This document discusses a study that assessed the diagnostic accuracy of thoracic ultrasound (TUS) in differentiating malignant and benign pleural disease. The study involved 52 patients with suspected malignant pleural effusion who underwent both TUS and contrast-enhanced CT (CECT). TUS correctly diagnosed malignancy in 26 of 33 patients and benign disease in 19 of 19 patients, demonstrating a sensitivity of 73% and specificity of 100% for diagnosing malignant pleural disease. Pleural thickening over 1 cm, pleural nodularity, and diaphragmatic thickening over 7 mm identified on TUS were highly suggestive of malignancy. The study concludes that TUS is useful for differentiating malignant and benign pleural disease in
Although the great majority of incidentalomas are adrenocortical adenomas, a number of them, depending on the size and radiological characteristics of the lesions, will turn out to be carci- nomas. These tumors may present as suspicious on initial evaluation and potentially malignant or malignant on histology. Adrenocortical carcinoma is a rare and aggressive malignancy with evolving diagnostic and therapeutic approaches. Laparoscopic surgery has become the gold standard for surgery of benign adrenal tumors. Despite the extensive experience gained in laparoscopic adrenalectomy, controversy still remains in the management of adrenal tumors with high suspicion or evidence of malignancy. The aim of this review is to update the existing information regarding the diagnostic approach and surgical management of suspicious and potentially malignant primary adrenal tumors. The interpretation of radiologic characteris- tics is a cornerstone in pre-operative assessment of large adrenal masses, since open surgery remains the preferred procedure when malignancy is suspected in large tumors with possible local invasion. Despite the improvement of imaging techniques, they lack sufficient accuracy to exclude primary malignancy in tumors from 4 cm to 10 cm in size. An initial laparoscopic approach can be used in this group of patients, but early conversion to open technique is mandatory if curative resection cannot be performed. Adrenal tumors >10 cm of malignant potential should be treated by the open approach from the start. Solitary adrenal metastasis from another primary malignancy is usually amenable to laparoscopic surgery. Patients with suspected adrenal cancer should be referred to tertiary centers that perform laparoscopic and open adrenal surgery with minimal morbidity and mortality.
Although the great majority of incidentalomas are adrenocortical adenomas, a number of them, depending on the size and radiological characteristics of the lesions, will turn out to be carci- nomas. These tumors may present as suspicious on initial evaluation and potentially malignant or malignant on histology. Adrenocortical carcinoma is a rare and aggressive malignancy with evolving diagnostic and therapeutic approaches. Laparoscopic surgery has become the gold standard for surgery of benign adrenal tumors. Despite the extensive experience gained in laparoscopic adrenalectomy, controversy still remains in the management of adrenal tumors with high suspicion or evidence of malignancy. The aim of this review is to update the existing information regarding the diagnostic approach and surgical management of suspicious and potentially malignant primary adrenal tumors. The interpretation of radiologic characteris- tics is a cornerstone in pre-operative assessment of large adrenal masses, since open surgery remains the preferred procedure when malignancy is suspected in large tumors with possible local invasion. Despite the improvement of imaging techniques, they lack sufficient accuracy to exclude primary malignancy in tumors from 4 cm to 10 cm in size. An initial laparoscopic approach can be used in this group of patients, but early conversion to open technique is mandatory if curative resection cannot be performed. Adrenal tumors >10 cm of malignant potential should be treated by the open approach from the start. Solitary adrenal metastasis from another primary malignancy is usually amenable to laparoscopic surgery. Patients with suspected adrenal cancer should be referred to tertiary centers that perform laparoscopic and open adrenal surgery with minimal morbidity and mortality.
Il colangiocarcinoma: Epidemiologia, Fattori di rischio e patogenesi - Gastro...Gastrolearning
Gastrolearning II modulo/7a lezione
Il colangiocarcinoma: Epidemiologia, Fattori di rischio e patogenesi
Prof. D. Alvaro - Università di Roma La Sapienza
Il colangiocarcinoma: Epidemiologia, Fattori di rischio e patogenesi - Gastro...Gastrolearning
Gastrolearning II modulo/7a lezione
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ICN Victoria presents Dr Andrew Hilton, Intensivist at the Austin Hospital in Melbourne, talking on the use of ultrasound in ICU to evaluate and treat lung pathology. Recorded at our November 2014 ICN Victoria meeting.
