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Bedaquiline is a novel drug designed to treat drug-resistant tuberculosis. Extensive clinical trials have shown it is effective against drug-resistant TB by inhibiting the ATP synthase enzyme in TB bacteria. Bedaquiline offers higher treatment success rates and shorter treatment durations than traditional antibiotics, but also has some potential side effects. It is recommended for use in combination with other antibiotics as part of a comprehensive treatment plan for drug-resistant TB.
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Antituberculosis Drugs 1 Manisacan Et Al( Midterm 2)
The document summarizes guidelines for treating tuberculosis using three lines of antituberculosis drugs. First-line drugs like isoniazid and rifampin are usually effective but second and third-line drugs may be needed if resistance develops. The drugs have various mechanisms of action and are always used together to improve outcomes and prevent resistance. Close monitoring is needed due to potential adverse effects and drug interactions that require dosage adjustments.
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ANTIBIOTICS RESISTANCE.pptx
This document discusses antibiotics resistance and its role in eradicating epidemics. It begins with definitions of antibiotics and resistance, describing the four categories of antibiotics resistance. The aim is to strengthen surveillance and research to reduce infections and optimize antimicrobial use. Resistance develops from misuse and overuse of antibiotics, costing lives and health resources. Antibiotics treat bacterial infections critically important for modern medicine. However, antimicrobial resistance results in substantial costs. The document concludes clinical guidelines and education can contribute to more prudent antibiotic use, while a robust national action plan is needed to tackle the global problem of resistance at all levels of healthcare.
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This document discusses antibiotics resistance and its role in eradicating epidemics. It begins with definitions of antibiotics and resistance, describing the four categories of antibiotics resistance. The aim is to strengthen surveillance and research to reduce infections and optimize antimicrobial use. Resistance develops from misuse and overuse of antibiotics, costing lives and health resources. Antibiotics treat bacterial infections critical for modern medicine; resistance results in increased costs and risks. A national action plan is recommended to monitor resistance, prevent infections, regulate medicine use, and promote appropriate disposal.
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This document discusses antibiotics resistance and its role in eradicating epidemics. It begins with definitions of antibiotics and resistance, describing the four categories of antibiotics resistance. The aim is to strengthen surveillance and research to reduce infections and optimize antimicrobial use. Resistance develops from misuse and overuse of antibiotics, costing lives and health resources. Antibiotics treat bacterial infections critically important for modern medicine. However, antimicrobial resistance results in substantial costs. The document concludes clinical guidelines and education can contribute to more prudent antibiotic use, while a robust national action plan is needed to tackle the global problem of resistance at all levels of healthcare.
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This review article discusses evidence that diabetes may be an inflammatory disease based on studies of traditional Chinese medicines (TCM) with anti-diabetic effects. The article reviews 15 top Chinese herbs commonly used to treat diabetes that have both anti-hyperglycemic and anti-inflammatory properties. Many studies show that the active compounds in these TCMs, such as polysaccharides, terpenoids and flavonoids, lower blood glucose levels and control inflammation, suggesting their anti-diabetic effects may be mediated by anti-inflammatory mechanisms. The article concludes that TCMs provide new evidence that diabetes could be a low-grade inflammatory disease, and that moderate inhibition of inflammation may help prevent diabetes development.
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Ultracentrifuges
• Operate at speed of 75,000rpm, providing the centrifugal force of 500,000g.
• Rotor chamber is sealed and evacuated by pump to attain vacuum.
• Refrigeration system (temp 0-4°C).
• Rotor chamber is always enclosed in a heavy armor plate.
• Centrifugation for isolation and purification of components is known as preparatory centrifugation, while that carried out with a desire for characterization is known as analytical centrifugation.
Operation
Tubes recommended by their manufacturer should be used.
Top of tube should not protrude so far above the bucket.
Properly balanced-weight of racks, tubes, and content on opposite side of a rotor should not differ by more than 1%. (Centrifuges auto balance are available).
Should centrifuge before unstopper the tubes.
Cleanliness-minimizing the possible of spread of infection (hep Virus).
Spillage and break of tube should be considered as the bloodborne pathogen hazard.
Speed of centrifuge should be checked once 3m.
Centrifuge timer to be checked per week.
