2. OBJECTIVES
What is vascular access?
How it all started?
Ideal vascular access
Methods to gain vascular access
Properties of Vascular access
Risk of AVF primary FALIURE
Selection and placement
Preparation for permanent HD access
Arteriovenous anastomosis
AVF maturation
Post dialysis Haemostasis
Vascular access complication
3. WHAT IS VASCULAR ACCESS?
Vascular access refers to a rapid, direct method of
introducing or removing devices or chemicals
from the bloodstream.
4. HOW IT ALL STARTED?
1896
Jaboulay and Briau (Lyon, France) published an
experimental technique in dogs which consisted of
suturing an artery-end-to-end-anastomosis.
5. Nephrol Dial Transplant, Volume 20, Issue 12, December 2005, Pages 2629–2635, https://doi.org/10.1093/ndt/gfi168
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ANIMAL EXPERIMENTS WITH VASCULAR
ANASTOMOSES BY JABOULAY AND BRIAU,
PUBLISHED 1896
6. 1924
In October 1924, Georg Haas (Giessen,
Germany) performed the first haemodialysis
treatment in humans which lasted 15 min.
He first used glass cannula to obtain arterial
blood from the radial artery, which he returned to
the cubital vein.
7. 1943
Modern haemodialysis therapy started on 17
March 1943
Willem Kolff, a young doctor in the small
hospital of Netherlands, treated a 29-year-old
suffering from malignant hypertension and
‘contracted kidneys’.
8. 1963
Thomas J. Fogarty from USA,
invented an intravascular
catheter with an inflatable
balloon at its distal tip designed
for embolectomy and
thrombectomy.
Essential device even today
9. 1965
The legendary paper ‘Chronic hemodialysis using
veni-puncture and a surgically created
arteriovenous fistula’ was published by Brescia,
Cimino, Appell and Hurwich .
Dr Appell was the surgeon in the team. The first
surgically created fistula for the purpose of
haemodialysis was placed on 19 February 1965.
10. 1967
One year after the article, M. Sperling
(Würzburg, Germany) reported the successful
creation of an end-to-end-anastomosis between
the radial artery and the cephalic vein in the
forearm of 15 patients using a stapler.
This type of AV anastomosis gained widespread
acceptance.
11. IDEAL VASCULAR ACCESS
Delivers adequate flow rate
Long life
Low rate of complications
Cannulated easily
12. METHODS TO GAIN VASCULAR ACCESS?
Three primary methods are used to gain access to the
blood:
Native Arteriovenous fistula (AVF)
Prosthetic arterio-venous graft (AVG)
Intravenous catheter
Temporary double lumen cathater
Permanent Cathater
14. PROPERTIES OF VASCULAR ACCESS
HD cath AVG AVF
Immediate use Yes 2-4 Wks No
Primary failure Less Less More
Survival Short Intermediate Long
Obstruction More Intermediate Less
Infection More Intermediate Less
15. RISK OF AVF PRIMARY FALIURE
Wrist fistulas
Age > 60 years old
Obesity
Diabetic
Peripheral vascular or cardiovascular disease
Non white race
Female sex
16. SELECTION AND PLACEMENT
AVF: First, if available
AVG: Next
HD Catheter : Last, should be avoid
Location
Placed distally and moved to proximal
17. FREQUENCY
AV fistulas in at least 50% of hemodialysis
patients
AV grafts in 40%, and
Dialysis catheters in no more than 10%
18. PREPARATION FOR PERMANENT HD ACCESS
Patients with GFR < 30 mL/min/1.73 m2 should
educated on all modalities, including
transplantation.
In patients with CKD stage 4 or 5, forearm and
upper arm veins suitable for placement of
vascular access.
19. Patients should have a functional permanent VA at
initiation of HD.
AVF should be placed > 6 months before start of HD.
This timing allows for access evaluation and additional
time for revision to ensure working fistula is available at
initiation of dialysis therapy.
A graft should, in most cases, be placed at least 3-6 weeks
before start of HD therapy.
20. EVALUATIONS FOR PERMANENT HD
ACCESS
History and physical examination
Duplex ultrasound of upper-extremity arteries and
veins.
Central vein evaluation in appropriate patient
known to have a previous catheter or pacemaker.
24. DUPLEX ULTRASOUND OF UPPER-
EXTREMITYARTERIES AND VEINS
Selection of the most appropriate vein and best
location of the access
Doppler ultrasonography
Minimal vein and artery size : venous diameter ~ 2.5
mm, artery diameter ~ 2 mm
Vein dilation test
During the Doppler study the proximal vein
is occluded Increase in internal diameter of 50% has
been associated with a good fistula outcome
25. ARTERIOVENOUS ANASTOMOSIS
• Easiest
• Highest fistula flow
• Risk for high output
cardiac failure
• Minimize turbulence
• Slightly lower fistula flow
• Twisting of artery during
construction
Side to Side
End to Side
26. • Decrease turbulence
• Highest venous flow
• Minimal venous hypertension
• More difficult than side to side
• Least arterial steal and
venous hypertension
• Lowest flow of the four
configurations
Side to End
End to End
27. AVF MATURATION
AVF should be matured before cannulation
Rule of 6s
1. Access flow of 600 mL/min
2. < 0.6 cm below surface of skin
3. Minimal diameter 0.6 cm
If fistula not matured in 6 wks → fistulogram
for access problem
28. POST DIALYSIS HAEMOSTASIS
Direct pressure over the site
Tip of one or two fingers > 10 minutes
Prolonged bleeding > 20 minutes : Increased
intra-access pressure
30. SURVEILLANCE
Prolong access longevity
Safe another vessel
Reduce infection rate from insert double lumen
catheter
Adequacy of hemodialysis
Frequency of hospitalization
Decrease the cost of hemodialysis access
management
32. AVF OR AVG DYSFUNCTION AND RELATED
COMPLICATION
Early: Non maturation
Late: Stenosis and thrombosis
Other: Hand ischemia (Steal syndrome)
Aneurysm and bleeding
High flow related heart failure
Infection