SlideShare a Scribd company logo
Turning Up The Volume On A Silent Killer -
The Study Of The Genetic Basis Of
Pancreatic Cancer
Shannon Nelson
2nd Year PhD Student
NICB
Pancreatic Cancer
• The Pancreas
• Produces enzymes
• Produces hormones
• Pancreatic Cancer
• 540 diagnosed in Ireland each year
• 5 year survival rate – 8%
• Poor Survival Rate
• Lack of symptoms
• Poor response to therapies
• No screening or tests
Projected Cancer Deaths
Rahib et al, Cancer Research, 2014
Pancreas
Lung
Colorectal
Breast
Prostate
0
20
40
60
80
100
120
140
160
180
2010 2012 2014 2016 2018 2020 2022 2024 2026 2028 2030
ProjectedCancerDeaths(Thousands)
Pancreatic Cancer Patients Non-Patients
Pancreatic Cancer Patients
Non-Patients
Growing Cancer Cells in the Lab
Cancer Cells in 2D
Growing Cancer Cells in the Lab
Cancer Cells in 3D
• Validation of biomarkers
• Earlier detection of pancreatic cancer
• 3D cancer model development
• Personalised therapy of pancreatic cancer
• Better treatment outcomes for pancreatic cancer patients
How My Work Will Make a Difference
Acknowledgements
• Dr Naomi Walsh
• Dr AnneMarie
Larkin
• Dr Denis Collins
• Dr Alex Eustace
• Dr Laura Breen
• Neil Conlon
• Nicola Gaynor
• Alacoque Browne
• Prof John Crown

More Related Content

What's hot

EPAD 2017 - Bertrand Tombal
EPAD 2017 - Bertrand TombalEPAD 2017 - Bertrand Tombal
EPAD 2017 - Bertrand Tombal
Marc van Gurp
 
1-uqu-presentation
 1-uqu-presentation 1-uqu-presentation
1-uqu-presentation
Basalama Ali
 
EPAD 2017 - Paul Enders
EPAD 2017 - Paul EndersEPAD 2017 - Paul Enders
EPAD 2017 - Paul Enders
Marc van Gurp
 
20171021 Cancer prevention in malaysia
20171021 Cancer prevention in malaysia20171021 Cancer prevention in malaysia
20171021 Cancer prevention in malaysia
R.O.C.Ministry of Health and Welfare
 
Pathways to lung cancer diagnosis
Pathways to lung cancer diagnosisPathways to lung cancer diagnosis
Pathways to lung cancer diagnosis
Sax Institute
 
Identifying individuals at high risk for lung cancer in Australia
Identifying individuals at high risk for lung cancer in AustraliaIdentifying individuals at high risk for lung cancer in Australia
Identifying individuals at high risk for lung cancer in Australia
Sax Institute
 
The 45 and Up Study Update
The 45 and Up Study UpdateThe 45 and Up Study Update
The 45 and Up Study Update
Sax Institute
 
Prevention and screening in brca mutation carriers for breast cancers
Prevention and screening in brca mutation carriers for breast cancersPrevention and screening in brca mutation carriers for breast cancers
Prevention and screening in brca mutation carriers for breast cancers
Dr. Rahul Shah
 
EPAD 2017 - Jochen Walz
EPAD 2017 - Jochen WalzEPAD 2017 - Jochen Walz
EPAD 2017 - Jochen Walz
Marc van Gurp
 
Monique Roobol: Risk Stratification
Monique Roobol: Risk Stratification Monique Roobol: Risk Stratification
Monique Roobol: Risk Stratification
European Association of Urology
 
State of the Art Radiotherapy in the Treatment of Colorectal Cancer: What Exa...
State of the Art Radiotherapy in the Treatment of Colorectal Cancer: What Exa...State of the Art Radiotherapy in the Treatment of Colorectal Cancer: What Exa...
State of the Art Radiotherapy in the Treatment of Colorectal Cancer: What Exa...
Health Sciences North | Horizon Santé Nord
 
When Cancer Comes Back, Sarah Adams, MD
When Cancer Comes Back, Sarah Adams, MDWhen Cancer Comes Back, Sarah Adams, MD
When Cancer Comes Back, Sarah Adams, MD
Ovarian Cancer Research Fund Alliance
 
Meeting the Cancer Survivorship Needs of Colorectal Cancer: The Wellness Beyo...
Meeting the Cancer Survivorship Needs of Colorectal Cancer: The Wellness Beyo...Meeting the Cancer Survivorship Needs of Colorectal Cancer: The Wellness Beyo...
Meeting the Cancer Survivorship Needs of Colorectal Cancer: The Wellness Beyo...
Health Sciences North | Horizon Santé Nord
 
