This document contains a summary of investigator projects related to HIV/STI prevention, diagnosis, treatment, and retention. It lists the project title, funder, and key populations for various studies focused on groups such as Black/Latino MSM, PWID, transgender individuals, Latino immigrants, African Americans, PLWH, youth, and female sex workers. The projects utilize methods like mHealth apps, social network interventions, peer navigation, and engage communities through ethnography.
HIV Prevention And Health Service Needs Of The Transgender Community In San F...Santé des trans
HIV Prevention and Health Service Needs of the Transgender Community in San Francisco by Kristen Clements, MPH, Willy Wilkinson, Kerrily Kitano, Rani Marx.
Il s'agit de l'un des articles parus dans le numéro spécial de l'International Journal of Transgenderism consacré en 1999 à "Transgenders and HIV : risks, prevention and care" (référence : IJT Volume 3, Number 1+2, January - June 1999).
Global Medical Cures™ | HIV Among Women
DISCLAIMER-
Global Medical Cures™ does not offer any medical advice, diagnosis, treatment or recommendations. Only your healthcare provider/physician can offer you information and recommendations for you to decide about your healthcare choices.
HIV Prevention And Health Service Needs Of The Transgender Community In San F...Santé des trans
HIV Prevention and Health Service Needs of the Transgender Community in San Francisco by Kristen Clements, MPH, Willy Wilkinson, Kerrily Kitano, Rani Marx.
Il s'agit de l'un des articles parus dans le numéro spécial de l'International Journal of Transgenderism consacré en 1999 à "Transgenders and HIV : risks, prevention and care" (référence : IJT Volume 3, Number 1+2, January - June 1999).
Global Medical Cures™ | HIV Among Women
DISCLAIMER-
Global Medical Cures™ does not offer any medical advice, diagnosis, treatment or recommendations. Only your healthcare provider/physician can offer you information and recommendations for you to decide about your healthcare choices.
This article co-written by Dr. Robert J. Winn which aims to quantify the number of lesbian, gay, bisexual, and transgender (LGBT) people in Philadelphia who report to be victims of domestic violence.
Young Gay Couples - How they use drugs and sex to stay safeYTH
Data collected from 199 young gay couples (YMSM couples) recruited through Facebook ads found that men were thoughtful about their drug use and HIV risk reduction strategies within their partnerships.
In an effort to reach a broader audience, the Lancet asked us to visualise the findings of a series of academic papers on HIV in sex workers. I analysed the papers to determine an over-arching story to communicate the series beyond the medical and science communities. The infographic was a huge success for the Lancet, who continue to work with the agency. It got lots of traction on Twitter, with hundreds of retweets. It was picked up by the Washington Post, Upworthy, Huffington Post and the Independent, who continued the conversation.
Producer: Aimée Stewart • Designer: Paulo Estriga
for The Guardian Digital Agency
Monitoring and evaluation proposal for National Gay Men’s Syphilis Action Plan. Presentation given by Rebecca Guy and Michelle McPherson at the AFAO National Syphilis Forum, 23 October 2009.
This article co-written by Dr. Robert J. Winn which aims to quantify the number of lesbian, gay, bisexual, and transgender (LGBT) people in Philadelphia who report to be victims of domestic violence.
Young Gay Couples - How they use drugs and sex to stay safeYTH
Data collected from 199 young gay couples (YMSM couples) recruited through Facebook ads found that men were thoughtful about their drug use and HIV risk reduction strategies within their partnerships.
In an effort to reach a broader audience, the Lancet asked us to visualise the findings of a series of academic papers on HIV in sex workers. I analysed the papers to determine an over-arching story to communicate the series beyond the medical and science communities. The infographic was a huge success for the Lancet, who continue to work with the agency. It got lots of traction on Twitter, with hundreds of retweets. It was picked up by the Washington Post, Upworthy, Huffington Post and the Independent, who continued the conversation.
Producer: Aimée Stewart • Designer: Paulo Estriga
for The Guardian Digital Agency
Monitoring and evaluation proposal for National Gay Men’s Syphilis Action Plan. Presentation given by Rebecca Guy and Michelle McPherson at the AFAO National Syphilis Forum, 23 October 2009.
Rape Victimization and High Risk Sexual Behaviors Longitudinal Stud.docxmakdul
Rape Victimization and High Risk Sexual Behaviors: Longitudinal Study of African-American Adolescent Females
Delia L. Lang, PhD, MPH,* Jessica M. Sales, PhD,* Laura F. Salazar, PhD,* James W. Hardin, PhD,†Ralph J. DiClemente, PhD,* Gina M. Wingood, ScD, MPH,* and Eve Rose, MSPH*
Author information ►Article notes ►Copyright and License information ►Disclaimer
This article has been cited by other articles in PMC.
