This document discusses key concepts related to forces and equilibrium. It defines parallel and perpendicular forces, and explains how forces can be added and resolved into components. It also discusses torque or moment of force, center of gravity, couples, and the conditions required for an object to be in equilibrium. Specifically, it explains that there are three states of equilibrium: stable, unstable, and neutral equilibrium.
In physics, a force is any interaction which tends to change the motion of an object.
In other words, a force can cause an object with mass to change its velocity (which includes to begin moving from a state of rest), i.e., to accelerate.
Force can also be described by intuitive concepts such as a push or a pull.
A force has both magnitude and direction, making it a vector quantity. It is measured in the SI unit of newtons and represented by the symbol F.
The original form of Newton's second law states that the net force acting upon an object is equal to the rate at which its momentum changes with time.
If the mass of the object is constant, this law implies that the acceleration of an object is directly proportional to the net force acting on the object, is in the direction of the net force, and is inversely proportional to the mass of the object.
As a formula, this is expressed as:
Related concepts to force include: thrust, which increases the velocity of an object; drag, which decreases the velocity of an object; and torque which produces changes in rotational speed of an object. In an extended body, each part usually applies forces on the adjacent parts; the distribution of such forces through the body is the so-called mechanical stress.
Pressure is a simple type of stress. Stress usually causes deformation of solid materials, or flow in fluids.
Aristotle famously described a force
this is my presentation of theory of machine subject. the topic of this presentation is static force analysis. In gujarat technological university mechanical engineering third year syllabus topic. there are many types of forces described in this ppt. and examples and domestic use.
In physics, a force is any interaction which tends to change the motion of an object.
In other words, a force can cause an object with mass to change its velocity (which includes to begin moving from a state of rest), i.e., to accelerate.
Force can also be described by intuitive concepts such as a push or a pull.
A force has both magnitude and direction, making it a vector quantity. It is measured in the SI unit of newtons and represented by the symbol F.
The original form of Newton's second law states that the net force acting upon an object is equal to the rate at which its momentum changes with time.
If the mass of the object is constant, this law implies that the acceleration of an object is directly proportional to the net force acting on the object, is in the direction of the net force, and is inversely proportional to the mass of the object.
As a formula, this is expressed as:
Related concepts to force include: thrust, which increases the velocity of an object; drag, which decreases the velocity of an object; and torque which produces changes in rotational speed of an object. In an extended body, each part usually applies forces on the adjacent parts; the distribution of such forces through the body is the so-called mechanical stress.
Pressure is a simple type of stress. Stress usually causes deformation of solid materials, or flow in fluids.
Aristotle famously described a force
this is my presentation of theory of machine subject. the topic of this presentation is static force analysis. In gujarat technological university mechanical engineering third year syllabus topic. there are many types of forces described in this ppt. and examples and domestic use.
Pedagogy of Physical Science (Part II) - Laws of motion, Laws of Motion, Science, X std Science Samacheerkalvi Science, II year B.Ed., Pedagogy, Physics, X chapter I
Pedagogy of Physical Science (Part II) - Laws of motion, Laws of Motion, Science, X std Science Samacheerkalvi Science, II year B.Ed., Pedagogy, Physics, X chapter I
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
2. LIKE AND UNLIKE PARALLEL
FORCES
A force is push or pull. It is a vector quantity because it has
direction.
Forces having their line of action parallel to each other are
called parallel forces.
If the forces are acting on a body are parallel and they are in the
same direction, then these forces are said to be like parallel
forces.
A tube light is suspended with two strings the tensionT1 and T2
in the string is pulling in the upward direction and parallel to one
another. So it is an example of like parallel forces.
If the force acting on a body are parallel but direction is opposite
then these forces are said to be unlike parallel forces.
During the tug of war five students pulling the rope towards right
with a force F1 and at the same time other five boys pulling the
same rope towards left with force F2. the force F1 and F2 are
parallel but opposite to each other these forces are called unlike
parallel forces.
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3. ADDITION OF FORCES
As force is a vector quantity, therefore it
can not be added, subtracted and
multiplied by ordinary methods.
