the three \"Worm Nobel Prizes\" mentioned by Martin Chalfie in his nobel prize lecture are Sydney, Bob Horvitz, and John Sulston won the Nobel Prize in physiology or medicine for their work on C. elegans. Andy Fire and Craig Mello for their discovery of RNA interference. Solution the three \"Worm Nobel Prizes\" mentioned by Martin Chalfie in his nobel prize lecture are Sydney, Bob Horvitz, and John Sulston won the Nobel Prize in physiology or medicine for their work on C. elegans. Andy Fire and Craig Mello for their discovery of RNA interference..