Quantitative – PCR:
Used to measure the specific amount of target DNA (or RNA) in a sample.
By measuring amplification only within the phase of true exponential increase, the amount of measured product more accurately reflects the initial amount of target.
Special thermal cyclers are used that monitor the amount of product during the amplification.
C
Types of rotor
Fixed angle rotors
• Tubes are held at angle of 14 to 40° to the vertical.
• Particles move radially outwards, travel a short distance.
• Useful for differential centrifugation
• Reorientation of the tube occurs during acceleration and deceleration of the rotor.
Vertical tube rotors
• Held vertical parallel to rotor axis.
• Particles distance. move short
• Time of separation is shorter.
• Disadvantage: pellet may fall back into solution at end of centrifugation.
êt
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Developed in 1983 by Kary Mullis, PCR is now a common and often indispensable technique used in medical and biological research labs for a variety of applications. These include diagnosis of infectious diseases, DNA sequencing and DNA-based phylogeny.
In 1993, Mullis was awarded the Nobel prize in Chemistry along with Michael Smith for his work on PCR.
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• Small peptide and fragment antigens may not be good antigens- monoclonal antibody may not recognize the original antigen.
• Hybridoma culture may be subject to contamination.
System is only well developed for limited animal and not for other animals.
More than 99% of the cells do not survive during the fusion process reducing the range of useful antibodies that can be produced against an antigen
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slidesgo-the-crucial-role-of-antibiotics-in-modern-medicine-20240506192312Qve...
Ultracentrifuges
• Operate at speed of 75,000rpm, providing the centrifugal force of 500,000g.
• Rotor chamber is sealed and evacuated by pump to attain vacuum.
• Refrigeration system (temp 0-4°C).
• Rotor chamber is always enclosed in a heavy armor plate.
• Centrifugation for isolation and purification of components is known as preparatory centrifugation, while that carried out with a desire for characterization is known as analytical centrifugation.
Operation
Tubes recommended by their manufacturer should be used.
Top of tube should not protrude so far above the bucket.
Properly balanced-weight of racks, tubes, and content on opposite side of a rotor should not differ by more than 1%. (Centrifuges auto balance are available).
Should centrifuge before unstopper the tubes.
Cleanliness-minimizing the possible of spread of infection (hep Virus).
Spillage and break of tube should be considered as the bloodborne pathogen hazard.
Speed of centrifuge should be checked once 3m.
Centrifuge timer to be checked per week.
Quantitative – PCR:
Used to measure the specific amount of target DNA (or RNA) in a sample.
By measuring amplification only within the phase of true exponential increase, the amount of measured product more accurately reflects the initial amount of target.
Special thermal cyclers are used that monitor the amount of product during the amplification.
C
Types of rotor
Fixed angle rotors
• Tubes are held at angle of 14 to 40° to the vertical.
• Particles move radially outwards, travel a short distance.
• Useful for differential centrifugation
• Reorientation of the tube occurs during acceleration and deceleration of the rotor.
Vertical tube rotors
• Held vertical parallel to rotor axis.
• Particles distance. move short
• Time of separation is shorter.
• Disadvantage: pellet may fall back into solution at end of centrifugation.
êt
polymerase chain reaction (PCR):
It is a molecular technology aim to amplify a single or few copies of the DNA to thousands or millions of copies.
Developed in 1983 by Kary Mullis, PCR is now a common and often indispensable technique used in medical and biological research labs for a variety of applications. These include diagnosis of infectious diseases, DNA sequencing and DNA-based phylogeny.
In 1993, Mullis was awarded the Nobel prize in Chemistry along with Michael Smith for his work on PCR.
Disadvantages of using Monoclonal Antibodies:
• Time consuming project - anwhere between 6-9 months.
• Very expensive and needs considerable effort to produce them.
• Small peptide and fragment antigens may not be good antigens- monoclonal antibody may not recognize the original antigen.
• Hybridoma culture may be subject to contamination.
System is only well developed for limited animal and not for other animals.
