This presentation outlines a breakthrough early stage cancer detection system developed by the BC Cancer Agency and UBC called Verisante Aura. It uses patented near infrared Raman spectroscopy technology to detect skin cancer with 97% accuracy for melanoma and 91% for other skin cancers. Clinical trials showed significantly higher accuracy than traditional clinical diagnosis. The system provides real-time results without biopsies and plans to expand to other cancer types. It has the potential for widespread adoption and significant cost savings if it achieves regulatory approval and market penetration goals.
Skin cancer exposed - Background informationXplore Health
This guide provides background information on melanoma, the most serious type of skin cancer. Explore all aspects of melanoma from the causes to treatment. Investigate the latest research, and uncover the ethical, legal and social issues surrounding this disease.
Skin cancer exposed - Background informationXplore Health
This guide provides background information on melanoma, the most serious type of skin cancer. Explore all aspects of melanoma from the causes to treatment. Investigate the latest research, and uncover the ethical, legal and social issues surrounding this disease.
Melanoma is the most serious type of skin cancer. Often the first sign of melanoma is a change in the size, shape, color or feel of a mole. Most melanomas have a black or black-blue area. Melanoma may also appear as a new mole. It may be black, abnormal or "ugly looking."
Thinking of "ABCD" can help you remember what to watch for:
Asymmetry - the shape of one half does not match the other
Border - the edges are ragged, blurred or irregular
Color - the color is uneven and may include shades of black, brown and tan
Diameter - there is a change in size, usually an increase
Melanoma can be cured if it is diagnosed and treated early. If melanoma is not removed in its early stages, cancer cells may grow downward from the skin surface and invade healthy tissue. If it spreads to other parts of the body it can be difficult to control.
A presentation created by Dr. Henry N. Ho, Medical Director, Head and Neck Program, Florida Hospital Cancer Institute, discussing everything you need to know about head and neck melanoma.
Malignant melanoma is one of the most aggressive neoplasms of the skin. It originates from the melanocytes, which are cells derived embryologically from the neural crest and migrate to the epidermal basal layer. It is characterized by producing pigmentation as well as being susceptible to metastasis. We report the case of a 36-year-old female patient with advanced clinical stage and distant commitment. The biopsy confirmed the presence of Grade III invasive nodular cutaneous melanoma in the left subscapular region with lymph node metastasis with reactive hyperplasia. An exploratory research is carried out with the bibliographic review in scientific journals with evidence level II–IV. In portals PubMed, Redalyc, BVS, and UpToDate. 81241 met criteria 2248 of which 629 were chosen for having access to the full text and of these 496 are more current (as of 2008), and in the end, 27 articles were selected that met all the inclusion criteria to this article. Due to the increase in the incidence of this disease in recent years and its poor prognosis in short to medium term, it is important to know and follow-up on patients with known risk factors for this disease such as the presence of previous nevi, with emphasis on measures of prevention.
Dr Patrick Treacy on Diagnosis and Treatment of Malignant Melanoma Dr. Patrick J. Treacy
A 23-year-old Siberian female patient presented with a changing lesion on her abdomen. The patient stated the lesion was present for about two years and it started
off from within a freckle, which started to grow larger and somewhat darken in appearance. It had the clinical appearance of a melanoma and the dermoscopy three-point checklist (designed to allow non-experts not to miss detection of melanomas) was used to determine whether this had a high likelihood of malignancy. It included:
Asymmetry: asymmetry of colour and structure in one or
two perpendicular axes
Atypical network: pigment network with irregular holes
and thick lines
Blue-white structures: there was some evidence of blue-
white veil and regression structures
MELA Sciences - Poster of the Day - Winter Clinical Dermatology ConferenceMELASciences
MELA Sciences Inc. (NASDAQ:MELA) poster wins Poster of the Day at Winter Clinical Derm Conf in HI.
Physical Properties, Novel Features and Clinical Validation of a Multispectral Digital Skin Lesion Analysis Device for Melanoma Detection
MelaFind is a multispectral digital skin lesion analysis device for melanoma detection and works as a non-invasive, objection computer vision system helping dermatologists in the detection of melanoma. By combining multispectral data acquisition with automatic quantitative analysis, this lesion classifier uses 75 features to evaluate the degree of 3-D morphological disorganization of pigmented lesions.
