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Figure 27-10. Treatment algorithm for erectile dysfunction recommended
by the International Consultations on Sexual Medicine.
PDE5, phosphodiesterase type 5.
3
Hackett G et al. British Society for Sexual Medicine Guidelines on the Management of Erectile
Dysfunction in Men – 2017. J Sex Med 2018;15:430-57. 4
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
5
RECOMENDACIONES
7. Clinicians should counsel men with ED who have comorbidities known to negatively affect
erectile function that lifestyle modifications, including changes in diet and increased physical
activity, improve overall health and may improve erectile function. (Moderate
Evidence Level: Grade C)
Initiate lifestyle changes and risk factor modification prior to or at the same time as initiating
erectile dysfunction (ED) treatments. Strong
Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD;
Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD;
Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile
Dysfunction: AUA Guideline (2018).
EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam
2020. ISBN 978-94-92671-07-3. 6
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
9
CLASE MEDICAMENTO ALTERNATIVA SUG.
ANTIHIPERTENSIV DIURETICO TIAZIDICOS
BETA BLOQUEADORES
NO SELECTIVOS
BLOQUEADOR DE CANAL
DE CALCIO
BETA BLOQUEADORES
ESPECIFICOS
ARA II
IECAS
PSICOTROPICO ANTISICOTICOS
ANTIDEPRESIVOS
ANSIOLITICOS
RECIENTES
(BUPROPION,
ANTIANDROGENO ANTIANDROGENOS
AGONISTAS DE LHRH
INHIBIDORES DE 5 A
REDUCTASA
OPIOIDES
ANTIRRETROVIRAL
S
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
10
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
11
Hackett G et al. British Society for Sexual Medicine Guidelines on the Management of Erectile
Dysfunction in Men – 2017. J Sex Med 2018;15:430-57. 12
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• SE DETERMINA MEJOR EVALUANDO LA RESPUESTA CLÍNICA
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
14
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
15
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
16
TRATAMIENTOS FARMACOLÓGICOS
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
17
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
18
Pocket Guide to Urology, 5th Edition, Jeff A.Wieder, J. Wieder Medical,
2014
19
20
21
MARCA ABSORCION
VIAGRA ÂŽ x
CIALISÂŽ
LEVITRAÂŽ x
STAXYNTM
STENDRATM
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
22
MARCA HORAS
VIAGRA ÂŽ 1
CIALISÂŽ 2
LEVITRAÂŽ 1
STAXYNTM 1.5
STENDRATM .5-.75
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
23
MARCA HORAS
VIAGRA ÂŽ 4
CIALISÂŽ 17.5
LEVITRAÂŽ 4-5
STAXYNTM 4-6
STENDRATM 5
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
24
MARCA HORAS
VIAGRA ÂŽ 6-8
CIALISÂŽ 24-36
LEVITRAÂŽ 6-8
STAXYNTM 6-8
STENDRATM 6
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
25
MARCA
VIAGRA ÂŽ
CIALISÂŽ
LEVITRAÂŽ SI
STAXYNTM SI
STENDRATM
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
26
MARCA
VIAGRA ÂŽ PRN
CIALISÂŽ PRN O DIARIA
LEVITRAÂŽ PRN
STAXYNTM PRN
STENDRATM PRN
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
27
MARCA
VIAGRA ÂŽ ZUIT ÂŽ LAMINILLA
CIALISÂŽ
LEVITRAÂŽ
STAXYNTM Se disuelve en la lengua
STENDRATM
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
28
MARCA ISOENZIMA
VIAGRA ÂŽ 6
CIALISÂŽ 11
LEVITRAÂŽ 6
STAXYNTM 6
STENDRATM
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
30
Hackett G et al. British Society for Sexual Medicine Guidelines on the Management of Erectile
Dysfunction in Men – 2017. J Sex Med 2018;15:430-57.
31
RECOMENDACIONES AUA
9. When men are prescribed an oral PDE5i for the treatment of ED, instructions should be
provided to maximize benefit/efficacy. (Strong Recommendation; Evidence Level: Grade C)
10. For men who are prescribed PDE5i, the dose should be titrated to provide optimal efficacy.
Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD; Lawrence S. Hakim, MD; Joel
Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD; Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D.
Seftel,
MD; Alan W. Shindel, MD. Erectile Dysfunction: AUA Guideline (2018).
32
RECOMENDACIONES
Use PDE5Is as first-line therapeutic option. Strong
Use topical/intraurethral alprostadil as an alternative first-line therapy in well-
informed patients who do not wish or are not suitable for oral vasoactive
therapy. Use topical/ intraurethral alprostadil as an alternative therapy to
intracavernous injections in patients who prefer a less-invasive therapy.
Weak
EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam 2020.
ISBN 978-94-92671-07-3.
33
11. Men who desire preservation of erectile function after treatment for prostate cancer by
radical prostatectomy (RP) or radiotherapy (RT) should be informed that early use of PDE5i
post-treatment may not improve spontaneous, unassisted erectile function. (Moderate
Recommendation; Evidence Level: Grade C)
Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD; Lawrence S. Hakim, MD; Joel
Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD; Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D.
Seftel,
MD; Alan W. Shindel, MD. Erectile Dysfunction: AUA Guideline (2018).
34
35
Pocket Guide to Urology, 5th Edition, Jeff A.Wieder, J. Wieder Medical,
2014
36
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
37
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
38
•
•
•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
39
Pocket Guide to Urology, 5th Edition, Jeff A.Wieder, J. Wieder Medical,
2014
40
•
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
41
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
42
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
43
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
44
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
45
Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD; Lawrence S. Hakim, MD; Joel
Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD; Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D.
Seftel,
MD; Alan W. Shindel, MD. Erectile Dysfunction: AUA Guideline (2018).
46
Hackett G et al. British Society for Sexual Medicine Guidelines on the Management of Erectile
Dysfunction in Men – 2017. J Sex Med 2018;15:430-57.
47
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•In Wein, A. J., In Kavoussi, L. R., Campbell, M.
F., & Walsh, P. C. (2016). Campbell-Walsh
urology.
50
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51
52
Pocket Guide to Urology, 5th Edition, Jeff A.Wieder, J. Wieder Medical,
2014
53
54
In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., &
Walsh, P. C. (2016). Campbell-Walsh urology.
55
In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., &
Walsh, P. C. (2016). Campbell-Walsh urology.
• VENTAJAS
• INCIDENCIA DISMINUIDA
• ERECCIÓN PROLONGADA
• EFECTOS ADVERSOS SISTÉMICOS
• FIBROSIS PENIANA.
• DESVENTAJA
• MAYOR INCIDENCIA DE ERECCIÓN DOLOROSA
• MAYOR COSTO
• UNA VEZ RECONSTITUIDO EN LÍQUIDO SE ACORTA SU VIDA MEDIA SI
NO SE O MANTIENE REFRIGERADO.
56
In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., &
Walsh, P. C. (2016). Campbell-Walsh urology.
PAPAVERINA
Bimix
• Papaverine
• Phentolamine
Trimix
• Papaverine
• Phentolamine
• Alprostadil
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Hackett G et al. British Society for Sexual Medicine Guidelines on the Management of Erectile
Dysfunction in Men – 2017. J Sex Med 2018;15:430-57. 60
RECOMENDACIONES
Use intracavernous injections as an alternative first-line
therapy in wellinformed patients or as second-line therapy.
Strong
EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam 2020.
ISBN 978-94-92671-07-3.
61
62
Figure 27-10. Treatment algorithm for erectile dysfunction recommended
by the International Consultations on Sexual Medicine.
