The document provides a comprehensive overview of vasculitis, defining it as the inflammatory destruction of blood vessels leading to various complications such as ischemia and hemorrhage. It classifies vasculitis into three categories based on vessel size: large vessel vasculitis, medium vessel vasculitis, and small vessel vasculitis, and outlines various associated conditions and etiologies. It also highlights the diagnostic classification and different types of vasculitis based on their pathogenesis.

1. VASCULITIS

2. DEFINITION CLASSIFICATION APPROACH TO
VASCULITIS
ANCA VASCULITIS
KDIGO
GUIDELINES

3. Vasculitis: Definition
Pathologist
• Inflammatory destruction of blood vessels
• Infiltration of vessel wall with inflammatory
cells
 Leukocytoclasis
 Elastic membrane disruption
• Fibrinoid necrosis of the vessel wall
• Ischemia, occlusion, thrombosis
• Aneurysm formation
• Rupture, hemorrhage
Rheumatologis
t
• A clinicopathologic process characterized
by inflammatory destruction of blood
vessels that results in occlusion or
destruction of the vessel and ischemia of
the tissues supplied by that vessel.
• “Systemic vasculitides”

4. Timeline of the nomenclature and
classification criteria of systemic vasculitis

10. LARGE VESSEL
VASCULITIS

11. MEDIUM
VESSEL
VASCULITIS

12. SMALL VESSEL
VASCULITIS

13. SMALL VESSEL
VASCULITIS

14. SMALL VESSEL
VASCULITIS

15. VARIABLE
VESSEL
VASCULITIS

16. SINGLE ORGAN
VASCULITIS

17. SYSTEMIC
VASCULITIS

18. ETIOPATHOGENIC CLASSIFICATION INCORPORATING
MODIFIED CHCC CLASSIFICATION BY LIE
DOMINANT VESSEL PRIMARY VASCULITIS PATHOGENESIS SECONDARY VASCULITIS
LARGE ARTERIES TEMPORAL ARTERITIS
TAKAYASU ARTERITIS
T cell mediated ASSOCIATED WITH RA, SYPHILLIS, TB
MEDIUM ARTERIES CLASSICAL PAN
KAWASAKI DISEASE
IMMUNE COMPLEX RELATED
ANTIBODY MEDIATED
HYPERSENSITIVITY
HBV ASSOCIATED PAN
SMALL AND
MEDIUM SIZED
WEGENER’S
GRANULOMATOSIS
CHURG STRAUSS
SYNDROME
MICROSCOPIC ANGITIS
ANCA MEDIATED ASSOCAITED WITH DRUGS, HIV,
INFECTIONS LIKE HIV
SMALL VESSEL HSP IMMUNE COMPLEX HCV INDUCED, DRUGS

30. Diagnostic Classification of
Vasculitis
1. Large vessel vasculitis
(Aorta /great vessels)
There are appox. 20 different types of Vasculitis.
2. Medium-sized vessel vasculitis
(Arteries with muscular wall)
3.Small-vessel vasculitis
(Capillaries, arterioles, venules)

31. Vessel size ?
• Large vessel - aorta and the largest branches directed towards the
major body regions (e.g.to the extremities and the head and neck).
• Medium-sized vessel - main visceral arteries (e.g., renal, hepatic,
coronary and mesenteric arteries)
• Small vessel - venules, capillaries, arterioles and the
intraparenchymal distal arterial radicals that connect with arterioles.

32. Some small and large vessel vasculitides may involve
medium-sized arteries, but large and medium-sized
vessel vasculitides do not involve smaller arteries

35. THANK YOU