This poster by Tom Hayman about RGD's Diabetes Disease Portal was presented at the December 2009 Rat Genomics and Models meeting at Cold Spring Harbor Laboratory.
Big data genómico
Presente y futuro en el manejo de datos genómicos en la práctica clínica
XXIII Jornadas Nacionales de Informática Sanitaria,
Málaga, 16 junio, 2016
http://www.seis.es/JornadasAndalucia16/
Big data genómico
Presente y futuro en el manejo de datos genómicos en la práctica clínica
XXIII Jornadas Nacionales de Informática Sanitaria,
Málaga, 16 junio, 2016
http://www.seis.es/JornadasAndalucia16/
Bioinformatics in the Clinical Pipeline: Contribution in Genomic Medicineiosrjce
In this review report we like to focus on the new challenges in methodology of modern biology be
used in medical science. Today human health is a primary issue to cure disease, undoubtedly the answer to this
is bioinformatics or (In-silco) tools has change the concept of treating patients to understand the need of
genomic medicine in use. Those with new modes of action in clinical treatment, is a major health concern in
medical science. On global prospective scientific role in constructing new ideas to remediate health care to
treat disease exciting in nature is challenging task. So awareness needs to accelerate store clinical datasets for
scientific represents to design genomic drugs. This new outline will drive the medical to discover public data
and create a cognitive approach to use technology cheaper at cost effective mode.
Precision medicine require high precision in all parts which contributes to it. This presentation outlines the methodologies and pin point a subsystem whose precision is lot to be desired.
Information Genetic Content (IGC): a comprehensive discovery platform for dis...Thermo Fisher Scientific
We developed Information Genetic Content (IGC), a comprehensive
knowledgebase and discovery tool for human genes and genetic disorders
research use. IGC comprises three components: the Disease-Association
Database (DAD), the Gene Scoring Algorithm (GSA), and the Virtual Panel
Library (VPL). The DAD module contains over 400,000 associations
between over 17,000 genes and 15,000 Mendelian and complex diseases
from both expert-curated and text-mined data. The DAD module also
features a hierarchical organization of human diseases using a UMLScontrolled
vocabulary, permitting queries at any level of the disease
ontology hierarchy. The GSA module aims to prioritize genes for a specific
disease of interest. This gene scoring algorithm is distinctive in the way it
combines the strength of association and the number of associated
diseases to provide an unbiased score for each gene. In conjunction with
the DAD module, the GSA module is able to produce a list of ranked genes
for one or more diseases at any level of the disease hierarchy. The VPL
module generates optimal gene grouping by disease classification using
hierarchical-clustering-based network analysis. Genes that are involved in
the same pathological pathways are grouped into the same cluster.
Bioinformatics in the Clinical Pipeline: Contribution in Genomic Medicineiosrjce
In this review report we like to focus on the new challenges in methodology of modern biology be
used in medical science. Today human health is a primary issue to cure disease, undoubtedly the answer to this
is bioinformatics or (In-silco) tools has change the concept of treating patients to understand the need of
genomic medicine in use. Those with new modes of action in clinical treatment, is a major health concern in
medical science. On global prospective scientific role in constructing new ideas to remediate health care to
treat disease exciting in nature is challenging task. So awareness needs to accelerate store clinical datasets for
scientific represents to design genomic drugs. This new outline will drive the medical to discover public data
and create a cognitive approach to use technology cheaper at cost effective mode.
Precision medicine require high precision in all parts which contributes to it. This presentation outlines the methodologies and pin point a subsystem whose precision is lot to be desired.
Information Genetic Content (IGC): a comprehensive discovery platform for dis...Thermo Fisher Scientific
We developed Information Genetic Content (IGC), a comprehensive
knowledgebase and discovery tool for human genes and genetic disorders
research use. IGC comprises three components: the Disease-Association
Database (DAD), the Gene Scoring Algorithm (GSA), and the Virtual Panel
Library (VPL). The DAD module contains over 400,000 associations
between over 17,000 genes and 15,000 Mendelian and complex diseases
from both expert-curated and text-mined data. The DAD module also
features a hierarchical organization of human diseases using a UMLScontrolled
vocabulary, permitting queries at any level of the disease
ontology hierarchy. The GSA module aims to prioritize genes for a specific
disease of interest. This gene scoring algorithm is distinctive in the way it
combines the strength of association and the number of associated
diseases to provide an unbiased score for each gene. In conjunction with
the DAD module, the GSA module is able to produce a list of ranked genes
for one or more diseases at any level of the disease hierarchy. The VPL
module generates optimal gene grouping by disease classification using
hierarchical-clustering-based network analysis. Genes that are involved in
the same pathological pathways are grouped into the same cluster.