Co-relation of multidetector CT scan based preoperative staging with intra-op...Apollo Hospitals
To assess the accuracy of CT scan in preoperative staging, to correlate preoperative findings with operative findings and with post-operative histopathological findings of colorectal carcinoma.
Evaluation of Obstructive Uropathy with Computed Tomography Urography and Mag...iosrjce
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Sarcoma is one of the leading cancer centers in Washington DC providing the best musculoskeletal cancer surgery. Dr. Martin Malawer is a highly specialized surgeon who had pioneered in the field of limb-sparing surgery.
Background: There is a global resolve among Clinicians towards adoption of imaging modalities in the evaluation of appendicitis because clinical algorithms have been disappointing. We sought to determine the authenticity of interobserver variability in ultrasound scan interpretation in a resourceconstrained mission hospital settings, northwestern region of Cameroon. Methods: In this study, we reviewed the standardized diagnostic approach in acute appendicitis and also performed prospective cross observational qualitative testing using sensitivity, specifi city, positive predictive value, negative predictive value, and accuracy to determine the interobserver variability of ultrasonography using the medical database of the two Mission Hospitals, northwestern region of Cameroon from January 2012 to December 2016. A sequential non-randomized convenient sampling was used and data was analyzed using the Statistical Package for the Social Sciences version 22.
Similar to Ulrassonagrafia de tórax em derrames pleurais (20)
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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The prostate is an exocrine gland of the male mammalian reproductive system
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
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1. Pleural disease
Thoracic ultrasound in the diagnosis of malignant
pleural effusion
N R Qureshi,1 N M Rahman,2 F V Gleeson3
See Editorial, p 97 ABSTRACT criteria established in previous studies.12 13 CECT is
Background: Malignant pleural effusion (MPE) is a recommended as the next investigation, with a
c Additional details of the
techniques, statistical analysis common clinical problem with described investigation view to subsequent histological diagnosis (blind,
and figures are published online pathways. While thoracic ultrasound (TUS) has been image-guided or thoracoscopic pleural biopsy).4 14
only at http://thorax.bmj.com/ shown to be accurate in pleural fluid detection, its use in Thoracic ultrasound (TUS) is a valuable clinical
content/vol64/issue2 tool which is increasingly being performed by chest
the diagnosis of malignant pleural disease has not been
1
Department of Radiology, assessed. A study was undertaken to assess the physicians. In the UK, guidelines have recently
Papworth Hospital NHS diagnostic accuracy of TUS in differentiating malignant been published with suggested training for physi-
Foundation Trust, Papworth
and benign pleural disease. cians with an interest in practising TUS.15
Everard, Cambridge, UK;
2
Oxford Centre for Respiratory Methods: 52 consecutive patients with suspected MPE Hitherto, the role of TUS has been limited to
Medicine and University of underwent TUS and contrast-enhanced CT (CECT). TUS pleural fluid detection (with high sensitivity) and
Oxford, Oxford Radcliffe was used to assess pleural surfaces using previously image-guided techniques (thoracocentesis, drain
Hospital, Oxford, UK; placement, lung biopsy).14
3
Department of Radiology,
published CT imaging criteria for malignancy, diaphrag-
Oxford Radcliffe Hospital, matic thickness/nodularity, effusion size/nature and The sonographic appearance of malignant
Oxford, UK presence of hepatic metastasis (in right-sided effusions). pleural effusion and the value of ultrasound in
A TUS diagnosis of malignant or benign disease was determining the nature of pleural effusion have
Correspondence to: made blind to clinical data/other investigations by a been described in previous studies.16 17 However,
Dr F V Gleeson, Department of
Radiology, Oxford Radcliffe second blinded operator using anonymised TUS video there are no published studies to our knowledge
Hospital, Headington, Oxford clips. The TUS diagnosis was compared with the definitive which have assessed the diagnostic accuracy of
OX3 7LJ, UK; fergus.gleeson@ clinical diagnosis and in addition to the diagnosis found at ultrasound for malignancy in patients with sus-
nds.ox.ac.uk
CECT. pected but undiagnosed malignant pleural effusion.