Go to:
Go to:Abstract
Go to:
Go to:Objectives:
African-American women are affected by disproportionately high rates of violence and sexually transmitted infections (STI)/human immunodeficiency virus (HIV) infection. It is imperative to address the intersection of these two urgent public health issues, particularly as these affect African-American adolescent girls. This study assessed the prevalence of rape victimization (RV) among a sample of African-American adolescent females and examined the extent to which participants with a history of RV engage in STI/HIV associated risk behaviors over a 12-month time period.
Go to:
Go to:Methods:
Three hundred sixty-seven African-American adolescent females ages 15–21, seeking sexual health services at three local teenager-oriented community health agencies in an urban area of the Southeastern United States, participated in this study. Participants were asked to complete an audio computer-assisted self-interview (ACASI) at baseline, 6- and 12-month follow-up. We assessed sociodemographics, history of RV and sexual practices. At baseline, participants indicating they had experienced forced sex were classified as having a history of RV.
Go to:
Go to:Results:
Twenty-five percent of participants reported a history of RV at baseline. At 6- and 12-months, victims of RV had significantly lower proportions of condom-protected sex (p=.008), higher frequency of sex while intoxicated (p=.005), more inconsistent condom use (p=.008), less condom use at last sex (p=.017), and more sex partners (p=.0001) than non-RV victims. Over the 12-month follow-up period, of those who did not report RV at baseline, 9.5% reported that they too had experienced RV at some point during the 12-month time frame.
Go to:
Go to:Conclusion:
African-American adolescent females who experience RV are engaging in more risky sexual behaviors over time than non-RV girls, thereby placing themselves at higher risk for contracting STIs. In light of the results from this unique longitudinal study, we discuss considerations for policies and guidelines targeting healthcare, law enforcement and educational and community settings. The complexities of RV screening in healthcare settings are examined as is the need for tighter collaboration between healthcare providers and law enforcement. Finally, we consider the role of prevention and intervention programs in increasing awareness about RV as well as serving as an additional safe environment for screening and referral.
Go to:
Go to:INTRODUCTION
Due to jeopardized health of adult and adolescent w ...
CHLAMYDIA AND PERIODIC SCANNING 2Chlamydia and Periodic Scann.docxbartholomeocoombs
CHLAMYDIA AND PERIODIC SCANNING 2
Chlamydia and Periodic Scanning Among Sex Workers
Student’s Name
Institution Affiliation
Course Number
Instructor’s Name
Date
Introduction
In recent years, sexually transmitted diseases (STDs) have increased at an alarming rate. 20% of the population in the US have had an STI since 2018 and their treatment cost has been approximately $16 billion. Among the STDs that have been on the rise include chlamydia. Chlamydia is an infection that affects both men and women and damages their reproductive organs. Because of this, it becomes hard for women to become pregnant and sometimes causes fatal ectopic pregnancy. Florida is among the worst affected population by STDs, and it ranks 7th supporting data shows that from 2010 to 2019, the rates of chlamydia in Florida rose an astonishing 313%. This condition is easily curable, but the shame people must get treated for STDs is the main cause of the high increase rates in of the disease.
It has been noted that this STD is particularly on the rise among young people aged 15-29. This population has been known for having unprotected and rampant sexual engagements. According to the most recent state data available, the illness affected 105,058 people overall in 2018. Florida reported 85,278 chlamydia infections among those between the ages of 15 and 29, which is a treatable bacterial STD. The number of cases the department reported in 2016 grew to 94,719 in 2017, reaching 100,002. Groups with the highest risk of developing an STD were identified by the health department as being young adults (15–24), gay and bisexual men, and those who have had several sex partners. According to the health department, 3 out of 4 STD carriers in Florida are between the ages of 15 and 29.
PICOT Question
For asymptomatic ureteral and anorectal Chlamydia trachomatis infection, would periodically screening sex workers be beneficial to reduce incidence and prevalence rates at the community level when compared to communities without intervention in six months?
Vulnerable Population
Sex workers are exposed to many health hazards including STDs such as Chlamydia, AIDs, gonorrhea, and syphilis. The most rampant of them all among sex workers and normal people in the population is chlamydia. The disease is bad if left unchecked but easily cured when it is detected and treated early. It affects the reproductive system to an extent it may cause ectopic pregnancy or even destruction of the uterus. Sex workers are highly subjected to this disease as they are mostly dealing with the most sexually active age group which carries the largest infection rate. The number of cases the department reported in 2016 grew to 94,719 in 2017, reaching 100,002. Groups with the highest risk of developing an STD were identified by the health department as being young adults (15–24), gay and bisexual men, and those who have had several sex partners. Chlamydial and gonococcal infections in females can cause pelvic.
