This document discusses antibiotics resistance and its role in eradicating epidemics. It begins with definitions of antibiotics and resistance, describing the four categories of antibiotics resistance. The aim is to strengthen surveillance and research to reduce infections and optimize antimicrobial use. Resistance develops from misuse and overuse of antibiotics, costing lives and health resources. Antibiotics treat bacterial infections critically important for modern medicine. However, antimicrobial resistance results in substantial costs. The document concludes clinical guidelines and education can contribute to more prudent antibiotic use, while a robust national action plan is needed to tackle the global problem of resistance at all levels of healthcare.