vitality™


           Dramatically improves medication
           adherence, through wireless packaging,
           reminders, reports, and rewards.




VITALITY
GlowCaps are recognized as important and innovative
This is what non-adherence looks like...
Each row is person, each column is a day. Red indicates a missed dose.




                     Control groups=70%
This is what adherence looks like with GlowCaps




                   Over 95%
cost effective



Existing studies have quantified the cost-
savings of high medication adherence:

                                  Low adherence High adherence                                   savings per
   Condition
                                    care costs    care costs                                        year

   Diabetes                               $8,867                        $4,570                       $4,297                48%


   High
                                         $6,888                         $3,924                       $2,964                43%
   Cholesterol
   High Blood
                                         $10,916                        $6,752                       $4,164                38%
   pressure
   Multiple
                                         $16,498                       $8,886                         $7,612               46%
   ailments
Medical Care, 2005, vol. 43, no6, pp. 521-530 SOKOL Michael C. ; MCGUIGAN Kimberly A. ; VERBRUGGE Robert R. ; EPSTEIN Robert S.
Source: IMS Health
Chronic disease affects 25% of adults in the US,
 yet most take medication 50% of the time.




VITALITY
Simple to use


• Plug it in to connect

• No PC, phone, or Internet required

• One-button refill
1) Pharmacist deliver your medication in a
GlowCap and explains how it works.
    “The smart pill cap will help you to remember with
    light, sound, and if you want, a reminder call.”
2) At home, you plug in the reminder light.
3) Every day, the GlowCap and reminder light
flash for an hour, then play a ring tone every few
minutes until you open the GlowCap.
4) If you forget, Vitality can call to remind you.
5) Weekly emails show which days you did,
or didn’t, take a medication.
6) Every month you receive a printed
progress report in the mail.
7) Cap embeds a “Push to refill” button




                                  =




                                      Patent pending
Vitality addresses each of the root causes of non-adherence
Adherence Issue        Vitality’s Approach


Forgetfulness          Reminders escalate from subtle to insistent

Poor Education         Personalized interactive media educates

No Social Support      Progress is shared with a buddy

No Accountability      Reports inform your doctor, via e-health record

Refill Inconvenience   Refill requests automatically flow into pharmacy


Low Motivation         Rewards motivate via loss aversion

    VITALITY                                                         confidential
Vitality addresses each of the root causes of non-adherence




 VITALITY
Working with Vitality: What you receive
   1) GlowCaps and Services
         • Wireless GlowCaps and Reminder light (cellular gateway)
         • Missed-dose calls
         • Weekly email summaries
         • Monthly printed reports mailed to patients’ homes
   2) Program Support
          • Dedicated IT administrative portal
          • eMail and printed reports customization
          • Customer surveys (periodic)
   3) Access to Real-Time Reports
         • Sort by condition, medication, member number, MPR, mean refill
         frequency, demographics, etc.
         • Consolidated physician reporting across patients
An unprecedented, secure data feed updates daily.

Vitality radar
  pharmacies
  CVS 145
  Walgreens 93
  Walmart 22
  Express Scripts 3
  RiteAid 1

  physicians
  Rose 1
  Smith 3
  Goldblatt, 8


  conditions
  Hypertension 65
  Asthma 3
  Diabetes 22


  medications
  Diovan 34
  Liptor 13
  Gleevec 5


  adherence
  >80%
  60-80%
  40-60%
  <40%
Vitality™

Contact:
David Rose
drose@Vitality.net
617 517 6037


One Broadway, 14th floor
Cambridge, MA 02142



VITALITY
APPENDIX

Patents pending
Medicine Bottle Cap with Embedded Curved Display
&'

     Medicine Bottle Cap with Embedded Trigger for Refilling
                       !!"#
                                                          !!"#


               $""                              $""




                                !!"#




                                   $""
Medication Compliance System, Method and Devices with
Configureable and Adaptable Escalation Engine
                                                                    115       External
        Local End                                  Back end
                                                                              Entities
 (e.g., Patient’s home)
                                                    Network Operations
  111                110                                               116
                                                    Center (NOC)
                                 Connector
          I                                                                     Doctor(s)
 112                                                              Patient
              Cap          106                                   Database
         S
        Medication                                                             Pharmacies
        Container                                    Learning
 108                             System              Algorithm
                                 manager
                                             102                                Other(s)
                                                     120
   Container                                                      Rules /
                                                                 Escalation
                                                       118        engine
         107                                 104
                                                                                 External
                                                                                messaging
 Peripheral
                            Feedback
  Sensors
                            Indicator
                                                           122
                                                                 Messaging
                             Messaging
                                                                  Platform
                    114      device(s)
Our patented learning engine adapts to the motivational
profile of each GlowCap owner to tailor services.


1. Enroll             2. Ingest               3. Survey                    4. Observe             Intervention plans
Patients via           Demographic             Attitudinal features        Patterns of behavior   Programs to motivate behavioral
pharmacy partner       features.               (ongoing)                                          change. Each intervention activates a
                                                                                                  specific personalty type, and has an
                                                                                                  associated $ and duration.


                                                                                                      Financial incentive
                                                                                                      Social incentives
                                                                                                      Strong social norming message
                                                                                                      Modality preference: SMS, paper
                                                          Bayesian classifier
                                                          statistically matches                       Doctor information sharing
       Profiles dB                                        interventions to people,
                                                          minimizing price while
        People features                                   optimizing behavioral
        and usage history                                 outcomes.
        is stored



                             Vitality Programs
                             Each individual is prescribed a tailored plan.
APPENDIX

Market details
Pharma   Vitality targets chronic asymptomatic
         conditions worth billions in drug sales
Pharma   Vitality targets chronic asymptomatic
         conditions worth billions in drug sales
Pharma   The market opportunity for a 25% lift in
         adherence amounts to over $24B.
Pharma
         The pharma market opportunity in
         heart disease alone is over $24B.