The MelaFind lesion classifier produces scores that range from -5.25 to +9.00, with scores below zero considered to be “low disorganization” and scores above to be considered “high disorganization.” A large prospective clinical study of melanoma detection showed sensitivity to melanoma and high-grade dysplastic lesions to be 98.3% with statistically higher biopsy specificity than dermatologists. In this poster, which evaluated over 1600 lesions, the average classifier score of melanomas, high-grade lesions, and non-melanoma/high grade lesions were 3.5, 2.7, and 1.6, respectively. This study validates MelaFind as a validated tool capable of aiding the dermatologist by capturing information that is not visible to the human eye to aid in the detection of high-grade dysplastic lesions as well as melanoma.
Nathan Halsey, of Dallas, Texas, is CEO of Bellatorra Skin Care, a luxury skin care and cosmetics company. Mr. Halsey is also a director of Bonamour Skin Care, and Bonamour International.
Nathan Halsey, of Dallas, Texas, is CEO of Bellatorra Skin Care LLC and a Director with Bonamour International LLC, both skin care & cosmetics companies.
The SlideShare 101 is a quick start guide if you want to walk through the main features that the platform offers. This will keep getting updated as new features are launched.
The SlideShare 101 replaces the earlier "SlideShare Quick Tour".
No need to wonder how the best on SlideShare do it. The Masters of SlideShare provides storytelling, design, customization and promotion tips from 13 experts of the form. Learn what it takes to master this type of content marketing yourself.
Melanoma is the most serious type of skin cancer. Often the first sign of melanoma is a change in the size, shape, color or feel of a mole. Most melanomas have a black or black-blue area. Melanoma may also appear as a new mole. It may be black, abnormal or "ugly looking."
Thinking of "ABCD" can help you remember what to watch for:
Asymmetry - the shape of one half does not match the other
Border - the edges are ragged, blurred or irregular
Color - the color is uneven and may include shades of black, brown and tan
Diameter - there is a change in size, usually an increase
Melanoma can be cured if it is diagnosed and treated early. If melanoma is not removed in its early stages, cancer cells may grow downward from the skin surface and invade healthy tissue. If it spreads to other parts of the body it can be difficult to control.
A presentation created by Dr. Henry N. Ho, Medical Director, Head and Neck Program, Florida Hospital Cancer Institute, discussing everything you need to know about head and neck melanoma.
Malignant melanoma is one of the most aggressive neoplasms of the skin. It originates from the melanocytes, which are cells derived embryologically from the neural crest and migrate to the epidermal basal layer. It is characterized by producing pigmentation as well as being susceptible to metastasis. We report the case of a 36-year-old female patient with advanced clinical stage and distant commitment. The biopsy confirmed the presence of Grade III invasive nodular cutaneous melanoma in the left subscapular region with lymph node metastasis with reactive hyperplasia. An exploratory research is carried out with the bibliographic review in scientific journals with evidence level II–IV. In portals PubMed, Redalyc, BVS, and UpToDate. 81241 met criteria 2248 of which 629 were chosen for having access to the full text and of these 496 are more current (as of 2008), and in the end, 27 articles were selected that met all the inclusion criteria to this article. Due to the increase in the incidence of this disease in recent years and its poor prognosis in short to medium term, it is important to know and follow-up on patients with known risk factors for this disease such as the presence of previous nevi, with emphasis on measures of prevention.
Dr Patrick Treacy on Diagnosis and Treatment of Malignant Melanoma Dr. Patrick J. Treacy
A 23-year-old Siberian female patient presented with a changing lesion on her abdomen. The patient stated the lesion was present for about two years and it started
off from within a freckle, which started to grow larger and somewhat darken in appearance. It had the clinical appearance of a melanoma and the dermoscopy three-point checklist (designed to allow non-experts not to miss detection of melanomas) was used to determine whether this had a high likelihood of malignancy. It included:
Asymmetry: asymmetry of colour and structure in one or
two perpendicular axes
Atypical network: pigment network with irregular holes
and thick lines
Blue-white structures: there was some evidence of blue-
white veil and regression structures
MELA Sciences - Poster of the Day - Winter Clinical Dermatology ConferenceMELASciences
MELA Sciences Inc. (NASDAQ:MELA) poster wins Poster of the Day at Winter Clinical Derm Conf in HI.