More than 99% of the cells do not survive during the fusion process reducing the range of useful antibodies that can be produced against an antigen
• It is possibility of genera
Potential Repurposed Drug Candidates for Tuberculosis Treatment.pptx
Drug repurposing untuk penyakit tuberkulosis
tb treatment
Title: Comprehensive Guide to Tuberculosis (TB) Treatment: Strategies and Approaches
Introduction:
Tuberculosis (TB) remains a significant global health concern, affecting millions of people worldwide. The disease, caused by the Mycobacterium tuberculosis bacterium, primarily affects the lungs but can also impact other parts of the body. While TB is a curable and preventable disease, it requires timely and appropriate treatment to ensure successful outcomes. In this article, we will explore the current strategies and approaches used in TB treatment.
Diagnosis:
Accurate and early diagnosis is crucial for effective TB treatment. Several diagnostic methods are available, including sputum microscopy, chest X-rays, molecular tests (such as GeneXpert), and culture-based techniques. These diagnostic tools help identify the presence of TB and determine drug susceptibility, enabling healthcare providers to tailor treatment regimens to individual patients.
Directly Observed Treatment (DOT):
DOT is a widely implemented strategy in TB treatment programs. It involves healthcare workers or trained volunteers directly observing patients taking their medication. This approach ensures adherence to the prescribed treatment regimen, reduces the risk of drug resistance, and enhances treatment success rates.
Drug Regimens:
TB treatment typically involves a combination of several antibiotics to combat the bacterium effectively. The standard treatment regimen for drug-sensitive TB consists of an intensive phase and a continuation phase. During the intensive phase, four drugs—isoniazid, rifampicin, pyrazinamide, and ethambutol—are administered for two months. Afterward, the continuation phase follows, consisting of isoniazid and rifampicin for an additional four to six months. This multi-drug approach helps eradicate both actively replicating and dormant bacteria, preventing relapse.
Drug-Resistant TB:
Drug-resistant TB, including multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB), poses a significant challenge to TB control efforts. Treating drug-resistant TB requires longer treatment durations (up to 20 months) and the use of second-line drugs, which are more expensive and can cause more side effects. Individualized treatment plans and close monitoring are essential to achieve successful outcomes in these cases.
Adverse Effects and Supportive Care:
TB medications may have side effects, including liver toxicity, gastrointestinal disturbances, and hypersensitivity reactions. Patients should be closely monitored, and healthcare providers must manage these side effects promptly. Adequate supportive care, including nutritional support and management of comorbidities, plays a vital role in optimizing treatment outcomes and reducing treatment-associated complications.
Treatment Monitoring:
Regular monitoring of treatment progress is essential to ensure the effectiveness of TB treatment. This includes clinical evaluation, sputum microscopy, radi
Drugs effectivness.ppt (T.Y. Bsc).pptx
Several complex factors influence the effectiveness of antimicrobial drugs. The drug must be able to reach the site of infection through proper administration and formulation. The pathogen must be susceptible to the drug. And the drug concentration at the site of infection must exceed the minimum inhibitory concentration of the pathogen. Overcoming drug resistance requires strategies like using drug combinations, limiting unnecessary antibiotic use, ensuring patient compliance, and developing new classes of antimicrobials through natural product discovery and structure-based drug design.
LS 6.4 Anti Tuberculosis Drugs.pptx
This document discusses anti-mycobacterial drugs used to treat tuberculosis, leprosy, and atypical mycobacterial infections. It describes the first-line drugs isoniazid, rifampicin, pyrazinamide, and ethambutol which are used in combination to treat tuberculosis. Second-line drugs discussed include fluoroquinolones, aminoglycosides, cycloserine, ethionamide, bedaquiline, and delaminid. Macrolides are highlighted as first choice to treat atypical Mycobacterium avium complex infections. Dapsone is noted as the primary drug used to treat leprosy.
Antimicrobial Stewardship
The document discusses antimicrobial stewardship and the need to curb antibiotic overuse and misuse. It notes that nearly half of hospitalized patients receive antimicrobial agents. While antibiotics have been life-saving, there has been too much use for trivial infections and without understanding principles of therapy. This has contributed to the rise of antibiotic resistance, which the CDC calls a "major public health crisis." The document outlines strategies for antimicrobial stewardship programs, including prospective audits, formulary restrictions, education, guidelines, and streamlining therapy based on culture results. The goal is to optimize outcomes while minimizing resistance by ensuring appropriate antibiotic use.