NRQ and NMR are joint first Results: A definitive malignant diagnosis was based on The primary aims of this study were therefore
authors with equal roles in histocytology (30/33; 91%) and clinical/CT follow-up (1) to assess the sensitivity and specificity of
design, delivery and publication. (3/33; 9%). Benign diagnoses were based on negative ultrasound in the detection of malignant disease
Received 29 June 2008 histocytology and follow-up over 12 months in 19/19 in patients with suspected malignant pleural
Accepted 23 September 2008 patients. TUS correctly diagnosed malignancy in 26/33 effusion using established morphological criteria
Published Online First patients (sensitivity 73%, specificity 100%, positive from CECT; and (2) to investigate the use of other
13 October 2008 morphological characteristics on TUS associated
predictive value 100%, negative predictive value 79%) and
benign disease in 19/19. Pleural thickening .1 cm, with malignant pleural disease. In addition, the
pleural nodularity and diaphragmatic thickening .7 mm overall TUS diagnostic rate and CECT diagnostic
were highly suggestive of malignant disease. rate were compared, in comparison to a definitive
Conclusion: TUS is useful in differentiating malignant clinical diagnosis for malignant effusion.
from benign pleural disease in patients presenting with
suspected MPE and may become an important adjunct in METHODS
the diagnostic pathway.
Subjects
The study was undertaken in a tertiary referral
Investigation of pleural effusion of unknown centre for respiratory/pleural disease and involved
aetiology is well described in British, American consecutive patients presenting with unilateral
and European guidelines.1–3 These guidelines and pleural effusion of unknown aetiology from both
other papers4 recommend clinical evaluation, basic inpatient and outpatient settings.
radiological investigation and diagnostic pleural
fluid sampling in the majority of unilateral pleural Inclusion criteria
effusions. Malignancy remains the most common c Chest radiograph evidence of pleural effu-
cause of unilateral pleural effusion in the UK and sion(s).
USA, with an estimated 250 000 new cases of c No established diagnosis (malignant or other-
malignant pleural effusions per year.2 5 Cytology- wise) of the cause of pleural effusion.
positive pleural fluid is found in 60% of cases of
c The patient would in normal clinical practice
malignant pleural effusion,1 6–8 with a substantially undergo further investigations to establish the
lower positive rate in mesothelioma,9 and further cause of pleural effusion.
investigations to establish diagnosis are recom-
mended in the context of cytology-negative uni-
lateral pleural exudates.1–4 10 Thoracic CT scanning Exclusion criteria
with contrast enhancement (contrast-enhanced c A clinical and/or histological diagnosis had
CT, CECT) is a sensitive and specific test for been established.
malignant pleural disease,11 with morphological c Clinical and radiographic features of empyema.
Thorax 2009;64:139–143. doi:10.1136/thx.2008.100545 139
2. Pleural disease
c The patient was too ill to warrant further investigation in final diagnosis. Given that around 8% of patients with
normal clinical practise (eg, moribund patients). apparently benign histology on pleural biopsy develop malig-
nancy over time,18 all patients with benign disease were
Patients were identified by a respiratory trainee (NMR) and followed up (as part of routine clinical practice in our or the
referred for TUS with no clinical information on past history, host institution) for a minimum of 12 months to confirm that
presenting features or relevant investigations. malignant disease did not develop. For the purposes of this
We routinely perform a TUS in all patients presenting as study, ‘‘definitive diagnosis’’ was considered to be the diagnosis
above before biopsy, drain insertion or thoracoscopy and, as imparted to the patient and on which basis the patient was
such, this study was considered an audit of our current practice treated (see Results).
for which local ethics committee approval is not required in our
institution.
Statistical analysis
Details of the statistical analysis are given in the online
Ultrasound supplement.
Precise details of the ultrasound technique and operators are
given in the online supplement. All patients underwent TUS,
before which the most recent chest radiograph was reviewed.
RESULTS
TUS was performed without clinical history and previous three- Patients
dimensional (CT/MRI) imaging data. Anonymised video clips From January to September 2005, 52 consecutive patients were
and still images of the examination were generated. From these recruited. Their baseline characteristics are summarised in
TUS findings an overall diagnosis of malignant or benign pleural table 1.