Physical Properties, Novel Features and Clinical Validation of a Multispectral Digital Skin Lesion Analysis Device for Melanoma Detection
MelaFind is a multispectral digital skin lesion analysis device for melanoma detection and works as a non-invasive, objection computer vision system helping dermatologists in the detection of melanoma. By combining multispectral data acquisition with automatic quantitative analysis, this lesion classifier uses 75 features to evaluate the degree of 3-D morphological disorganization of pigmented lesions.
The MelaFind lesion classifier produces scores that range from -5.25 to +9.00, with scores below zero considered to be “low disorganization” and scores above to be considered “high disorganization.” A large prospective clinical study of melanoma detection showed sensitivity to melanoma and high-grade dysplastic lesions to be 98.3% with statistically higher biopsy specificity than dermatologists. In this poster, which evaluated over 1600 lesions, the average classifier score of melanomas, high-grade lesions, and non-melanoma/high grade lesions were 3.5, 2.7, and 1.6, respectively. This study validates MelaFind as a validated tool capable of aiding the dermatologist by capturing information that is not visible to the human eye to aid in the detection of high-grade dysplastic lesions as well as melanoma.
Nathan Halsey, of Dallas, Texas, is CEO of Bellatorra Skin Care, a luxury skin care and cosmetics company. Mr. Halsey is also a director of Bonamour Skin Care, and Bonamour International.
Nathan Halsey, of Dallas, Texas, is CEO of Bellatorra Skin Care LLC and a Director with Bonamour International LLC, both skin care & cosmetics companies.
The SlideShare 101 is a quick start guide if you want to walk through the main features that the platform offers. This will keep getting updated as new features are launched.
The SlideShare 101 replaces the earlier "SlideShare Quick Tour".
No need to wonder how the best on SlideShare do it. The Masters of SlideShare provides storytelling, design, customization and promotion tips from 13 experts of the form. Learn what it takes to master this type of content marketing yourself.
10 Ways to Win at SlideShare SEO & Presentation OptimizationOneupweb
Thank you, SlideShare, for teaching us that PowerPoint presentations don't have to be a total bore. But in order to tap SlideShare's 60 million global users, you must optimize. Here are 10 quick tips to make your next presentation highly engaging, shareable and well worth the effort.
For more content marketing tips: http://www.oneupweb.com/blog/
SlideShare now has a player specifically designed for infographics. Upload your infographics now and see them take off! Need advice on creating infographics? This presentation includes tips for producing stand-out infographics. Read more about the new SlideShare infographics player here: http://wp.me/p24NNG-2ay
This infographic was designed by Column Five: http://columnfivemedia.com/
Are you new to SlideShare? Are you looking to fine tune your channel plan? Are you using SlideShare but are looking for ways to enhance what you're doing? How can you use SlideShare for content marketing tactics such as lead generation, calls-to-action to other pieces of your content, or thought leadership? Read more from the CMI team in their latest SlideShare presentation on SlideShare.
How to Make Awesome SlideShares: Tips & TricksSlideShare
Turbocharge your online presence with SlideShare. We provide the best tips and tricks for succeeding on SlideShare. Get ideas for what to upload, tips for designing your deck and more.
Deciphering Your Skin Cancer Diagnosis and the Options Available.pdfMole Check Clinic
Every year, a large number of Australians receive skin cancer diagnosis; nevertheless, non-melanoma skin malignancies account for the majority of these cases.
Melanoma is a particularly dangerous type of skin cancer and is hard to treat in its later stages. Therefore, early detection is key in reducing mortality rates. In order to assist dermatologists in doing this, computer-aided systems have been designed for desktop computers. However, there is a desire for the development of mobile, at-home diagnostics for melanoma risk assessment. Here, we introduce a smartphone application that captures images and extracts ABCD features to classify skin lesions as either malignant or benign. The algorithms used are adaptive to make the process light and user-friendly, as well as reliable in diagnosis. Images can be taken with the phone's camera or imported from public datasets. The entire process of taking the image, performing preprocessing, segmentation and classification is completed on an Android smartphone in a short time. Our application is evaluated on a dataset of 200 images, and achieved either comparable or better performance metrics than other methods. Additionally, it is easy-to-download and easy-to-navigate for the user, which is important for the widespread use of such diagnostics.