Running Head: COMMUNITY ANALYSIS 1
Community Analysis
The most prevalent risk factors among racial and ethnic minorities are unprotected vaginal or anal sex, inadequate sex education, improving access to prevention and care services and drug use. Jackson, MS has a population of 173,212, with median household income of $32,250. Poverty is one of the major contributing factors to the risky behaviors and the rise of HIV infections within racial/ethnic minority youths. The residents with incomes below the poverty level in Jackson, MS by 2015 was 39.9%, and those with income below 50% of the poverty level was 19.2%, the breakdown is between ages 13 to 19 years of poor residents in Jackson, MS and the percentage is below half of poverty level of 20%. The most common race or ethnicity living below the poverty line in Jackson, MS is Black or African American, followed by White and Hispanic or Latino. The state of homelessness is on the rise and many of these shelters in Jackson, MS now have waiting lists with majority of its occupants are racial/ethnic minority. Even with the waiting lists, those that need to be sheltered will have to call ahead to confirm (City Data, 2015).
Mississippi is one of the most rustic states in the United States and its population is perhaps the poorest. According to the 2010 Census, Mississippi has a population of 2,967,297 people, with a racial distribution of 59% white, 37% black, 3% Hispanic, and 2% other. Mississippi ranks second in the nation (after the District of Columbia) for the highest proportion of African Americans. Through U.S. Census Bureau 2011 American Community Surveys, Mississippi levels the first in the country for the number of people living in poverty (22.6% of the total population) and the lowest middle household revenue ($36,919) (United State Census Bureau, 2011). According to the 2011 National HIV Surveillance Report, Mississippi had the 4th highest rate of HIV infection in the United States. The state’s capital city, Jackson, had the third highest rate of HIV diagnoses within aged 13 to 19 years and the eighth highest AIDS diagnosis by metropolitan statistical area (MSA) in 2011. For the past twenty years, numbers of peoples living with HIV in Mississippi has risen yearly. By the end of December 31, 2013, there was approximately 10,473 Mississippians living with HIV (National HIV Surveillance Report, 2013).
Secondary data
Jackson, MS the state’s capital city and with the most new HIV disease cases are identified in the West Central Public Health District V, which includes the metropolitan Jackson Hinds area, where 47% of all persons with HIV disease in Mississippi reside presently (Mississippi State Department of Health, 2015). According to data for states and metropolitan areas, it’s shown that racial and ethnic minority youths aged between 13 to 19 years rank 4th in the diagnose of HIV at 44.7%. The education b ...
American Research Journal of Humanities & Social Science (ARJHSS) is a double blind peer reviewed, open access journal published by (ARJHSS).
The main objective of ARJHSS is to provide an intellectual platform for the international scholars. ARJHSS aims to promote interdisciplinary studies in Humanities & Social Science and become the leading journal in Humanities & Social Science in the world.
Madridge Journal of AIDS (ISSN: 2638-1958); HIV-related stigma is a global issue. Its perpetuation varies in magnitude across and within countries, and serves as a major barrier to HIV prevention efforts.
Leandro Mena, MD, MPH
Chair and Professor of Population Health Science
Department of Population Health Science
University of Mississippi Medical Center
This is technical writing Assignment, no emotions go straight to t.docxchristalgrieg
This is technical writing Assignment, no emotions go straight to the point.
