The document discusses the importance of using hydrophobic filters with insufflators during endoscopic surgery to prevent contamination. It notes that procedures using insufflators, such as laparoscopic surgeries, are increasing in frequency. Without proper hydrophobic filters, there is a risk of cross-contamination between patients if body fluids enter the insufflator. The document recommends filters that can retain 99.99% of 0.1 micron particles and have a hydrophobicity rating of 50mm Hg to block fluid backflow during insufflation pressures. It also discusses customizing filters, tubing, and packaging for different insufflator devices and surgical needs.
We are a products, solutions and services wholesale supplier in water treatment. We provide only businesses companies such as distributors, retailers, manufacturers and assemblers.A catalog including carefully selected products, from the most prestigious brands in the Water Treatment market, operative website, personalized services, precise and efficient logistics, flexible organization, but also the basic importance that is attributed to human factors and relationships with partners, make of Sinergroup Srl a reference for many companies of the market. A continuous and consistent effort, the ability to anticipate the evolution of the market demand and orientation to the understanding and satisfaction of our customers has always characterizes us in our work.
Born with the objective view in the exclusive distribution: Continue to be "Leader of the Brand Leader ", with activities and services of value. A choice of specialization that in recent years has allowed us to develop a unique knowledge and experience in the market. The thorough water treatment market understanding and high commercial performance, make us able to offer to our customers many products and services more personalized and appropriate to the individual end user. Our mission is to become your best business Partner!
We are a products, solutions and services wholesale supplier in water treatment. We provide only businesses companies such as distributors, retailers, manufacturers and assemblers.A catalog including carefully selected products, from the most prestigious brands in the Water Treatment market, operative website, personalized services, precise and efficient logistics, flexible organization, but also the basic importance that is attributed to human factors and relationships with partners, make of Sinergroup Srl a reference for many companies of the market. A continuous and consistent effort, the ability to anticipate the evolution of the market demand and orientation to the understanding and satisfaction of our customers has always characterizes us in our work.
Born with the objective view in the exclusive distribution: Continue to be "Leader of the Brand Leader ", with activities and services of value. A choice of specialization that in recent years has allowed us to develop a unique knowledge and experience in the market. The thorough water treatment market understanding and high commercial performance, make us able to offer to our customers many products and services more personalized and appropriate to the individual end user. Our mission is to become your best business Partner!
Guidance on gloves maintenance in Isolator and RABSPalash Das
A faulty glove or sleeve assembly represents a route of contamination and a critical breach of Isolator integrity. Within this article we will discuss about all these aspects.
Possible Reuse of Anesthesia Breathing Circuits on Multiple Patients Under Ge...Steve Koontz
Power point presentation about the possible reuse of anesthesia breathing circuits by Steve Koontz, Director of Sales Training, ARC Medical. August 2012
Potential Impact of Draft Annex 1 on Sterilizing FiltrationMilliporeSigma
Access the interactive recording here: https://bit.ly/2mvFxs7
Abstract:
The support for EMA GMPs related to sterile medicinal products is Annex 1. EMA, PICS and WHO have collaborated on the largest and most comprehensive revision of Annex 1 since it was first written in 1997.
There are a number of proposed changes to the sections in Annex 1 dealing with filtration, integrity testing and single-use.
This presentation will compare the current version with the proposed changes and highlight areas of specific interest to companies who either manufacture in or export to EMA countries, PICS member countries, and WHO compliant countries.
An Over View of Sterile Filtration Validation: A Key Elements for Sterile Dru...semualkaira
Sterile filter validation is an important process in the pharmaceutical, biotechnology, and healthcare industries to ensure the effectiveness and integrity of sterile filtration systems. The validation
process involves testing and verifying the performance of sterile
filters to ensure they can effectively remove microorganisms and
particles from a fluid stream while maintaining sterility. Selecting
a sterilizing grade filter requires consideration of many important
issues, such as materials of construction and their compatibility
with the product to be filtered.