Kalwa, U.; Legner, C.; Kong, T.; Pandey, S. Skin Cancer Diagnostics with an All-Inclusive Smartphone Application. Symmetry 2019, 11, 790. https://doi.org/10.3390/sym11060790
https://www.mdpi.com/2073-8994/11/6/790
SkinCure: An Innovative Smart Phone Based Application to Assist in Melanoma E...sipij
Melanoma spreads through metastasis, and therefore it has been proven to be very fatal. Statistical
evidence has revealed that the majority of deaths resulting from skin cancer are as a result of melanoma.
Further investigations have shown that the survival rates in patients depend on the stage of the infection;
early detection and intervention of melanoma implicates higher chances of cure. Clinical diagnosis and
prognosis of melanoma is challenging since the processes are prone to misdiagnosis and inaccuracies due
to doctors’ subjectivity. This paper proposes an innovative and fully functional smart-phone based
application to assist in melanoma early detection and prevention. The application has two major
components; the first component is a real-time alert to help users prevent skin burn caused by sunlight; a
novel equation to compute the time for skin to burn is thereby introduced. The second component is an
automated image analysis module which contains image acquisition, hair detection and exclusion, lesion
segmentation, feature extraction, and classification. The proposed system exploits PH2 Dermoscopy image
database from Pedro Hispano Hospital for development and testing purposes. The image database
contains a total of 200 dermoscopy images of lesions, including normal, atypical, and melanoma cases.
The experimental results show that the proposed system is efficient, achieving classification of the normal,
atypical and melanoma images with accuracy of 96.3%, 95.7% and 97.5%, respectively.
Among the different types of skin cancer, melanoma is considered to be the deadliest and is difficult to treat at advanced stages. Detection of melanoma at earlier stages can lead to reduced mortality rates. Desktop-based computer-aided systems have been developed to assist dermatologists with early diagnosis. However, there is significant interest in developing portable, at-home melanoma diagnostic systems which can assess the risk of cancerous skin lesions. Here, we present a smartphone application that combines image capture capabilities with preprocessing and segmentation to extract the Asymmetry, Border irregularity, Color variegation, and Diameter (ABCD) features of a skin lesion. Using the feature sets, classification of malignancy is achieved through support vector machine classifiers. By using adaptive algorithms in the individual data-processing stages, our approach is made computationally light, user friendly, and reliable in discriminating melanoma cases from benign ones. Images of skin lesions are either captured with the smartphone camera or imported from public datasets. The entire process from image capture to classification runs on an Android smartphone equipped with a detachable 10x lens, and processes an image in less than a second. The overall performance metrics are evaluated on a public database of 200 images with Synthetic Minority Over-sampling Technique (SMOTE) (80% sensitivity, 90% specificity, 88% accuracy, and 0.85 area under curve (AUC)) and without SMOTE (55% sensitivity, 95% specificity, 90% accuracy, and 0.75 AUC). The evaluated performance metrics and computation times are comparable or better than previous methods. This all-inclusive smartphone application is designed to be easy-to-download and easy-to-navigate for the end user, which is imperative for the eventual democratization of such medical diagnostic systems.
Melanoma: Prevention, Detection and Treatment - Stephanie Badalamenti, MD - L...Summit Health
Sun safety needs to start at an early age, and continue throughout life, in order to reduce the risk for skin cancer. Learn about prevention and ways to reduce your risk, screening for skin cancer and innovations in treatments.
Johnny Depp Long Hair: A Signature Look Through the Yearsgreendigital
Johnny Depp, synonymous with eclectic roles and unparalleled acting prowess. has also been a significant figure in fashion and style. Johnny Depp long hair is a distinctive trademark among the various elements that define his unique persona. This article delves into the evolution, impact. and cultural significance of Johnny Depp long hair. exploring how it has contributed to his iconic status.