Section 1: Introduction
The rise in the numbers of Human Immunodeficiency Virus (HIV) diagnoses is notable especially for racial and ethnic minority youth and adolescents aged 13 to 19 years (National Institute of Health, 2013). Approximately one half of all new HIV infections in the United States occur among person(s) younger than 25 years. Nearly 4 million new sexually transmitted infection (STI) cases each year occur among youth and adolescents (NIH, 2013). Reconciling data of 2015, 54.2% of high school students reported having sexual intercourse; of students reported sex during the previous months, 39% stated they didn’t use a condom during their last sexual encounter (United States Census Bureau, 2014). The number of sexually active among youth and adolescents, from 2001 to 2014, there’s been a significant increase in the percentage of youth and adolescents who were never taught about HIV/AIDS. Unified national HIV/AIDS surveillance system has enhanced the ability to monitor and characterize racial and ethnic minority youth populations affected by the HIV epidemic and provide information on the entire population of HIV infected persons who have been tested confidentially (NIH, 2014). Approximately 1.2 million people were living with HIV in the United States in 2014, 49% and 51% undiagnosed infections. Almost 50,000 people become newly infected each year, and in 2014, the estimated rate of diagnoses of HIV infection was 13.8 per 100,000 population (National Institute of Health, 2014). Social trust is associated with lowering the of course mortality rates and that associated HIV infection varied within racial and ethnic minority youth and adolescents. The risk factors that will be addressed in this paper are unprotected vaginal or anal sex, improving access to prevention and care services, inadequate sex education and drug use
Unprotected vaginal and anal sex
Participating in unprotected vaginal and anal sex, or sex without latex or polyurethane condoms is a major contributing factor of HIV rate in racial and ethnic minority youth and adolescents. In an infected youth or adolescents, the semen and blood contains high amount of HIV. During unprotected vaginal and anal sex HIV can easily pass from one person to another. Several studies link alcohol and drug use to higher rates of unprotected anal intercourse, higher numbers of sex partners, and inconsistent condom use (NIH, 2014). With these trends among racial and ethnic minority National HIV Behavioral Surveillance (2015) reported 21% minority youth and adolescent are infected with HIV while 79% youth and adolescent don’t know their status (National HIV Behavioral Surveillance, 2015).
Improving access to prevention and care services
Access to HIV prevention and treatment is an important step in helping achieve an HIV free generation, especially among racial and ethnic minority youth and adolescent. If someone ...
Global Medical Cures™ | HIV TESTING IN USA
DISCLAIMER-
Global Medical Cures™ does not offer any medical advice, diagnosis, treatment or recommendations. Only your healthcare provider/physician can offer you information and recommendations for you to decide about your healthcare choices.
NIH AIDS Executive Committee (NAEC) FY 2019 Ending the HIV Epidemic (EHE) in ...HopkinsCFAR
The NIH Office of AIDS Research (OAR) is pleased to release the NIH AIDS Executive Committee (NAEC) FY 2019 Ending the HIV Epidemic (EHE) in the U.S. Report.
NIMH funding on PrEP use Among Adolescent Girls and Young Women in sub-Sahara...HopkinsCFAR
Dr. Susannah Allison. Dr. Allison is a Program Officer at the National Institute of Mental Health within the Division of AIDS Research. She oversees a portfolio of research focused on the prevention of HIV infection among infants, children, and adolescents as well as research to enhance health outcomes among youth living with HIV. She is also the training director for the division. Prior to working at NIMH, Dr. Allison worked with children and families infected and affected by HIV in Baltimore, Miami, and Washington, DC. She completed her doctorate at George Washington University where she received her Ph.D. in Clinical Child Psychology with an emphasis in child health psychology.
High Sensitivity HIV Testing and Translational Science around PrEPHopkinsCFAR
Joanne Stekler, MD MPH
Associate Professor, Department of Medicine
University of Washington
Inter-Center for AIDS ResearchAntiretroviralsfor Prevention Working Group
November 13, 2017
Providing safe, affirming and evidence based care for transgender persons: Th...HopkinsCFAR
