vasculitis classification takayasu giant cell arteritis microscopic polyaNgitis polyarteritis nodosa wegeners granulomatosis w churg strauss syndrome

1. VASCULITIS

4. • MOST COMMON VASCULITIS IN CHILDREN IS HSP
• MOST COMMON VASCULITIS CAUSING DEATH IN CHILDREN IS
KAWASAKI
• MOST COMMON VASCULITIS IN ADULT IS GIANT CELL ARTERITIS

8. GIANT CELL ARTERITIS
• FOCAL GRANULOMATOUS INFLAMMATION OF CRANIAL VESSELS
MAINLY SUPERFICIAL TEMPORAL ARTERIES
• ALSO INVOLE VERTEBRAL & OPHTHALMIC ARTERIES
• INVOLVEMENT OF OPHTHALMIC ARTERY  BLINDNESS

9. ASSOCIATED WITH
POLYMYALGIA
RHEUMATICA
RAISED ESR

10. CF
• JAW CLAUDICATION  MOST SPECIFIC SYMPTOM
• TEMPORAL HEADACHE  MOST COMMON SYMPTOM

11. SEGMENTAL NODULAR
THICKENING

12. DIAGNOSIS
• ELEVATED ESR
• TEMPORAL ARTERY BIOPSY

14. FRGAMENTATION &
MULTIPLICATION OF
INTERNAL ELASTIC LAMINA
MULTINUCLEATE GIANT
CELLS
NARROW LUMEN

16. TREATED WITH STEROIDS

17. TAKAYASU ARTERITIS

18. TAKAYASU ARTERITIS
• PULSELESS DISEASE
• MARKED WEAKENING OF PULSE OF UPPER LIMB ARTERIES
• UNEQUAL BP
• AORTIC ARCH SYNDROME
• GRANULOMATOUS VASCULITIS OF AORTIC ARCH OR ITS BRANCHES

19. YOUNG INDIVIDUALS
<50 YEARS

20. • MOST COMMONLY INVOLVES SUBCLAVIAN VESSELS
• LEAST COMMONLY INVOLVED  CORONARY ARTERIES

21. INVESTIGATIONS
• TRANSESOPHAGEAL ECHO
• ANGIOGRAPHY

22. Rx OF TAKAYASU
• BALLOON DILATION & STENTING

23. MEDIUM VESSEL VASCULITIS

24. POLYSRTERITIS NODOSA
• NECROSTISING VASCULITIS
OF MEDIUM SIZED
MUSCULAR ARTERIES
• CAUSES FIBRINOID
NECROSIS
• MOST COMMONLY AFFECT
KIDNEY & PULMONARY
CAPILLARIES ARE SPARED
• ANCA IS NOT POSITIVE
• ASSOCIATED WITH
HEPATITIS B

27. CF
• MOST COMMON
VASCULITIS A/W
MONONEURITIS
MULTIPLEX
• MOST COMMON CAUSE OF
MONONEURITIS IS DM (BUT AMONG
VASCULITIS MOST COMMON CAUSE IS

28. • PAN IS ASSOCIATED WITH
LIVIDO RETICULARIS

30. SEGMENTAL
TRANSMURAL
NECROTISING
INFLAMMATION OF
ARTERIES ELASTIC
LAMINA
FRAGMENTATION &
FIBRINOID NECROSIS
MOST COMMON CAUSE OF
DEATH IS RENAL FAILURE

31. • ALL STAGES OF ACTIVITY CO EXIST IN DIFFERENT VESSELS

32. • RX
• STEROIDS

33. KAWASAKI DISEASE
• MUCOCUTANEOUS LN SYNDROME
• INFECT CHILDREN 3MONTHS TO 5 YEARS
• ANTIENDOTHELIAL Ab

35. RED DRY CRACKED LIPS
NON SUPPURATIVE
CONJUNCTIVITIS
STRAWBERRY
TONGUE

38. PERIUNGAL PEELING OF SKIN

40. Rx
• IVIG

41. COMPLICATIONS
CORONARY DUCT
ECTASIA & CORONARY
ANEURYSM
MAIN CAUSE OF DEATH IS
MYOCARDIAL INFARCTION
ECHOCARDIOGRAPHY IS DONE TO
DETECT CORONARY ARTERY
ANEURYSM

42. SMALL VESSEL VASCULITIS

43. MICROSCOPIC POLYANGITIS
• HYPERSENSITIVITY VASCULITIS OR LEUKOCYTOCLASTIC VASCULITIS
• POSITIVE p ANCA

44. MICROSCOPIC POLYANGITIS
• NO GRANULOMA
• SEGMENTAL FIBRINOID NECROSIS OF MEDIA
• POST CAPILLARY VENULES SHOW FRAGMENTED NEUTROPHILIC
NUCLEI
• NECROTISING GN

