1. The document discusses research into the factors that cause eye migration in flatfish during development from childhood to adulthood. 2. An experiment showed that injecting colchicine to inhibit cell division around the eyes prevented migration, proving that cell division is the main driver of eye migration. 3. Further research identified a gene called EPIGEN that may be related to cell division and thus eye migration.

2. Migrated eye
settled eye
childhood adult

3. 头盖骨の
额骨ひずみ 目が移動
ひずみ
start change of the Change in Migration Finish…
frontal bone Front potion of an eye
of harnpan

4. Front side counter
force
Thrust
Cells in division
Back side
before In migrating Migrating
migration finish
It’s far from enough if eye migration only dues to the distort of bones it should
be something involves in dermal cell division around the two eyes.

5. situ hybridization microinjection Check outcome
• Quantity of dividing cells near
Before injection
After injection
each eyes • Inject
colchicine to
inhibit cell
division

6. Conclusion:
1. by injecting the colchicine we successfully prevented the eye form migrating which
proved that cell division is the main factor induce eye migration .
2.The further research demonstrate that the expression of a gene named EPIGEN
may be related with cell division nearby eyes.
Conjecture:
It maybe helps if flatfish migrate two eyes into one side when live in the bottom of
the sea because they can both hide itself into sand to avoid predator and disguise to
catch its lure.
All in all
Eye migration make life easier for them.

7. THANK
YOU