Vitality introduction 2010

  • 1.
    vitality™ Dramatically improves medication adherence, through wireless packaging, reminders, reports, and rewards. VITALITY
  • 2.
    GlowCaps are recognizedas important and innovative
  • 7.
    This is whatnon-adherence looks like... Each row is person, each column is a day. Red indicates a missed dose. Control groups=70%
  • 8.
    This is whatadherence looks like with GlowCaps Over 95%
  • 9.
    cost effective Existing studieshave quantified the cost- savings of high medication adherence: Low adherence High adherence savings per Condition care costs care costs year Diabetes $8,867 $4,570 $4,297 48% High $6,888 $3,924 $2,964 43% Cholesterol High Blood $10,916 $6,752 $4,164 38% pressure Multiple $16,498 $8,886 $7,612 46% ailments Medical Care, 2005, vol. 43, no6, pp. 521-530 SOKOL Michael C. ; MCGUIGAN Kimberly A. ; VERBRUGGE Robert R. ; EPSTEIN Robert S.
  • 10.
  • 11.
    Chronic disease affects25% of adults in the US, yet most take medication 50% of the time. VITALITY
  • 12.
    Simple to use •Plug it in to connect • No PC, phone, or Internet required • One-button refill
  • 13.
    1) Pharmacist deliveryour medication in a GlowCap and explains how it works. “The smart pill cap will help you to remember with light, sound, and if you want, a reminder call.”
  • 14.
    2) At home,you plug in the reminder light.
  • 15.
    3) Every day,the GlowCap and reminder light flash for an hour, then play a ring tone every few minutes until you open the GlowCap.
  • 16.
    4) If youforget, Vitality can call to remind you.
  • 17.
    5) Weekly emailsshow which days you did, or didn’t, take a medication.
  • 18.
    6) Every monthyou receive a printed progress report in the mail.
  • 19.
    7) Cap embedsa “Push to refill” button = Patent pending
  • 20.
    Vitality addresses eachof the root causes of non-adherence Adherence Issue Vitality’s Approach Forgetfulness Reminders escalate from subtle to insistent Poor Education Personalized interactive media educates No Social Support Progress is shared with a buddy No Accountability Reports inform your doctor, via e-health record Refill Inconvenience Refill requests automatically flow into pharmacy Low Motivation Rewards motivate via loss aversion VITALITY confidential
  • 21.
    Vitality addresses eachof the root causes of non-adherence VITALITY
  • 22.
    Working with Vitality:What you receive 1) GlowCaps and Services • Wireless GlowCaps and Reminder light (cellular gateway) • Missed-dose calls • Weekly email summaries • Monthly printed reports mailed to patients’ homes 2) Program Support • Dedicated IT administrative portal • eMail and printed reports customization • Customer surveys (periodic) 3) Access to Real-Time Reports • Sort by condition, medication, member number, MPR, mean refill frequency, demographics, etc. • Consolidated physician reporting across patients
  • 23.
    An unprecedented, securedata feed updates daily. Vitality radar pharmacies CVS 145 Walgreens 93 Walmart 22 Express Scripts 3 RiteAid 1 physicians Rose 1 Smith 3 Goldblatt, 8 conditions Hypertension 65 Asthma 3 Diabetes 22 medications Diovan 34 Liptor 13 Gleevec 5 adherence >80% 60-80% 40-60% <40%
  • 24.
    Vitality™ Contact: David Rose drose@Vitality.net 617 5176037 One Broadway, 14th floor Cambridge, MA 02142 VITALITY
  • 25.
  • 26.
    Medicine Bottle Capwith Embedded Curved Display
  • 27.
    &' Medicine Bottle Cap with Embedded Trigger for Refilling !!"# !!"# $"" $"" !!"# $""
  • 28.
    Medication Compliance System,Method and Devices with Configureable and Adaptable Escalation Engine 115 External Local End Back end Entities (e.g., Patient’s home) Network Operations 111 110 116 Center (NOC) Connector I Doctor(s) 112 Patient Cap 106 Database S Medication Pharmacies Container Learning 108 System Algorithm manager 102 Other(s) 120 Container Rules / Escalation 118 engine 107 104 External messaging Peripheral Feedback Sensors Indicator 122 Messaging Messaging Platform 114 device(s)
  • 29.
    Our patented learningengine adapts to the motivational profile of each GlowCap owner to tailor services. 1. Enroll 2. Ingest 3. Survey 4. Observe Intervention plans Patients via Demographic Attitudinal features Patterns of behavior Programs to motivate behavioral pharmacy partner features. (ongoing) change. Each intervention activates a specific personalty type, and has an associated $ and duration. Financial incentive Social incentives Strong social norming message Modality preference: SMS, paper Bayesian classifier statistically matches Doctor information sharing Profiles dB interventions to people, minimizing price while People features optimizing behavioral and usage history outcomes. is stored Vitality Programs Each individual is prescribed a tailored plan.
  • 30.
  • 31.
    Pharma Vitality targets chronic asymptomatic conditions worth billions in drug sales
  • 32.
    Pharma Vitality targets chronic asymptomatic conditions worth billions in drug sales
  • 33.
    Pharma The market opportunity for a 25% lift in adherence amounts to over $24B.
  • 34.
    Pharma The pharma market opportunity in heart disease alone is over $24B.