"Exploring Anti-Infective API Drugs: A Comprehensive Overview"
This article delves into the realm of anti-infective Active Pharmaceutical Ingredients (APIs), elucidating their critical role in combating infectious diseases. From antibiotics to antivirals, this piece explores the diverse classes of anti-infective APIs, their mechanisms of action, and their significance in pharmaceutical development. Readers will gain insights into the challenges and advancements in this vital sector of pharmaceutical research, aiming to address the ever-evolving landscape of infectious diseases.
Rational use of otc medication
This document discusses rational use of over-the-counter (OTC) medications. It provides examples of common OTC drug categories and explains that rational use means using the appropriate medication, in the proper dose, for the right duration and indication. Irrational or improper use can lead to antimicrobial resistance, adverse reactions, financial costs, and erosion of patient confidence in the healthcare system. Factors contributing to irrational use include lack of knowledge and unethical drug promotion. Improving rational use requires guidelines, education, availability of essential medicines, and eliminating financial incentives for improper prescribing. Several examples of irrational fixed-dose drug combinations are also provided that combine drugs with different mechanisms or indications.
Should all diabetics with TB be on insulin?
1. Rifampicin, a potent inducer of cytochrome P450, lowers the levels of sulfonylureas and metformin, requiring increased doses of these oral hypoglycemic agents.
2. Diabetics with tuberculosis have impaired immune function and pulmonary dysfunction, worsening tuberculosis infection and treatment outcomes. Tight glycemic control is important.
3. Insulin is preferable to oral agents for treating diabetes in tuberculosis due to drug interactions and the need for tight glycemic control through diet. Indications for insulin include severe or uncontrolled diabetes, contraindications for oral agents, and during tuberculosis treatment.
Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Con...
Cannabidiol (CBD) is the main non-intoxicating component in the Cannabis sativa L. plant and has recently attracted interest as a therapeutic for the treatment of a number of diseases and conditions due to observed beneficial effects in many preclinical disease models, including epilepsy, cardiovascular disease, inflammation, and cancer (Pacher, Kogan, & Mechoulam, 2020). Like other drugs, CBD has intrinsic pharmacologic effects and thus has the potential for adverse drug events (ADEs) along with the potential for pharmacokinetic and pharmacodynamic drug–drug interactions (DDIs). Given CBD use among patients with complex conditions and treatment regimens, as well as its expanded consumer use, awareness of potential safety issues with CBD is needed. Prescribing information for federally approved products containing CBD were reviewed. Common ADEs include transaminase elevations, sedation, sleep disturbances, infection, and anemia. Given CBD effects on common biological targets implicated in drug metabolism (e.g., CYP3A4/2C19) and excretion (e.g., P-glycoprotein), the potential for DDIs with commonly used medication is high. General clinical recommendations of reducing substrate doses, monitoring for ADEs, and finding alternative therapy should be considered, especially in medically complex patients. CBD is implicated as both a victim and perpetrator of DDIs and has its own ADE profile. These effects should be considered in the risk-benefit assessment of CBD therapy and patients and consumers made aware of potential safety issues with CBD use.
*Article adapted from Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use (Brown & Winterstein, 2019), licensed by a Creative Commons Attribution license (CC BY 4.0).
journal club presentation .pptx
Bedaquiline is a new drug approved to treat multidrug-resistant tuberculosis (MDR-TB). However, it has some challenges including cardiotoxicity and hepatotoxicity likely due to its highly lipophilic structure. Researchers have worked to develop analogues of bedaquiline with reduced lipophilicity to minimize these toxicities. One study developed a 6-cyano analogue that showed significantly decreased lipophilicity while maintaining similar antibacterial activity. Other studies substituted the naphthalene unit of bedaquiline's structure with different heterocycles. Optimizing the balance of lipophilicity, basicity, and other structural properties may help address the toxicity issues and make bedaquiline a better treatment for MDR-
Drug response biomcare webinar - jan 2022
WEBINAR: The role of the Gut Microbiome for Drug Response
Varying drug response is a key factor in both drug development and clinical practice and result in sub-optimal treatment and failed clinical trials.
Resent years research has detailed how the gut microbiome plays an essential role for drug response, and how the inter-individual variation in the composition of the gut microbiome is an important factor, both in drug trials and treatment.
