Only HIV-negative people should use PrEP. An HIV test is required before starting PrEP and then every 3 months while taking it. The document discusses a pilot program called Targeted PrEP Implementation Program (TPIP) that provided PrEP to high-risk HIV-negative men who have sex with men and transgender women. It evaluates the program and provides data on participant demographics, enrollment numbers, adherence rates, reasons for discontinuing PrEP, and STI diagnosis rates.