PDE5, phosphodiesterase type 5.
63
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•
•
•
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
64
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•
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
65
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•
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
66
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•
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
67
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Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
68
•
〈 8.5 HABOUS M
ET AL BJUI 2017
69
• KEY TO SUCCESS
• IMPROVE
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• NOT IMPROVE
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•
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
70
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Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
71
72
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CIRUGÍA PROTÉSICA PENIANA
74
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•
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
75
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
76
PENOESCROTAL
77
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
78
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
79
4
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
80
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
81
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
82
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
83
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
84
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
85
Corporotomy
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
86
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
87
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
88
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
89
Reservoir placement: retropubic space
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
90
Ectopic (aka intraabdominal wall or high submuscular)
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
91
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
92
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
93
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
94
Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
95
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Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
96
INFRAPUBIC
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Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
98
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Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical
approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4),
628–638. https://doi.org/10.21037/tau.2017.07.32
99
Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD;
Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD;
Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile
Dysfunction: AUA Guideline (2018).
100
INSERTION OF PENIL PROTHESES (IMPLANTS) FOR ERECTIL DYSFUCTION, BAUS, JUNE 2017, Leaflet No:
16/082 , http://www.baus.org.uk/_userfiles/pages/files/Patients/Leaflets/Penile prostheses.pdf
101
INSERTION OF PENIL PROTHESES (IMPLANTS) FOR ERECTIL DYSFUCTION, BAUS, JUNE 2017, Leaflet No:
16/082 , http://www.baus.org.uk/_userfiles/pages/files/Patients/Leaflets/Penile prostheses.pdf 102
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RECOMENDACIONES
20. Penile prosthetic surgery should not be performed in the presence of systemic, cutaneous,
or urinary tract infection. (Clinical Principle)
Use implantation of a penile prosthesis if other treatments fail or based upon patient
Strong
Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD;
Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD;
Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile
Dysfunction: AUA Guideline (2018).
EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam
2020. ISBN 978-94-92671-07-3.
105
Trost LW, Munarriz R, Wang R, Morey A, Levine L. External Mechanical Devices and Vascular
Surgery for Erectile Dysfunction. J Sex Med. 2016;13(11):1579-1617.
doi:10.1016/j.jsxm.2016.09.008
106
•
•
•
•
•
Trost, L. W., Munarriz, R., Wang, R., Morey, A., & Levine, L. (2016). External
Mechanical Devices and Vascular Surgery for Erectile Dysfunction. The Journal of
Sexual Medicine, 13(11), 1579–1617. https://doi.org/10.1016/j.jsxm.2016.09.008
107
•
•
•
•
•
Trost, L. W., Munarriz, R., Wang, R., Morey, A., & Levine, L. (2016). External
Mechanical Devices and Vascular Surgery for Erectile Dysfunction. The Journal of
Sexual Medicine, 13(11), 1579–1617. https://doi.org/10.1016/j.jsxm.2016.09.008
108
RECOMENDACIONES
21. For young men with ED and focal pelvic/penile arterial occlusion and without documented
generalized vascular disease or veno-occlusive dysfunction, penile arterial reconstruction may
be considered.
(Conditional Recommendation; Evidence Level: Grade C)
22. For men with ED, penile venous surgery is not recommended.
(Moderate Recommendation; Evidence Level: Grade C)
Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD;
Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD;
Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile
Dysfunction: AUA Guideline (2018).
EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam
2020. ISBN 978-94-92671-07-3.
109
• Although early proposed mechanisms suggested
that tumescence was achieved by passive
retrograde venous flow, more recent data have
indicated:
• penile oxygen saturations reached 79.2%
immediately after VED placement
• 58% arterial
• 42% venous
Trost, L. W., Munarriz, R., Wang, R., Morey, A., & Levine, L. (2016). External
Mechanical Devices and Vascular Surgery for Erectile Dysfunction. The Journal of
Sexual Medicine, 13(11), 1579–1617. https://doi.org/10.1016/j.jsxm.2016.09.008
110
•
•
•
Trost, L. W., Munarriz, R., Wang, R., Morey, A., & Levine, L. (2016). External
Mechanical Devices and Vascular Surgery for Erectile Dysfunction. The Journal of
Sexual Medicine, 13(11), 1579–1617. https://doi.org/10.1016/j.jsxm.2016.09.008
111
Hackett G et al. British Society for Sexual Medicine Guidelines on the Management of Erectile
Dysfunction in Men – 2017. J Sex Med 2018;15:430-57.
112
RECOMENDACIONES
Use vacuum erection devices as a first-line therapy in well-informed patients with infrequent
sexual intercourse and comorbidities requiring non-invasive, drugfree management of ED.
Weak
The vacuum erection device (VED) is effective in creating an erection satisfactory for
intercourse, even in difficult-to-treat populations such as DM, spinal cord injury, and after
radical proctectomy
(RP; LOE . 2; strength of recommendation . B; recommended).
EAU Guidelines. Edn. presented at the EAU Annual Congress
Amsterdam 2020. ISBN 978-94-92671-07-3.
113
•
SWT
•
•
•
• NO
114
LI-
ESWT
•
•
•
•
•
•
•
•
Yang, H., & Seftel, A. D. (2019). Controversies in low intensity extracorporeal shockwave
therapy for erectile dysfunction. International Journal of Impotence Research, 31(3), 239–242.
https://doi.org/10.1038/s41443-019-0124-0
115
•
•
•
•
•
•
•
Yang, H., & Seftel, A. D. (2019). Controversies in low intensity extracorporeal shockwave
therapy for erectile dysfunction. International Journal of Impotence Research, 31(3), 239–242.
https://doi.org/10.1038/s41443-019-0124-0
116
•
• ONLY VASCULOGENIC
Yang, H., & Seftel, A. D. (2019). Controversies in low intensity extracorporeal shockwave
therapy for erectile dysfunction. International Journal of Impotence Research, 31(3), 239–242.
https://doi.org/10.1038/s41443-019-0124-0
117
RECOMENDACIONES
For men with ED, low-intensity extracorporeal shock wave therapy (ESWT) should be
considered investigational.
(Conditional Recommendation; Evidence Level: Grade C)
Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD;
Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD;
Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile
Dysfunction: AUA Guideline (2018).
118
•
•
•
•
HTTPS://DOI.ORG/10.1016/J.JSXM.2016.09.008
•
•
HTTPS://DOI.ORG/10.1016/J.JSXM.2016.09.008
•
HTTPS://DOI.ORG/10.21037/TAU.2017.07.32
•
• JEFF A.WIEDER
•
119
120
121
Philippou YA, Jung J, Steggall MJ, O'Driscoll ST, Bakker CJ, Bodie JA, Dahm P. Penile rehabilitation for
postprostatectomy erectile dysfunction. Cochrane Database of Systematic Reviews 2018, Issue 10. Art.
No.: CD012414. DOI: 10.1002/14651858.CD012414.pub2
122
TREATMENT OPTIONS

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TREATMENT OPTIONS

  • 1.
  • 2.
