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activeFX
deepFX
    totalFX
       UltraPulse                            ®




       Fractional Laser Treatments
   ActiveFX | DeepFX | TotalFX
           ™             ™               ™




                 www.aesthetic.lumenis.com
UltraPulse                          innovative
                               versatile
                                   profitable
Since 1966, Lumenis has been dedicated to engineering, manufacturing and
distributing the world’s most advanced laser and intense-pulsed light systems.
Between its five divisions it holds more than 160 patents on which much of the
laser industry rests. With more than 80,000 systems installed in Dermatology,
Urology, Ophthalmology, Otolaryngology and Aesthetic offices worldwide,
Lumenis has committed itself to light-based medicine.




                                              Introduced 1020             Introduced UltraPulse         Launched ActiveFX,
                First CO2 laser               CO2 for surgical            Encore; revolutionized        the world’s first
                supplied to Albert            applications                aesthetic laser industry      Fractional CO2
                Einstein Hospital




                               1973       1980        1986        1990         1998         2002        2005        2007


                               Introduced                                                Received FDA
                               SuperPulse CO2,                   Introduced              approval for
                               established as the                                        UltraPulse            Launched DeepFX,
                                                                 UltraPulse
                               standard in modern                                        SurgiTouch;           the world’s first micro-
                                                                 technology
                               laser applications                                        the world’s first     fractional CO2
                                                                                         application-guided
                                                                                         pulsed CO2 laser




           UltraPulse         ®
                                  technology was introduced more than 18 years ago,
           and has proven itself with over 34            FDA-cleared indications.
           Considered the gold standard of CO2 lasers, UltraPulse has been
           referenced in over 90        peer-reviewed publications. With its
           long history of fractional capabilities, UltraPulse has led the way
           in fractional resurfacing.
UltraPulse                                                                 innovation
    The evolution of UltraPulse
    The first CO2 lasers delivered energy in continuous waves. These lasers could not produce
    very high peak powers for sustained periods so had limited pulse energy. As a result
    charring often occurred when attempting to resurface tissue with practical spot sizes.

                                                         UltraPulse
                                                         CW
                                                         Super-Pulse
                                                                                              UltraPulse high-energy short pulse:
                                                                                              • ablates tissue quickly and provides hemostasis
                                                                                              • delivers four times more energy per pulse than
                                                                                                the super-pulse laser 1
                                                                                              • results in more new collagen formation than
                                                                                                the super-pulse laser 2




                                           UltraPulse fractional laser treatments were introduced to optimize outcomes
                                           and downtime. The introduction of ActiveFX and DeepFX —the first
                                                                                                                    ™            ™




                                           fractional CO2 treatments available—reduced downtime and provided
                                           dramatic results. Both procedures require only one system, one pass and
                                           one treatment.


   TotalFX
                                                                       inter-channel efficacy
                                                                       TUNEL microscopy demonstrates a continuum of
                                                                       thermal damage throughout the dermis. Areas of red
                                                                       represent viable cells, while green and orange show
                                                                       areas of thermal damage. Only the UltraPulse DeepFX
                                                                       has scientifically demonstrated the ability to ablate
                                                                       narrow microchannels and also thermally affect the entire
                                                                       area of tissue between these channels.
   histology courtesy of UTSW Dept. of Plastic Surgery




1
  Goldman, Mitchel P and Fitzpatrick, Richard E. Cutaneous Laser Surgery. 2nd ed. St Louis: Mosby 1999.
2
 Alster, TS, Nanni CA, Williams CM. Comparison of Four Carbon Dioxide Resurfacing Lasers. Dermatol Surg. 1999 Mar;25(3):153-8.
UltraPulse                                                                                versatile
single system | multi-technology platform
The UltraPulse® system provides a full spectrum of resurfacing and surgical
capabilities with a single-platform interface. With multiple spot sizes and delivery
options, the UltraPulse is the industry’s most versatile CO2 system available.




                    ActiveFX               DeepFX                   TrueSpot             focused incisional           UltraFlex
                UltraScan CPG            microscanner         collimated handpiece          handpiece                waveguide




                       ActiveFX                         DeepFX                       TotalFX
                                     ™                              ™                           ™




                       Treat fine lines, texture        Treat deep wrinkles          COMBINE treatments
                       and dyschromia                   and scars                    for total outcomes



   Adjustable
 Healing Zone
       Volume




    Spot Size

                          1.3 mm                          0.12 mm




       Depth




                                                                                                         variable treatment patterns
                                                                                                          Multiple shapes, sizes and densities




                                                                                                          ActiveFX
UltraPulse                                                                                  versatile

                 total fractional capabilities
                 Fractional procedures ablate discrete columns of tissue, deposit heat and
                 promote regeneration throughout the underlying layers of the skin. ActiveFX and
                 DeepFX fractional laser treatments are single-pass procedures that ensure even
                 coverage and eliminate the possibility of overlap.