GenomeTrakr: Whole-Genome Sequencing for Food Safety and A New Way Forward in...ExternalEvents
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
GenomeTrakr: Whole-Genome Sequencing for Food Safety and A New Way Forward in the Microbiological Testing & Traceability for Foodborne Pathogens. Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management -23-25 May 2016, Rome, Italy.
HGP was conceived in 1984 & officially begun in earnest in October 1990.
HGP is a large multicentric, international collaborative venture, the main aim of which is to determine the nucleotide sequence of the entire human nuclear genome.
In 1997, United States established the National Human Genome Research Institute (NHGRI).
The HGP was an international research groups from six countries- USA, UK, France, Germany, Japan and China, & several laboratories and a large no. of scientists and technicians from various disciplines.
NGS for Infectious Disease Diagnostics: An Opportunity for Growth Alira Health
Infectious diseases are a major public health concern causing over 3.5 million deaths worldwide. Diagnosing patients as quickly and effectively as possible is crucial for managing disease outbreaks. Next-generation sequencing (NGS) provides unique capabilities to understand the genetic profile of infectious disease patients that no other technology can match.
Whole-genome metagenomics allows clinicians to take a deeper dive into pathogens by generating big-data about their characteristics. This data can be rapidly analyzed using complex bioinformatics software algorithms to achieve clinical-grade diagnostic accuracy. In a healthcare system shifting towards personalized medicine, NGS can provide clinicians the tools that they need to prescribe individualized treatments to save patients who were previously untreatable. The result is improved quality of care, better treatment regimes, and cost-saving healthcare.
Descripción de diversas herramientas para el análisis de datos masivos (Real World Data) de las Comorbilidades en la Historia Clínica Electrónica (HCE). Ponencia invitada en el Summer School de la Universidad de Barcelona (UB), 5 julio 2019. Hospital Clínico de Barcelona.
This poster by Mary Shimoyama about RGD's PhenoMiner Phenotype Database and Data Mining tool was presented at the December 2009 Rat Genomics and Models meeting at Cold Spring Harbor Laboratory.
This poster by Melinda Dwinell about RGD's Phenotypes and Models Portal was presented at the December 2009 Rat Genomics and Models meeting at Cold Spring Harbor Laboratory.
Human QTL Data within the Rat Genome DatabaseJennifer Smith
This poster by Tim Lowry about RGD's human QTL data was presented at the December 2009 Rat Genomics and Models meeting at Cold Spring Harbor Laboratory.
RGD--A Repository and Cumulative Resource for Rat StrainsJennifer Smith
This poster by Rajni Nigam about RGD's rat strain data was presented at the December 2009 Rat Genomics and Models meeting at Cold Spring Harbor Laboratory.
This poster by Diane Munzenmaier about RGD's new Physiological Pathways Portal was presented at the December 2009 Rat Genomics and Models meeting at Cold Spring Harbor Laboratory.
Pathway resources at the Rat Genome DatabaseJennifer Smith
This poster by Victoria Petri about RGD's pathway resources was presented at the December 2009 Rat Genomics and Models meeting at Cold Spring Harbor Laboratory.
This poster by Jennifer Smith about methods of education and community outreach and input at the Rat Genome Database was presented at the December 2009 Rat Genomics and Models meeting at Cold Spring Harbor Laboratory.
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Essentials of Automations: The Art of Triggers and Actions in FMESafe Software
In this second installment of our Essentials of Automations webinar series, we’ll explore the landscape of triggers and actions, guiding you through the nuances of authoring and adapting workspaces for seamless automations. Gain an understanding of the full spectrum of triggers and actions available in FME, empowering you to enhance your workspaces for efficient automation.
We’ll kick things off by showcasing the most commonly used event-based triggers, introducing you to various automation workflows like manual triggers, schedules, directory watchers, and more. Plus, see how these elements play out in real scenarios.
Whether you’re tweaking your current setup or building from the ground up, this session will arm you with the tools and insights needed to transform your FME usage into a powerhouse of productivity. Join us to discover effective strategies that simplify complex processes, enhancing your productivity and transforming your data management practices with FME. Let’s turn complexity into clarity and make your workspaces work wonders!
