Transforming Big Pharma into Big
              Academia
     Yale University West Campus

                  Christopher Incarvito, PhD
Director of Research Technology, Yale University West Campus
West Campus by the Numbers
                                                   136 Acres, 17 buildings

                                              •   Research Labs       434,000 GSF
                                              •   Administration          346,000
                                              •   Specialty Storage   426,000
                                              •   General Storage             257,000
                                              •   Campus Support      105,000
                                              •   Other functions             32,000
                                              •   Total Building      1,600,000 GSF




April 25, 2012   243rd ACS National Meeting, San Diego, CA                     2
Aerial View of Yale West
                         Campus




April 25, 2012         243rd ACS National Meeting, San Diego, CA   3
Aerial View of Yale West
                         Campus



                   Office,                          Researc         Specialt
                                                       h               y,
                  Facilities                                        Storage




April 25, 2012          243rd ACS National Meeting, San Diego, CA              4
Yale University Strategic Goals
• Maintain the position of Yale’s fine arts schools as the
  strongest university-based programs in the nation.
• Improve the international standing of science and
  engineering at Yale
• Broaden and deepen the clinical excellence of the
  School of Medicine
• Establish global leadership in environmental
  education, research, and practice
• Make Yale a leader in the digital dissemination of
  scholarly resources

April 25, 2012     243rd ACS National Meeting, San Diego, CA   5
Yale West Campus Challenges
• Ac c es s
   – Distance from the main campuses
• Id e n t it y
   – How to integrate the West Campus with the rest of
     Yale
• S pac e
   – Medicinal chemistry facility with corporate focus
• V is io n
   – Short time frame from purchase to implementation


April 25, 2012    243rd ACS National Meeting, San Diego, CA   6
West Campus Operating
                       Principles
• Scientific focus on challenges of human sustainability
   – Health, Environment and Energy
• Institute based research programs that cross
  traditional departmental boundaries
• Strengthen and integrate science and engineering
  faculty across the University
   – Medical School, School of Engineering, Yale
     College
• Expand core facilities to support research


April 25, 2012        243rd ACS National Meeting, San Diego, CA   7
Chemical      Cancer
                     Biology YCGA Biology
                          HPC              SMDC
                 Energy                        Biodesign
                                              Nanobiology
                                      Cores CMD
                                       CS
                 Scienc
                 MicrobialWCAC
                   es
                             G                 Ri
                                               HTCB        Cell
                 Diversity                                Biology
                                Systems
                                Biology

April 25, 2012         243rd ACS National Meeting, San Diego, CA    8
April 25, 2012   243rd ACS National Meeting, San Diego, CA   9
April 25, 2012   243rd ACS National Meeting, San Diego, CA   10
Facilities Planning
• Work directly with Architects and Builders
       – Conduit for end users
                 • Get what they want
       – Scientific representation
                 • Get what they need
       – Administrative representation
                 • Get what is best




April 25, 2012                243rd ACS National Meeting, San Diego, CA   11
Facilities Planning
• Work directly with Architects and Builders
       – Conduit for end users
                 • Get what they want
       – Scientific representation
                 • Get what they need
       – Administrative representation
                 • Get what is best




April 25, 2012                243rd ACS National Meeting, San Diego, CA   12
Facilities Planning
• Work directly with Architects and Builders
       – Conduit for end users
                 • Get what they want
       – Scientific representation
                 • Get what they need
       – Administrative representation
                 • Get what is best




April 25, 2012                243rd ACS National Meeting, San Diego, CA   13
Facilities Planning
• Work directly with Architects and Builders
       – Conduit for end users
                 • Get what they want
       – Scientific representation
                 • Get what they need
       – Administrative representation
                 • Get what is best




April 25, 2012                243rd ACS National Meeting, San Diego, CA   14
Active Projects




April 25, 2012     243rd ACS National Meeting, San Diego, CA   15
Case Studies
1. Open design concept
        – Integrated Science and Technology Center
            (B24-2/3)
2. Old design vs. new design
        – Advanced Biosciences Center (B31-2/3)
3. Ideal Space
        – Molecular Innovations Center (B27)
4. Unique offerings
        – High-energy Experimental Station (C23)
5. Arts integration
        – Center for Cultural Preservation (A21)
6. Student life
April 25, 2012          243rd ACS National Meeting, San Diego, CA   16
Aerial View of Yale West
                         Campus




April 25, 2012         243rd ACS National Meeting, San Diego, CA   17
Integrated Science and Technology
                      Center