Elements in the webinar
In this seminar, we will dive into this interesting topic, and take you through
-Key research into how the microbiome can affect drug response
-How microbiome profiling of patients can be used to gain insight and control in clinical trials at all stages,
-How microbiome profiling can be used to detect a novel type of biomarkers.
Biomcare is providing sampling support, sequencing, and data analysis for the microbiome aspects of the large NORDIC-SUN clinical trial of Immune Checkpoint Inhibitors, and we will finish the seminar by introducing this project and our solution for microbiome analysis in clinical studies and trials.
Antimicrobial stewardship to prevent antimicrobial resistance
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
Is there a role for Homeobotanicals in Conventional Medicine?
This document discusses Dynamic Phytotherapy (DP), an alternative treatment approach that combines herbalism and homeopathy. It summarizes a clinical evaluation of DP that found it significantly reduced the duration of cold and flu symptoms compared to a non-treatment control group. The evaluation also found DP applications effectively treated other conditions like pain and neurological symptoms. The document concludes DP remedies show promise as a complementary treatment that could be incorporated into conventional and integrative medicine to strengthen treatments for various resistant medical conditions.
Systemic antibiotics and chemo therapeutics in periodontics
The rationale for using antibiotics and chemotherapeutics in the periodontal disease treatment is its polymicrobial nature of disease. Antibiotic use should be done cautiously in treating various periodontal infection as improper use of it can lead to its resistance by bacterial strains. Antibiotic in periodontics is a very helpful adjunct in controlling the bacteria in the oral cavity
Decision making in systemic antibiotic therapy.pptx
This document discusses the use of systemic antibiotics as an adjunct to scaling and root planing in the treatment of periodontal disease. It provides information on types of antibiotic therapy, current understanding of the microbial etiology of periodontal disease, and guidelines for periodontal therapy. Systematic reviews have found additional benefits of adjunctive antibiotics including improved clinical attachment level gains and reduced risk of further attachment loss. However, questions remain about which specific antibiotics or combinations are most appropriate for different forms of periodontal infections. The document also discusses the rationale for using systemic antibiotics as well as their limitations when biofilms are present. It provides criteria for an ideal antibiotic for periodontal therapy and discusses various antibiotic options and their administration.
A Modality in the Diagnosis and Treatment of Oral Candidiasis
Candidiasis as an infection spread all over the oral cavity finds the appropriate conditions to show the clinical appearance, mainly in patients with reduced immune status. For the purpose of facilitating the case diagnosis of case studies, supported also in literature, the study aims at the application of blue methylene as an indicator of Candida colonies in various areas of oral cavity mucosa. Identification with blue methylene is a simple procedure that reduces the microbiological stages of planting and testing the candidate’s candidacy, shortening the timing of diagnosis, and performing this procedure at the dental chair. Based on the literature, though few, in number, the references indicate Lugol’s application, the 2% iodine solution as a candidate for treatment of candidiasis previously detected with blue methylene in the patients involved in the studies referred to in the literature. Iodine delivery in patients is progressively carried out, ranging from 1 drop to day, 2.5 mg, to a maximum of 5 drops/day, 12.5 mg, proportionally divided by day. Patients involved declare for lack of iodine allergies, and during subtype in this therapy, were kept under control for systemic sensations previously unpublished but based on literature, as sleeping disturbances, worries in the nutritional constituents of the individual diet, or any other concern.
Rare Genomics paper Hailey-Hailey disease
This document discusses the potential use of low-dose naltrexone (LDN) as a treatment for Hailey-Hailey disease (HHD). HHD is a rare genetic skin condition characterized by painful lesions. Current treatments are often ineffective. The document notes that LDN has shown promise in treating various conditions by modulating the immune system and opioid receptors. Patients with HHD who have used LDN have reported reduced symptoms and improved quality of life. However, no clinical studies have tested LDN's efficacy for HHD. The document argues that such studies are needed to determine if LDN could be an effective and safe treatment option.
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Potential Repurposed Drug Candidates for Tuberculosis Treatment.pptx
Potential Repurposed Drug Candidates for Tuberculosis Treatment.pptx
"Exploring Anti-Infective API Drugs: A Comprehensive Overview"
"Exploring Anti-Infective API Drugs: A Comprehensive Overview"
Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Con...
Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Con...