disease was recorded on a reporting proforma (see online
supplement). Anonymised TUS data were then reviewed Definitive diagnosis
separately by a consultant radiologist experienced in thoracic Malignancy
ultrasound (FVG), blind to clinical history, previous investiga- Thirty-three patients of median age 68 years (range 41–89) were
tions (including radiology), physical status and appearance of diagnosed with malignant disease and 19 patients of median age
the patient. The final results of the blind analysis were recorded 68 years (range 22–88) were diagnosed with benign disease
by one of the authors (NRQ). (table 1). The mode of final diagnosis is shown in table 2. In 30/
33 cases (91%) the definitive diagnosis of malignancy was based
TUS diagnosis on histocytological confirmation. In the remaining 3 cases (9%)
Morphological criteria established as sensitive and specific to the diagnosis of pleural malignancy was based on follow-up CT
malignant pleural disease on CECT were used as the basis of appearances over a period of 6 months in association with a
TUS diagnosis. If a patient had any one of the following criteria clinical course (including death in all cases) consistent with
on TUS, a diagnosis of malignant disease was recorded: malignant disease.
c Diaphragmatic and parietal pleural nodule or nodules.
c Pleural thickening .1 cm. Benign disease
c Hepatic metastasis. After initial negative histocytological investigations, all cases of
A provisional diagnosis of malignant or benign pleural disease benign disease (19/19) were followed up for a minimum period
was recorded on the proforma prior to other investigations and of 12 months. This included patients with positive microbiol-
separately by each operator. ogy or ‘‘inflammation’’ on pleural biopsies. There were no
clinical or radiological features of malignancy during the follow-
Contrast-enhanced CT up period.
Precise details of CECT examinations are presented in the online
supplement. CECT examinations were reviewed in all cases and TUS overall characteristics
were reported blind to the previous TUS result (as the TUS Pleural effusion was right-sided in 32 patients, left-sided in 13
results were anonymised). In 40/52 patients, CECT was and bilateral in 7 (in which cases the larger effusion was
conducted in our institution; in 12/52 patients CECT studies assessed as this was considered to be the clinically relevant side).
had already been performed at the referring hospital. It was not The effusions were considered large in 13 patients, moderate in
considered ethical to subject these patients to further radio- 24 and small in 15 cases (table 3). Effusions were anechoic in 47/
logical examination for the purpose of this study. The hard copy 52 (90%), 22 were septated and 5 were diffusely echogenic. Liver
CT images from these institutions were reviewed blind to the ultrasound demonstrated metastases in 2 patients and was the
TUS result. An overall CT diagnosis of malignant or benign sole abnormality suggestive of malignancy in 1 (table 3).
disease was recorded based on the criteria of Leung et al,12 in
addition to the presence of metastatic disease or clear TUS diagnoses compared with definitive diagnosis
intraparenchymal evidence of malignancy (see online supple- There was good inter-observer agreement between the two TUS
ment). operators in the overall diagnosis of benign or malignant pleural
effusion (kappa 0.96, p,0.001), and the results of the more
Definitive diagnosis experienced operator (FVG) have been used for analysis in all
A histocytological diagnosis of malignancy was taken as subsequent results.
definitive confirmation of malignant aetiology. Microbiological The diagnosis based on the TUS overall correctly diagnosed
confirmation (most commonly tuberculosis) was taken as 26/33 patients with malignant disease and all 19 patients with
definitive confirmation of benign aetiology. In the absence of benign disease (sensitivity 79% (95% CI 61% to 91%), specificity
the above, the combination of clinical features and/or prolonged 100% (95% CI 82% to 100%), positive predictive value (PPV) 100%
radiological follow-up as appropriate was used to define the and negative predictive value (NPV) 73% for differentiating
140 Thorax 2009;64:139–143. doi:10.1136/thx.2008.100545
3. Pleural disease
Table 1 Summary of baseline patient characteristics Table 2 Method of final diagnosis
and final diagnoses Diagnostic method No of patients
Characteristics
Malignant disease (n = 33)
Number of patients 52 Pleural histology: 14
Women 17 Percutaneous biopsy 10
Median (range) age (years) 68 (22–89) Thoracoscopic biopsy 4
Men 35 Other histology: 5
Median (range) age (years) 61 (41–86) Bronchoscopy 2
Malignant disease (n = 33) Supraclavicular lymph node biopsy 2
Mesothelioma 14* Axillary lymph node biopsy 1
Adenocarcinoma 13 Pleural fluid cytology: 11
Lymphoma 2 Clinical follow-up and repeat radiology 3
Small cell lung carcinoma 2 Total 33
Squamous cell lung carcinoma 1 Benign disease* (n = 19)
Bronchogenic carcinoma (radiological diagnosis only) 1 Pleural histology{: 6
Benign disease (n = 19) Percutaneous biopsy 4
Congestive cardiac failure 6 Thoracoscopic biopsy 2
Benign pleural fibrosis 7 Other histology: 3
Parapneumonic effusion 2 Supraclavicular lymph node biopsy 2
Tuberculous pleuritis 2 Pericardectomy 1
Benign asbestos-related effusion 1 Pleural fluid cytology negative 10
Constrictive pericarditis 1 Total 19
*12 cases of mesothelioma were diagnosed histocytologically; the Pleural fluid cytology was taken as confirmation of malignancy only in the presence of
remaining 2 were diagnosed on clinical and radiological follow-up a confident histopathology opinion reporting confirmed malignant cells on cytology ¡
with a history of asbestos exposure. immunostaining as required. In these cases, no further investigation to establish
diagnosis was required. Negative pleural fluid cytology was not taken as definitive
proof of benign aetiology (hence clinical follow-up as below was pursued).
