This document discusses the impact of religion, culture, and stigma on HIV prevention strategies for men who have sex with men (MSM) in sub-Saharan Africa. It notes that MSM are a key population with higher estimated HIV prevalence than national figures, but population size is unknown due to widespread prohibition and criminalization. Religion and culture strongly influence identities and behaviors in sub-Saharan Africa and stigma surrounding diseases is common. As a result, most HIV prevention strategies aimed at MSM, including behavior change communication, structural prevention policies, and biomedical approaches face high levels of impact from religion, culture, and stigma in the region. More research and integration of MSM-specific health services into mainstream public health are recommended to