An Over View of Sterile Filtration Validation: A Key Elements for Sterile Dru...semualkaira
Sterile filter validation is an important process in the pharmaceutical, biotechnology, and healthcare industries to ensure the effectiveness and integrity of sterile filtration systems. The validation
process involves testing and verifying the performance of sterile
filters to ensure they can effectively remove microorganisms and
particles from a fluid stream while maintaining sterility.
The water to be used for the preparation of haemodialysis fluids needs treatment to achieve the appropriate quality. The water treatment is provided by a water pre-treatment system which may include various components such as sediment filters, water softeners, carbon tanks, micro-filters, ultraviolet disinfection units, reverse osmosis units, ultrafilters and storage tanks. The components of the system will be determined by the quality of feed water and the ability of the overall system to produce and maintain appropriate water quality.
PILOT Gaskets technical article on the importance of Fugitive Emissions Control in Process Refinery and Chemicals Plants to seal Valves, Pumps, Gland Packings, Flanges and Joints.
Backflow Best Practices and Standard Details: Part 2Safe-T-Cover
This presentation focuses on the current backflow preventer placement practices including vaults, indoors and backflow enclosures.
This is the second of a three part series on backflow preventer installation, standard details, and best practices. The series focuses on three key facts: Water utilities are seeking more premise-isolation cross connection control. More containment systems are being specified as RPZ regardless of hazard threshold. The AWWA, ASPE, & the legal community recognize “outside aboveground” as ‘best practice’ for backflow installation.
Part 1: http://www.slideshare.net/CraigCarmon/backflow-best-practices-and-standard-details-part-1
Part 3: http://www.slideshare.net/CraigCarmon/backflow-best-practices-and-standard-details-part-3
ONdrugDelivery - The advantages of designing high-resistance swirl chambers f...Team Consulting Ltd
In this article, David Harris, Head of Respiratory Drug Delivery, Team Consulting, taps into a powerful combination of detailed anatomical and functional understanding of the human respiratory system, pulmonary drug delivery technology and formulation expertise, and mathematical modelling techniques, in order to put forward the case for high-resistance swirl chambers in dry-powder inhalers, and a rational strategy for optimising the design and thus maximising therapeutic efficacy.
Guidance on gloves maintenance in Isolator and RABSPalash Das
A faulty glove or sleeve assembly represents a route of contamination and a critical breach of Isolator integrity. Within this article we will discuss about all these aspects.
Possible Reuse of Anesthesia Breathing Circuits on Multiple Patients Under Ge...Steve Koontz
Power point presentation about the possible reuse of anesthesia breathing circuits by Steve Koontz, Director of Sales Training, ARC Medical. August 2012
Potential Impact of Draft Annex 1 on Sterilizing FiltrationMilliporeSigma
Access the interactive recording here: https://bit.ly/2mvFxs7
Abstract:
The support for EMA GMPs related to sterile medicinal products is Annex 1. EMA, PICS and WHO have collaborated on the largest and most comprehensive revision of Annex 1 since it was first written in 1997.
There are a number of proposed changes to the sections in Annex 1 dealing with filtration, integrity testing and single-use.
This presentation will compare the current version with the proposed changes and highlight areas of specific interest to companies who either manufacture in or export to EMA countries, PICS member countries, and WHO compliant countries.
An Over View of Sterile Filtration Validation: A Key Elements for Sterile Dru...semualkaira
Sterile filter validation is an important process in the pharmaceutical, biotechnology, and healthcare industries to ensure the effectiveness and integrity of sterile filtration systems. The validation
process involves testing and verifying the performance of sterile
filters to ensure they can effectively remove microorganisms and
particles from a fluid stream while maintaining sterility. Selecting
a sterilizing grade filter requires consideration of many important
issues, such as materials of construction and their compatibility
with the product to be filtered.