Monique Roobol: PSA History
Monique Roobol: PSA HistoryMonique Roobol: PSA History
Monique Roobol: PSA History
European Association of Urology
 
Breast Cancer Health Equity - Root Cause Coalition
Breast Cancer Health Equity - Root Cause CoalitionBreast Cancer Health Equity - Root Cause Coalition
Breast Cancer Health Equity - Root Cause Coalition
Parkland Center for Clinical Innovation
 
Peter Albers: Risk adapted screening
Peter Albers: Risk adapted screening Peter Albers: Risk adapted screening
Peter Albers: Risk adapted screening
European Association of Urology
 
Nicolas Mottet: How to organize PSA screening
Nicolas Mottet: How to organize PSA screeningNicolas Mottet: How to organize PSA screening
Nicolas Mottet: How to organize PSA screening
European Association of Urology
 
Newly Diagnosed, Stephanie Wethington, MD
Newly Diagnosed, Stephanie Wethington, MDNewly Diagnosed, Stephanie Wethington, MD
Newly Diagnosed, Stephanie Wethington, MD
Ovarian Cancer Research Fund Alliance
 
Non-Communicable Diseases: The Unheralded Global Epidemic_Tsu_5.12.11
Non-Communicable Diseases: The Unheralded Global Epidemic_Tsu_5.12.11Non-Communicable Diseases: The Unheralded Global Epidemic_Tsu_5.12.11
Non-Communicable Diseases: The Unheralded Global Epidemic_Tsu_5.12.11
CORE Group
 
Sex and Cancer, Jeanne Carter, PhD
Sex and Cancer, Jeanne Carter, PhDSex and Cancer, Jeanne Carter, PhD
Sex and Cancer, Jeanne Carter, PhD
Ovarian Cancer Research Fund Alliance
 

What's hot (20)

EPAD 2017 - Bertrand Tombal
EPAD 2017 - Bertrand TombalEPAD 2017 - Bertrand Tombal
EPAD 2017 - Bertrand Tombal
 
1-uqu-presentation
 1-uqu-presentation 1-uqu-presentation
1-uqu-presentation
 
EPAD 2017 - Paul Enders
EPAD 2017 - Paul EndersEPAD 2017 - Paul Enders
EPAD 2017 - Paul Enders
 
20171021 Cancer prevention in malaysia
20171021 Cancer prevention in malaysia20171021 Cancer prevention in malaysia
20171021 Cancer prevention in malaysia
 
Pathways to lung cancer diagnosis
Pathways to lung cancer diagnosisPathways to lung cancer diagnosis
Pathways to lung cancer diagnosis
 
Identifying individuals at high risk for lung cancer in Australia
Identifying individuals at high risk for lung cancer in AustraliaIdentifying individuals at high risk for lung cancer in Australia
Identifying individuals at high risk for lung cancer in Australia
 
The 45 and Up Study Update
The 45 and Up Study UpdateThe 45 and Up Study Update
The 45 and Up Study Update
 
Prevention and screening in brca mutation carriers for breast cancers
Prevention and screening in brca mutation carriers for breast cancersPrevention and screening in brca mutation carriers for breast cancers
Prevention and screening in brca mutation carriers for breast cancers
 
EPAD 2017 - Jochen Walz
EPAD 2017 - Jochen WalzEPAD 2017 - Jochen Walz
EPAD 2017 - Jochen Walz
 
Monique Roobol: Risk Stratification
Monique Roobol: Risk Stratification Monique Roobol: Risk Stratification
Monique Roobol: Risk Stratification
 
State of the Art Radiotherapy in the Treatment of Colorectal Cancer: What Exa...
State of the Art Radiotherapy in the Treatment of Colorectal Cancer: What Exa...State of the Art Radiotherapy in the Treatment of Colorectal Cancer: What Exa...
State of the Art Radiotherapy in the Treatment of Colorectal Cancer: What Exa...
 
When Cancer Comes Back, Sarah Adams, MD
When Cancer Comes Back, Sarah Adams, MDWhen Cancer Comes Back, Sarah Adams, MD
When Cancer Comes Back, Sarah Adams, MD
 
Meeting the Cancer Survivorship Needs of Colorectal Cancer: The Wellness Beyo...
Meeting the Cancer Survivorship Needs of Colorectal Cancer: The Wellness Beyo...Meeting the Cancer Survivorship Needs of Colorectal Cancer: The Wellness Beyo...
Meeting the Cancer Survivorship Needs of Colorectal Cancer: The Wellness Beyo...
 
