This document discusses opportunities in the health resources and tissue engineering markets. It analyzes trends in healthcare spending, demographics of aging populations in the US and EU, and market sizes for pharmaceuticals, medical devices, and tissue engineering. Specifically, it sees potential for peptide-based hydrogels to deliver compounds that prevent dental caries, whiten teeth, and treat periodontal issues. Such technologies could carry fluoride, hydrogen peroxide, or antibiotics to locally address common oral health problems. The global dental market is sizable, with demand for whitening and treatments for gum disease.

1. 1
Health Resources Industry

2. 2
Analysis of the Health Resources market
Doctors
Nurses
Pharmacists
Etc.
Outpatient care
Hospital care
Long-term care
Pharmaceuticals
Medical devices
Biotechnology
Health
Resources
Human Resources
Health Spending
Tissue engineering
Profile

3. 3
Attractiveness of the Health Resources market by region
1.United states of America:
15% of total population is 65> years
old (accounts for 50 million
inhabitants)
Expanded consumer
access to health care
through the 2010 Patient
Protection and
Affordable Care Act (ACA)
Spending in 2014:
$3 Trillion with a GAGR
of 4.9%
2. Europe Union:
20% of the total EU population which
accounts for 100 million inhabitants
are 65 years and older
Lengthening life
expectancies
Spending in 2014:
$2 Trillion with a GAGR
of 2.5%
N.B.: Spending for the world reached $10 Trillion in 2014

4. 4
Pharmaceutical Industry

5. 5
Analysis of the Pharmaceutical industry
Segments:
Originator chemical drugs, generics,
over-the-counter drugs,
active pharmaceutical ingredients, excipients
and biosimilars.
Profile

6. 6
Attractiveness of the Pharmaceutical industry
World spending in 2014:
$1,6 Trillion
CAGR: 6.4%
CAGR: 2.2%

7. 7
50% of the largest pharmaceutical companies are based in the US and
the rest in the EU

8. 8
Spending per capita in 2016
Belgium in as among the top 15 countries for Pharma spending per capita

9. 9
Tissue Engineering Market

10. 10
Analysis and attractiveness of the Tissue engineering market
Overview
Market size
$89.7 billion in 2016 at a CAGR
of 8.4% with the US in the lead
followed by the EU.
Industry classification
Tissue engineering is present
mainly in :
• Pharmaceutical
• Biotechnology
• medical devices sector
Market classification by application
Organ and Tissue Regeneration,
cardiovascular, oral care, dermal,
orthopedic, dermatology, oncology,
neurology and urology.

11. 11
Tissue engineering: The Oral care segment
Dental in Numbers:
Oral care in Numbers
 National dental care expenditure reached $111 billion in 2012 in the US.
 Spending per patient in USA on dental by age:
1. USA

12. 12
Dental in Numbers:
Oral care in Numbers
2. Europe
 The EU27 spending on dental was equal to $79 billion in 2012 with a global CAGR of 5.7%.
 Different dental segments by share in the European market:
Peptide-based hydrogel dental
applications
Tissue engineering: The Oral care segment

13. 13
Caries prevention Periodontal medication
Teeth bleaching
Tissue engineering and Regenerative medicine
Improve Dental and Periodontal opportunities

14. 14
What is it about
What can the technology
do
What would be
required
How big is the
market
Tissue engineering: Dental applications
Prevention from caries by Peptide-based hydrogel
Combining the hydrogel with different
compounds and using it as a platform.
A tray would be important or simply
transforming the hydrogel into
toothpaste.
Furthermore, Fluoride should be mixed
with the gel.
Delivers protective compounds
locally to fight against teeth
corrosion and caries perseverance.
 Fluoride usage in Belgium exceeds 85% of the total population
(So demanded).
 Existing applications: Fluoride gel.
Examples of existing products:
o Oral-B® Minute-Foam® 1.23% APFTopical Fluoride poured in a
tray and costs >$35
o Oral-B®Neutra-Foam®2.0% Neutral Sodium Fluoride poured in a
tray and costs >$35
>25% consume drinks with high sugar level
> 30% consume alcohol
>85% consume candies.
15% have had difficulty chewing,
biting and eating food because of
caries
 According to European polls:

15. 15
Tissue engineering: Dental applications
Teeth Whitening hydrogel
What is it about
What can the technology
do
What would be
required
How big is the market
 According to European polls:
-7% felt embarrassed because of the appearance of their teeth
-4% of Europeans have avoided a conversation or reduced
their participation in social because of their teeth colours.
-In Belgium, More than 20% consumes tobacco regularly and on daily
basis.
 The American Association of Orthodontists also found that nearly
90% of patients requested tooth whitening.
 Examples of existing products:
o Opalescence is one of the best in teeth whitening.
(400 Euro for the kit includes 4 syringes of 1,2mL, a toothpaste and a tray.)
o Whiter Image: US$ 55 for the deluxe kit includes 2 syringes of 1,2mL
and a tray (or not it depends)
Hydrogen Peroxide or Carbamide Peroxide
should be added to the gel.
Also, The tray, that contains the Hydrogel,
should be placed on the patient’s teeth for
more or less 8 hours (during the night).
Mixing the Hydrogel with other
elements for teeth bleaching
applications.
Turn degraded teeth into whiter
ones by applying the hydrogel locally
using a tray.

16. 16
Tissue engineering: Periodontal application
Medication for gum matters
What is it about
What can the technology
do
What would be
required
How big is the market
Carries and distributes antibiotics
(or other combinations) locally to
cope with gum bleeding, periodontal
pockets and other irritating concerns.
Chlorhexidine, doxycycline and
minocycline can be added to the
hydrogel depending on the issue that
should be treated.
Joining antibacterial elements
with the hydrogel to tackle gum
issues.
 According to the Department of Health studies:
-16% have sore gums or irritation.
-Around 50% of adults have early stage of gum diseases (64 million
In the USA).
-Half of adults have gum pockets and 20% of those are 15-18 years old.
-8 in 100 adults were found to have severe gum pockets that, eventually,
need surgery.
 Existing applications for gum treatments:
o Perio-cleaning at the dentist is more than US$ 200.
o G.U.M Perio-Balance Oral Probiotic (30 lozenges £14.51)
o Boots Co-Enzyme Q10 (30 capsules, £4.99)
o Colgate Peroxyl Oral Rinse (300ml, £3.58)
o Corsodyl Spray (60ml, £5.15)
o Gengigel Gel (20ml, £6.99)