April 25, 2012    243rd ACS National Meeting, San Diego, CA   18
Integrated Science and Technology Center
            Open Design, Interactive Areas


                                                              Nanobiology




                                                          23,524 GSF



April 25, 2012    243rd ACS National Meeting, San Diego, CA                 19
April 25, 2012   243rd ACS National Meeting, San Diego, CA   20
Open concept
                 Shared facilities/equipment
                 Faculty close to laboratories


April 25, 2012    243rd ACS National Meeting, San Diego, CA   21
Aerial View of Yale West
                         Campus




April 25, 2012         243rd ACS National Meeting, San Diego, CA   22
Advanced Biosciences Center
                                                                Cance
                                                                   r
                                                                Biolog
                                                                  y

                                                             29,675 GSF




April 25, 2012   243rd ACS National Meeting, San Diego, CA               23
Advanced Biosciences Center
                                                                 Cance
                                                                    r
                                                                 Biolog
                                                                   y

                                                             29,675 GSF
                                                                Systems
                                                                Biology

                                                                 Microbial
                                                                 Diversity


April 25, 2012   243rd ACS National Meeting, San Diego, CA                24
A Tale of Two Floors


            2008 design                                  2011 design




April 25, 2012            243rd ACS National Meeting, San Diego, CA    25
A Tale of Two Floors


                                                 • 1 small conference
            2008 design
                                                   room
                                                 • 1 warm room, 1 cold
                                                 • No shared space
                                                 • No flex space




April 25, 2012            243rd ACS National Meeting, San Diego, CA      26
2008 design




  April 25, 2012   243rd ACS National Meeting, San Diego, CA   27
2008 design




  April 25, 2012   243rd ACS National Meeting, San Diego, CA   28
2008 design




  April 25, 2012   243rd ACS National Meeting, San Diego, CA   29
2008 design




  April 25, 2012   243rd ACS National Meeting, San Diego, CA   30
2008 design




  April 25, 2012   243rd ACS National Meeting, San Diego, CA   31
Conference
                    A Tale of Two Floors


              2008 design                                  2011 design




  April 25, 2012            243rd ACS National Meeting, San Diego, CA    32
Conference
Cold                A Tale of Two Floors


              2008 design                                  2011 design




  April 25, 2012            243rd ACS National Meeting, San Diego, CA    33
Conference
Cold                A Tale of Two Floors
Flex




              2008 design                                  2011 design




  April 25, 2012            243rd ACS National Meeting, San Diego, CA    34
Conference
Cold                A Tale of Two Floors
Flex
Shared Specialty




              2008 design                                  2011 design




  April 25, 2012            243rd ACS National Meeting, San Diego, CA    35
Conference
Cold                A Tale of Two Floors
Flex
Shared Specialty
Shared Radiation



              2008 design                                  2011 design




  April 25, 2012            243rd ACS National Meeting, San Diego, CA    36
Conference
Cold                A Tale of Two Floors
Flex
Shared Specialty
Shared Radiation
Shared Safety


              2008 design                                  2011 design




  April 25, 2012            243rd ACS National Meeting, San Diego, CA    37
Bayer Hydrogenation Plant




April 25, 2012    243rd ACS National Meeting, San Diego, CA   38
Anchor or Unexpected Asset?
•    No need for the intended use
•    Isolated
•    Dated
•    Less than ideal use of building space

• But… it can house extreme experiments
• Worry less about what it can do, and more
  about what we can’t do elsewhere

April 25, 2012   243rd ACS National Meeting, San Diego, CA   39
Anchor or Unexpected Asset
                                                             Zhengrong Wang
                                                             Geology and Geophysics




April 25, 2012   243rd ACS National Meeting, San Diego, CA                  40
Anchor or Unexpected Asset
                                                             Zhengrong Wang
                                                             Geology and Geophysics




                        200 bar, 500 °C




April 25, 2012   243rd ACS National Meeting, San Diego, CA                  41
Anchor or Unexpected Asset
                                                             Zhengrong Wang
                                                             Geology and Geophysics




April 25, 2012   243rd ACS National Meeting, San Diego, CA                  42
Repurpose




April 25, 2012   243rd ACS National Meeting, San Diego, CA   43
Repurpose
                                        • 50,000 reinforced
                                          concrete roof
                                        • Update life-safety
                                          apparatus
                                        • Hand over keys




April 25, 2012   243rd ACS National Meeting, San Diego, CA     44
Energy
                                                                 Sciences




6.5 km lithostatic pressue!!!

