Meet Braeden Rogers and his beloved German shepherd, Jill, a dynamic duo battling diabetes
Read our annual report to learn how we're making a difference in thousands of young lives.
See how generous donors like you are giving brighter futures to patients at Children's Hospital.
Arizona Moves Backward on Health Care Coveragejoshuaoehler
Although Arizona is operating without an adopted, balanced budget in place for this fiscal year, state agencies are implementing dramatic budget cuts that endanger children and families throughout our state. Due to a failure of the legislature to appropriate funding for KidsCare Parents, nearly 10,000 working parents are scheduled to lose their health insurance on September 30, 2009.
Meet Braeden Rogers and his beloved German shepherd, Jill, a dynamic duo battling diabetes
Read our annual report to learn how we're making a difference in thousands of young lives.
See how generous donors like you are giving brighter futures to patients at Children's Hospital.
Arizona Moves Backward on Health Care Coveragejoshuaoehler
Although Arizona is operating without an adopted, balanced budget in place for this fiscal year, state agencies are implementing dramatic budget cuts that endanger children and families throughout our state. Due to a failure of the legislature to appropriate funding for KidsCare Parents, nearly 10,000 working parents are scheduled to lose their health insurance on September 30, 2009.
Associate Professor Ian Scott - Princess Alexandra Hospital; University of Qu...Informa Australia
Associate Professor Ian Scott
Director
Internal Medicine & Clinical Epidemiology; Associate Professor of Medicine
Princess Alexandra Hospital; University of Queensland
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Associate Professor Ian Scott - Princess Alexandra Hospital; University of Qu...Informa Australia
Associate Professor Ian Scott
Director
Internal Medicine & Clinical Epidemiology; Associate Professor of Medicine
Princess Alexandra Hospital; University of Queensland
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
6. Dahl v Purcell (1993) 15 QLR 33
• Failed vasectomy
• Pratt DCJ awarded damages including
• Prenatal distress and pain and suffering of child birth
• Past and future costs of bringing up the child
• Out of pocket expenses – maternity clothes and medical expenses
• Loss of consortium
• And parents’ voluntary services, past and future, associated with raising the
child BUT reduced by ¼ to reflect the intangible benefits of a healthy child
• Public policy considerations did not prevent P’s claim
Tina Cockburn + Bill Madden - August 2017 6
7. Cattanach v Melchior (2003) 215 CLR 1
• Failed tubal ligation
• Held: past and future costs of raising child recoverable, regardless of
whether child suffers a disability
• Without reference to benefits and pleasures derived, or to be derived, from
the child
• Kirby J: “it is not the birth of the child that constitutes the harm,
injury or damage for which the parents sue. Instead, it is for the
economic harm inflicted upon them by the injury they have suffered
as a consequence of the negligence that they have proved.” (57)
Tina Cockburn + Bill Madden - August 2017 7
8. Gentile v Ferri [2004] WADC 144
• Failed tubal ligation with Filshie clips
• Costs of raising child awarded
• Additional claim, for voluntary services based on commercial costs of
paying someone to discharge the parents’ duty of bringing up the
child, unsuccessful
Tina Cockburn + Bill Madden - August 2017 8
13. CES v Superclinics (1995) 38 NSWLR 47
• CES alleged loss of opportunity to terminate pregnancy because medical
practitioners failed to detect her pregnancy despite repeated consultations
• CES visited D 5 times over a period of 2 months, concerned that she was
pregnant and wishing to terminate the pregnancy if she was
• When pregnancy finally diagnosed CES was 19 weeks pregnant and was
told that it was too late to perform a lawful termination
• Held: Kirby ACJ and Priestly J disallowed damages from the point at which
adoption could occur. (at 73)
• Justice Meagher dissented - abhorrent that the birth of a healthy child could lead to
an award of damages. It might be damaging to the child to become aware that she
was an unwanted child. (at 79)
Tina Cockburn + Bill Madden - August 2017 13
14. Veivers v Connolly [1995] 2 QdR 326
• Failure to test a pregnant woman for rubella (German measles)
• Baby subsequently born with congenital rubella embryopathy leading to
severe disabilities
• Mother asserted that she would have terminated the pregnancy had she
been informed that she had Rubella at an early stage in her pregnancy
• Mother successfully sued for extra costs of raising a disabled child
• De Jersey J: damages award reduced by 5% to reflect that the case was
essentially for loss of chance to terminate pregnancy and there was a
possibility that she may not have been able to obtain a lawful termination.
Tina Cockburn + Bill Madden - August 2017 14
22. Backwell v AAA (1996) Aust Torts Rep 81-387
• D inseminated P with incorrect donor sperm.
• D discovered error > told P not to worry & return next week for pregnancy test.