malignant from benign pleural disease with a likelihood ratio *All patients with a diagnosis of benign disease were followed up for a period of
(LR+ve) = infinite). 12 months (at our institution or the referring institution), in which time there was no
Parietal pleural thickening was detected in 21 patients, evidence of malignancy developing within the pleura or elsewhere as the cause of the
presenting pleural effusion.
measuring .1 cm in 14/33 (42%) patients with a malignant {Two patients underwent non-diagnostic percutaneous pleural biopsy and subsequent
effusion and 1/19 (5%) patients with a benign effusion (x2 1df diagnostic thoracoscopy. These patients are only listed once as thoracoscopic
8.11, p = 0.004), and ,1 cm in 2/33 (6%) malignant and 4/19 biopsies.
(21%) benign patients (x2 1df 2.66, p = 0.10). Using a TUS
threshold value of pleural thickening .1 cm as suggestive of were identified in 10/33 patients with a malignant effusion and in
malignancy, TUS has a sensitivity of 42% (95% CI 26% to 61%), none of the patients with a benign effusion (table 3 and fig 4b in
specificity 95% (95% CI 74% to 99%), PPV 93% and NPV 49% online supplement). The diaphragm was thickened in 23 patients;
for differentiating malignant from benign disease (LR+ve = 8.4; this was nodular/irregular in 15 cases (fig 4c in online supplement)
see fig 1a and fig 1b in online supplement). and smooth in 8. Using a TUS threshold value of diaphragmatic
The presence of nodular pleural thickening was observed in thickness of .7 mm as suggestive of malignancy, TUS has a
14/33 patients (42%) with malignant effusions and in 0/19 sensitivity of 42% (95% CI 26% to 61%), specificity of 95% (95%
benign cases (x2 1df 11.03, p = 0.009), giving a sensitivity of 42% CI 74% to 99%), PPV 93% and NPV 49% (LR+ve = 8.4) for
(95% CI 26% to 61%), specificity 100% (95% CI 82% to 100%), differentiating malignant from benign disease.
PPV 100% and NPV 50%, LR+ve = infinite).
Thickening/nodularity of the visceral pleura was detected on CT diagnosis
TUS in 5/33 patients with malignant effusions (15%) and 0/19 The median time interval between the CT examinations and
benign cases (sensitivity 15%), and was not seen on CECT in the ultrasound examination was 1 day (range 0–41 days). CT
any case. correctly differentiated malignant from benign pleural effusion
in 49/52 patients (sensitivity 97% (95% CI 84% to 99%),
Other TUS morphological characteristics specificity 89% (95% CI 67% to 99%), PPV 94% and NPV 94%,
Visceral pleural thickening was observed in five patients (all LR+ve = 8.8). CT identified two patients as false positive (ie,
with malignancy) and occurred in the absence of associated scored malignant on CT, final diagnosis benign). Both of these
parietal pleural thickening in four cases (see fig 2 in online patients had extensive supraclavicular and mediastinal lymph-
supplement). adenopathy with distortion of the airways and bilateral
Pleural thickening was hypoechoic relative to the intercostal effusions suggestive of lymphoma. Subsequent ultrasound-
muscles in all patients with benign pleural thickening (n = 5; see guided core biopsy of the supraclavicular lymphadenopathy
fig 3a and 3b in online supplement). In malignant pleural diagnosed tuberculosis in both cases.