 April 25, 2012      243rd ACS National Meeting, San Diego, CA              45
Aerial View of Yale West
                         Campus




April 25, 2012         243rd ACS National Meeting, San Diego, CA   46
Molecular Innovations Center
                                                                Chemica
                                                                   l
                                                                Biology


                                                             55,984 GSF




April 25, 2012   243rd ACS National Meeting, San Diego, CA                47
Small Project Kickstart




April 25, 2012        243rd ACS National Meeting, San Diego, CA   48
Shared Microbial Culture
April 25, 2012   243rd ACS National Meeting, San Diego, CA   49
Shared Radiation
April 25, 2012   243rd ACS National Meeting, San Diego, CA   50
Solvent Storage
April 25, 2012   243rd ACS National Meeting, San Diego, CA   51
Instrumentation
April 25, 2012   243rd ACS National Meeting, San Diego, CA   52
Save for the future
April 25, 2012   243rd ACS National Meeting, San Diego, CA   53
Aerial View of Yale West
                         Campus




April 25, 2012         243rd ACS National Meeting, San Diego, CA   54
Center for Cultural Preservation




April 25, 2012   243rd ACS National Meeting, San Diego, CA   55
Center for Cultural Preservation




April 25, 2012   243rd ACS National Meeting, San Diego, CA   56
Acknowledgements
•    Lisa D’Angelo
•    Scott Strobel
•    Yale University
•    www.yale.edu/westcampus

      CHAS 24 – T r a n s f o r m i n g B i g P h a r m a i n t o B i g A c a d e m i a – Y a l e U n i v e r s i t y W e s t C a m p u s

                            C hallenges of D esign, C onstruction and T ransitioning to Operations for N ew Laboratory F acilities
                                                                  Wednesday, March 28
                                                                          9:05 AM
                                                          San Diego Mariott Marquis & Marina
                                                                      Balboa / SMMM




April 25, 2012                                    243rd ACS National Meeting, San Diego, CA                                                 57

