Patrick Stox discusses the need for SEOs to adapt to modern JavaScript frameworks, highlighting various rendering methods such as server-side, pre-rendering, client-side, and isomorphic rendering. He emphasizes the importance of understanding how these frameworks affect SEO performance and provides insights on URL customization, link structures, and rendering in Google's context. The presentation concludes with advice on indexing challenges and tools to help SEOs verify if their content is properly indexed by search engines.