GraphSummit Singapore | The Future of Agility: Supercharging Digital Transfor...Neo4j
Leonard Jayamohan, Partner & Generative AI Lead, Deloitte
This keynote will reveal how Deloitte leverages Neo4j’s graph power for groundbreaking digital twin solutions, achieving a staggering 100x performance boost. Discover the essential role knowledge graphs play in successful generative AI implementations. Plus, get an exclusive look at an innovative Neo4j + Generative AI solution Deloitte is developing in-house.
How to Get CNIC Information System with Paksim Ga.pptxdanishmna97
Pakdata Cf is a groundbreaking system designed to streamline and facilitate access to CNIC information. This innovative platform leverages advanced technology to provide users with efficient and secure access to their CNIC details.
A tale of scale & speed: How the US Navy is enabling software delivery from l...sonjaschweigert1
Rapid and secure feature delivery is a goal across every application team and every branch of the DoD. The Navy’s DevSecOps platform, Party Barge, has achieved:
- Reduction in onboarding time from 5 weeks to 1 day
- Improved developer experience and productivity through actionable findings and reduction of false positives
- Maintenance of superior security standards and inherent policy enforcement with Authorization to Operate (ATO)
Development teams can ship efficiently and ensure applications are cyber ready for Navy Authorizing Officials (AOs). In this webinar, Sigma Defense and Anchore will give attendees a look behind the scenes and demo secure pipeline automation and security artifacts that speed up application ATO and time to production.
We will cover:
- How to remove silos in DevSecOps
- How to build efficient development pipeline roles and component templates
- How to deliver security artifacts that matter for ATO’s (SBOMs, vulnerability reports, and policy evidence)
- How to streamline operations with automated policy checks on container images
Goodbye Windows 11: Make Way for Nitrux Linux 3.5.0!SOFTTECHHUB
As the digital landscape continually evolves, operating systems play a critical role in shaping user experiences and productivity. The launch of Nitrux Linux 3.5.0 marks a significant milestone, offering a robust alternative to traditional systems such as Windows 11. This article delves into the essence of Nitrux Linux 3.5.0, exploring its unique features, advantages, and how it stands as a compelling choice for both casual users and tech enthusiasts.
Climate Impact of Software Testing at Nordic Testing DaysKari Kakkonen
My slides at Nordic Testing Days 6.6.2024
Climate impact / sustainability of software testing discussed on the talk. ICT and testing must carry their part of global responsibility to help with the climat warming. We can minimize the carbon footprint but we can also have a carbon handprint, a positive impact on the climate. Quality characteristics can be added with sustainability, and then measured continuously. Test environments can be used less, and in smaller scale and on demand. Test techniques can be used in optimizing or minimizing number of tests. Test automation can be used to speed up testing.
Threats to mobile devices are more prevalent and increasing in scope and complexity. Users of mobile devices desire to take full advantage of the features
available on those devices, but many of the features provide convenience and capability but sacrifice security. This best practices guide outlines steps the users can take to better protect personal devices and information.
Sudheer Mechineni, Head of Application Frameworks, Standard Chartered Bank
Discover how Standard Chartered Bank harnessed the power of Neo4j to transform complex data access challenges into a dynamic, scalable graph database solution. This keynote will cover their journey from initial adoption to deploying a fully automated, enterprise-grade causal cluster, highlighting key strategies for modelling organisational changes and ensuring robust disaster recovery. Learn how these innovations have not only enhanced Standard Chartered Bank’s data infrastructure but also positioned them as pioneers in the banking sector’s adoption of graph technology.
GraphSummit Singapore | The Art of the Possible with Graph - Q2 2024Neo4j
Neha Bajwa, Vice President of Product Marketing, Neo4j
Join us as we explore breakthrough innovations enabled by interconnected data and AI. Discover firsthand how organizations use relationships in data to uncover contextual insights and solve our most pressing challenges – from optimizing supply chains, detecting fraud, and improving customer experiences to accelerating drug discoveries.
Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...SOFTTECHHUB
The choice of an operating system plays a pivotal role in shaping our computing experience. For decades, Microsoft's Windows has dominated the market, offering a familiar and widely adopted platform for personal and professional use. However, as technological advancements continue to push the boundaries of innovation, alternative operating systems have emerged, challenging the status quo and offering users a fresh perspective on computing.