                                                                                         immediate volume reduction
                                                                                         Each laser pulse ablates a column of tissue causing
                                                                                         volumetric skin reduction. The ablation removes
                                                                                         surface discolorations and deposits heat deep in the
                                                                                         dermis. The deep heating causes immediate collagen
                                                                                         contraction and long-term collagen remodeling.
         histology courtesy of Vladimir Lemberg, PhD




                customizable treatment
                                                       customized coverage                                       customized depth
                                                       5–100% ablation                                           50 –2000 µm




                                                       histology courtesy of Vladimir Lemberg, PhD               histology courtesy of Vladimir Lemberg, PhD


                                                       Customize treatments for each patient                     Target dyschromia, fine lines, deep
                                                       based on their indication and needs by                    wrinkles and scars by choosing the depth
                                                       selecting the density of tissue treated.                  of ablation. Use ActiveFX for indications
                                                       Only the UltraPulse gives the flexibility                 with epidermal components, and DeepFX
                                                       of 5-100% coverage in a single pass.                      for deep dermal stimulation.


DeepFX
UltraPulse                                                                             profitable
   One system, one treatment, one pass.

                                            ActiveFX                                                          DeepFX                          TotalFX
conomy
         Adjustable
         Healing Zone
         Volume




         Delivery
         Devices




      Return on Investment*                                                                                   $ 3.0

                                                                                                               2.5
                                                                                       total ROI (millions)




        • Low-cost consumables                                                                                 2.0

                                                                                                               1.5
        • Single treatment results
                                                                                                               1.0

        • Exceptional per treatment                                                                            0.5
          compensation                                                                                           0

                                                                                                                      1    2             3            4             5
             *Assumes 20 treatments per month at $2500 each, less cost of operation.                                                  years




                 You’re going to get this immediate effect and then you get the                                           I like the flexibility because we treat some patients
                 long-term collagen stimulation. The nice thing is that patients                                          with pigment. Both Asian patients and Hispanic
                 come in and get an instant result. So the satisfaction from the                                          patients have been treated up to and including skin
                 patient is high and the risk of complication is extremely low. It is                                     type five, with moderate settings and negligible risk
                 easy for the patient to take care of and easy for the physician                                          of hyperpigmentation.
                 to deal with in the post-operative care period.
                                                                                                                          Jeffrey Kenkel, MD
                 James Heinrich, MD
UltraPulse
PIGMENTATION
                                                          Clinical Case Studies
                                                                SCARS
BEFORE                                            AFTER         BEFORE                                            AFTER




photos courtesy of Matteo Tretti Clementoni, MD                 photos courtesy of Matteo Tretti Clementoni, MD




PERIORAL WRINKLES
BEFORE                                            AFTER         BEFORE                                            AFTER




photos courtesy of Robert Weiss, MD                             photos courtesy of Girish Munavalli, MD




PERIORBITAL WRINKLES
BEFORE                                            AFTER         BEFORE                                            AFTER




photos courtesy of Glenn DeBias, DO                             photos courtesy of Glenn DeBias, DO
AESThETiC



            Support Services:
            • Clinical / Scientific Training is provided by practitioners who use systems daily and utilizes their deep
              knowledge of clinical science and real world experience. Advanced training options are also available at the
              offices of local luminaries or with CME-accredited associations.

            • Marketing Support is delivered through Building Blocks kits. Build your practice with a series of
              customizable advertisements, presentations, education materials, letters and much more. Additionally, with
              registration, your practice is listed on www.skinandhealth.com, a resource for patients and a source of
              referrals for you.

            • Technical Support is ready to take your call. Whether your system is serviced at the factory or by our
              team of regionally based service engineers, we are committed to keeping your practice running smoothly.