thickening, echotexture was non-specific and appeared hypo-
echoic, hyperechoic or isoechoic. TUS versus CT diagnosis
The morphological characteristics of the diaphragm were Comparison of TUS and CECT diagnosis is made as CECT is
compared between malignant and benign groups. Resolution of considered to be the gold standard investigation for patients
all five layers of the diaphragm was not possible in 10/33 with suspected malignant effusion. The CECT true positive rate
patients (30%) with malignant effusions and 1/19 (5%) patients was 97% (32/33) compared with 79% (26/33) for TUS. Of the
with a benign effusion (x2 1df 4.53, p = 0.033; see fig 4a in online seven patients with a false negative diagnosis on TUS, in six the
supplement). Diaphragmatic nodules measuring 2–22 mm in size pleural surfaces appeared normal on both US and CT and the
Thorax 2009;64:139–143. doi:10.1136/thx.2008.100545 141
4. Pleural disease
Table 3 Sonographic findings in patients with malignant and benign Table 4 Sensitivities and specificities for ultrasound and CT-
pleural effusions determined criteria that are suggestive of malignant pleural disease.
Malignant Benign p value This study Leung et al12
disease disease (Fisher (n = 52) (n = 74)
Sonographic finding (n = 33) (n = 19) exact x2)
Ultrasound CT scanning
Parietal pleural thickening 16 5 0.090 Sensitivity Specificity Sensitivity Specificity
.1 cm 14 1 0.004 (%) (%) (%) (%)
,1 cm 2 4 0.175
Parietal pleural 42 95 56 88
Nodular 14 0 0.001 thickening .1 cm
Smooth 2 5 0.085 Nodular pleural 42 100 36 85
Visceral pleural thickening/ 5 0 0.145 thickening
nodularity Visceral pleural 15 100 NA NA
Diaphragmatic thickening 19 4 0.019 thickening
Nodular 15 0 ,0.001 Diaphragmatic thickening 42 95 NA NA
Smooth 4 4 0.443 .7 mm
Diaphragmatic nodules 10 0 0.009 Diaphragmatic layers 30 95 NA NA
Size of effusion resolved
Small 9 6 0.541 Diaphragmatic nodules 30 100 NA NA
Moderate 17 7 0.391 Overall 79 100 72 83
Large 7 6 0.510 NA, not assessed.
Nature of effusion
Anechoic/simple 14 11 0.389
malignant effusion with CECT alone (table 4), although this
Anechoic/septated 14 8 1.000
was not the primary aim of the study. TUS is a quick, relatively
Echogenic 5 0 0.145
inexpensive and harmless procedure which is increasingly being
Liver metastases* 2 0 0.527
performed by chest physicians; if these results are confirmed in
Overall TUS diagnostic rate{ 26/33 19/19 N/A
Sensitivity 79% Specificity
larger studies, TUS may become a valuable adjunct in the
100% diagnosis of malignant pleural effusion.
NPV = 73% PPV = 100% Beyond the criteria defined in previous CT studies, we have
NPV, negative predictive value; PPV, positive predictive value; TUS, thoracic found several TUS morphological features apparently associated
ultrasound. with malignant pleural effusion. In the absence of parietal
*Liver metastases were the sole abnormality detected in one patient on TUS. pleural thickening, visceral thickening and visceral nodularity
{Diagnostic rate of TUS based on the criteria mentioned in the Methods section (ie,
diaphragmatic and parietal pleural nodule or nodules, pleural thickening .1 cm or were associated with malignancy and not apparently visible on
hepatic metastasis). CECT. Necropsy reports have shown that the parietal pleura
may be less frequently involved with metastatic disease than
CT diagnosis of malignancy was based on the presence of the visceral pleura.19 This suggested pathogenesis would be in
intraparenchymal masses, nodal enlargement or pulmonary keeping with our findings in which 4/5 patients demonstrated
metastasis. In the remaining patient (false negative on both visceral pleural thickening or nodularity suggestive of visceral
CECT and TUS) there was a previous history of asbestos deposits in the absence of associated parietal pleural thickening.