Follow us on: Pinterest
Introduction
Johnny Depp is an actor known for his chameleon-like ability to transform into a wide range of characters. from the eccentric Captain Jack Sparrow in "Pirates of the Caribbean" to the introspective Edward Scissorhands. His long hair is one constant throughout his evolving roles and public appearances. Johnny Depp long hair is not a style choice but a significant aspect of his identity. contributing to his allure and mystique. This article explores the journey and significance of Johnny Depp long hair. highlighting how it has become integral to his brand.
The Early Years: A Budding Star with Signature Locks
1980s: The Rise of a Young Heartthrob
Johnny Depp's journey in Hollywood began in the 1980s. with his breakout role in the television series "21 Jump Street." During this time, his hair was short, but it was already clear that Depp had a penchant for unique and edgy styles. By the decade's end, Depp started experimenting with longer hair. setting the stage for a lifelong signature.
1990s: From Heartthrob to Icon
The 1990s were transformative for Johnny Depp his career and personal style. Films like "Edward Scissorhands" (1990) and "Benny & Joon" (1993) saw Depp sporting various hair lengths and styles. But, his long, unkempt hair in "What's Eating Gilbert Grape" (1993) began to draw significant attention. This period marked the beginning of Johnny Depp long hair. which became a defining feature of his image.
The Iconic Roles: Hair as a Character Element
Edward Scissorhands (1990)
In "Edward Scissorhands," Johnny Depp's character had a wild and mane that complemented his ethereal and misunderstood persona. This role showcased how long hair Johnny Depp could enhance a character's depth and mystery.
Captain Jack Sparrow: The Pirate with Flowing Locks
One of Johnny Depp's iconic roles is Captain Jack Sparrow from the "Pirates of the Caribbean" series. Sparrow's long, dreadlocked hair symbolised his rebellious and unpredictable nature. The character's look, complete with beads and trinkets woven into his hair. was a collaboration between Depp and the film's costume designers. This style became iconic and influenced fashion trends and Halloween costumes worldwide.
Other Memorable Characters
Depp's long hair has also been featured in other roles, such as Ichabod Crane in "Sleepy Hollow" (1999). and Roux in "Chocolat" (2000). In these films, his hair added a layer of authenticity and depth to his characters. proving that Johnny Depp with long hair is more than a style—it's a storytelling tool.
Off-Screen Influenc
Have you ever wondered about the lost city of Atlantis and its profound connection to our modern world? Ruth Elisabeth Hancock’s podcast, “Visions of Atlantis,” delves deep into this intriguing topic in a captivating conversation with Michael Le Flem, author of the enlightening book titled “Visions of Atlantis.” This podcast episode offers a thought-provoking blend of historical inquiry, esoteric wisdom, and contemporary reflections. Let’s embark on a journey of discovery as we unpack the mysteries of ancient civilizations and their relevance to our present existence.
From Stress to Success How Oakland's Corporate Wellness Programs are Cultivat...Kitchen on Fire
Discover how Oakland's innovative corporate wellness initiatives are transforming workplace culture, nurturing the well-being of employees, and fostering a thriving environment. From comprehensive mental health support to flexible work arrangements and holistic wellness workshops, these programs are empowering individuals to navigate stress effectively, leading to increased productivity, satisfaction, and overall success.
Is your favorite ring slipping and sliding on your finger? You're not alone. Must Read this Guide on What To Do If Your Ring Is Too Big as shared by the experts of Andrews Jewelers.
MRS PUNE 2024 - WINNER AMRUTHAA UTTAM JAGDHANEDK PAGEANT
Amruthaa Uttam Jagdhane, a stunning woman from Pune, has won the esteemed title of Mrs. India 2024, which is given out by the Dk Exhibition. Her journey to this prestigious accomplishment is a confirmation of her faithful assurance, extraordinary gifts, and profound commitment to enabling women.
Care Instructions for Activewear & Swim Suits.pdfsundazesurf80
SunDaze Surf offers top swimwear tips: choose high-quality, UV-protective fabrics to shield your skin. Opt for secure fits that withstand waves and active movement. Bright colors enhance visibility, while adjustable straps ensure comfort. Prioritize styles with good support, like racerbacks or underwire tops, for active beach days. Always rinse swimwear after use to maintain fabric integrity.