             To learn about what Lumenis has to offer, visit www.lumenis.com or call 877-LUMENIS.



            specifications
            Specifications
            Device Type                                                                                                                     UltraPulse Fractionated CO2
            Wavelength                                                                                                                      10,600 nm
            Laser Type                                                                                                                      UltraPulse or CW
            Spot Sizes                                                                                                                      2000 µm, 1300 µm, 1000 µm, 200 µm, 120 µm
            Power to Tissue                                                                                                                 240 Watts
            Percent Coverage per Pass                                                                                                       5-100%
            Depth of Penetration                                                                                                            up to 2000 µm per pulse
            FDA-Cleared indications                                                                                                         >100
            FDA-Cleared Aesthetic indications                                                                                               34
            Full Resurfacing Capabilities                                                                                                   yes
            Fractional Capabilities                                                                                                         yes
            incisional Capabilities                                                                                                         yes
            Excisional Capabilities                                                                                                         yes
            Recommended Passes per Treatment                                                                                                1
            Estimated Time per Pass                                                                                                         15-20 minutes
            Estimated Time per Treatment                                                                                                    15-20 minutes
            Consumable Cost per Treatment                                                                                                   $0-$40




                         Products manufactured in Salt Lake City (CE 0044)




                                                                                             10/07
                                                                                             Hello Andrew
                                                                        AMERICAS                                                            EUROPE / MIDDLE EAST
                                                                                             Lumenis has 2 manufacturing sites, Yokneam in Israel and Salt
                                                                                                                                                                          JAPAN                                 ASIA / PACIFIC
                                                                                             Lake City.

                         Products manufactured in Yokneam (CE 0473)     Lumenis Inc. Due to historical reasons, we have the ISO andNotified Bodies (the (GERMANY) GmbH
                                                                                      organization that certifies us with
                                                                                                                          2 separate
                                                                                                                                      Lumenis
                                                                                                                                     CE approvals)                        Lumenis (JAPAN) Co. Ltd.              Lumenis (CHINA) Ltd.
                                                                        Santa Clara, CA, USA by Amtac from UK. Products manufactured
                                                                                      Yokneam is certified                            Dreieich-Dreieichenhain,            Tokyo, Japan                          Beijing, China
                                                                        Tel +1 408 764 3000                                           Germany                             Tel + 81 3 6743 8300                  Tel + 86 10 6510 2620
                                                                                      in Yokneam are marked with the CE 0473, this is the Amtac ID
                                                                                      number.

                                                                              1 877 586 Lake is certified by TUVmarkedand0044. Telall products49 6103 8335 0
                                                                                       Salt 3647
                                                                                      manufactured by them are
                                                                                                                    Essen,
                                                                                                                           CE
                                                                                                                               accordingly     +                          Fax + 81 3 6743 8301                  Fax + 86 10 6510 2621
                                                                        Fax +1 408 764number accompanying the CE is the ID number for the 49 6103 8335 300
                                                                                      The
                                                                                            3999                                      Fax +
                                                                              1 800 505 1133
                                                                                      Notified Body, 0473 for Amtac and 0044 for TUV Essen

                                                                                             0197 is not applicable for Lumenis products.

                                                                                             I hope this clarifies the issue,
                                                                                             Best regards

                                                                             ©2008, the Lumenis Group of Companies. All rights reserved. Lumenis, its logo, UltraPulse, ActiveFX, DeepFX, TotalFX, TrueSpot and SurgiTouch are trademarks or registered
                                                                                              Dorit Rabkin
                                                                             trademarks of theRegulatory Manager
                                                                                                Lumenis Group of Companies. Specifications are subject to change without notice. Printed in the U.S.A. This product is CE marked. 8/09
                                                                                              Lumenis Ltd., Israel
                                                                                                                                                                                                                                       PB-1013680 rev D
                                                                                             Phone: 972-4--959 9033
                                                                                             Fax: 972-4-959 9275
                                                                                             E-mail: DRabkin@lumenis.com

                         AuraPT only (CE 0197)