Monique Roobol: PSA History
Monique Roobol: PSA HistoryMonique Roobol: PSA History
Monique Roobol: PSA History
 
Breast Cancer Health Equity - Root Cause Coalition
Breast Cancer Health Equity - Root Cause CoalitionBreast Cancer Health Equity - Root Cause Coalition
Breast Cancer Health Equity - Root Cause Coalition
 
Peter Albers: Risk adapted screening
Peter Albers: Risk adapted screening Peter Albers: Risk adapted screening
Peter Albers: Risk adapted screening
 
Nicolas Mottet: How to organize PSA screening
Nicolas Mottet: How to organize PSA screeningNicolas Mottet: How to organize PSA screening
Nicolas Mottet: How to organize PSA screening
 
Newly Diagnosed, Stephanie Wethington, MD
Newly Diagnosed, Stephanie Wethington, MDNewly Diagnosed, Stephanie Wethington, MD
Newly Diagnosed, Stephanie Wethington, MD
 
Non-Communicable Diseases: The Unheralded Global Epidemic_Tsu_5.12.11
Non-Communicable Diseases: The Unheralded Global Epidemic_Tsu_5.12.11Non-Communicable Diseases: The Unheralded Global Epidemic_Tsu_5.12.11
Non-Communicable Diseases: The Unheralded Global Epidemic_Tsu_5.12.11
 
Sex and Cancer, Jeanne Carter, PhD
Sex and Cancer, Jeanne Carter, PhDSex and Cancer, Jeanne Carter, PhD
Sex and Cancer, Jeanne Carter, PhD
 

Similar to Turning up the volume on a silent killer: Pancreatic Cancer

CCSN Breast Screening for Women in the 40s(1).pptx
CCSN Breast Screening for Women in the 40s(1).pptxCCSN Breast Screening for Women in the 40s(1).pptx
CCSN Breast Screening for Women in the 40s(1).pptx
Canadian Cancer Survivor Network
 
Prostate cancer Diagnosis and management
Prostate cancer Diagnosis and managementProstate cancer Diagnosis and management
Prostate cancer Diagnosis and management
aeymon1
 
Clinical translation of prostate cancer genomics, Department of Biosciences a...
Clinical translation of prostate cancer genomics, Department of Biosciences a...Clinical translation of prostate cancer genomics, Department of Biosciences a...
Clinical translation of prostate cancer genomics, Department of Biosciences a...
Copenhagenomics
 
Investor & Analyst Day 2015: Pancreatic Cancer Pipeline (5/8)
Investor & Analyst Day 2015: Pancreatic Cancer Pipeline (5/8)Investor & Analyst Day 2015: Pancreatic Cancer Pipeline (5/8)
Investor & Analyst Day 2015: Pancreatic Cancer Pipeline (5/8)
Exact Sciences
 
Third Annual Early Age Onset Colorectal Cancer Symposium - Optimizing Outcome...
Third Annual Early Age Onset Colorectal Cancer Symposium - Optimizing Outcome...Third Annual Early Age Onset Colorectal Cancer Symposium - Optimizing Outcome...
Third Annual Early Age Onset Colorectal Cancer Symposium - Optimizing Outcome...
Colon Cancer Challenge Foundation
 
Approach to a case of localized prostate cancer
Approach to a case of localized prostate cancerApproach to a case of localized prostate cancer
Approach to a case of localized prostate cancer
Dr Santosh Kumaraswamy
 
Prevention of cancer in women
Prevention of cancer in women Prevention of cancer in women
Prevention of cancer in women
vandana bansal
 
Public talk on Colon Cancer
Public talk on Colon CancerPublic talk on Colon Cancer
Public talk on Colon Cancer
Chea Chan Hooi
 
Colorectal Cancer 101- Research Advocacy Training Webinar
Colorectal Cancer 101- Research Advocacy Training WebinarColorectal Cancer 101- Research Advocacy Training Webinar
Colorectal Cancer 101- Research Advocacy Training Webinar
Fight Colorectal Cancer
 
Prostate Cancer And Screening
Prostate Cancer And ScreeningProstate Cancer And Screening
Prostate Cancer And Screening
Summit Health
 
CCRCB cancer talk
CCRCB cancer talkCCRCB cancer talk
CCRCB cancer talk
Richard Kennedy
 