  • 4. Figure 27-10. Treatment algorithm for erectile dysfunction recommended by the International Consultations on Sexual Medicine. PDE5, phosphodiesterase type 5. 3
  • 5. Hackett G et al. British Society for Sexual Medicine Guidelines on the Management of Erectile Dysfunction in Men – 2017. J Sex Med 2018;15:430-57. 4
  • 6. • • • • • • • • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 5
  • 7. RECOMENDACIONES 7. Clinicians should counsel men with ED who have comorbidities known to negatively affect erectile function that lifestyle modifications, including changes in diet and increased physical activity, improve overall health and may improve erectile function. (Moderate Evidence Level: Grade C) Initiate lifestyle changes and risk factor modification prior to or at the same time as initiating erectile dysfunction (ED) treatments. Strong Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD; Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD; Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile Dysfunction: AUA Guideline (2018). EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam 2020. ISBN 978-94-92671-07-3. 6
  • 8. • • • • • • • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 7
  • 9. • • • • • • • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 8
  • 10. • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 9
  • 11. CLASE MEDICAMENTO ALTERNATIVA SUG. ANTIHIPERTENSIV DIURETICO TIAZIDICOS BETA BLOQUEADORES NO SELECTIVOS BLOQUEADOR DE CANAL DE CALCIO BETA BLOQUEADORES ESPECIFICOS ARA II IECAS PSICOTROPICO ANTISICOTICOS ANTIDEPRESIVOS ANSIOLITICOS RECIENTES (BUPROPION, ANTIANDROGENO ANTIANDROGENOS AGONISTAS DE LHRH INHIBIDORES DE 5 A REDUCTASA OPIOIDES ANTIRRETROVIRAL S •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 10
  • 12. •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 11
  • 13. Hackett G et al. British Society for Sexual Medicine Guidelines on the Management of Erectile Dysfunction in Men – 2017. J Sex Med 2018;15:430-57. 12
  • 14. • • • • • SE DETERMINA MEJOR EVALUANDO LA RESPUESTA CLÍNICA • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 13
  • 15. • • • • • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 14
  • 16. •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 15
  • 17. •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 16
  • 18. TRATAMIENTOS FARMACOLÓGICOS • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 17
  • 19. •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 18
  • 20. Pocket Guide to Urology, 5th Edition, Jeff A.Wieder, J. Wieder Medical, 2014 19
  • 21. 20
  • 22. 21
  • 23. MARCA ABSORCION VIAGRA ÂŽ x CIALISÂŽ LEVITRAÂŽ x STAXYNTM STENDRATM •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 22
  • 24. MARCA HORAS VIAGRA ÂŽ 1 CIALISÂŽ 2 LEVITRAÂŽ 1 STAXYNTM 1.5 STENDRATM .5-.75 •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 23
  • 25. MARCA HORAS VIAGRA ÂŽ 4 CIALISÂŽ 17.5 LEVITRAÂŽ 4-5 STAXYNTM 4-6 STENDRATM 5 •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 24
  • 26. MARCA HORAS VIAGRA ÂŽ 6-8 CIALISÂŽ 24-36 LEVITRAÂŽ 6-8 STAXYNTM 6-8 STENDRATM 6 •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 25
  • 27. MARCA VIAGRA ÂŽ CIALISÂŽ LEVITRAÂŽ SI STAXYNTM SI STENDRATM •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 26
  • 28. MARCA VIAGRA ÂŽ PRN CIALISÂŽ PRN O DIARIA LEVITRAÂŽ PRN STAXYNTM PRN STENDRATM PRN •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 27
  • 29. MARCA VIAGRA ÂŽ ZUIT ÂŽ LAMINILLA CIALISÂŽ LEVITRAÂŽ STAXYNTM Se disuelve en la lengua STENDRATM •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 28
  • 30. MARCA ISOENZIMA VIAGRA ÂŽ 6 CIALISÂŽ 11 LEVITRAÂŽ 6 STAXYNTM 6 STENDRATM •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 29
  • 31. • • • • • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 30
  • 32. Hackett G et al. British Society for Sexual Medicine Guidelines on the Management of Erectile Dysfunction in Men – 2017. J Sex Med 2018;15:430-57. 31
  • 33. RECOMENDACIONES AUA 9. When men are prescribed an oral PDE5i for the treatment of ED, instructions should be provided to maximize benefit/efficacy. (Strong Recommendation; Evidence Level: Grade C) 10. For men who are prescribed PDE5i, the dose should be titrated to provide optimal efficacy. Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD; Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD; Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile Dysfunction: AUA Guideline (2018). 32
  • 34. RECOMENDACIONES Use PDE5Is as first-line therapeutic option. Strong Use topical/intraurethral alprostadil as an alternative first-line therapy in well- informed patients who do not wish or are not suitable for oral vasoactive therapy. Use topical/ intraurethral alprostadil as an alternative therapy to intracavernous injections in patients who prefer a less-invasive therapy. Weak EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam 2020. ISBN 978-94-92671-07-3. 33
  • 35. 11. Men who desire preservation of erectile function after treatment for prostate cancer by radical prostatectomy (RP) or radiotherapy (RT) should be informed that early use of PDE5i post-treatment may not improve spontaneous, unassisted erectile function. (Moderate Recommendation; Evidence Level: Grade C) Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD; Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD; Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile Dysfunction: AUA Guideline (2018). 34
  • 36. 35
  • 37. Pocket Guide to Urology, 5th Edition, Jeff A.Wieder, J. Wieder Medical, 2014 36
  • 38. • • • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 37
  • 39. • • • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 38
  • 40. • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 39
  • 41. Pocket Guide to Urology, 5th Edition, Jeff A.Wieder, J. Wieder Medical, 2014 40
  • 42. • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 41
  • 43. • • • • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 42
  • 44. • • • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 43
  • 45. • • • • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 44
  • 46. • • • • • • • • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 45
  • 47. Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD; Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD; Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile Dysfunction: AUA Guideline (2018). 46
  • 48. Hackett G et al. British Society for Sexual Medicine Guidelines on the Management of Erectile Dysfunction in Men – 2017. J Sex Med 2018;15:430-57. 47
  • 51. • • • • • • • • •In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology. 50
  • 53. 52
  • 54. Pocket Guide to Urology, 5th Edition, Jeff A.Wieder, J. Wieder Medical, 2014 53
  • 55. 54 In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology.
  • 56. 55 In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology.
  • 57. • VENTAJAS • INCIDENCIA DISMINUIDA • ERECCIÓN PROLONGADA • EFECTOS ADVERSOS SISTÉMICOS • FIBROSIS PENIANA. • DESVENTAJA • MAYOR INCIDENCIA DE ERECCIÓN DOLOROSA • MAYOR COSTO • UNA VEZ RECONSTITUIDO EN LÍQUIDO SE ACORTA SU VIDA MEDIA SI NO SE O MANTIENE REFRIGERADO. 56 In Wein, A. J., In Kavoussi, L. R., Campbell, M. F., & Walsh, P. C. (2016). Campbell-Walsh urology.
