PANGAEA is integrating ORCID identifiers to improve linking of researchers and their published datasets. Researchers can now claim their PANGAEA dataset publications to their ORCID record to clarify authorship. This allows PANGAEA to accurately link datasets to the authors who published them. The integration also benefits researchers by making their full publication portfolio, including datasets, visible in their ORCID profile. PANGAEA aims to further improve cross-linking between datasets and other research outputs like literature, projects, and samples.
FAIR for the future: embracing all things dataARDC
FAIR for the future: embracing all things data - Natasha Simons, Keith Russell and Liz Stokes, presented at Taylor & Francis Scholarly Summits in Sydney 11 Feb 2019 and Melbourne 14 Feb 2019.
Managing and sharing confidential data in Australian social scienceARDC
The “problem” of “sensitive data” - the 5 Safes model
The “problem” of open and transparent research – the FAIR principles
From problems to solutions – Access to sensitive data in Australia – ADA as a model for journal data access system
Improving Integrity, Transparency, and Reproducibility Through Connection of ...Andrew Sallans
The Center for Open Science (COS) was founded as a non-profit technology start-up in 2013 with the goal of improving transparency and reproducibility by connecting the scholarly workflow. COS achieves this goal through the development of a free, open source web application called the Open Science Framework (OSF), providing features like file sharing and citing, persistent urls, provenance tracking, and automated versioning. Initial workflow API connections focused on storage services and included Figshare, GitHub, Amazon S3, Dropbox, and Dataverse. The team is now working to connect other parts of the workflow with services like DMPTool, Databib/re3data, and Databrary. This session will introduce the core architecture and the problems that it solves, and illustrate how connecting services can benefit everyone involved in supporting the research ecosystem. COS is funded through the generosity of grants from the Laura and John Arnold Foundation, the John Templeton Foundation, the Alfred P. Sloan Foundation, the Association of Research Libraries, and others.
Presented at CNI Fall 2014, Washington, DC.
RDAP13 Elizabeth Moss: The impact of data reuseASIS&T
Kathleen Fear, ICPSR, University of Michigan
“The impact of data reuse: a pilot study of 5 measures”
Panel: Data citation and altmetrics
Research Data Access & Preservation Summit 2013
Baltimore, MD April 4, 2013 #rdap13
An update on the latest BioSharing work; including work with ELIXIR and NIH BD2K, also our survey to assess user needs (530 replies) and the work on the recommender tool
Research information management: making sense of it allDigital Science
"Research information management: making sense of it all" - Julia Hawks, VP North America, Symplectic
Slides from Shaking It Up: Challenges and Solutions in Scholarly Information Management, San Francisco, April 22, 2015
Data for Science: How Elsevier is using data science to empower researchersPaul Groth
Each month 12 million people use Elsevier’s ScienceDirect platform. The Mendeley social network has 4.6 million registered users. 3500 institutions make use of ClinicalKey to bring the latest in medical research to doctors and nurses. How can we help these users be more effective? In this talk, I give an overview of how Elsevier is employing data science to improve its services from recommendation systems, to natural language processing and analytics. While data science is changing how Elsevier serves researchers, it’s also changing research practice itself. In that context, I discuss the impact that large amounts of open research data are having and the challenges researchers face in making use of it, in particular, in terms of data integration and reuse. We are at just beginning to see of how technology and data is changing science correspondingly this impacts how best to empower those who practice it.
Linked Data: from Library Entities to the Web of DataRichard Wallis
Presentation to the ALCTS session "International Developments in Library Linked Data: Think Globally" at the American Library Association Conference in Las Vegas - June 2014
FAIR for the future: embracing all things dataARDC
FAIR for the future: embracing all things data - Natasha Simons, Keith Russell and Liz Stokes, presented at Taylor & Francis Scholarly Summits in Sydney 11 Feb 2019 and Melbourne 14 Feb 2019.
Managing and sharing confidential data in Australian social scienceARDC
The “problem” of “sensitive data” - the 5 Safes model
The “problem” of open and transparent research – the FAIR principles
From problems to solutions – Access to sensitive data in Australia – ADA as a model for journal data access system
Improving Integrity, Transparency, and Reproducibility Through Connection of ...Andrew Sallans
The Center for Open Science (COS) was founded as a non-profit technology start-up in 2013 with the goal of improving transparency and reproducibility by connecting the scholarly workflow. COS achieves this goal through the development of a free, open source web application called the Open Science Framework (OSF), providing features like file sharing and citing, persistent urls, provenance tracking, and automated versioning. Initial workflow API connections focused on storage services and included Figshare, GitHub, Amazon S3, Dropbox, and Dataverse. The team is now working to connect other parts of the workflow with services like DMPTool, Databib/re3data, and Databrary. This session will introduce the core architecture and the problems that it solves, and illustrate how connecting services can benefit everyone involved in supporting the research ecosystem. COS is funded through the generosity of grants from the Laura and John Arnold Foundation, the John Templeton Foundation, the Alfred P. Sloan Foundation, the Association of Research Libraries, and others.
