Overview and introduction to transient elastography (Fibroscan)

1. Transient
Elastography:
Fibroscan
An overview
AHMED ELMOUGHAZY

2. Introduction
Transient elastography (TE, FibroScan®) is a novel non-invasive method that has been proposed for
the assessment of hepatic fibrosis in patients with chronic liver diseases, by measuring liver stiffness.

3. Advantages and limitations
TE is a rapid and user-friendly technique that can be easily performed at the
bedside or in the outpatient clinic with immediate results and good
reproducibility.
TE has been mostly validated in chronic hepatitis C, with diagnostic
performance equivalent to that of serum markers for the diagnosis of significant
fibrosis. Combining TE with serum markers increases diagnostic accuracy and as
a result, liver biopsy could be avoided for initial assessment in most patients
with chronic hepatitis C.
Limitations include failure in around 5% of cases, mainly in obese patients.

4. How it works
Ultrasound transducer probe is
mounted on the axis of a vibrator
Vibrations of mild amplitude and
low frequency (50 Hz) are
transmitted by the transducer,
inducing an elastic shear wave that
propagates through the underlying
tissues.

5. How it works
Pulse-echo ultrasound
acquisition is used to follow the
propagation of the shear wave
and to measure its velocity,
which is directly related to
tissue stiffness :the stiffer the
tissue, the faster the shear
wave propagates

6. How it works
TE measures liver stiffness in a
volume that approximates a
cylinder 1 cm wide and 4 cm
long, between 25 mm and
65 mm below the skin surface.
This volume is at least 100
times bigger than a biopsy
sample, and is therefore far
more representative of the
hepatic parenchyma

7. The procedure
The examination is performed on a non-
fasting patient lying flat on his/her back, with
the right arm tucked behind the head to
facilitate access to the right upper quadrant.
The tip of the probe transducer is placed on
the skin between the rib bones at the level of
the right lobe of the liver where liver biopsy
would be performed.

8. The procedure
Once the measurement area has been
located, the operator presses the probe
button (shot) to start an acquisition. The
software determines whether each
measurement is successful or not. When a
shot is unsuccessful, the machine does not
give any reading.

14. Validity
The validity of TE results also depends on two
important parameters:
(1) the interquartile range (IQR), which
reflects the variability of the validated
measures, and should not exceed 30% of the
median value
(2) the success rate (the ratio of the number
of successful measurements to the total
number of acquisitions) should be at least
60%.

18. Clinical applications
The combination of TE and FibroTest offered the best diagnostic performance, both for significant
fibrosis (F ⩾ 2) and for severe fibrosis-cirrhosis (F3–F4). When TE and FibroTest matched, which was
the case in 70–80% of cases, the results also matched with those of liver biopsy in 84% of cases of
significant fibrosis (Metavir F ⩾ 2), in 95% of cases of severe fibrosis (F ⩾ 3) and in 94% of cases of
cirrhosis (F = 4).

19. Using this algorithm, liver biopsy would have been avoided in 140 (77%) of the 183 patients.