• Test revealed P pregnant
• D advised termination – risk of stillbirth
• D threatened P that if baby stillborn, her identity might be revealed & publicity
might cause closure of clinic.
• D told P that if she did not terminate, further IVF might be difficult to receive
• P terminated pregnancy
• P suffered depressive disorder
• Held: compensatory damages and $60,000 exemplary damages
Tina Cockburn + Bill Madden - August 2017 22
23. ACB v Thomson Medical Pte Ltd
[2017] 1 SLR 918
• A and H sought to conceive a child through IVF – baby P born
• Mistake: A’s ovum fertilised using unknown donor sperm instead of H’s
sperm
• A Chinese Singaporean woman – H Caucasian male – donor sperm mistakenly used
was Indian
• Court drew attention to the race of the parties involved not because of any approval of
outmoded attitudes towards race and ethnicity, but because of a recognition of ‘the complex
role that physical resemblance, race, and cultural and ethnic identity have had and continue
to have on our individual well-being’, as they so evidently did have on A’s. [134]
• Claims:
• Financial costs of raising child to age 21
• Loss of autonomy
• Punitive damages
Tina Cockburn + Bill Madden - August 2017 23
24. ACB v Thomson Medical Pte Ltd (cont…)
• Costs of child rearing claim failed – compare Australian position
• ‘[t]he duty to maintain one’s child is a duty which lies at the very heart of
parenthood, and thus the expenses which are incurred towards the discharge
of this estate are not capable of characterisation as a loss.’ [93]
• Loss not recognised by the Court as legally actionable
• Conflict of interest between parent’s private interests in litigation and their duties
vis a vis their children
• A only entitled to recover damages for: pain and suffering arising from the
pregnancy AND costs of failed IVF procedure
Tina Cockburn + Bill Madden - August 2017 24
25. ACB v Thomson Medical Pte Ltd (cont…)
• Loss of autonomy claim failed – compare English position
• Conceptual objection: concept of autonomy too nebulous and contested a
concept
• Coherence: action for loss of autonomy akin to action for vindication of a legal
right BUT negligence action sees damage in terms of objective detriment and
damages are compensatory in nature
• Over-inclusiveness objection: recognition of loss of autonomy would allow for
circumvention of “damage requirement” as any form of damage could be
potentially reconceptualised in terms of damage to autonomy
Tina Cockburn + Bill Madden - August 2017 25
27. ACB v Thomson Medical Pte Ltd (cont…)
• Assessment of damages for a loss of genetic affinity - fraught with difficulty.
• Loss of genetic affinity could be seen as an element of non-pecuniary loss, akin in some
ways to an award for pain and suffering, but with distinct incidents.
• As in all cases involving non-pecuniary loss, there was no objective yardstick which could
be used, and the sum which was awarded was ‘conventional’ in the sense that it was not
the product of precise calculation but was instead a sum that afforded reasonable
compensation in the circumstances of the case.
• In the absence of comparable precedents, the Court held that the award would be
benchmarked as a percentage of the financial costs of raising Baby P. [149]
• This did not derogate from the finding that the obligations of parenthood were incapable
of being regarded as loss, but was a practical approach that prevented the court from
having to pluck a figure out of thin air. Having regard to all the circumstances of the case,
the Court found that an award equivalent to 30 per cent of the financial costs of raising
Baby P properly reflected the seriousness of the appellant’s loss and would be just,
equitable, and proportionate.[150]
Tina Cockburn + Bill Madden - August 2017 27
28. ACB v Thomson Medical Pte Ltd (cont…)
• Exemplary damages declined - facts too scant to support a finding of outrageous
conduct.
• Allegation in the statement of claim that the mix-up had taken place because
more than one sample had been handled in the laminar hood at the same time
and because the disposable pipettes were not discarded promptly after each use.
• Held: Even accepting both of these assertions to be correct, Court could not
conclude — from this single instance of negligence alone — that the respondents’
conduct was of such a character as to be considered outrageous.
• However, if an award of punitive damages had been justified, it would have been
an additional head of damages, and the sum awarded would be additional to,
and not in lieu of any compensatory award that might be made. [209]
• Compare: Civil Liability legislation abolition of exemplary and aggravated damages in negligence claims
Tina Cockburn + Bill Madden - August 2017 28
38. Cattanach v Melchior
• McHugh, Gummow J (obiter)
• “the relevant damage suffered by the Melchiors is the expenditure that they
have incurred or will incur in the future, not the creation or existence of the
parent-child relationship. If, for example, their child had been voluntarily
cared for up to the date of trial, they could have recovered no damages for
that part of the child’s upbringing.”
Tina Cockburn + Bill Madden - August 2017 38