This document proposes a new model for biomedical computing called the NIH Commons that aims to improve data sharing, reduce costs, and increase access to computational resources. It would provide investigators with credits that can be used at multiple cloud computing providers. This 3-year pilot program seeks to test if this approach can enhance data sharing and lower costs compared to current practices. Key aspects that will need to be defined include the requirements for cloud providers to participate, criteria for approving credit requests, and metrics to evaluate the model's effectiveness. Feedback will be sought from experts to help design and implement this new biomedical computing framework.