The Zen of Python outlines Python's core philosophies which emphasize simplicity, readability, and practicality over complexity and purity. Some of the key principles discussed include: preferring simple and explicit constructs over complex implicit ones; writing code that is easy for humans to read and understand; handling errors explicitly rather than letting them pass silently; striving for a single obvious way to do things while avoiding unnecessary complexity; and embracing namespaces as a useful mechanism. The document provides examples of how these philosophies are reflected in Python's design choices.