45. NEUTROPHIL NUCLEAR REMNANTS
AROUND SMALL VESSELS

46. FIBRINOID NECROSIS OF TUNICA MEDIA

47. NECROTISING GLOMERULONEPHRITIS

48. • MPA IS NOT HAVING
• ANY GRANULOMA OR NODULES & CAVITIES IN LUNGS IN MPA
• UNLIKE IN WEGNWERS

49. WEGENERS GRANULOMATOSIS
• NECROTISING SMALL VESSEL VASCULITIS
NECROTISING OR
GRANULOMATOUS VASCULITIS
OF UPPER & LOWER AIRWAY
NECROTISING
GRANULOMATOUS OF LUNGS
FOCAL NECROTISING &
CRESCENTIC GN
LIMITED FORMS OF DISEASE
WILL AFFECT RESPIRATORY
TRACT

50. MULTIPLE CAVITARY
LESIONS
FOCAL NECROTISING GN

52. CF
• PERSISTENT PNEUMONITIS WITH B/L NODULAR & CAVITARY
INFILTRATES
• C/C SINUSITIS
• MUCOSAL ULCERATION OF NASOPHARYNX
• RENAL LESIONS  HEMATURIA

53. • GRANULOMA WITH
GEOGRAPHIC NECROSIS
• GRANULOMA WILL
FORM NODULES &
CAVITIES

54. STAIN +VE FOR c ANCA & p ANCA

55. SADDLE NOSE DEFORMITY IN WEGENERS
GRANULOMATOSIS

56. Rx
• STEROIDS
• CYCLOPHOSPHAMIDE
• TNF α AGONIST

57. CHURG STRAUSS SYNDROME
• ALLERGIC GRANULOMATOSIS & ANGITIS
• SMALL NECROTISING VASCULITIS WITH
• ASTHMA
• ALLERGIC RHINITIS
• PERIPHERAL EOSINOPHILIA
• EXTRAVASCULAR NECROTISING GRANULOMA

59. CHURG STRAUSS SYNDROME EOSINOPHILIC GRANULOMA

60. • EOSINOPHILIC
INFILTRATE ARE
ASSOCIATED WITH
CARDIOMYOPATHY &
CARDIAC
INVOLVEMENT 
MOST COMMON CAUSE
OF MORTALITY
EOSINOPHILIC INFILTRATE IN
MYOCARDIUM

61. HENOCH SCHONLEIN PURPURA
• MOST COMMON VASCULITIS IN CHILDREN
• MOST COMMONLY SEEN IN EXTENSOR SURFACE  EXTENSOR
PURPURA
• IgA ELEVATED ABNORMALLY

63. MOST COMMONLY SEEN IN
EXTENSOR SURFACE
PALAPABLE PURPURA D/T VASCULITIS
(NOT D/T THROMBOCYTOPENIA)

64. DIAGNOSIS
• ELEVATED IgA
• IOC  SKIN BIOPSY
• PLATELET IS NORMAL

65. THROMANGITIS OBLITERANS
• BUERGERS DISEASE
• SMOKERS
• YOUNG AGE < 35 YEARS

66. • INVOLVES SMALL ARTERIES WITH SECONDARY EXTENSION IN TO VEIN
AND NERVES

67. HLA B12 IS
PROTECTIVE
AGAINST
TAO
HLA A9 & HLA B5
INCREASED RISK

68. PATHOLOGY IN TAO
NEUTROPHILIC
MICROABSCESS FORMATION
SURROUNDED BY
GRANULOMATOUS
INFLAMMATION

69. CF
• SEGMENTAL THROMBOSING VASCULITIS EXTENDING IN TO VEINS &
NERVE
• PAIN EVEN AT REST D/T NEURAL INVOVEMENT
• INTERMITTENT CLAUDICATION

71. PERINUCLEAR ANCA (p ANCA)
MYELOPEROXIDASE
• CHURG STRAUSS
SYNDROME
• GOOD PASTURE SYNDRME
• MICROSCOPIC POLYANGITIS
• IDIOPATHIC CRESCENTIC GN
CYTOPLASMIC ANCA ( c
ANCA)
PROTEINASE 3
• WEGENER
GRANULOMATOSIS
(GRANULOMATOSIS WITH
POLYANGITIS)

72. WEGENERS GRANULOMATOSIS

75. BEHCET DISEASE

76. BEHCET DISEASE
• ORO OCULO GENITAL SYNDROME
• SMALL VESSEL NEUTROPHILIC VASCULITIS

77. BEHCET DISEASE

78. • HLA B5 & HLA B51 ASSOCIATION

79. RECURRENT ORAL ULCER

80. RECURRENT GENITAL ULCER

81. POSITIVE PATHERGY TEST

82. STERILE PUSTULE AFTER 24 – 48 HOURS 
POSITIVE PATHERGY TEST