  • 58. PAPAVERINA Bimix • Papaverine • Phentolamine Trimix • Papaverine • Phentolamine • Alprostadil 57
  • 61. Hackett G et al. British Society for Sexual Medicine Guidelines on the Management of Erectile Dysfunction in Men – 2017. J Sex Med 2018;15:430-57. 60
  • 62. RECOMENDACIONES Use intracavernous injections as an alternative first-line therapy in wellinformed patients or as second-line therapy. Strong EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam 2020. ISBN 978-94-92671-07-3. 61
  • 63. 62
  • 64. Figure 27-10. Treatment algorithm for erectile dysfunction recommended by the International Consultations on Sexual Medicine. PDE5, phosphodiesterase type 5. 63
  • 65. • • • • • • Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 64
  • 66. • • • • • Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 65
  • 67. • • • • • • Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 66
  • 68. • • • • • Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 67
  • 69. • • • • • • • • Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 68
  • 70. • 〈 8.5 HABOUS M ET AL BJUI 2017 69
  • 71. • KEY TO SUCCESS • IMPROVE • • • NOT IMPROVE • • • • Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 70
  • 72. • • • • • • • Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 71
  • 73. 72
  • 74. 73
  • 76. • • • • • • • • • Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 75
  • 77. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 76
  • 79. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 78
  • 80. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 79
  • 81. 4 Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 80
  • 82. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 81
  • 83. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 82
  • 84. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 83
  • 85. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 84
  • 86. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 85
  • 87. Corporotomy Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 86
  • 88. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 87
  • 89. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 88
  • 90. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 89
  • 91. Reservoir placement: retropubic space Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 90
  • 92. Ectopic (aka intraabdominal wall or high submuscular) Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 91
  • 93. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 92
  • 94. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 93
  • 95. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 94
  • 96. Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 95
  • 97. • • • • • Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 96
  • 99. • • • • • • Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 98
  • 100. • • • • • • Gupta, N. K., Ring, J., Trost, L., Wilson, S. K., & KĂśhler, T. S. (2017). The penoscrotal surgical approach for inflatable penile prosthesis placement. Translational Andrology and Urology, 6(4), 628–638. https://doi.org/10.21037/tau.2017.07.32 99
  • 101. Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD; Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD; Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile Dysfunction: AUA Guideline (2018). 100
  • 102. INSERTION OF PENIL PROTHESES (IMPLANTS) FOR ERECTIL DYSFUCTION, BAUS, JUNE 2017, Leaflet No: 16/082 , http://www.baus.org.uk/_userfiles/pages/files/Patients/Leaflets/Penile prostheses.pdf 101
  • 103. INSERTION OF PENIL PROTHESES (IMPLANTS) FOR ERECTIL DYSFUCTION, BAUS, JUNE 2017, Leaflet No: 16/082 , http://www.baus.org.uk/_userfiles/pages/files/Patients/Leaflets/Penile prostheses.pdf 102
  • 106. RECOMENDACIONES 20. Penile prosthetic surgery should not be performed in the presence of systemic, cutaneous, or urinary tract infection. (Clinical Principle) Use implantation of a penile prosthesis if other treatments fail or based upon patient Strong Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD; Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD; Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile Dysfunction: AUA Guideline (2018). EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam 2020. ISBN 978-94-92671-07-3. 105
  • 107. Trost LW, Munarriz R, Wang R, Morey A, Levine L. External Mechanical Devices and Vascular Surgery for Erectile Dysfunction. J Sex Med. 2016;13(11):1579-1617. doi:10.1016/j.jsxm.2016.09.008 106
  • 108. • • • • • Trost, L. W., Munarriz, R., Wang, R., Morey, A., & Levine, L. (2016). External Mechanical Devices and Vascular Surgery for Erectile Dysfunction. The Journal of Sexual Medicine, 13(11), 1579–1617. https://doi.org/10.1016/j.jsxm.2016.09.008 107
  • 109. • • • • • Trost, L. W., Munarriz, R., Wang, R., Morey, A., & Levine, L. (2016). External Mechanical Devices and Vascular Surgery for Erectile Dysfunction. The Journal of Sexual Medicine, 13(11), 1579–1617. https://doi.org/10.1016/j.jsxm.2016.09.008 108
  • 110. RECOMENDACIONES 21. For young men with ED and focal pelvic/penile arterial occlusion and without documented generalized vascular disease or veno-occlusive dysfunction, penile arterial reconstruction may be considered. (Conditional Recommendation; Evidence Level: Grade C) 22. For men with ED, penile venous surgery is not recommended. (Moderate Recommendation; Evidence Level: Grade C) Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD; Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD; Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile Dysfunction: AUA Guideline (2018). EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam 2020. ISBN 978-94-92671-07-3. 109
  • 111. • Although early proposed mechanisms suggested that tumescence was achieved by passive retrograde venous flow, more recent data have indicated: • penile oxygen saturations reached 79.2% immediately after VED placement • 58% arterial • 42% venous Trost, L. W., Munarriz, R., Wang, R., Morey, A., & Levine, L. (2016). External Mechanical Devices and Vascular Surgery for Erectile Dysfunction. The Journal of Sexual Medicine, 13(11), 1579–1617. https://doi.org/10.1016/j.jsxm.2016.09.008 110
  • 112. • • • Trost, L. W., Munarriz, R., Wang, R., Morey, A., & Levine, L. (2016). External Mechanical Devices and Vascular Surgery for Erectile Dysfunction. The Journal of Sexual Medicine, 13(11), 1579–1617. https://doi.org/10.1016/j.jsxm.2016.09.008 111
  • 113. Hackett G et al. British Society for Sexual Medicine Guidelines on the Management of Erectile Dysfunction in Men – 2017. J Sex Med 2018;15:430-57. 112
  • 114. RECOMENDACIONES Use vacuum erection devices as a first-line therapy in well-informed patients with infrequent sexual intercourse and comorbidities requiring non-invasive, drugfree management of ED. Weak The vacuum erection device (VED) is effective in creating an erection satisfactory for intercourse, even in difficult-to-treat populations such as DM, spinal cord injury, and after radical proctectomy (RP; LOE . 2; strength of recommendation . B; recommended). EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam 2020. ISBN 978-94-92671-07-3. 113
  • 116. • • • • • • • • Yang, H., & Seftel, A. D. (2019). Controversies in low intensity extracorporeal shockwave therapy for erectile dysfunction. International Journal of Impotence Research, 31(3), 239–242. https://doi.org/10.1038/s41443-019-0124-0 115
  • 117. • • • • • • • Yang, H., & Seftel, A. D. (2019). Controversies in low intensity extracorporeal shockwave therapy for erectile dysfunction. International Journal of Impotence Research, 31(3), 239–242. https://doi.org/10.1038/s41443-019-0124-0 116
  • 118. • • ONLY VASCULOGENIC Yang, H., & Seftel, A. D. (2019). Controversies in low intensity extracorporeal shockwave therapy for erectile dysfunction. International Journal of Impotence Research, 31(3), 239–242. https://doi.org/10.1038/s41443-019-0124-0 117
  • 119. RECOMENDACIONES For men with ED, low-intensity extracorporeal shock wave therapy (ESWT) should be considered investigational. (Conditional Recommendation; Evidence Level: Grade C) Arthur L. Burnett, MD; Ajay Nehra, MD; Rodney H. Breau, MD; Daniel J. Culkin, MD; Martha M. Faraday, PhD; Lawrence S. Hakim, MD; Joel Heidelbaugh, MD; Mohit Khera, MD; Kevin T. McVary, MD; Martin M. Miner, MD; Christian J. Nelson, PhD; Hossein Sadeghi-Nejad, MD; Allen D. Seftel, MD; Alan W. Shindel, MD. Erectile Dysfunction: AUA Guideline (2018). 118
  • 121. 120
  • 122. 121
  • 123. Philippou YA, Jung J, Steggall MJ, O'Driscoll ST, Bakker CJ, Bodie JA, Dahm P. Penile rehabilitation for postprostatectomy erectile dysfunction. Cochrane Database of Systematic Reviews 2018, Issue 10. Art. No.: CD012414. DOI: 10.1002/14651858.CD012414.pub2 122

Editor's Notes

  1. El objetivo es restaurar una relacion sexual satisfactoria no solo la ereccion rigida del pene, es por eso que tenemos que abordar el progrma desde multiples modalidades, la siguiente tabla es el algoritmo propuesto por la consulta internacional de medicina sexual,
  2. El tratamiento de la DE se debe individualizar en cada paciente, de acuerdo a su problema de base. Se encontrĂł que las dietas mediterrĂĄneas y una reducciĂłn en la ingesta calĂłrica mejoran la funciĂłn erĂŠctil en hombres con sĂ­ndrome metabĂłlico (Esposito y cols., 2006). En la prĂĄctica del ciclismo se encontrĂł que el cambio del asiento convencional por uno sin punta resultĂł en la recuperaciĂłn de la funciĂłn erĂŠctil, tal vez por disminuir el trauma perineal
  3. Ambos nos hablan sobre cambios del estilo de vida, cambio de los factores de riesgo, la dieta, el inicio y de una vida sana con actividad fisica.