An Over View of Sterile Filtration Validation: A Key Elements for Sterile Dru...semualkaira
Sterile filter validation is an important process in the pharmaceutical, biotechnology, and healthcare industries to ensure the effectiveness and integrity of sterile filtration systems. The validation
process involves testing and verifying the performance of sterile
filters to ensure they can effectively remove microorganisms and
particles from a fluid stream while maintaining sterility.
The water to be used for the preparation of haemodialysis fluids needs treatment to achieve the appropriate quality. The water treatment is provided by a water pre-treatment system which may include various components such as sediment filters, water softeners, carbon tanks, micro-filters, ultraviolet disinfection units, reverse osmosis units, ultrafilters and storage tanks. The components of the system will be determined by the quality of feed water and the ability of the overall system to produce and maintain appropriate water quality.
PILOT Gaskets technical article on the importance of Fugitive Emissions Control in Process Refinery and Chemicals Plants to seal Valves, Pumps, Gland Packings, Flanges and Joints.
Backflow Best Practices and Standard Details: Part 2Safe-T-Cover
This presentation focuses on the current backflow preventer placement practices including vaults, indoors and backflow enclosures.
This is the second of a three part series on backflow preventer installation, standard details, and best practices. The series focuses on three key facts: Water utilities are seeking more premise-isolation cross connection control. More containment systems are being specified as RPZ regardless of hazard threshold. The AWWA, ASPE, & the legal community recognize “outside aboveground” as ‘best practice’ for backflow installation.
Part 1: http://www.slideshare.net/CraigCarmon/backflow-best-practices-and-standard-details-part-1
Part 3: http://www.slideshare.net/CraigCarmon/backflow-best-practices-and-standard-details-part-3
ONdrugDelivery - The advantages of designing high-resistance swirl chambers f...Team Consulting Ltd
In this article, David Harris, Head of Respiratory Drug Delivery, Team Consulting, taps into a powerful combination of detailed anatomical and functional understanding of the human respiratory system, pulmonary drug delivery technology and formulation expertise, and mathematical modelling techniques, in order to put forward the case for high-resistance swirl chambers in dry-powder inhalers, and a rational strategy for optimising the design and thus maximising therapeutic efficacy.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
1. THE CONTAMINATION OF INSUFFLATORS – THE NEXT MAJOR PROBLEM IN ENDOSCOPY SURGERY?<br />By: Charles E. Meisch<br />Endoscopic Consultant <br />NBS Group Supply<br />257 Livingston Avenue<br />New Brunswick, NJ 08901, USA<br />1-888-800-8192<br />As the U.S. and Europe continues to see the breakthrough use of Endoscopic Surgery verses conventional surgery in all areas, it appears the procedures increasing most rapidly are Cholecystectomies, Female Sterilization, Lap Bariatric, Bowel Resection, Hernia Repair, Hysterectomy, Appendectomy, Anti-Reflux, and Nephrectomy, most of which require the use of an Insufflator. Usually electronic in design, insufflators are determined by flow rates. They can range from 9.9 LPM to 45 LPM at 1 PSI or lower. They are also pressure-limited gas flow regulators used to produce a pneumoperitoneum.<br />According to AORN’s 1995 Standards and Recommended Practices, “Insufflator equipment should include a disposable hydrophobic (liquid blocking) filter”. Over the past few years, health care providers in the United States have come to the consensus that filter devices are a necessary part of all laparoscopic procedures, which employ insufflation. The need for filters for the retention of particulates such as inorganic debris, rust, metal filings, and Teflon has been recognized by the majority of practioners. However, it is important to choose a filter which also prevents body fluids from entering insufflators. For this purpose, the filter must be hydrophobic (liquid blocking). <br />In January of 1996, The Medical Devices Agency released a Safety Notice stating that patient fluid contamination continues to be found in the internal gas circuits of laparoscopic insufflators and that practioners should, “ensure that any bacterial filter/liquid trap assembly provided and recommended by the manufacturer of the insufflators be used and disposed of appropriately”. In May of 1992, The Emergency Care Research Institute (ECRI) released a statement which warned, “…blood was being delivered to a patient via an insufflator”. This blood apparently came from a prior patient. Manufacturers and various hospital clinic engineers confirm this is a common occurrence. The right hydrophobic filter (liquid trap) stops the reflux (backflow) of blood and other body fluids as well as particulate, preventing contamination of the insufflators and cross contamination between patients.