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Ultra pulse encore

  • 1. activeFX deepFX totalFX UltraPulse ® Fractional Laser Treatments ActiveFX | DeepFX | TotalFX ™ ™ ™ www.aesthetic.lumenis.com
  • 2. UltraPulse innovative versatile profitable Since 1966, Lumenis has been dedicated to engineering, manufacturing and distributing the world’s most advanced laser and intense-pulsed light systems. Between its five divisions it holds more than 160 patents on which much of the laser industry rests. With more than 80,000 systems installed in Dermatology, Urology, Ophthalmology, Otolaryngology and Aesthetic offices worldwide, Lumenis has committed itself to light-based medicine. Introduced 1020 Introduced UltraPulse Launched ActiveFX, First CO2 laser CO2 for surgical Encore; revolutionized the world’s first supplied to Albert applications aesthetic laser industry Fractional CO2 Einstein Hospital 1973 1980 1986 1990 1998 2002 2005 2007 Introduced Received FDA SuperPulse CO2, Introduced approval for established as the UltraPulse Launched DeepFX, UltraPulse standard in modern SurgiTouch; the world’s first micro- technology laser applications the world’s first fractional CO2 application-guided pulsed CO2 laser UltraPulse ® technology was introduced more than 18 years ago, and has proven itself with over 34 FDA-cleared indications. Considered the gold standard of CO2 lasers, UltraPulse has been referenced in over 90 peer-reviewed publications. With its long history of fractional capabilities, UltraPulse has led the way in fractional resurfacing.
  • 3. UltraPulse innovation The evolution of UltraPulse The first CO2 lasers delivered energy in continuous waves. These lasers could not produce very high peak powers for sustained periods so had limited pulse energy. As a result charring often occurred when attempting to resurface tissue with practical spot sizes. UltraPulse CW Super-Pulse UltraPulse high-energy short pulse: • ablates tissue quickly and provides hemostasis • delivers four times more energy per pulse than the super-pulse laser 1 • results in more new collagen formation than the super-pulse laser 2 UltraPulse fractional laser treatments were introduced to optimize outcomes and downtime. The introduction of ActiveFX and DeepFX —the first ™ ™ fractional CO2 treatments available—reduced downtime and provided dramatic results. Both procedures require only one system, one pass and one treatment. TotalFX inter-channel efficacy TUNEL microscopy demonstrates a continuum of thermal damage throughout the dermis. Areas of red represent viable cells, while green and orange show areas of thermal damage. Only the UltraPulse DeepFX has scientifically demonstrated the ability to ablate narrow microchannels and also thermally affect the entire area of tissue between these channels. histology courtesy of UTSW Dept. of Plastic Surgery 1 Goldman, Mitchel P and Fitzpatrick, Richard E. Cutaneous Laser Surgery. 2nd ed. St Louis: Mosby 1999. 2 Alster, TS, Nanni CA, Williams CM. Comparison of Four Carbon Dioxide Resurfacing Lasers. Dermatol Surg. 1999 Mar;25(3):153-8.
  • 4. UltraPulse versatile single system | multi-technology platform The UltraPulse® system provides a full spectrum of resurfacing and surgical capabilities with a single-platform interface. With multiple spot sizes and delivery options, the UltraPulse is the industry’s most versatile CO2 system available. ActiveFX DeepFX TrueSpot focused incisional UltraFlex UltraScan CPG microscanner collimated handpiece handpiece waveguide ActiveFX DeepFX TotalFX ™ ™ ™ Treat fine lines, texture Treat deep wrinkles COMBINE treatments and dyschromia and scars for total outcomes Adjustable Healing Zone Volume Spot Size 1.3 mm 0.12 mm Depth variable treatment patterns Multiple shapes, sizes and densities ActiveFX
  • 5. UltraPulse versatile total fractional capabilities Fractional procedures ablate discrete columns of tissue, deposit heat and promote regeneration throughout the underlying layers of the skin. ActiveFX and DeepFX fractional laser treatments are single-pass procedures that ensure even coverage and eliminate the possibility of overlap. immediate volume reduction Each laser pulse ablates a column of tissue causing volumetric skin reduction. The ablation removes surface discolorations and deposits heat deep in the dermis. The deep heating causes immediate collagen contraction and long-term collagen remodeling. histology courtesy of Vladimir Lemberg, PhD customizable treatment customized coverage customized depth 5–100% ablation 50 –2000 µm histology courtesy of Vladimir Lemberg, PhD histology courtesy of Vladimir Lemberg, PhD Customize treatments for each patient Target dyschromia, fine lines, deep based on their indication and needs by wrinkles and scars by choosing the depth selecting the density of tissue treated. of ablation. Use ActiveFX for indications Only the UltraPulse gives the flexibility with epidermal components, and DeepFX of 5-100% coverage in a single pass. for deep dermal stimulation. DeepFX
