Yale University has transformed its former pharmaceutical campus into a research hub known as Yale West Campus. The 136-acre campus contains over 1.6 million square feet of research labs, administrative offices, and specialty storage facilities. Yale aims to establish interdisciplinary institutes that bring together faculty from across the university to work on challenges in health, environment and energy. The director of research technology discusses challenges in integrating the new campus, developing its identity and vision, and planning state-of-the-art research facilities. Several case studies highlight how old buildings have been repurposed and new centers designed to foster collaboration among researchers.