Antimicrobial stewardship to prevent antimicrobial resistance
Antimicrobial stewardship to prevent antimicrobial resistance
Is there a role for Homeobotanicals in Conventional Medicine?
Is there a role for Homeobotanicals in Conventional Medicine?
Systemic antibiotics and chemo therapeutics in periodontics
Systemic antibiotics and chemo therapeutics in periodontics
Decision making in systemic antibiotic therapy.pptx
Decision making in systemic antibiotic therapy.pptx
A Modality in the Diagnosis and Treatment of Oral Candidiasis
A Modality in the Diagnosis and Treatment of Oral Candidiasis
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My burning issue is homelessness K.C.M.O.
My burning issue is homelessness in Kansas City, MO
To: Tom Tresser
From: Roger Warren
一比一原版(牛布毕业证书)牛津布鲁克斯大学毕业证如何办理
毕业原版【微信:41543339】【(牛布毕业证书)牛津布鲁克斯大学毕业证】【微信:41543339】成绩单、外壳、offer、留信学历认证（永久存档真实可查）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【我们承诺采用的是学校原版纸张（纸质、底色、纹路），我们拥有全套进口原装设备，特殊工艺都是采用不同机器制作，仿真度基本可以达到100%，所有工艺效果都可提前给客户展示，不满意可以根据客户要求进行调整，直到满意为止！】
【业务选择办理准则】
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三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
留信网服务项目：
1、留学生专业人才库服务（留信分析）
2、国（境）学习人员提供就业推荐信服务
3、留学人员区块链存储服务
→ 【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：客户在留信官方认证查询网站查询到认证通过结果后付款，不成功不收费！
在线办理(英国UCA毕业证书)创意艺术大学毕业证在读证明一模一样
学校原件一模一样【微信：741003700 】《(英国UCA毕业证书)创意艺术大学毕业证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
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如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】
◇面对父母的压力，希望尽快拿到；
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◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
一比一原版(Coventry毕业证书)考文垂大学毕业证如何办理
毕业原版【微信:41543339】【(Coventry毕业证书)考文垂大学毕业证】【微信:41543339】成绩单、外壳、offer、留信学历认证（永久存档真实可查）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【我们承诺采用的是学校原版纸张（纸质、底色、纹路），我们拥有全套进口原装设备，特殊工艺都是采用不同机器制作，仿真度基本可以达到100%，所有工艺效果都可提前给客户展示，不满意可以根据客户要求进行调整，直到满意为止！】
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信41543339】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信41543339】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
留信网服务项目：
1、留学生专业人才库服务（留信分析）
2、国（境）学习人员提供就业推荐信服务
3、留学人员区块链存储服务
→ 【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：客户在留信官方认证查询网站查询到认证通过结果后付款，不成功不收费！
一比一原版(Chester毕业证书)切斯特大学毕业证如何办理
毕业原版【微信:41543339】【(Chester毕业证书)切斯特大学毕业证】【微信:41543339】成绩单、外壳、offer、留信学历认证（永久存档真实可查）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【我们承诺采用的是学校原版纸张（纸质、底色、纹路），我们拥有全套进口原装设备，特殊工艺都是采用不同机器制作，仿真度基本可以达到100%，所有工艺效果都可提前给客户展示，不满意可以根据客户要求进行调整，直到满意为止！】
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信41543339】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信41543339】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
留信网服务项目：
1、留学生专业人才库服务（留信分析）
2、国（境）学习人员提供就业推荐信服务
3、留学人员区块链存储服务
→ 【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：客户在留信官方认证查询网站查询到认证通过结果后付款，不成功不收费！
一比一原版(爱大毕业证书)爱丁堡大学毕业证如何办理
毕业原版【微信:41543339】【(爱大毕业证书)爱丁堡大学毕业证】【微信:41543339】成绩单、外壳、offer、留信学历认证（永久存档真实可查）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【我们承诺采用的是学校原版纸张（纸质、底色、纹路），我们拥有全套进口原装设备，特殊工艺都是采用不同机器制作，仿真度基本可以达到100%，所有工艺效果都可提前给客户展示，不满意可以根据客户要求进行调整，直到满意为止！】
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信41543339】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信41543339】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
留信网服务项目：
1、留学生专业人才库服务（留信分析）
2、国（境）学习人员提供就业推荐信服务
3、留学人员区块链存储服务
→ 【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：客户在留信官方认证查询网站查询到认证通过结果后付款，不成功不收费！
4th Modern Marketing Reckoner by MMA Global India & Group M: 60+ experts on W...
