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A
Report on Industrial Training
At
A Solution Pharmaceuticals Pvt. Ltd.
SUBMITTED BY
Tushar N. Sonawane
DEPARTMENT OF BIOTECHNOLOGY
Shram Sadhana Bombay Trust's
COLLEGE OF ENGINEERING AND TECHNOLOGY, BAMBHORI
JALGAON-425001.(M.S.)
(2015)

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ACKNOWLEDGEMENT
I would like to thank A Solution Pharmaceutical Pvt Ltd. for giving me opportunity to
work with your company. I want to express my deep sense of gratitude to Mr. Sandeep
Kurkure. I am thankful to CEO Mr. Nandkumar Chodankar for his valuable guidance and
helping me in each and every aspect of my Industrial Training. I would also like to thank all the
staff members for their support and help.
Yours sincerely,
Tushar N. Sonawane

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INDEX:
1. Introduction …04
2. Location …04
3. General Process Flowchart …05
4. Raw Material …06
5. Warehouse …06
6. Research And Development …06
7. Quality Control …06
8. Production …06
9. Departments …07
9.1. Research And Development …07
9.2. Quality Control …08
9.3. Production …09
10. Conclusion …10

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1. INTRODUCTION:
M/s ASolution Pharmaceuticals Private Limited proposes to manufacture Active Pharmaceutical
Ingredients, Intermediates and Specialty chemicals, herbal and natural products, specialty
chemicals, organic chemicals & Formulation of total capacity 3,590 MT/Annum. It is a proposed
manufacturing unit with MPCB consent for Research and Development facility
2. LOCATION:
The manufacturing plant of M/s ASolution Pharmaceuticals Pvt Ltd, is located at plot no: K-3/8
owned by the company in Additional Ambernath, MIDC, Ambernath (E), Dist: Thane,
Maharashtra. The site is 5 km from Ambernath town.

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3. GENERAL PROCESS FLOWCHART:
Raw Material
Warehouse
Sampling
Quality Control
Production Batch
Intermediate Testing By QC
Product Dispatch
Research& Development

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4. RAW MATERIAL:
 Raw material is nothing but the starting material for the production.
 It can be water, solvents or reagents.
5. WAREHOUSE:
 It is the storage space available for raw material as well as product.
 A specific number is given to each material.
6. RESEARCHAND DEVELOPMENT:
 A raw material is tested for the various developments.
 The yield can be improved by carrying out the reaction at different parameters.
 The parameters can be temperature, pH.
7. QUALITY CONTROL:
 The quality of the raw materials is checked here.
 The specifications of raw materials are checked at this department.
 The properties of the material are checked.
 If the properties do not match with the specification, then the material is rejected.
 The intermediate testing of product is also done by QC department.
8. PRODUCTION:
 The material from warehouse is sent to production department after testing in quality
control.
 The material is utilized batch wise for the production.
 There are equipments like reactor, centrifuge, multi-mill, dryer, sifter, etc.

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9. DEPARTMENTS:
9.1 ResearchAnd Development:
 Material is sent to R & D from warehouse.
 A particular batch number is given to each sample.
 Various tests are carried out on the material.
 Highest yielding reaction is selected for the production.
 Chemicals are ordered, analyzed and stored in R & D.
Equipments:
9.1.1 Rota-Vapour:
 It is used for distillation of desired product.
 It works under the vaccum.
 Out of mixture, only desired product remains in the rota flask and remaining compounds
are evaporated under vaccum.
9.1.2 Melting Point Apparatus:
 It is used for determining compounds on the basis of their molecular weight .
 The compound is introduced into the capillary.
 Then the capillary is placed in the silicon oil.
9.1.3 UV Cabinet:
 The equipment is used to check whether the reaction is completed or not.
 A silicon coated strip is used for the purpose.
 Different spots of sample are seen on the strip.
9.1.4 Ultrasonication:
 It is used to dissolve the compound in the solution.
 High frequency ultrasonic waves are generated for the purpose.

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9.2 Quality Control:
 The samples are tested for various parameters.
 The tests are carried out for moisture content, loss on drying, etc.
 It is the most important department.
 Sample is also sent to QC for intermediate testing.
Equipments:
9.2.1 HPLC:
 High-performance liquid chromatography.
 It is used to separate the components in a mixture.
 Also to identify each component, and to quantify each component.
9.2.2 GC:
 Gas centrifuge.
 It is used in analytical chemistry.
 GC is used for separating and analyzing the compounds that can be vaporized without
decomposition.
 In some situations, GC may used to identify the compound.
9.2.3 Karl FischerTitrator:
 This is used for the moisture determination.
 Small quantities of samples are required.
 The analysis takes very less time.

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9.3 Production:
 The tested sample is sent to the production department.
 Production is done in batches.
Equipments:
9.3.1 Reactor:
 It is the place where the actual reaction takes place.
 It is made up of different materials.
 Mild Steel Reactor: Alkaline material.
 Stainless Steel Reactor: Alkaline material.
 Glass Line Reactor: Acidic as well as alkaline material.
 Rubber Line Reactor: Acidic materials.
 Hastalloy Reactor: Acidic as well as alkaline material.
9.3.2 Centrifuge:
 It is used for the separation of the product from rest material.
 There are two types of centrifuge.
 Stainless Steel Centrifuge: Alkaline material.
 Hallar Coated Centrifuge: Acidic as well as alkaline material.
9.3.3 Dryer:
 The dryer is used to dry the product.
 Drying is done on the fluidized bed.
 Air is introduced in the dryer from suction pump.
 It is heated and with the help of that heated air, the product is dried.
9.3.4 Multi-Mill:
 It is used to grind the product in desired particle sizes.
 It is very powerful equipment.
 Different particle sizes can be obtained with the help of the multi mill.

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10. Conclusion:
In such a way I have seen the general manufacturing process of Pharmaceutical
Compounds in A Solution Pvt. Ltd. Ambernath, Mumbai.