  4. se recomendara a la pareja se abstenga de tener coito , con el fin de promover un ambiente libre de presiĂłn.
  5. En la prĂĄctica, el tratamiento psicosexual representa una combinaciĂłn mal definida de intervenciones e interpretaciones en basea conceptos conductuales, relacionales, psicoanalĂ­ticos y de la psicologĂ­a cognitiva.
  6. Por ejemplo, con el cambio de antihipertensivos de tipo diurĂŠticos tiazĂ­dicos y bloqueantes beta adrenĂŠrgicos por bloqueantes de los canales de calcio e inhibidores del sistema renina-angiotensina la suspensiĂłn transitoria de la medicaciĂłn, la reducciĂłn de la dosis
  7. Sobre los antihipertensivos In one recent study, atenolol was associated with fewer sexual attempts, lower level of serum testosterone after 16 weeks, and a rate of ED of 18% compared with 0% with the angiotensin II inhibitor valsartan Nebivolol is a beta-blocker with nitric oxide donor properties that may improve ed
  8. 3 Trials suggest that angiotensin receptor blockers may actually improve sexual function and may be the drug of choice in the ED patient newly diagnosed with hypertension
  9. En el paciente en el que se identifica un desequilibrio hormonal que afecta la presentaciĂłn clĂ­nica de la disfunciĂłn erĂŠctil se considera la prescripciĂłn de un tratamiento hormonal. En este contexto, el rol delurĂłlogo es implementar el tratamiento para el hipogonadismo primario y la hiperprolactinemia, mientras que se debe consultar con un endocrinĂłlogon para otras endocrinopatĂ­as.
  10. Oral Las preparaciones de testosterona de administraciĂłn oral son limitadas. Existen problemas asociados con la toxicidad hepĂĄtica de la testosterona relacionados con las grandes dosis necesarias para alcanzar niveles sĂŠricos normales (hepatitis, ictericia colestĂĄsica, quistes hepĂĄticos hemorrĂĄgicos y carcinoma hepatocelular) Se requieren grandes dosis por vĂ­a oral debido a que gran parte de la dosis administrada se vuelve metabĂłlicamente inactiva durante el "primer paso" hepĂĄtico enantato de testosterona, una preparaciĂłn de depĂłsito inyectable, se administra mediante inyecciĂłn intramuscular (150 a 300 mg cada 2 a 4 semanas). El plan terapĂŠutico resulta en niveles suprafisiolĂłgicos durante 72 horas, con una disminuciĂłn exponencial constante hasta niveles subfisiolĂłgicos hacia el dĂ­a 10 o 12. Se puede considerar una dosis alternativa de 100 mg cada 7 a 10 dĂ­as, cuando el paciente experimenta fluctuaciones sexuales o del estado de ĂĄnimo
  11. Las opciones de administraciĂłn transdĂŠrmica son parches y geles, con una estrategia de administraciĂłn que busca similar los niveles circadianos normales de testosterona. Cuando los paciente se aplican la medicaciĂłn por la maĂąana, la mayor absorciĂłn inicial simula la variaciĂłn diurna normal. parches se han asociado con prurito, irritaciĂłn crĂłnica de la piel y dermatitis alĂŠrgica de contacto. La irritaciĂłn cutĂĄnea se alivia mediante la aplicaciĂłn local de cortisona en crema. Los pacientes reciben asesoramiento sobre sitios de aplicaciĂłn alternativos y se les aconseja evitar las ĂĄreas expuestas a la luz solar. AndroGelÂŽ (gel de testosterona) al 1 % es un gel de aplicaciĂłn tĂłpica que contiene 50, 75 o 100 mg de testosterona, de la cual se absorbe solo el 10% en un perĂ­odo de 24 horas Ambos se aplican de modo similar una vez por dĂ­a por la maĂąana sobre la piel limpia y seca de hombros, brazos o abdomen, y se debe dejar secar antes de vestirse Bucal Se aplica 2 veces por dĂ­a en la encĂ­a por encima de los incisivos, lo que permite la absorciĂłn de la testosterona a travĂŠs de la mucosa bucal.
  12. En el nivel perifĂŠrico, estos mecanismos influyen sobre el tono del mĂşsculo liso de los cuerpos cavernosos.
  13. la erecciĂłn se logra induciendo la activaciĂłn del mĂşsculo liso corporal a travĂŠs de agonistas de las vĂ­as de relajaciĂłn tisular estimulando la sĂ­ntesis de segundos mensajeros de tipo nucleĂłtidos cĂ­clicos [monofosfato cĂ­clico de guanosina o monofosfato cĂ­clico de adenosina]) inhibiendo la inactivaciĂłn de las vĂ­as de relajaciĂłn del mĂşsculo liso (p. ej., inhibiendo las fosfodiesterasas), mientras que el bloqueo de los mecanismos que inhiben la erecciĂłn se logra disminuyendo la contracciĂłn del mĂşsculo liso a travĂŠs de antagonistas de los receptores involucrados en las vĂ­as contrĂĄctiles (p. ej., inhibidores ALFA-adrenĂŠrgicos). A nivel del SNC(encĂŠfalo o mĂŠdula espinal) se afectan las vĂ­as neuronales y existen oportunidades potenciales para promover las vĂ­as que favorecen la erecciĂłn agonistas dopaminĂŠrgicos D2 en el hipotĂĄlamo medio o para contrarrestar las vĂ­as que la inhiben antagonistas serotoninĂŠrgicos en la mĂŠdula espinal).
  14. Se conocen 11 tipos de fosfodiesterasas el Tipo 6 predomina en la retina, la 11 en testĂ­culos y prĂłstata (sin saber su funciĂłn exacta), en el tejido erĂŠctil predominan los tipos 3, 4 y 5, 3 y 4 se concentran en el metabolismo del AMPc y la tipo 5 en el metabolismo del GMPc. La enzima 5 pde hidroliza el monofosfato de guanosinaciclico en el tejdio del cuepro cavernoso del pene, La inhibiciĂłn de la PDE5 provoca un aumento de flujoarterial, disminuciĂłn del calcio intracelular, lo que orgina relajaciĂłn del musculo liso, vasodilataciĂłn y erecciĂłn del pene
  15. Existen 4 inhibidores potentes y selectivos de 5pde, aprobados por la agencia europea del medicamento y la Food and drug administration explica la selectividad de su efecto Las altas concentraciones de fosfodiesterasa de tipo 5 en el músculo liso de los cuerpos cavernosos penianos Revatio reduce la tensión sanguínea en los pulmones dilatando los vasos sanguíneos de los pulmones. Revatio se utiliza para tratar la tensión sanguínea elevada en los vasos sanguíneos del pulmón (hipertensión arterial pulmonar)
  16. Es importante recordar que este grupo de fĂĄrmacos no inician por si solos el proceso de erecciĂłn, si no que requieren de estimulaciĂłn sexual para lograrlas Su efecto depende de la integridad de la via nerviosa , el estimulo sexual y la presencia de cantidades adecuadas de OXIDO NITRICO Se considera que su efectivdiad llega al 80% en pacientes con alteraciones organicas y psicolĂłgicas, En PX con daĂąo neurolĂłgico, muestran menor respuesta debido a la falta de integridad de la via neuronal.
