopa.
They can act as chemical antagonist to pyridoxine.

8. Clinical features:

9. Laboratory diagnosis:
Through Serum pyridoxal phosphate.
Low Plasma PLP value: <20nmol/L.

10. Treatment:
• 50 mg/day is given for deficiency
• For deficiency related medication
Use : higher dose of 100 - 200 mg/day given.
Toxicity:
safe upper limit: 100mg/day.
If toxicity occurs, It may cause
Sensory neuropathy
Photosensitivity
Dermatitis in some cases.

11. Reference:
1. Davidson essentials of medicine.
2. Harrison principle of internal medicine.

12. Thank you!