Transforming pharma to academia

  • 1.
    Transforming Big Pharmainto Big Academia Yale University West Campus Christopher Incarvito, PhD Director of Research Technology, Yale University West Campus
  • 2.
    West Campus bythe Numbers 136 Acres, 17 buildings • Research Labs 434,000 GSF • Administration 346,000 • Specialty Storage 426,000 • General Storage 257,000 • Campus Support 105,000 • Other functions 32,000 • Total Building 1,600,000 GSF April 25, 2012 243rd ACS National Meeting, San Diego, CA 2
  • 3.
    Aerial View ofYale West Campus April 25, 2012 243rd ACS National Meeting, San Diego, CA 3
  • 4.
    Aerial View ofYale West Campus Office, Researc Specialt h y, Facilities Storage April 25, 2012 243rd ACS National Meeting, San Diego, CA 4
  • 5.
    Yale University StrategicGoals • Maintain the position of Yale’s fine arts schools as the strongest university-based programs in the nation. • Improve the international standing of science and engineering at Yale • Broaden and deepen the clinical excellence of the School of Medicine • Establish global leadership in environmental education, research, and practice • Make Yale a leader in the digital dissemination of scholarly resources April 25, 2012 243rd ACS National Meeting, San Diego, CA 5
  • 6.
    Yale West CampusChallenges • Ac c es s – Distance from the main campuses • Id e n t it y – How to integrate the West Campus with the rest of Yale • S pac e – Medicinal chemistry facility with corporate focus • V is io n – Short time frame from purchase to implementation April 25, 2012 243rd ACS National Meeting, San Diego, CA 6
  • 7.
    West Campus Operating Principles • Scientific focus on challenges of human sustainability – Health, Environment and Energy • Institute based research programs that cross traditional departmental boundaries • Strengthen and integrate science and engineering faculty across the University – Medical School, School of Engineering, Yale College • Expand core facilities to support research April 25, 2012 243rd ACS National Meeting, San Diego, CA 7
  • 8.
    Chemical Cancer Biology YCGA Biology HPC SMDC Energy Biodesign Nanobiology Cores CMD CS Scienc MicrobialWCAC es G Ri HTCB Cell Diversity Biology Systems Biology April 25, 2012 243rd ACS National Meeting, San Diego, CA 8
  • 9.
    April 25, 2012 243rd ACS National Meeting, San Diego, CA 9
  • 10.
    April 25, 2012 243rd ACS National Meeting, San Diego, CA 10
  • 11.
    Facilities Planning • Workdirectly with Architects and Builders – Conduit for end users • Get what they want – Scientific representation • Get what they need – Administrative representation • Get what is best April 25, 2012 243rd ACS National Meeting, San Diego, CA 11
  • 12.
    Facilities Planning • Workdirectly with Architects and Builders – Conduit for end users • Get what they want – Scientific representation • Get what they need – Administrative representation • Get what is best April 25, 2012 243rd ACS National Meeting, San Diego, CA 12
  • 13.
    Facilities Planning • Workdirectly with Architects and Builders – Conduit for end users • Get what they want – Scientific representation • Get what they need – Administrative representation • Get what is best April 25, 2012 243rd ACS National Meeting, San Diego, CA 13
  • 14.
    Facilities Planning • Workdirectly with Architects and Builders – Conduit for end users • Get what they want – Scientific representation • Get what they need – Administrative representation • Get what is best April 25, 2012 243rd ACS National Meeting, San Diego, CA 14
  • 15.
    Active Projects April 25,2012 243rd ACS National Meeting, San Diego, CA 15
  • 16.
    Case Studies 1. Opendesign concept – Integrated Science and Technology Center (B24-2/3) 2. Old design vs. new design – Advanced Biosciences Center (B31-2/3) 3. Ideal Space – Molecular Innovations Center (B27) 4. Unique offerings – High-energy Experimental Station (C23) 5. Arts integration – Center for Cultural Preservation (A21) 6. Student life April 25, 2012 243rd ACS National Meeting, San Diego, CA 16
  • 17.
    Aerial View ofYale West Campus April 25, 2012 243rd ACS National Meeting, San Diego, CA 17
  • 18.
    Integrated Science andTechnology Center April 25, 2012 243rd ACS National Meeting, San Diego, CA 18
  • 19.
    Integrated Science andTechnology Center Open Design, Interactive Areas Nanobiology 23,524 GSF April 25, 2012 243rd ACS National Meeting, San Diego, CA 19
  • 20.
    April 25, 2012 243rd ACS National Meeting, San Diego, CA 20
  • 21.
    Open concept Shared facilities/equipment Faculty close to laboratories April 25, 2012 243rd ACS National Meeting, San Diego, CA 21
  • 22.
    Aerial View ofYale West Campus April 25, 2012 243rd ACS National Meeting, San Diego, CA 22
  • 23.
    Advanced Biosciences Center Cance r Biolog y 29,675 GSF April 25, 2012 243rd ACS National Meeting, San Diego, CA 23
  • 24.
    Advanced Biosciences Center Cance r Biolog y 29,675 GSF Systems Biology Microbial Diversity April 25, 2012 243rd ACS National Meeting, San Diego, CA 24
  • 25.
    A Tale ofTwo Floors 2008 design 2011 design April 25, 2012 243rd ACS National Meeting, San Diego, CA 25
  • 26.
    A Tale ofTwo Floors • 1 small conference 2008 design room • 1 warm room, 1 cold • No shared space • No flex space April 25, 2012 243rd ACS National Meeting, San Diego, CA 26
  • 27.
    2008 design April 25, 2012 243rd ACS National Meeting, San Diego, CA 27
  • 28.