Tonia Poteat, PhD, PA-C, MPH
Assistant Professor
Johns Hopkins Bloomberg School of Public Health
Jean-Michel Brevelle
Sexual Minorities Program Manager
Maryland Department of Health and Mental Hygiene
Johns Hopkins School of Medicine
August 5, 2016
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
1. Investigator Project Title Funder Key Pop.
Dangerfield At-home HIV and STI self-testing to virtual PrEP care participants CFAR Black/Latino MSM
Gaydos
I Want the Kit (IWTK): Acceptability of and Characteristics of Users of An
Internet Based Program for At-Home Self-Testing for HIV
NIBB U54
Bio-behavioral examination of unrecognized HIV infection in Baltimore CFAR MSM, PWID
BESURE, Baltimore site of CDC National HIV Behavioral Surveillance MDH and CDC
MSM, PWID, High risk
heterosexual
German BESURE transgender health project MDH Transgender
Grieb Leveraging Latino immigrant social networks to reduce HIV-related stigma NIH Latino
Hsieh
A Novel Emergency Department (ED) mHealth Peer Referral Program for the
Training in Naloxone Use to Prevent Opioid Overdose and HIV/HCV Epidemics
BCHD/CFAR PWID
Page
LaMocha: developing a cell phone app for timely HIV diagnosis among Latino
men
CFAR Latino
Stewart Development of a Church Based HIV Testing and Linkage to Care CFAR African American
Benke
Developing a Precision Medicine Approach to Improving HIV outcomes in
Persons with Mental Health Disorders with or without Substance Use
CFAR PLWH
Dangerfield Exploring treatment adherence strategies among virally suppressed black MSM CFAR Black MSM
Denison Support for youth with HIV NCCIH K01 Youth
Farley Getting to Zero Baltimore BCHD/CDC PLWH
Irvin
Understanding the Role of Alcohol Use in Hepatitis C Care Engagement among
HIV/HCV Coinfected and HCV Mono-Infected People Who Inject Drugs
CFAR HIV PWID
Jones
Project RHAE: a pilot study of Rapid HIV treatment initiation, Access and
Engagement in care
CFAR PLWH
Page, Chang
Leveraging mHealth and peers to Engage African- Americans and Latinxs in HIV
care (LEAN)
PCORI Black/Latino PLWH
Page, Lucas Building on Needle Exchange to Optimize HIV Prevention/Treatment NIDA RO1 PWID
Sibinga
Improving Treatment Adherence in HIV-Positive Youth Through Mindfulness
Training
NIH RO1 HIV+ youth
Starbird
Care2Cure Study. Nurse Case Management to Improve Hepatitis C Linkage to
Care and Treatment in HIV Coinfection
NIH F31 PLWH and HCV
Latkin, Tobin
RCT of a Social-Network oriented Mhealth based intervention to increase access
and adherence to HCV treatment and HIV viral suppression
NIDA R01 PLWH and HCV
Berry, Dowdy Impact of PrEP among MSM in Baltimore: An Agent‐Based Model CFAR MSM
Celentano,
Sanders
Prevent HIV in young black or Latino men NIDA R01 Black/Latino Men
Chander,
Hutton
Using CBPR to engage hazardous drinking women in the HIV prevention and
care continuum
NIAAA U34 At-risk women
Decker
Developing and Piloting a Gender-based Violence Intervention Module to
Reduce HIV Risk among FSWs
CFAR FSW
Farley PrEP Care Anywhere: A telemedicine study for PrEP adherence and retention. Gilead Black MSM
I met him on Jack’D” – Exploring Sex Partner Selection Patterns, HIV Risk
Behavior, and Risk Perceptions of YBMSM using GeoSocial Networking (GSN)
CFAR YBMSM
Phylogenetic and affiliation network analysis to inform PrEP uptake among
young MSM
CFAR YBMSM
Fields
Safe Spaces and Places Project: Targeted PrEP Implementation – Interrupting
HIV Transmission Among Young Black MSM
CDC YBMSM
Diagnosis
Treatment
and Retention
Prevention
2. Footer
Community-based ethnography to inform the feasibility and acceptability of a
PrEP engagement intervention among trans women sex workers (TSW) in
Baltimore
CFAR FSW
Kaufman
Role of Youth Mentoring in HIV Prevention/Care among Adolescent MSM in 3
cities
CFAR
Supplement
YBMSM
Page
Typology of Latina immigrant sex work in Baltimore to identify research and
program needs
CFAR Latina FSW
Poteat
Reducing HIV Vulnerability among Adolescent and Adult Transgender Women
of Color: A community based assessment of risks and unmet needs
CFAR Black TGW
The sex worker and police promoting health in risky environment study NIDA R01 FSW
Sherman Feasibility of a PrEP intervention for FSWs NIDA R34 FSW
A Community-level HIV prevention intervention targeting FSWs NIDA R01 FSW
Weir
Prevention and linkage to care through secondary syringe exchange networks in
Baltimore
CFAR PWID
Wirtz
American Cohort to Study HIV Acquisition among Transgender Women in High
Risk Areas (LITE study)
NIAID UG3 TGW HIV+ and HIV-
EMA of alcohol use and sexual behaviors among men who have sex with men in
Baltimore, MD
CFAR MSM
Yang
Using Open Contest and Neuro-influence experiment to develop and evaluate
PrEP promotion messages among high risk men
NIH R34 MSM
m-health-enhanced peer navigation intervention for PrEP delivery among MSM
at STD clinics
CFAR
Supplement
MSM
Genberg
Overlap in Baltimore City and non-urban PWID Networks: Potential for HIV
Transmission
CFAR PWID
Social dynamics of HIV in Baltimore, Maryland CFAR AA MSM
Social networks, social resources, and HIV transmission NIDA PWID
Jennings Understanding Sexual Health in Networks (USHINE) CDC MSM
Mehta ALIVE NIDA R01 PWID
Prevention
Respond German