  17. Viagra y levitra tienen mala absorcion si se consumen con alimentos grasos, a pesar de que que levitra y staxyn son vardenafil , staxyn es subligual y se absorve evitado el primer paso , asi que viagra y levitra se tienen que tomar con el estomago vacio , o almenos una hora despues de haber consumido alimentos. Viagra. sindelafil Cialis tadalafil Levitra vardenafil Staxyn vardenafil Stendra. avanafil
  18. TIEMPO NECESARIO PARA ALCANZAR LA CONCENTRACION PLASMATICA MAXIMA De acuerdo con las recomendaciones de administraciĂłn estĂĄndar, a los pacientes se les indica tomar la medicaciĂłn a demanda alrededor de una hora antes de la actividad sexual programada. Este intervalo de tiempo tiene como objetivo aprovechar el momento en el cual la concentraciĂłn sĂŠrica de la medicaciĂłn alcanza su valor mĂĄximo (alrededor de 1 hora para sildenafilo y vardenafilo y 2 horas para tadalafilo) Viagra. sindelafil Cialis tadalafil Levitra vardenafil Staxyn vardenafil Stendra. avanafil
  19. VIDA MEDIA, cialis es el que mas dura, Viagra. sindelafil Cialis tadalafil Levitra vardenafil Staxyn vardenafil Stendra. avanafil
  20. Cialis el la pastilla del fin de semana, por su larga duracion Viagra. sindelafil Cialis tadalafil Levitra vardenafil Staxyn vardenafil Stendra. avanafil
  21. VARDENAFIL ESTA CONTRANIDCIDO EN PACIENTES QUE CONSUMEN ANTIARRITMICOS, ( PROCAINAMIDA QUINIDINA, AMIODARONA, SOTALOL ) Y PACIENTES CON ALARGAMIENTO CONGENITO DEL QT YA QUE PROVOCA ALARGAMIENTO DEL QT El resto de los inhibidores no alteral la contractilidad cardiaca, el gasto caridaco ni el consumo micoardico. , sin embargo si estĂĄn contraindicados en pacientes con enfermedad cardiovascular severa. Viagra. sindelafil Cialis tadalafil Levitra vardenafil Staxyn vardenafil Stendra. avanafil
  22. Es importante hablar con el paciente para asi poder saber que es lo que a el mas le interesa y que es lo mas conveninente para el paciente, si ya sea una pastilla pago por evento o si prefieren tomar un medicamento que cuando ellos lo requieran tenga funcion . Viagra. sindelafil Cialis tadalafil Levitra vardenafil Staxyn vardenafil Stendra. avanafil
  23. SINDELAFILO en la presentacon de zuit, se encuentra en LAMINILLA Verdenafil se disuelve debajo de la lengua.
  24. sildenafilo y vardenafilo tienen una leve reacciĂłn cruzada con la fosfodiesterasa de tipo 6, la cual se expresa en la retina; esta diferencia puede explicar los trastornos visuales Tadalafilo presenta una reacciĂłn cruzada mĂ­nima con la fosfodiesterasa de tipo 11, la cual no existe con los otros dos inhibidores de la fosfodiesterasa de tipo 5, aunque la importancia de este efecto no estĂĄ clara, sin embargo algunos pacientes llegan a referir dolor muscular Viagra. sindelafil Cialis tadalafil Levitra vardenafil Staxyn vardenafil Stendra. avanafil
  25. Enrojecimieno y efecos colaterales visuales sildenafilo o vardenafilo, mientras que el dolor de espalda/mialgia es más frecuente en pacientes que reciben tadalafilo. Priapismo es muy raro, sin embargo se ve cuando toman mucha medicación dosis elevadas, o se toma con inyecciones intra cavernosas, trazadona, o pacientes con consumo de cocaína. La trazodona es un fármaco antidepresivo de segunda generación del grupo químico de las fenilpiperazinas. Es un antagonista e inhibidor de la recaptación de serotonina, con efecto ansiolítico e hipnótico.​ Funciona al aumentar la cantidad de serotonina en el cerebro.
  26. La utilización de nitratos en cualquiera de sus formas (p. ej., nitroglicerina sublingual, dinitrato de isosorbida, otras preparaciones con nitratos utilizadas para tratar la angina de pecho, nitrito amilo y nitrato amilo) representa una contraindicación absoluta La coadministración con cimetidina, ketoconazol, itraconazol y eritromicina incrementa los niveles plasmáticos de sildenafil, ya que éstos inhiben al citocromo P-450 CYP3A4. La rifampicina al contrario puede disminuir los niveles plasmáticos del sildenafil, ya que induce las enzimas del citocromo P-450 CYP3A4
  27. Es importante explicar bien el uso y preescripcion al os pacientes para maximizar el beneficio y la eficacia de estos medicamentos, la dosis se debe ajustar y graduar segĂşn cada paciente para tener una optima eficacia
  28. El uso de los inhibidores de la 5 fosfodiesterasa se usan como primera opcion de tratamiento, , la recomendaciĂłn de usar alprostadil topico o intrauretral, como alternativa a pacientes que no quieres usar los inhibidores es debil.
  29. Se presume que su mecanismo de acción es ocasionar la relajación del músculo liso de los cuerpos cavernosos al bloquear el receptor postsinåptico a¥-adrenÊrgico (con acción inhibidora de la erección) además produce vasodilatación periférica y estimulación cardíaca, cuyo resultado es una disminución de la tensión arterial en la mayoría de los pacientes
  30. El mesilato de fentolamina es un antagonista a-adrenÊrgico no específico con igual afinidad por los receptors adrenÊrgicos a1 y a 2. El mesilato de fentolamina se absorbe en forma regular por vía oral y tiene una baja biodisponibilidad. Alcanza concentraciones plamáticas máximas de 27 ¹ 12 ng/ml a los 30 minutos después de la administración oral de 40 mg. Se excreta por la ruta renal en un 10 a 13% como fármaco inalterado. Se metaboliza en el hígado y su vida media plasmática es de 19 minutos
  31. un alcaloide obtenido a partir de la corteza del ĂĄrbol yohimbe, ejerce efectos centrales sobre la regulaciĂłn de la erecciĂłn peniana al actuar como un antagonista alfa adrenĂŠrgico Sin embargo, este fĂĄrmaco no parece permitir una actividad sexual exitosa superior al placebo en hombres con disfunciĂłn erĂŠctil orgĂĄnica Aunque la yohimbina puede ser bien tolerada, sus modestos resultados sugieren que es mejor restringirla a los pacientes con disfunciĂłn erĂŠctil psicĂłgena Efectos adversos hipertensiĂłn, ansiedad, taquicardia y cefalea.