Lines of ttt of p ca
Lines of ttt of p caLines of ttt of p ca
Lines of ttt of p ca
Ahmed Eliwa
 
Innovations in Pancreatic Cancer: A Reason to Hope
Innovations in Pancreatic Cancer: A Reason to HopeInnovations in Pancreatic Cancer: A Reason to Hope
Innovations in Pancreatic Cancer: A Reason to Hope
Christopher Kanski
 
WEBINAR: Breast Screening and Breast Density
WEBINAR: Breast Screening and Breast DensityWEBINAR: Breast Screening and Breast Density
WEBINAR: Breast Screening and Breast Density
Canadian Cancer Survivor Network
 
Badheeb najran cancer unit 2013
Badheeb najran cancer unit 2013Badheeb najran cancer unit 2013
Badheeb najran cancer unit 2013
Prof. Ahmed Mohamed Badheeb
 
CANSA The Big 5 Cancers affecting Men in South Africa 2017
CANSA The Big 5 Cancers affecting Men in South Africa 2017CANSA The Big 5 Cancers affecting Men in South Africa 2017
CANSA The Big 5 Cancers affecting Men in South Africa 2017
CANSA The Cancer Association of South Africa
 
Brian Sick, M.D.
Brian Sick, M.D.Brian Sick, M.D.
Brian Sick, M.D.
smsherman
 
Role of primary physicians in early detection of cancer
Role of primary physicians in early detection of cancerRole of primary physicians in early detection of cancer
Role of primary physicians in early detection of cancer
Vivek Verma
 
Cervical Cancer Screening Modalities
Cervical Cancer Screening ModalitiesCervical Cancer Screening Modalities
Cervical Cancer Screening Modalities
Dr. Rahul Shah
 
Prostate disease prevention and new guidelines
Prostate disease prevention and new guidelinesProstate disease prevention and new guidelines
Prostate disease prevention and new guidelines
Naval Verma
 

Similar to Turning up the volume on a silent killer: Pancreatic Cancer (20)

CCSN Breast Screening for Women in the 40s(1).pptx
CCSN Breast Screening for Women in the 40s(1).pptxCCSN Breast Screening for Women in the 40s(1).pptx
CCSN Breast Screening for Women in the 40s(1).pptx
 
Prostate cancer Diagnosis and management
Prostate cancer Diagnosis and managementProstate cancer Diagnosis and management
Prostate cancer Diagnosis and management
 
Clinical translation of prostate cancer genomics, Department of Biosciences a...
Clinical translation of prostate cancer genomics, Department of Biosciences a...Clinical translation of prostate cancer genomics, Department of Biosciences a...
Clinical translation of prostate cancer genomics, Department of Biosciences a...
 
Investor & Analyst Day 2015: Pancreatic Cancer Pipeline (5/8)
Investor & Analyst Day 2015: Pancreatic Cancer Pipeline (5/8)Investor & Analyst Day 2015: Pancreatic Cancer Pipeline (5/8)
Investor & Analyst Day 2015: Pancreatic Cancer Pipeline (5/8)
 
Third Annual Early Age Onset Colorectal Cancer Symposium - Optimizing Outcome...
Third Annual Early Age Onset Colorectal Cancer Symposium - Optimizing Outcome...Third Annual Early Age Onset Colorectal Cancer Symposium - Optimizing Outcome...
Third Annual Early Age Onset Colorectal Cancer Symposium - Optimizing Outcome...
 
Approach to a case of localized prostate cancer
Approach to a case of localized prostate cancerApproach to a case of localized prostate cancer
Approach to a case of localized prostate cancer
 
Prevention of cancer in women
Prevention of cancer in women Prevention of cancer in women
Prevention of cancer in women
 
Public talk on Colon Cancer
Public talk on Colon CancerPublic talk on Colon Cancer
Public talk on Colon Cancer
 
Colorectal Cancer 101- Research Advocacy Training Webinar
Colorectal Cancer 101- Research Advocacy Training WebinarColorectal Cancer 101- Research Advocacy Training Webinar
Colorectal Cancer 101- Research Advocacy Training Webinar
 
Prostate Cancer And Screening
Prostate Cancer And ScreeningProstate Cancer And Screening
Prostate Cancer And Screening
 
CCRCB cancer talk
CCRCB cancer talkCCRCB cancer talk
CCRCB cancer talk
 
Lines of ttt of p ca
Lines of ttt of p caLines of ttt of p ca
Lines of ttt of p ca
 