One such alternative that has garnered significant attention and acclaim is Nitrux Linux 3.5.0, a sleek, powerful, and user-friendly Linux distribution that promises to redefine the way we interact with our devices. With its focus on performance, security, and customization, Nitrux Linux presents a compelling case for those seeking to break free from the constraints of proprietary software and embrace the freedom and flexibility of open-source computing.
Alt. GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using ...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
FIDO Alliance Osaka Seminar: The WebAuthn API and Discoverable Credentials.pdf
The Diabetes Portal at the Rat Genome Database
1. THE DIABETES PORTAL AT THE RAT GENOME DATABASE
G. Thomas Hayman, Mary Shimoyama, Stanley Laulederkind, Timothy Lowry, Rajni Nigam, Victoria Petri, Jennifer R. Smith, Jeffrey
de Pons, Alexander Stoddard, Simon Twigger, Melinda Dwinell, Diane Munzenmaier, Howard J. Jacob; the RGD Team
Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI
3. The RGD Diabetes Portal page provides easily obtained and condensed
diabetes-related data. Drop-down lists allow the user to choose a broader 12. Clicking the Tools tab displays links to many useful genome analysis tools, including an
Abstract:
view of the complete set of data (4) or to narrow their search to a specific updated, expanded version of Gviewer, which provides a genome-wide view of genes with
The Diabetes Portal is the fifth comprehensive platform for physiological
disease (5). Tabs across the top of the page (6) facilitate similar access to annotations for gene function/ process/location, disease, pathway and phenotype, and
genomics discovery supplied by the Rat Genome Database (RGD),
diabetes-related phenotypes, biological processes and pathways. QTLs with annotations for phenotype and disease; Gbrowser, which provides numerous
joining the Cancer, Cardiovascular Disease, Neurological Disease and
tracks including genes, QTLs and SNPs, allowing data export, to facilitate searches for
Obesity/Metabolic Syndrome Portals. These initiatives are designed to
3 disease- or phenotype-linked variants; and VCMap, which compares genomic regions,
highlight genetic and genomic data generated from disease-related rat
genes and QTLs across six species.
research for the broad community of users served by the RGD who often
have specific disease research interests. As with the others, this newest 14 Gviewer
4
portal provides ready access for both the novice and experienced user to 12
a comprehensive, integrated knowledge base, essential for diabetes 13
research, that can be tailored to the specific interests of the user. These
portals additionally help define the scope and focus for data acquisition 6
and curation projects at the RGD. Current and upcoming components of
the portal include 1) comprehensive human, rat and mouse gene sets
associated with related, categorized diseases, phenotypes, biological 5
processes and pathways using multiple ontologies; 2) all rat QTLs related
to diabetes, including associated mouse and human QTLs; 3)
comparative maps of diabetes-related regions; 4) annotation of function
and cellular localization of gene products; 5) relevant references; 6) rat 10. The Disease Portal
strains used as models to study diabetes; 7) genome mining and analysis Gbrowser
Gviewer displays the rat VCMap
tools, such as Gviewer, enabling genome-wide display and study of chromosomes with QTLs
diabetes-related genes and QTLs. Portals to be deployed in the future will (bars) and genes
include digestive, immune and musculoskeletal systems. The Rat 10
(triangles) associated with
Genome Database is funded by the National Heart Lung and Blood the selected disease.
Institute grant (HL64541). Mouse and human
synteny displays can also
1. From the RGD homepage, select Diseases via the tab or 7 be chosen.
8 9
panel to access any of the five Disease Portals.
1
60187797
71987956
1
11 13. The Related Links tab leads to numerous
database and website links related to diabetes, as
well as links to an ample collection of reviews on
the topic; samples are shown below.
11. Clicking on a chromosome
will isolate it. Mousing over a
gene or QTL icon displays the
symbol and position information
2. The Diabetes Portal is the newest of the five RGD Disease for that object. Shift+click the
Portals, which provide convenient access to and consolidation icon to access the corresponding
of disease-related data. detailed gene or QTL report
page. Clicking on user-defined
boundaries to the left of the
chromosome displays the region
in more detail in the Gbrowser.
14. The Rat Strain Models tab leads to information on
2 rat strains used as models for diabetes, such as the
table below.
7. The Diabetes Portal page features lists of genes, QTLs and strains
which are annotated to the selected disease, phenotype, pathway or
biological process terms. Symbols link to the respective object report
pages for genes (7), QTLs (8) and strains (9), providing simplified
navigation between the collected data in the portals and the more specific
and detailed data on the report pages. All three report pages contain links
to references; an example from the gene report page is shown.