    2008 design April 25, 2012 243rd ACS National Meeting, San Diego, CA 28
  • 29.
    2008 design April 25, 2012 243rd ACS National Meeting, San Diego, CA 29
  • 30.
    2008 design April 25, 2012 243rd ACS National Meeting, San Diego, CA 30
  • 31.
    2008 design April 25, 2012 243rd ACS National Meeting, San Diego, CA 31
  • 32.
    Conference A Tale of Two Floors 2008 design 2011 design April 25, 2012 243rd ACS National Meeting, San Diego, CA 32
  • 33.
    Conference Cold A Tale of Two Floors 2008 design 2011 design April 25, 2012 243rd ACS National Meeting, San Diego, CA 33
  • 34.
    Conference Cold A Tale of Two Floors Flex 2008 design 2011 design April 25, 2012 243rd ACS National Meeting, San Diego, CA 34
  • 35.
    Conference Cold A Tale of Two Floors Flex Shared Specialty 2008 design 2011 design April 25, 2012 243rd ACS National Meeting, San Diego, CA 35
  • 36.
    Conference Cold A Tale of Two Floors Flex Shared Specialty Shared Radiation 2008 design 2011 design April 25, 2012 243rd ACS National Meeting, San Diego, CA 36
  • 37.
    Conference Cold A Tale of Two Floors Flex Shared Specialty Shared Radiation Shared Safety 2008 design 2011 design April 25, 2012 243rd ACS National Meeting, San Diego, CA 37
  • 38.
    Bayer Hydrogenation Plant April25, 2012 243rd ACS National Meeting, San Diego, CA 38
  • 39.
    Anchor or UnexpectedAsset? • No need for the intended use • Isolated • Dated • Less than ideal use of building space • But… it can house extreme experiments • Worry less about what it can do, and more about what we can’t do elsewhere April 25, 2012 243rd ACS National Meeting, San Diego, CA 39
  • 40.
    Anchor or UnexpectedAsset Zhengrong Wang Geology and Geophysics April 25, 2012 243rd ACS National Meeting, San Diego, CA 40
  • 41.
    Anchor or UnexpectedAsset Zhengrong Wang Geology and Geophysics 200 bar, 500 °C April 25, 2012 243rd ACS National Meeting, San Diego, CA 41
  • 42.
    Anchor or UnexpectedAsset Zhengrong Wang Geology and Geophysics April 25, 2012 243rd ACS National Meeting, San Diego, CA 42
  • 43.
    Repurpose April 25, 2012 243rd ACS National Meeting, San Diego, CA 43
  • 44.
    Repurpose • 50,000 reinforced concrete roof • Update life-safety apparatus • Hand over keys April 25, 2012 243rd ACS National Meeting, San Diego, CA 44
  • 45.
    Energy Sciences 6.5 km lithostatic pressue!!! April 25, 2012 243rd ACS National Meeting, San Diego, CA 45
  • 46.
    Aerial View ofYale West Campus April 25, 2012 243rd ACS National Meeting, San Diego, CA 46
  • 47.
    Molecular Innovations Center Chemica l Biology 55,984 GSF April 25, 2012 243rd ACS National Meeting, San Diego, CA 47
  • 48.
    Small Project Kickstart April25, 2012 243rd ACS National Meeting, San Diego, CA 48
  • 49.
    Shared Microbial Culture April25, 2012 243rd ACS National Meeting, San Diego, CA 49
  • 50.
    Shared Radiation April 25,2012 243rd ACS National Meeting, San Diego, CA 50
  • 51.
    Solvent Storage April 25,2012 243rd ACS National Meeting, San Diego, CA 51
  • 52.
    Instrumentation April 25, 2012 243rd ACS National Meeting, San Diego, CA 52
  • 53.
    Save for thefuture April 25, 2012 243rd ACS National Meeting, San Diego, CA 53
  • 54.
    Aerial View ofYale West Campus April 25, 2012 243rd ACS National Meeting, San Diego, CA 54
  • 55.
    Center for CulturalPreservation April 25, 2012 243rd ACS National Meeting, San Diego, CA 55
  • 56.
    Center for CulturalPreservation April 25, 2012 243rd ACS National Meeting, San Diego, CA 56
  • 57.
    Acknowledgements • Lisa D’Angelo • Scott Strobel • Yale University • www.yale.edu/westcampus CHAS 24 – T r a n s f o r m i n g B i g P h a r m a i n t o B i g A c a d e m i a – Y a l e U n i v e r s i t y W e s t C a m p u s C hallenges of D esign, C onstruction and T ransitioning to Operations for N ew Laboratory F acilities Wednesday, March 28 9:05 AM San Diego Mariott Marquis & Marina Balboa / SMMM April 25, 2012 243rd ACS National Meeting, San Diego, CA 57

Editor's Notes

  • #3 Intro to include promo for Big Pharma/Academia talk Brief comment on size complexity and how DoRT fits here but works all around
  • #6 Intro to include promo for Big Pharma/Academia talk Brief comment on size complexity and how DoRT fits here but works all around
  • #7 Intro to include promo for Big Pharma/Academia talk Brief comment on size complexity and how DoRT fits here but works all around
  • #8 Intro to include promo for Big Pharma/Academia talk Brief comment on size complexity and how DoRT fits here but works all around
  • #16 History and vision Background Not doing this, but something much larger
  • #26 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #27 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #28 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #29 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #30 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #31 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #32 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #33 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #34 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #35 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #36 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #37 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #38 Cold room / warm room Lobby pics Shared equipment rooms Upstairs has flex space
  • #56 Whole building Conservation core
  • #57 Whole building Conservation core