Innovations in Pancreatic Cancer: A Reason to Hope
Innovations in Pancreatic Cancer: A Reason to HopeInnovations in Pancreatic Cancer: A Reason to Hope
Innovations in Pancreatic Cancer: A Reason to Hope
 
WEBINAR: Breast Screening and Breast Density
WEBINAR: Breast Screening and Breast DensityWEBINAR: Breast Screening and Breast Density
WEBINAR: Breast Screening and Breast Density
 
Badheeb najran cancer unit 2013
Badheeb najran cancer unit 2013Badheeb najran cancer unit 2013
Badheeb najran cancer unit 2013
 
CANSA The Big 5 Cancers affecting Men in South Africa 2017
CANSA The Big 5 Cancers affecting Men in South Africa 2017CANSA The Big 5 Cancers affecting Men in South Africa 2017
CANSA The Big 5 Cancers affecting Men in South Africa 2017
 
Brian Sick, M.D.
Brian Sick, M.D.Brian Sick, M.D.
Brian Sick, M.D.
 
Role of primary physicians in early detection of cancer
Role of primary physicians in early detection of cancerRole of primary physicians in early detection of cancer
Role of primary physicians in early detection of cancer
 
Cervical Cancer Screening Modalities
Cervical Cancer Screening ModalitiesCervical Cancer Screening Modalities
Cervical Cancer Screening Modalities
 
Prostate disease prevention and new guidelines
Prostate disease prevention and new guidelinesProstate disease prevention and new guidelines
Prostate disease prevention and new guidelines
 

Recently uploaded

8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
Holistified Wellness
 
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
rishi2789
 
Best Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and IndigestionBest Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and Indigestion
Swastik Ayurveda
 
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
19various
 
Journal Article Review on Rasamanikya
Journal Article Review on RasamanikyaJournal Article Review on Rasamanikya
Journal Article Review on Rasamanikya
Dr. Jyothirmai Paindla
 
The Electrocardiogram - Physiologic Principles
The Electrocardiogram - Physiologic PrinciplesThe Electrocardiogram - Physiologic Principles
The Electrocardiogram - Physiologic Principles
MedicoseAcademics
 
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấuK CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
HongBiThi1
 
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptxshare - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
Tina Purnat
 
Complementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLSComplementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLS
chiranthgowda16
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in IndiaTop 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Swastik Ayurveda
 
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
bkling
 
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxDoes Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
walterHu5
 
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdfCHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
rishi2789
 
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdfCHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
rishi2789
 
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
Donc Test
 
A Classical Text Review on Basavarajeeyam
A Classical Text Review on BasavarajeeyamA Classical Text Review on Basavarajeeyam
A Classical Text Review on Basavarajeeyam
Dr. Jyothirmai Paindla
 
Aortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 BernAortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 Bern
suvadeepdas911
 
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
rishi2789
 
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
rishi2789
 

Recently uploaded (20)

8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
 
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
 
Best Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and IndigestionBest Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and Indigestion
 
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
 
Journal Article Review on Rasamanikya
Journal Article Review on RasamanikyaJournal Article Review on Rasamanikya
Journal Article Review on Rasamanikya
 
The Electrocardiogram - Physiologic Principles
The Electrocardiogram - Physiologic PrinciplesThe Electrocardiogram - Physiologic Principles
The Electrocardiogram - Physiologic Principles
 
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấuK CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
 
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptxshare - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
 
Complementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLSComplementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLS
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
 
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in IndiaTop 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in India
 
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
 
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxDoes Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
 
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdfCHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
 
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdfCHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
 
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
 
A Classical Text Review on Basavarajeeyam
A Classical Text Review on BasavarajeeyamA Classical Text Review on Basavarajeeyam
A Classical Text Review on Basavarajeeyam
 
Aortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 BernAortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 Bern
 