  32. producto químico idéntico a la prostaglandina El (PGE1), que posee diversos efectos farmacológicos, entre ellos vasodilatación e inhibición de la agregación plaquetaria
  33. Esta tĂŠcnica consiste en la absorciĂłn de la medicaciĂłn a travĂŠs del revestimiento mucoso de la uretra hacia el cuerpo esponjoso circundante, con paso a travĂŠs de pequeĂąos canales vasculares hacia los cuerpos cavernosos supositorio introducido a travĂŠs del orificio uretral que libera una micro esfera semisĂłlida (1 x 3 mm) de alprostadilo en la uretra distal (a 3 cm desde el meato uretral externo) los principales cuerpos erĂŠctiles, los cuerpos cavernosos
  34. Una tasa final calculada de respuesta al MUSEÂŽ es de alrededor del 50%, y entre los respondedores, aproximadamente el 70% de las aplicaciones resulta en actividad sexual
  35. La primera vez que se prescriba alprostadil, el médico debe explicarle la técnica de administración del supositorio uretral en el consultorio
  36. Antes de tomar el alprostadil, el paciente debe de informar datos de enf de peyrone, anemia de células falciformes, leucemia o tumores de médula ósea, ya que éstas condiciones pueden incrementar el riesgo de tener una erección no apropiada que puede durar hasta seis horas. Asi mismo se debe de pregutnar sobre embarazo en la paraje y se debe recomendar el uso obligatorio de condon.
  37. Sepa (leve potenciador de la absorciĂłn percutĂĄnea) Se estima que el etilo ĂŠster de prostaglandina El' el cual es un precursor de la prostaglandina El' tiene una mayor absorciĂłn transdĂŠrmica y genera menor irritaciĂłn cutĂĄnea que los agentes potenciadores debido a su esterificaciĂłn
  38. agente dopaminĂŠrgico que activa los receptores DÂĄ y D2 en el nivel central dentro del nĂşcleo paraventricular
  39. Estos fĂĄrmacos actĂşan a nivel central sobre los receptores de melanocortina de tipo 4, los cuales se han vinculado con el control de la ingestde alimentos y del gasto de energĂ­a, asĂ­ como en la modulaciĂłn de la funciĂłn erĂŠctil y del comportamiento sexual. Como efectos adversos se ha informado enrojecimiento y nĂĄusea. Esta medicaciĂłn no ha sido aprobada para el tratamiento de la disfunciĂłn erĂŠctil.
  40. El descubrimiento en 1982 de que los agentes vasoactivos inyectados en el pene inducĂ­an erecciones promoviĂł el estudio de tratamientos Aunque muchos medicamentos se han explorado con este objetivo, tres se utilizan de modo regular en la prĂĄctica clĂ­nica alprostadilo, papaverina y fentolami
  41. La papaverina, un alcaloide obtenido a partir de la amapola, es un inhibidor no especĂ­fico de fosfodiesterasas, que inhibe la degradaciĂłn de monofosfato cĂ­clico de guanosina como de adenosina de forma tal que estos nucleĂłtidos cĂ­clicos se acumulan en las cĂŠlulas de mĂşsculo liso y asĂ­ promueven la relajaciĂłn tisular progresiva tambiĂŠn bloquea canales de calcio dependientes de voltaje ubicados en la membrana, e impide asĂ­ el ingreso de calcio en la cĂŠlula, un proceso que evoca la contracciĂłn del mĂşsculo liso
  42. El tratamiento combinado con estos agentes vasoactivos ofrece un mecanismo sinĂŠrgico a fin de obtener respuestas erĂŠctiles mĂĄximas, en particular en paciente en quienes la monoterapia ha fracasado Una regla fundamental es comenzar con una pequeĂąa dosis, en especial en pacientes con formas no vasculares de disfunciĂłn erĂŠctil. Se recomienda el entrenamiento y la educaciĂłn del paciente en el consultorio con respecto a la autoinyecciĂłn antes de continuar con el tratamiento en el hogar
  43. En las dosis de 10 a 20 /lg, el alprostadilo produce erecciones completas en el 70 al 80% de los paciente con disfunciĂłn erĂŠctil
  44. del alprostadil para la farmacoterapia intracavernosa
  45. es un inhibidor no especĂ­fico de fosfodiesterasas, tanto de las 2, 3,4,y 5
  46. (debido al riesgo de precipitar una crisis hipertensiva en potencia fatal en caso de utilizar un agonista u-adrenĂŠrgico de administraciĂłn intracavernosa para revertir un episodio de priapismo)
  47. Que pasa si ninguna de estas medidas sirve
  48. such as an elevated residual urine volume secondary to bladder outlet obstruction or neurogenic bladder
  49. 902 implant procedures were performed over the study period 2009 A 2015 infection rates were: 1.3% with HbA1c level of <6.5%, 1.5% for 6.5–7.5%, 6.5% for 7.6–8.5%, 14.7% for 8.6–9.5%, we determined that a HbA1c threshold level of 8.5% predicted infection with a sensitivity of 80% and a specificity of 65%.
  50. You should not have sexual intercourse for at least 6 weeks after your implant surgery  Typically, an implant lasts 10 years, after which it will need to be exchanged for a new one.    You should not have sexual intercourse for at least 6 weeks after your implant surgery 
  51. Antibioitocs hasta 48 hrs iv, y continuar al alta The “no touch” technique involves discarding all surgical instruments and changing all surgical gloves after an incision is made in the penoscrotal raphe and the dissection is carried down through the subcutaneous tissue and dartos to the level of Buck’s fascia. 
  52. The disadvantages of this approach are blind placement of the reservoir and increased scrotal swelling when compared to the infrapubic incision. 
  53. La limpieza es necesaria y debe ser excepcional, un dia antes se afeita la zona , y el dia de la cirugía se debe tener buena higiene, Antibiotic infusion is started in the holding area approximately 1 hour before the operation 
  54. Proper exposure and retractor set-up are extremely important. Poor exposure obscures anatomy, making the case longer and more difficult and increases the chances of inadvertent injury or infection.  The patient is catheterized after draping is complete and the indwelling catheter is used to empty the bladder, An empty bladder is crucial for standard, retropubic placement of the reservoir to minimize the possibility of bladder injury  the “SKW” deep scrotal retractor from Boston Scientific and the “Wilson” scrotal retractor from Coloplast. 
  55. Penis stretched and elevated over beaded strap with sharp hook. An incision is made transversely about 1–2 cm below the penoscrotal junction to a total length of about 4-cm.  Incision and cautery through dartos creating a hole.
  56. The incision is then held in place over the base of the penis and retracted open with blunt hooks. First 2 hooks are placed superiorly at 11 and 1 o’clock with loose tension, then 2 hooks are placed inferiorly at 5 and 7 o’clock with medium tension, then 2 hooks are placed laterally at 3 and 9 o’clock with tight tension 
  57. Using the index and middle fingers, with blunt dissection the scrotal contents are dissected away, revealing the proximal corpora cavernosa and urethra the “cobra kai maneuver according to Dr. Köhler;(qula) the “barrido de Henry” according to Dr. Henry 
  58. The overlying dartos tissue overlying the corpora cavernosa is then sharply dissected, revealing the “squeaky clean”, gleaming white tunica albuginea  After blunt and sharp dissection, the tunica should be “squeaky clean” with no overlying tissue. 
  59. cleaning off the dartos and then cleaning off Buck’s fascia. Both hands can be used in opposite directions, for more direct power, continuing until the corpora cavernosa and corpus spongiosum are cleaned off anteriorly.
  60. Here the scrotal septum is demonstrated prior to and after sharp dissection of the septum off the urethra. Note the exposure afforded by the cowboy blanket roll and additional rake retractors. 
