This document discusses antibiotics resistance and its role in eradicating epidemics. It begins with definitions of antibiotics and resistance, describing the four categories of antibiotics resistance. The aim is to strengthen surveillance and research to reduce infections and optimize antimicrobial use. Resistance develops from misuse and overuse of antibiotics, costing lives and health resources. Antibiotics treat bacterial infections critical for modern medicine; resistance results in increased costs and risks. A national action plan is recommended to monitor resistance, prevent infections, regulate medicine use, and promote appropriate disposal.