The Modern Marketing Reckoner (MMR) is a comprehensive resource packed with POVs from 60+ industry leaders on how AI is transforming the 4 key pillars of marketing – product, place, price and promotions.
The Building Blocks of QuestDB, a Time Series Database
Talk Delivered at Valencia Codes Meetup 2024-06.
Traditionally, databases have treated timestamps just as another data type. However, when performing real-time analytics, timestamps should be first class citizens and we need rich time semantics to get the most out of our data. We also need to deal with ever growing datasets while keeping performant, which is as fun as it sounds.
It is no wonder time-series databases are now more popular than ever before. Join me in this session to learn about the internal architecture and building blocks of QuestDB, an open source time-series database designed for speed. We will also review a history of some of the changes we have gone over the past two years to deal with late and unordered data, non-blocking writes, read-replicas, or faster batch ingestion.
一比一原版(Glasgow毕业证书)格拉斯哥大学毕业证如何办理
毕业原版【微信:41543339】【(Glasgow毕业证书)格拉斯哥大学毕业证】【微信:41543339】成绩单、外壳、offer、留信学历认证（永久存档真实可查）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【我们承诺采用的是学校原版纸张（纸质、底色、纹路），我们拥有全套进口原装设备，特殊工艺都是采用不同机器制作，仿真度基本可以达到100%，所有工艺效果都可提前给客户展示，不满意可以根据客户要求进行调整，直到满意为止！】
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信41543339】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信41543339】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
留信网服务项目：
1、留学生专业人才库服务（留信分析）
2、国（境）学习人员提供就业推荐信服务
3、留学人员区块链存储服务
→ 【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：客户在留信官方认证查询网站查询到认证通过结果后付款，不成功不收费！
06-04-2024 - NYC Tech Week - Discussion on Vector Databases, Unstructured Dat...
06-04-2024 - NYC Tech Week - Discussion on Vector Databases, Unstructured Data and AI
Discussion on Vector Databases, Unstructured Data and AI
https://www.meetup.com/unstructured-data-meetup-new-york/
This meetup is for people working in unstructured data. Speakers will come present about related topics such as vector databases, LLMs, and managing data at scale. The intended audience of this group includes roles like machine learning engineers, data scientists, data engineers, software engineers, and PMs.This meetup was formerly Milvus Meetup, and is sponsored by Zilliz maintainers of Milvus.
Population Growth in Bataan: The effects of population growth around rural pl...
A population analysis specific to Bataan.
University of New South Wales degree offer diploma Transcript
澳洲UNSW毕业证书制作新南威尔士大学假文凭定制Q微168899991做UNSW留信网教留服认证海牙认证改UNSW成绩单GPA做UNSW假学位证假文凭高仿毕业证申请新南威尔士大学University of New South Wales degree offer diploma Transcript
End-to-end pipeline agility - Berlin Buzzwords 2024
We describe how we achieve high change agility in data engineering by eliminating the fear of breaking downstream data pipelines through end-to-end pipeline testing, and by using schema metaprogramming to safely eliminate boilerplate involved in changes that affect whole pipelines.
A quick poll on agility in changing pipelines from end to end indicated a huge span in capabilities. For the question "How long time does it take for all downstream pipelines to be adapted to an upstream change," the median response was 6 months, but some respondents could do it in less than a day. When quantitative data engineering differences between the best and worst are measured, the span is often 100x-1000x, sometimes even more.
A long time ago, we suffered at Spotify from fear of changing pipelines due to not knowing what the impact might be downstream. We made plans for a technical solution to test pipelines end-to-end to mitigate that fear, but the effort failed for cultural reasons. We eventually solved this challenge, but in a different context. In this presentation we will describe how we test full pipelines effectively by manipulating workflow orchestration, which enables us to make changes in pipelines without fear of breaking downstream.
Making schema changes that affect many jobs also involves a lot of toil and boilerplate. Using schema-on-read mitigates some of it, but has drawbacks since it makes it more difficult to detect errors early. We will describe how we have rejected this tradeoff by applying schema metaprogramming, eliminating boilerplate but keeping the protection of static typing, thereby further improving agility to quickly modify data pipelines without fear.