La transidentité, un sujet qui fractionne les FrançaisIpsos France
Ipsos, l’une des principales sociétés mondiales d’études de marché dévoile les résultats de son étude Ipsos Global Advisor “Pride 2024”. De ses débuts aux Etats-Unis et désormais dans de très nombreux pays, le mois de juin est traditionnellement consacré aux « Marches des Fiertés » et à des événements festifs autour du concept de Pride. A cette occasion, Ipsos a réalisé une enquête dans vingt-six pays dressant plusieurs constats. Les clivages des opinions entre générations s’accentuent tandis que le soutien à des mesures sociétales et d’inclusion en faveur des LGBT+ notamment transgenres continue de s’effriter.
2. 2
Forward Looking Statements
This presentation contains certain forward-looking statements. These
statements relate to future events or future performance and reflect
management’s expectations and assumptions regarding growth,
results of operations, performance and business prospects and
opportunities. Such forward-looking statements reflect
management’s current beliefs and are based on information
currently available to management.
A number of factors could cause actual events to differ materially. In
evaluating these statements, prospective purchasers should
specifically consider various risks as more fully outlined in the
prospectus, a copy of which can be obtained online at
www.sedar.com.
2
3. 3
“There’s an epidemic of skin cancer”
- Howard Rogers, Dermatologist, Lead on Medicare research
Skin cancer strikes 1 in 5 in the U.S.1
It is the most common form of cancer
40-50% of Americans who live to 65 expected to get skin cancer 2
Melanoma kills one person every hour in the US 3
Melanoma is the #1 cancer killer of women 25-30 4
Incidence of melanoma rising faster than any other cancer 5
Melanoma is Deadly
Accounts for 75% of
skin cancer deaths6
3
4. 4
Early detection vital to saving lives
100 95% Melanoma Five Year Survival Rate by Tumor Stage 6
80
60
40
20
15%
0
Stage I Stage II Stage III Stage IV
5. 5
Early detection would save billions of dollars
2 million Americans get skin cancer each year 7 Cost of Treating Melanoma
by Tumor Stage (per patient) 9
Treating melanoma alone costs $1.5 billion 110.1
($ US thousands)
annually in the U.S. 8 105.5
Advanced stage melanoma 22 times more
costly to treat than early stage
35.4 38.3
22.5 24.3
11.0 13.7
5.0
Early Stage Late Stage
6. 6
Current skin cancer detection methods limited
Primary diagnosis done by GPs with varying
Clinical Diagnosis Histological Diagnosis
levels of experience
Full body examinations seldom conducted
33.8% sensitivity for melanoma for GPs 10
› Squamous Cell Carcinoma – 41.1%
› Basal Cell Carcinoma – 63.9%
Punch Biopsy
Biopsies invasive and costly
› Permanent scarring
~80% of biopsies test negative 11
7. 7
Breakthrough early stage cancer detection system
Initial Focus: Early detection of skin cancer
Detects melanoma with 97% accuracy vs. 33.8%
for primary clinical diagnosis
All forms of
Skin Cancer
Developed by BC Cancer Agency and UBC
Patented technology
Exclusively licensed to Verisante Technology, Inc.
Gastrointestinal,
Lung, and Cervical
Cancers
8. 8
Highly automated detection process
Skin cancer: Verisante AuraTM
Near Infrared Raman
Pathology on Spectroscopy
every lesion scanned
Differentiates between
malignant and benign tissue Handheld probe scans
for 21 biomarkers in
an instant
Provides data on chemical
composition of skin based Rapid speed enables
on molecular vibrations full body scans
9. 9
Highly automated detection process
Skin cancer: Verisante AuraTM
Safe, Non-invasive, Fast
Increased survival rates
Reduced treatment costs
No unnecessary biopsies
Reduced waiting times
Real time results
97% accurate for melanoma
91% for other skin cancers
10. 10
Proven in clinical trials by the BC Cancer Agency
Skin cancer: Verisante AuraTM
6 year clinical study at Vancouver General
Hospital’s Skin Care Center Melanoma
97% sensitivity
Focused on differentiating cancerous lesions “Percentage identified”
from benign lesions 78% specificity
“Confirmed by biopsy”
1,000 skin lesions scanned
Preliminary results published in 2008 based on Cancerous and Precancerous Lesions
274 lesions 12
91% sensitivity
“Percentage identified”
75% specificity
“Confirmed by biopsy”
11. 11
Superior technology over competing systems
Verisante Aura™ Scibase Inc.