  61. Corpotomia, Right corpora is exposed with urethra pulled toward left corpora.  The corporotomies should be proximal enough on the corpus cavernosum to ensure the tubing exits the corporotomy into the scrotum, not the penile skin.  1.5-cm corporotomies are made with a 15-blade  The 2-0 vicryl stay sutures are placed around the intended corporotomy on each corpus cavernosum  For a Coloplast device, corporotomy should just accept the 12 Fr Brooks dilator 
  62. Distal dilation is begun with scissors or the suction tip to about 50–75% of the way to the glans penis. The instrument should deform the lateral wall of the penis to prevent crossover  Distally we ensure the dilator points slightly laterally to avoid crossover throughout the dilation. Squeezing the glans prevents distal perforation 
  63. In order to check for urethral injury after the distal dilation, forceful injection of fluid with a bulb syringe is done on each side distally while observing for urethral discharge  The proximal dilation is done following the path of the crura of the corpora as they flare laterally onto the pubic bone.  “field-goal test” checks the proximal dilation by placing a dilator on each side proximally. The dilator handles should be parallel and of equal depth penetration (Paired dilators can then be inserted in both corpora simultaneously to ensure an equal dilatation with no posterior crural perforation.
  64. A subdartos pouch is made for the pump in the middle of the scrotum or the hemiscrotum. A small incision is made through the dartos fascia and a long-blade nasalspeculum or ring forceps is used to create the space
  65. The external ring is identified using a small Deaver retractor and the index finger is used to palpate the spermatic cord, pushing it medially to protect it. A closed Metzenbaum scissors is then used to puncture the transversalis fascia. This permits access to the retropubic space.  The index finger is inserted again to create a space.  The reservoir is then filled with normal saline up to 5 mL above its manufactured capacity.  With the tubing to the filling syringe left open, the syringe should spontaneously fill to 5 ml.  If it fills more than this, the position of the reservoir space needs to be checked again to ensure that there is no pressure around the reservoir. A finger is surprisingly effective with proper retraction. In our hands, if a finger cannot pierce the fascia, then the reservoir is placed ectopically 
  66. Coloplast 125 cc cloverleaf reservoir which we intentionally under-fill (to minimum cylinder requirements) to prevent an obvious bulge.  All overlying tissue is cleaned off of the pubic tubercle with a finger or Metzenbaum scissors. The tubercle must be free of all overlying Scarpa’s fascia to avoid reservoir placement superficial to the musculature  Otherwise the reservoir will be placed in a subcutaneous location instead of submuscular, creating a visible and palpable bulge in the abdominal wall 
  67. Cadaver demonstration of ectopic reservoir location in abdominal esta subcutaneo
  68. The device is then inflated to seat the cylinders correctly and to test the device. The guide strings help position the distal ends of the cylinders underneath the glans if pulled during the initial inflation (Figure 12). When satisfied with the position, we keep the device inflated to about 60% for 24 hours to aid in hemostasis. 
  69. A 2-0 vicryl is used to close the deep dartos layer with a gathering stitch, with careful attention is to keep the device tubing in the scrotum and preventing its migration under the skin of the penis.  A “figure of eight” type of method is used to wrap the entire external genitalia until the dressing roll is finished
  70. >90% patient and partner satisfaction in many series • Inflatable > malleable • Similar across implant brands •Overall ~7-10 year average revision free rate
  71. The 2008 AUA best practice policy on the use of parenteral antibiotics for broad spectrum coverage prior to penile prosthesis surgery recommends use of vancomycin or a first- or second-generation cephalosporin as well as an aminoglycoside 1 hour before surgery and up to 24 hours after surgery.  Kanamycina , aminoglucosido Bacitrocina antibiotico polipeptidico. H202 peroxido de hidrogeno
  72. first description in 1973. The specific objective of the surgery is to increase the erection (cavernosal) artery blood inflow in patients with blood flow related ED secondary to trauma. Indications <55 years old Better outcomes for younger patients Recently acquired ED from focal atrial occlusive disease Absence of other risk factors (e.g. smoking, DM, etc.)
  73. All young patients with a history suggestive of trauma-associated impotence (pelvic fractures and perineal trauma) undergo routine hormonal evaluation to ensure adequate circulating levels of testosterone. The patients undergo a night-time penile erection test to rule out nerve damage or psychological ED. Finally, they undergo blood flow assessment, using either duplex Doppler ultrasound of the penis or dynamic infusion cavernosometry/cavernosography (DICC) Doppler ultrasonography, if the peak systolic velocity is less than 25 cm/s. Angiography, whilst being the benchmark for all arterial investigations, is reserved with the aim of concurrent embolisation or angioplasty if an arteriovenous fistula or stenosis is suspected
  74.  They devised PRS using the anastomosis of the inferior epigastric artery (IEGA) to the CC. Subsequently, DDV arterialisations, either with no extensive venous ligation or with venous ligation, the Furlow– Fisher procedure (Fig. 4 ), in which IEGA was made in an end-to-side anastomosis to the DDV, while several ligations were made at the lateral circumflex veins, in proximal and distal locations
  75. VOD, solo de manera experimental.
  76. The vacuum chamber creates an erection by generating negative pressure within the penis, increasing blood flow, and distending the corporeal sinusoids, Then, constriction rings are applied to maintain an erection sufficient for penetration.
  77.  This can be maintained for up to 30 minutes
  78. The 2008 AUA best practice policy on the use of parenteral antibiotics for broad spectrum coverage prior to penile prosthesis surgery recommends use of vancomycin or a first- or second-generation cephalosporin as well as an aminoglycoside 1 hour before surgery and up to 24 hours after surgery. 
  79. vascular endothelial growth factors (VEGF) and their receptor Flt-1 La terapia de ondas de choque se basa en fuentes de energĂ­a externas que depositan pulsos (ondas) en un entorno fluido (gel) y luego propagan la energĂ­a hasta su despliegue en el tejido del pene
  80. Sin embargo aun Hay controversia sobre la frecuencia , duración del tratamiento, el número de pulsos, los resultados a largo plazo y la utilidad en la disfunción eréctil neurogénica
  81. los estudios experimentales en investigaciĂłn deben centrarse en determinar quĂŠ tipo de paciente responderĂĄ mejor a esta terapia y cĂłmo identificar al mejor candidato.
  82. Las limitaciones de estudios previos, incluyendo la heterogeneidad de los criterios de inclusión, la contaminación con PDE5i y diferentes protocolos de tratamiento, han comprometido la evaluación de la eficacia del tratamiento. La SMSNA (Sociedad de Medicina Sexual de Norteamérica) el SWT debe considerarse experimental.
  83. en el contexto clínico de la prostatectomía radical en particular y se la introdujo como estrategia terapÊutica en la "rehabilitación peniana", Pregunta ;: ¿Cuál es la efectividad de los tratamientos que restauran la capacidad de tener erecciones en hombres, después de la cirugía por cáncer de próstata? Se identificaron ocho ensayos controlados aleatorios (estudios clínicos en que los participantes se asignan al azar a uno de dos o más grupos de tratamiento), con 1699 pacientes. Cinco ensayos compararon el uso programado de inhibidores de la fosfodiesterasa con ningún tratamiento o un placebo (un fármaco inactivo). Dos estudios compararon la administración de inhibidores de la fosfodiesterasa como prescripción diaria o según necesidad. Un estudio comparó el uso diario de un inhibidor de la fosfodiesterasa o el fármaco prostaglandina E1 que se coloca en la punta del pene como un supositorio. Los resultados principales de esta revisión que los autores consideran sumamente importantes para los hombres fueron: la calidad percibida en las erecciones (potencia informada por el paciente), la calidad de las erecciones según un cuestionario especializado sobre erección (calidad de las erecciones) y si hubo efectos secundarios graves. Sobre la base de evidencia en su mayoría de muy baja calidad y en algunos casos de baja calidad, las estrategias de rehabilitación del pene que consistieron en el uso programado de PDE5I después de la prostatectomía radical puede no promover la potencia informada por el paciente y la función eréctil en mayor grado que el uso en base a la necesidad.