Intelligence supported media monitoring in veterinary medicine
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DSSML24_tspann_CodelessGenerativeAIPipelines
Codeless Generative AI Pipelines
(GenAI with Milvus)
https://ml.dssconf.pl/user.html#!/lecture/DSSML24-041a/rate
Discover the potential of real-time streaming in the context of GenAI as we delve into the intricacies of Apache NiFi and its capabilities. Learn how this tool can significantly simplify the data engineering workflow for GenAI applications, allowing you to focus on the creative aspects rather than the technical complexities. I will guide you through practical examples and use cases, showing the impact of automation on prompt building. From data ingestion to transformation and delivery, witness how Apache NiFi streamlines the entire pipeline, ensuring a smooth and hassle-free experience.
Timothy Spann
https://www.youtube.com/@FLaNK-Stack
https://medium.com/@tspann
https://www.datainmotion.dev/
milvus, unstructured data, vector database, zilliz, cloud, vectors, python, deep learning, generative ai, genai, nifi, kafka, flink, streaming, iot, edge
ViewShift: Hassle-free Dynamic Policy Enforcement for Every Data Lake
Dynamic policy enforcement is becoming an increasingly important topic in today’s world where data privacy and compliance is a top priority for companies, individuals, and regulators alike. In these slides, we discuss how LinkedIn implements a powerful dynamic policy enforcement engine, called ViewShift, and integrates it within its data lake. We show the query engine architecture and how catalog implementations can automatically route table resolutions to compliance-enforcing SQL views. Such views have a set of very interesting properties: (1) They are auto-generated from declarative data annotations. (2) They respect user-level consent and preferences (3) They are context-aware, encoding a different set of transformations for different use cases (4) They are portable; while the SQL logic is only implemented in one SQL dialect, it is accessible in all engines.
#SQL #Views #Privacy #Compliance #DataLake
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- 1. Bedaquiline's Clinical Efficacy in the Management of Drug- Resistant TB Drug-resistant tuberculosis (TB) is a critical global health issue. This presentation aims to explore the clinical efficacy of Bedaquiline as a novel drug for the management of drug-resistant TB.
- 2. Introduction 1 Drug-Resistant TB Drug-resistant TB is a form of tuberculosis that is resistant to the standard antibiotics used for treatment. 2 Importance of Effective Treatments Finding effective treatments is crucial to combat this growing public health concern and reduce mortality rates.
- 3. Bedaquiline 1 Overview Bedaquiline is a novel medication specifically designed to target drug-resistant TB. 2 Mechanism of Action Bedaquiline inhibits the ATP synthase enzyme, disrupting energy production in TB bacteria and leading to their death. 3 Clinical Trials Extensive clinical trials have demonstrated Bedaquiline's effectiveness in treating drug-resistant TB.
- 4. Management of Drug-Resistant TB with Bedaquiline 1 Guidelines for Use Bedaquiline is recommended for use in combination with other antibiotics as part of a comprehensive treatment plan. 2 Challenges and Considerations Proper monitoring, dosing, and potential drug interactions are important factors in the successful management of drug-resistant TB with Bedaquiline. 3 Treatment Adherence Ensuring patient adherence to the prescribed Bedaquiline regimen is crucial for treatment success.
- 5. Benefits and Limitations Benefits of Bedaquiline Bedaquiline offers higher treatment success rates and shorter treatment duration compared to traditional antibiotics. Potential Side Effects While generally safe, some potential side effects of Bedaquiline include nausea, headache, and QT interval prolongation.
- 6. Case Studies Case Study 1 A male patient with extensively drug-resistant TB showed significant improvement after incorporating Bedaquiline into his treatment regimen. Case Study 2 A hospital-based study demonstrated the substantial reduction of treatment failure and disease relapse when Bedaquiline was administered. Case Study 3 A clinical trial showcased Bedaquiline's efficacy in treating multidrug-resistant TB among patients with HIV co- infection.
- 7. Conclusion 1 Summary Bedaquiline demonstrates promising clinical efficacy as a novel drug in the management of drug-resistant TB. 2 Future Research Further studies and development are needed to optimize treatment regimens and improve patient outcomes.