• Electrical Impedance Spectroscopy
Proven technology • 98% sensitivity; specificity < 5%
• Slightly invasive
Detects all skin cancers • 5 minutes per lesion
• Large probe/expensive disposables
97% Sensitivity; 78% Specificity Mela Sciences
for melanoma
• Computerized Imaging Technology
• FDA Panel recommends approval by narrow margin
Measures 21 biomarkers • Key Concern: too many false positives
• 98% sensitivity; 9.5% specificity
Virtually instant scan • Large probe
Lucid Inc.
Non-invasive
• Confocal Microscopy
Tiny Probe • 10-20 min. per lesion
• Dermatologist required
• Large probe
Inexpensive disposable covers
12. 12
Endoscopic system enables detection of other cancers
Verisante CoreTM
Clinical studies underway at VGH for early detection of lung & colon cancer
Lung Cancer 13
World’s #1 cancer killer with
1.4 million deaths/year
Colon Cancer
#2 deadliest cancer in U.S.
Cervical Cancer
World’s #2 cause of cancer
deaths among women
13. 13
Strong scientific pedigree
Focused on developing systems for the early detection of cancer
Dr. Branko Palcic
Ph.D.
• Honorary Professor, Dept. of Pathology and Laboratory Medicine, UBC
• Founder, Cancer Imaging and Technology Departments, BC Cancer Agency
• Co-inventor of LIFE-Lung device, used in over 150 major medical centers world-wide
• Friesen-Rygiel Award for Outstanding Canadian Academic Discovery (1999)
• King George V Silver Jubilee Cancer Research Fellow
Dr. Haishan Zeng
Ph.D.
• Senior Scientist, Integrative Oncology Dept. BC Cancer Agency
• Associate Professor, Dermatology and Skin Science, University of British Columbia
• Co-inventor - Verisante™ technology
14. 14
Strong scientific pedigree
Focused on developing systems for the early detection of cancer
Dr. David McLean
MD, FRCPC
• Professor, Dept. of Dermatology and Skin Science, UBC
• President, Cancer Prevention Institute of Canada
• Former President, Canadian Dermatology Association
• Co-inventor - Verisante™ technology
Dr. Harvey Lui
MD, FRCPC
• Professor and Head, Dept. of Dermatology and Skin Science, UBC
• Former Clinical Fellow, Massachusetts General Hospital, Harvard Medical School
• University Killam Prize (2001)
• Co-inventor - Verisante™ technology
15. 15
Clear regulatory pathway to commercialization
Skin cancer: Verisante AuraTM
2010 2011 2012 2013 2014 2015
Production Prototype &
Health Canada Approval Marketing and Sales (Canada)
CE Mark Marketing and Sales (EU, South Africa, Australia)
Clinical Study Clinical Study
Prep. USA
Approval Marketing and Sales (USA)
16. 16
Significant market potential with multiple end users
Skin cancer: Verisante AuraTM
Initial Geographic Markets Staged Rollout Strategy
Recurring revenue from sale of disposable probe shields
STEP 1
Early adopters
~32,000 Dermatologists
Canada
EU
USA
STEP 2
Innovators
South ~950,000 General Practitioners
Africa
STEP 3
Australia Skin Care Clinics
NZ Oncology and Imaging Clinics
HMOs
17. 17
Initial focus on early adopters and innovators
Will drive broader market acceptance
2000
Targeting 14%
penetration by year 5
1600 Dermatologists
United States
1200
Canada, European Union, South Africa,
800
Australia, New Zealand
400
0
Yr. 1 Yr. 2 Yr. 3 Yr. 4 Yr. 5
18. 18
Initial focus on early adopters and innovators
Will drive broader market acceptance
35000
Targeting 6%
30000 penetration by year 5
General Practitioners
25000
United States
20000
15000 Canada, European Union, South Africa,
Australia, New Zealand
10000
5000
0
Yr. 1 Yr. 2 Yr. 3 Yr. 4 Yr. 5
19. 19
Experienced management
Focus: controlling costs, accelerating product development & regulatory approval process
Thomas Braun
BA, JD, LLM – Chief Executive Officer
• Public company experience
• Extensive experience in executing M&As and raising capital
• Advised high tech companies on international business transactions
• Expertise in technology licensing
• Member California Bar Association
Anna Trinh
B.Comm, LLB – Chief Financial Officer and Corporate Counsel
• Experience in counseling companies on regulatory and compliance filings
• M&A and financial transaction experience
• Practiced corporate securities law in private practice
20. 20
Strong, independent Board of Directors
Joe Biegel Chris Dennis
BS, MS (Medical Imaging) MBA
• Vice-President, Product Management & Marketing • Former President, Comcare Health Services
• McKesson Medical Imaging Group • Senior positions with Angiotech
• Senior positions with Agfa Healthcare, Hewlett Pharmaceuticals, Johnson & Johnson / Ortho
Packard, Polaroid Medical Imaging Neutrogena
Karen Boodram Jake Thiessen
BSc, MBA Ph.D.