  • 6. UltraPulse profitable One system, one treatment, one pass. ActiveFX DeepFX TotalFX conomy Adjustable Healing Zone Volume Delivery Devices Return on Investment* $ 3.0 2.5 total ROI (millions) • Low-cost consumables 2.0 1.5 • Single treatment results 1.0 • Exceptional per treatment 0.5 compensation 0 1 2 3 4 5 *Assumes 20 treatments per month at $2500 each, less cost of operation. years You’re going to get this immediate effect and then you get the I like the flexibility because we treat some patients long-term collagen stimulation. The nice thing is that patients with pigment. Both Asian patients and Hispanic come in and get an instant result. So the satisfaction from the patients have been treated up to and including skin patient is high and the risk of complication is extremely low. It is type five, with moderate settings and negligible risk easy for the patient to take care of and easy for the physician of hyperpigmentation. to deal with in the post-operative care period. Jeffrey Kenkel, MD James Heinrich, MD
  • 7. UltraPulse PIGMENTATION Clinical Case Studies SCARS BEFORE AFTER BEFORE AFTER photos courtesy of Matteo Tretti Clementoni, MD photos courtesy of Matteo Tretti Clementoni, MD PERIORAL WRINKLES BEFORE AFTER BEFORE AFTER photos courtesy of Robert Weiss, MD photos courtesy of Girish Munavalli, MD PERIORBITAL WRINKLES BEFORE AFTER BEFORE AFTER photos courtesy of Glenn DeBias, DO photos courtesy of Glenn DeBias, DO
  • 8. AESThETiC Support Services: • Clinical / Scientific Training is provided by practitioners who use systems daily and utilizes their deep knowledge of clinical science and real world experience. Advanced training options are also available at the offices of local luminaries or with CME-accredited associations. • Marketing Support is delivered through Building Blocks kits. Build your practice with a series of customizable advertisements, presentations, education materials, letters and much more. Additionally, with registration, your practice is listed on www.skinandhealth.com, a resource for patients and a source of referrals for you. • Technical Support is ready to take your call. Whether your system is serviced at the factory or by our team of regionally based service engineers, we are committed to keeping your practice running smoothly. To learn about what Lumenis has to offer, visit www.lumenis.com or call 877-LUMENIS. specifications Specifications Device Type UltraPulse Fractionated CO2 Wavelength 10,600 nm Laser Type UltraPulse or CW Spot Sizes 2000 µm, 1300 µm, 1000 µm, 200 µm, 120 µm Power to Tissue 240 Watts Percent Coverage per Pass 5-100% Depth of Penetration up to 2000 µm per pulse FDA-Cleared indications >100 FDA-Cleared Aesthetic indications 34 Full Resurfacing Capabilities yes Fractional Capabilities yes incisional Capabilities yes Excisional Capabilities yes Recommended Passes per Treatment 1 Estimated Time per Pass 15-20 minutes Estimated Time per Treatment 15-20 minutes Consumable Cost per Treatment $0-$40 Products manufactured in Salt Lake City (CE 0044) 10/07 Hello Andrew AMERICAS EUROPE / MIDDLE EAST Lumenis has 2 manufacturing sites, Yokneam in Israel and Salt JAPAN ASIA / PACIFIC Lake City. Products manufactured in Yokneam (CE 0473) Lumenis Inc. Due to historical reasons, we have the ISO andNotified Bodies (the (GERMANY) GmbH organization that certifies us with 2 separate Lumenis CE approvals) Lumenis (JAPAN) Co. Ltd. Lumenis (CHINA) Ltd. Santa Clara, CA, USA by Amtac from UK. Products manufactured Yokneam is certified Dreieich-Dreieichenhain, Tokyo, Japan Beijing, China Tel +1 408 764 3000 Germany Tel + 81 3 6743 8300 Tel + 86 10 6510 2620 in Yokneam are marked with the CE 0473, this is the Amtac ID number. 1 877 586 Lake is certified by TUVmarkedand0044. Telall products49 6103 8335 0 Salt 3647 manufactured by them are Essen, CE accordingly + Fax + 81 3 6743 8301 Fax + 86 10 6510 2621 Fax +1 408 764number accompanying the CE is the ID number for the 49 6103 8335 300 The 3999 Fax + 1 800 505 1133 Notified Body, 0473 for Amtac and 0044 for TUV Essen 0197 is not applicable for Lumenis products. I hope this clarifies the issue, Best regards ©2008, the Lumenis Group of Companies. All rights reserved. Lumenis, its logo, UltraPulse, ActiveFX, DeepFX, TotalFX, TrueSpot and SurgiTouch are trademarks or registered Dorit Rabkin trademarks of theRegulatory Manager Lumenis Group of Companies. Specifications are subject to change without notice. Printed in the U.S.A. This product is CE marked. 8/09 Lumenis Ltd., Israel PB-1013680 rev D Phone: 972-4--959 9033 Fax: 972-4-959 9275 E-mail: DRabkin@lumenis.com AuraPT only (CE 0197)