exposure, smooth pleural thickening on CT scanning which was Diaphragmatic abnormalities have been shown in this study to
not visualised on TUS and subsequent thoracoscopic-guided predict malignant disease. The normal diaphragm is usually well
biopsy showed benign fibrinous thickening. A repeat CT scan defined on TUS (due to the presence of fluid in the costophrenic
performed 3 months later due to increasing chest pain and recess), ,5 mm thick and divided into five distinct layers
clinical deterioration showed increased pleural thickening and a sonographically. Inability to resolve diaphragmatic layers, the
clinicoradiological diagnosis of mesothelioma was made. The presence of diaphragmatic nodules and diaphragm thickness of
patient’s clinical course was consistent with this diagnosis .7 mm were associated with malignant pleural disease in this
(death occurred 2 weeks later). Benign disease (n = 19) was study. TUS appears to be more sensitive than CECT in demonstrat-
correctly diagnosed in all cases using TUS and in 89% (17/19) ing visceral pleural disease and diaphragmatic nodularity.
using CECT (tuberculosis misdiagnosed as malignancy in two Although previous studies suggest that differentiating malig-
cases as above). nant parietal pleural thickening and chronic pleural fibrosis can
be difficult on TUS,20 our results suggest that TUS is relatively
accurate. In our series, six patients were diagnosed with chronic
DISCUSSION pleural fibrosis following percutaneous or thoracoscopic biopsy
This is the first analysis to specifically assess the usefulness of and TUS diagnosed all six cases as benign. In contrast to this,
TUS in the diagnosis of suspected malignant pleural effusion. the CT appearances were highly suspicious of malignancy in
The ‘‘definitive’’ diagnosis used in this patient population was one patient, indeterminate in one and benign in four cases.
well defined and included clinical follow-up data of 12 months Of the seven false negative cases on TUS, six (86%) had
for all patients with presumed benign disease. Hitherto, TUS normal pleural surfaces when assessed by CECT. The absence of
has been used as a technique to confirm the presence of fluid, detectable pleural disease on thoracic CT in the presence of a
assess fluid characteristics (eg, septated/echogenic) or to guide malignant pleural effusion has been previously reported.21 In
intervention. Using similar morphological criteria as those used this case, CECT has the clear advantage over TUS of being able
in CECT,12 our results show that TUS is able to distinguish to assess for the presence of disease elsewhere (eg, lung
malignant from benign effusions with an overall sensitivity of parenchyma, mediastinal nodes, distant metastases), although
79% and specificity of 100% (table 3). These figures are TUS may be used to assess for the presence of liver metastasis,
comparable to the previously published data on diagnosis of which was the only abnormality found in one patient.
142 Thorax 2009;64:139–143. doi:10.1136/thx.2008.100545
5. Pleural disease
There are several limitations to this study. Initial TUS nodularity or thickening .7 mm, visceral pleural thickening
examinations were performed by a single observer with 5 years and pleural nodularity/irregularity are associated with malig-
experience in ultrasound but only 6 months experience in nancy. TUS may therefore be useful, not only in guiding
pleural US. Although the results might have been improved if a thoracocentesis and biopsy, but also as an adjunct to aid
more experienced operator had performed the scans, the close diagnosis. Further studies are required to confirm this finding.
agreement achieved between observers is reassuring. Second, the
mediastinal surfaces were not scanned in this study. Although Funding: None specific to this study. NMR is funded by an MRC Training Fellowship.
technically challenging, this is possible in patients with a large Competing interests: None.
pleural effusion and may have improved the diagnostic Ethics approval: The study was discussed with the Chair of the Oxford Research
accuracy. Third, this study comprised a relatively small number Ethics Committee and considered an audit of practice not requiring specific ethics
of patients (n = 52) recruited from a tertiary referral centre for approval.
pleural disease. The incidence of malignancy in this population
is likely to be higher than that seen in a less specialist centre, REFERENCES
and many of these patients had already undergone prior 1. Maskell NA, Butland RJ. BTS guidelines for the investigation of a unilateral pleural
investigations with negative results (most commonly, cytol- effusion in adults. Thorax 2003;58(Suppl 2):ii8–17.
ogy-negative pleural aspirate). However, there is no reason to 2. American Thoracic Society. Management of malignant pleural effusions.
Am J Respir Crit Care Med 2000;162:1987–2001.
believe that the morphological characteristics on TUS here 3. Antony VB, Loddenkemper R, Astoul P, et al. Management of malignant pleural
shown to be associated with malignant pleural disease should be effusions. Eur Respir J 2001;18:402–19.
any different. The relatively high incidence of mesothelioma in 4. Rahman NM, Davies RJ, Gleeson FV. Investigating suspected malignant pleural
this series is likely to be attributable to the institution being the effusion. BMJ 2007;334:206–7.