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
 
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
 

Turning up the volume on a silent killer: Pancreatic Cancer

  • 1. Turning Up The Volume On A Silent Killer - The Study Of The Genetic Basis Of Pancreatic Cancer Shannon Nelson 2nd Year PhD Student NICB
  • 2. Pancreatic Cancer • The Pancreas • Produces enzymes • Produces hormones • Pancreatic Cancer • 540 diagnosed in Ireland each year • 5 year survival rate – 8% • Poor Survival Rate • Lack of symptoms • Poor response to therapies • No screening or tests
  • 3. Projected Cancer Deaths Rahib et al, Cancer Research, 2014 Pancreas Lung Colorectal Breast Prostate 0 20 40 60 80 100 120 140 160 180 2010 2012 2014 2016 2018 2020 2022 2024 2026 2028 2030 ProjectedCancerDeaths(Thousands)
  • 4.
  • 5.
  • 6.
  • 9. Growing Cancer Cells in the Lab Cancer Cells in 2D
  • 10. Growing Cancer Cells in the Lab Cancer Cells in 3D
  • 11. • Validation of biomarkers • Earlier detection of pancreatic cancer • 3D cancer model development • Personalised therapy of pancreatic cancer • Better treatment outcomes for pancreatic cancer patients How My Work Will Make a Difference
  • 12. Acknowledgements • Dr Naomi Walsh • Dr AnneMarie Larkin • Dr Denis Collins • Dr Alex Eustace • Dr Laura Breen • Neil Conlon • Nicola Gaynor • Alacoque Browne • Prof John Crown

Editor's Notes

  1. Hello everyone, I am Shannon Nelson and I am here today to talk about my research into the devastating disease that is pancreatic cancer. My work focuses on finding new early detection biomarkers for the disease – a biomarker is a substance when found in the found is indicative of cancer. I am also developing newer and better ways of growing cells in the lab to better represent how they grow in the body.
  2. To start, I will tell you a little about the pancreas. It is an organ which lies just behind the stomach. And it has two very important functions it Produces enzymes to aid digestion and it Produces hormones to regulate blood sugar There are 540 cases of pancreatic cancer diagnosed in Ireland every year, and this number is set to increase. Pancreatic cancer has a very poor survival. Only 8 of each one hundred people will be alive 5 years following their diagnosis, making pancreatic cancer one of the deadliest of all cancers. This Poor Survival Rate is due to A Lack of symptoms, pancreatic cancer is a silent killer. meaning patients are not diagnosed until the cancer has progressed. It also has a poor response to chemotherapies – and becomes resistant to treatment very quickly There are also no screening or diagnostic tests currently available
  3. This graph shows the projected number of cancer deaths between 2010 and 2030. Research, and drug development has meant that the number of deaths due to other cancers such as breast, prostate and lung are expected to decrease. However, deaths due to pancreatic cancer, as shown in purple, are expected to increase, and it will become the second leading cause of cancer related death in the USA. Therefore, my research into the discovery of early biomarkers of pancreatic cancer is vital, because we know that the earlier pancreatic cancer is detected the better the treatment outcome for the patient
  4. To help you understand cancer, I want you Think of each cell as a Swiss watch Just as cogs in the watch work to move the other cogs to tell time, the genes within our cells act in a pathway making other genes activate. These gene pathways are responsible for different functions such as the production of enzymes, and hormones, cell division, and for recognising mistakes in the genetic code and inducing cell death.
  5. Cancer is when there are changes to the DNA in the genes in these pathways, and they don’t work properly. The cell is then able to change its function and divide faster, allowing the cells to grow out of control This uncontrolled division of the cell is what causes the tumour
  6. To identify new early detection biomarkers for pancreatic cancer, we are looking for these changes in the DNA
  7. In order to do this, a study was done looking at the changes which occur more frequently in the DNA of people with pancreatic cancer compared to those who don’t have pancreatic cancer.
  8. This study found that changes in the DNA of pancreatic cancer patients occurred in genes in several different pathways, including a pathway of genes which are implicated in a heritable form of diabetes. My PhD will work to study these pathways and to see if they can be used as biomarkers of pancreatic cancer.
  9. In order to aid my research into biomarkers of pancreatic cancer, I am developing anew and better way of growing cancer cells. The usual method of growing cells in the lab is to grow them flat in a flask, as shown here, which does not reflect how they act in the pancreas.
  10. I have been developing a of growing cancer cells from patient samples. These cells are grown in 3D clusters, so that they reflect how the pancreatic cancer cells develop in the body. Here are some of the patient cells which I have successfully grown
  11. So why is my research important? Validation of the biomarkers of pancreatic cancer could be used to make a diagnostic test which is not currently available, allowing for screening and earlier detection of pancreatic cancer The development of 3D pancreatic cancer clusters will allow for better research in the lab. These 3D clusters could also be made from each patient’s tumour when they are diagnosed, can be used to screen multiple chemotherapy treatments, to ensure they get a treatment which will work to kill their cancer. This will result in Better treatment outcomes for pancreatic cancer patients, and help to turn up the volume on this silent killer
  12. I would like to thank you all for listening, and I would just like to take this opportunity to thank my supervisor Naomi Walsh, and the cancer research group in the NICB. Thank you!