Presented at CNI Fall 2014, Washington, DC.
RDAP13 Elizabeth Moss: The impact of data reuseASIS&T
Kathleen Fear, ICPSR, University of Michigan
“The impact of data reuse: a pilot study of 5 measures”
Panel: Data citation and altmetrics
Research Data Access & Preservation Summit 2013
Baltimore, MD April 4, 2013 #rdap13
An update on the latest BioSharing work; including work with ELIXIR and NIH BD2K, also our survey to assess user needs (530 replies) and the work on the recommender tool
Research information management: making sense of it allDigital Science
"Research information management: making sense of it all" - Julia Hawks, VP North America, Symplectic
Slides from Shaking It Up: Challenges and Solutions in Scholarly Information Management, San Francisco, April 22, 2015
Data for Science: How Elsevier is using data science to empower researchersPaul Groth
Each month 12 million people use Elsevier’s ScienceDirect platform. The Mendeley social network has 4.6 million registered users. 3500 institutions make use of ClinicalKey to bring the latest in medical research to doctors and nurses. How can we help these users be more effective? In this talk, I give an overview of how Elsevier is employing data science to improve its services from recommendation systems, to natural language processing and analytics. While data science is changing how Elsevier serves researchers, it’s also changing research practice itself. In that context, I discuss the impact that large amounts of open research data are having and the challenges researchers face in making use of it, in particular, in terms of data integration and reuse. We are at just beginning to see of how technology and data is changing science correspondingly this impacts how best to empower those who practice it.
Linked Data: from Library Entities to the Web of DataRichard Wallis
Presentation to the ALCTS session "International Developments in Library Linked Data: Think Globally" at the American Library Association Conference in Las Vegas - June 2014
ESA Ignite talk on UC3 Dash platform for data sharingCarly Strasser
Ignite talk (20 slides / 15 seconds per slide) for ESA 2014 meeting in Sacramento, CA 12 August 2014. On the Dash platform for helping researchers manage and share their data via institutional repositories
Enabling better science - Results and vision of the OpenAIRE infrastructure a...Paolo Manghi
Enabling better science: presentation on the results and vision of the OpenAIRE infrastructure and RDA Publishing Data Services Working Group in this direction.
3.7.17 DSpace for Data: issues, solutions and challenges Webinar SlidesDuraSpace
Hot Topics: The DuraSpace Community Webinar Series,
“Introducing DSpace 7: Next Generation UI”
Curated by Claire Knowles, Library Digital Development Manager, The University of Edinburgh.
DSpace for Data: issues, solutions and challenges
March 7, 2017 presented by: Claire Knowles & Pauline Ward - The University of Edinburgh & Ryan Scherle - Dryad Digital Repository
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
3. PANGAEA
• Data curation and publishing
• Static datasets following classic publication pattern
• Rich curated metadata, including coordinates, features, …
• Dataset DOI, resolvable via doi.org, indexed at DataCite
• Citable dataset publications
• Human and machine readable citation exports
• Integrated in some journals with direct article-dataset link
4. Advances at PANGAEA
• Meet Dr. Alice Lefebvre
MARUM Center for Marine Environmental Sciences
• Alice has heard of ORCID
“They did ask about it when I submitted my last paper”
• However, she
“Never took the time to look into it”
• Until recently when she was told how to claim her PANGAEA dataset
publications to her ORCID Record
5. Dataset publications by Alice
• PANGAEA knows of 16 dataset publications by “Lefebvre, Alice”
• Are they by the same author?
• Alice decides to clarify by
claiming her datasets to ORCID
6. Link ORCID iD
Sign into PANGAEA and connect
her PANGAEA account with her
ORCID iD
11. What’s next at PANGAEA
• Cross linking identifier systems
• Datasets with literature (ongoing)
• Datasets with datasets, funders, projects, software
• Samples with contributors
• Dynamic data
• Resolution and citation of dynamic data
• Dataset versions, collections, subsets
• Streamed (sensor) data