5. Dresler CM. Systemic distribution of talc. Chest 1999;116:266.
local tertiary referral centre for pleural disease. This may have 6. Hirsch A, Ruffie P, Nebut M, et al. Pleural effusion: laboratory tests in 300 cases.
resulted in a biased estimate of the diagnostic performance of Thorax 1979;34:106–12.
TUS if mesothelioma is more easily detected at ultrasound. 7. Prakash UB, Reiman HM. Comparison of needle biopsy with cytologic analysis for
Finally, although we have compared the specificity and the evaluation of pleural effusion: analysis of 414 cases. Mayo Clin Proc
1985;60:158–64.
sensitivity of TUS with CECT, this study is underpowered to 8. Salyer WR, Eggleston JC, Erozan YS. Efficacy of pleural needle biopsy and pleural
conduct a non-inferiority analysis of the two techniques. fluid cytopathology in the diagnosis of malignant neoplasm involving the pleura. Chest
What implications does this study have for clinical practice? 1975;67:536–9.
CECT has a high sensitivity and specificity for malignant 9. Renshaw AA, Dean BR, Antman KH, et al. The role of cytologic evaluation of pleural
fluid in the diagnosis of malignant mesothelioma. Chest 1997;111:106–9.
pleural effusion and is the usual next radiological investigation 10. Antunes G, Neville E, Duffy J, et al. BTS guidelines for the management of malignant
after the chest radiograph. The sensitivity of CECT in published pleural effusions. Thorax 2003;58(Suppl 2):ii29–38.
studies is high, although the specificity for TUS in this study is 11. Traill ZC, Davies RJ, Gleeson FV. Thoracic computed tomography in patients with
higher than that reported for CECT (table 4). However, there suspected malignant pleural effusions. Clin Radiol 2001;56:193–6.
12. Leung AN, Muller NL, Miller RR. CT in differential diagnosis of diffuse pleural disease.
are often delays in obtaining CT scans and TUS is easier to AJR Am J Roentgenol 1990;154:487–92.
access and is increasingly being performed by chest physicians. 13. Scott EM, Marshall TJ, Flower CD, et al. Diffuse pleural thickening: percutaneous CT-
The reasonable specificity and high PPV demonstrated using guided cutting needle biopsy. Radiology 1995;194:867–70.
TUS in this study suggest that TUS may be useful as an initial 14. Qureshi NR, Gleeson FV. Imaging of pleural disease. Clin Chest Med 2006;27:193–213.
15. Royal College of Radiology. Ultrasound training recommendations for medical and
test (for example, in the outpatient setting) in the investigation surgical specialties. 2006. http://www.rcr.ac.uk/docs/radiology/pdf/ultrasound.pdf.
of patients with pleural effusion of unknown aetiology, which 16. Gorg C, Restrepo I, Schwerk WB. Sonography of malignant pleural effusion. Eur
may streamline the diagnostic process. Larger studies in Radiol 1997;7:1195–8.
populations with a lower pretest probability of malignant 17. Yang PC, Luh KT, Chang DB, et al. Value of sonography in determining the nature of
pleural effusion: analysis of 320 cases. AJR Am J Roentgenol 1992;159:29–33.
pleural disease are required to assess this fully, including studies 18. Venekamp LN, Velkeniers B, Noppen M. Does ‘idiopathic pleuritis’ exist? Natural
to determine whether TUS conducted by non-radiologists has a history of non-specific pleuritis diagnosed after thoracoscopy. Respiration
similar predictive value. 2005;72:74–8.
In conclusion, blinded assessment of TUS has shown that the 19. Sahn SA. Malignant pleural effusions. Semin Respir Crit Care Med 2001;22:607–16.
20. Tsai TH, Yang PC. Ultrasound in the diagnosis and management of pleural disease.
technique has a reasonable sensitivity and high specificity and Curr Opin Pulm Med 2003;9:282–90.
PPV for malignant pleural effusion in the absence of empyema. 21. Waite RJ, Carbonneau RJ, Balikian JP, et al. Parietal pleural changes in empyema:
The presence of pleural thickening .1 cm, diaphragmatic appearances at CT. Radiology 1990;175:145–50.
Thorax 2009;64:139–143. doi:10.1136/thx.2008.100545 143