Forces are added graphically by a rule
known as head to tail rule.
A resultant force is a single force that
has the same effect as the combined
effect of all the forces to be added.
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4. RESOLUTION OF FORCE
The resolution of force is its splitting into two components
which are perpendicular to each other.
These components are called rectangular components of
force.
The components of force along x-axis is given by Fx =
Fcos θ and is called horizontal component of the force.
The component of force along y-axis is given by Fy = Fsin
θ and is called vertical component of the force.
If rectangular components of a force i.e. Fx and Fy are
known, the magnitude and direction of the force can be
determined by the following relations.
F=√Fx^2 + Fy^2 and θ = tan^-1 (Fy/Fx).
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5. TORQUE OR MOMENT OF
FORCE
The turning effect of force is known as torque or moment of force. It
measures the rotational effect of a force.
Torque is given by the product of force and the perpendicular distance
between the axis of rotation and the line of action of the force.
POINT OF ROTATION:-
The point about which a body can rotate is called point of rotation.
AXIS OF ROTATION:-
It is the line around which a rigid body rotates.
LINE OF ACTION OF FORCE:-
It is the line along which a force acts.
MOMENT ARM:-
It is perpendicular distance between the axis of rotation and the line of
action of force
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6. CENTRE OF GRAVITY
The centre of gravity of a body is the
point at which the whole weight of the
body acts vertically downward through
the centre of earth.
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7. COUPLE
Two forces with the same magnitude but in
opposite direction with different line of
action are said to form a couple.
Couple is equal to the sum of two equal
torques at point 0 and are acting in the
same direction, i.e. anticlockwise.
couple= force × perpendicular distance
between the forces
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8. CENTRE OF MASS
Centre of mass of a body is a point in the body where, the
applied force will move, the body in a straight line without
any rotation.
EQUILIBRIUM:-
A body is said to be in equilibrium if the body is at rest or
moving with uniform velocity.
When a body is at rest the body is said to be in static
equilibrium e.g. a book on the table.
When a body is moving with uniform velocity then the
body is said to be in dynamic equilibrium.
A paratrooper coming down with uniform velocity is an
example of dynamic equilibrium.
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9. CONDITIONS FOR
EQUILIBRIUM
There are two condition to keep a body in equilibrium.
FIRST CONDITION OF EQUILIBRIUM/TRANSNATIONAL
EQUILIBRIUM:-
The sum of forces acting along the positive direction of x-axis must be
equal to the sum of forces acting along the negative direction of x-axis
and the sum of forces acting along the positive direction of y-axis must
be equal to the sum of forces acting along the negative direction of y-
axis.
“The algebraic sum of all the forces acting along x-axis must be zero
and the algebraic sum of all the forces acting along y-axis must be
zero”.
ΣFx = 0 and ΣFy = 0
SECOND CONDITION OF EQUILIBRIUM/ROTATIONAL
EQUILIBRIUM:-
If the sum of all the torques acting in the clockwise direction is equal to
the sum of the torques acting in the anticlockwise direction, the body is
said to be in rotational equilibrium.
“A body is said to be in rotational equilibrium, if the algebraic sum of all
torque acting on the body is zero”.
Σt = 0
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10. States of equilibrium
There are three states of equilibrium.
(i) stable equilibrium
(ii) unstable equilibrium
(iii)neutral equilibrium
STABLE EQUILIBRIUM:-
When the centre of gravity of body lies below point of suspension or support,
the body is said to be in stable equilibrium.
A book lying on a horizontal surface is an example of stable equilibrium.
UNSTABLE EQUILIBRIUM:-
When the centre of gravity of a body lies above the point of suspension or
support, the body is said to be in unstable equilibrium.
A pencil on its tip or a cone in vertically standing position are example of
unstable equilibrium.
NEUTRAL EQUILIBRIUM:-
When the centre of the gravity of a body lies at the point of suspension or
support, the body is said to be in neutral equilibrium.
EXAMPLE: rolling ball
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