<br />Because of this dual hazard, it is important to specifiy both the particle retention rating and the level of hydrophobicity required when selecting a filter for use with insufflation. NBS Group Supply recommends that an insufflations filter be rated at 99.99% retention of particles. 0.1 micron, and should have a hydrophobicity rating of 50mm Hg. NBS Group Supply offers a variety of insufflations filters with a wide range of media and connectors to address the specific needs of your application. These specifications ensure not only the retention of particulate, but under operating conditions, the retention of aqueous fluids as well.<br />PARTICULATE RETENTION<br />The particle retention specification of a filter designates what percentage of particulate of a certain size or greater will be trapped b that filter.<br />HOW MUCH HYDROPHOBICITY IS ENOUGH?<br />Recently the Canadian Government issued a warning in their alert to all hospital administrators basically stating once the internal gas circuit of an insufflator is contaminated with liquids or gases from the patient cavity, a potential hazard of cross contamination is usually created.<br />In one of the incidents reported, a filter had been used, but it failed to provide protection against liquid backflow. Subsequent discussions with the manufacturer revealed that the filter was not recommended for the purpose of insufflations backflow preventions.<br />Hydrophobicity is the characteristic of a filter media, which allows it to repel water, or water based substances such as body fluids. To provide protection against reflux during insufflations, a filter must have a hydrophobicity rating above the pressure, which can be exerted in a reverse direction. For insufflation, that rating is 50mm Hg for 10 minutes. In the above example, the filter being discussed was considered to be “hydrophobic”, but it did not carry a hydrophobic rating strong enough to retain body fluids under these conditions.<br />Every hydrophobic filter media has a pressure level at which aqueous liquids can be forced through the pores. This level is the “water breakthrough” pressure. Water breakthrough is also affected by the length of time the pressure is applied. While many filter suppliers claim their filters are hydrophobic, this statement does not mean that the filter will be hydrophobic at all pressures, or that it is hydrophobic enough for a particular application.<br />Hydrophobicity is only a relative characteristic and must be accompanied by a specific pressure and time designation to be valid. For example, the claim “this filter is hydrophobic” would be more valid if it read “this filter has a hydrophobicity rating of 50mm Hg pressure”.<br />CUSTOMIZATION<br />NBS Group Supply offers a wide range of options to ensure the correct performance of an insufflator. The filter specification, retention rating, level of hydrophobicity, sterile or non-sterile, labeling, tube length, connectors, and packaging are all calculated to be used with most insufflators. It is important to remember insufflation tubing in the U.S. falls under a Class I status. This means that any company can take a common medical gas filter, assemble it to tubing, and call it an insufflation tubing set. All that is required is to register with the FDA and comply with the FDA’s cGMP’s ,but not necessarily submit for premarket approval. Under this criteria, the set may or may not work with your insufflators. NBS Group Supply specifically tests filters so that they meet all necessary medical and FDA criteria. Unlike other companies, our tubing sets go beyond what is required by the FDA and have been submitted to the FDA for premarket approval as Class II devices. This means not only the product, but the packaging, the method of sterilization and the labeling are all carefully reviewed. The FDA has reviewed our application and has approved it for the intended use thereby removing any doubts that our sets are truly manufactured as insufflation tubing sets and not just gas filtering systems. We feel this is important for you to know. For a copy of the approval, please contact our corporate office in New Brunswick, NJ. <br />