• Vice-President, Business Development, SemBiosys • Professor Emeritus, University of Toronto
• Former Life Sciences Analyst, PI Financial • Founding Director, School of Pharmacy and
• More than 25 years healthcare experience Health Sciences Campus, University of
Waterloo
• Ten years with Novartis
21. 21
Share Capital
Common Shares 46,188,117
Common Shares (held by Founders) 14,700,000
Total Common Shares Outstanding 60,888,117
Warrants 17,568,600
Incentive Stock Options 3,545,000
Fully Diluted Share Capital 82,001,717
22. 22
Market Comparables
Company Market Capitalization
MELA Sciences, Inc. (NASDAQ: MELA) $93,000,000
Novadaq (TSX: NDQ) $126,000,000
ALI Technologies Inc.
$530,000,000
*Sold to McKesson (NYSE: MCK) in 2002 for $530 Million
23. 23
Summary
Breakthrough early stage skin cancer detection device
Patented technology with exclusive worldwide license from BC Cancer Agency
Clear regulatory pathway to commercialization with significant market potential
Endoscopic device for early stage detection of lung, colon and cervical cancers in clinical trials
Strong scientific pedigree and experienced management
24. 24
End Notes
References
1. American Cancer Society. Cancer Facts & Figures 2009
2. National Cancer Institute. Cancer Trends Progress Report 2007, Update April 2008
3. American Cancer Society. Cancer Facts and Figures 2009
4. Melanoma Research Foundation
5. National Cancer Institute. SEER Cancer Statistics Review, 1975-2004
6. National Center for Chronic Disease Prevention and Health Promotion
7. Rogers HW, Weinstock MA, et al. Incidence Estimate of Non Melanoma Skin Cancer in the U.S., 2006, Archives of Dermatology 2010
8. National Cancer Institute. Cancer Trends Progress Report 2007
9. Doru Traian Alexandrescu. Melanoma Costs: A Dynamic Model Comparing Estimated Overall Costs of Various Clinical Stages,
Dermatology Online Journal, Nov 2009
10. Heal CF, Raasch BA, Buettner PG, Weeden D. Accuracy of Clinical Diagnosis of Skin Lesions, British Journal of Dermatology 2009
11. Jones TP, Boiko PE, Piepkorn MW. Skin biopsy indications in primary care practice: a population-based study. JABFP 1996; 9:397–404.
12. Raman Spectroscopy for In Vivo Tissue Analysis and Diagnosis, Instrument Development to Clinical Applications, Journal of
Innovation in Optical Health Sciences 2008
13. Cancer Research UK
14. National Cancer Institute. SEER Database, 1998 – 2000
15. Melamed MR, Flehinger BJ, Zamen MB, et al. Screening for early lung cancer: results of the Memorial Sloan-Kettering study In New
York. Chest 86:44-53, 1984.
16. Cortese DA, Pairolero PC, Bergstralh EJ, et al. Roentgenographically occult lung cancer. A ten-year experience. J Thorac Cardiovasc
Surg 86:373—80, 1983