THE APPLICATION OF CENTRAL COMPOSITE DESIGN FOR OPTIMIZATION OF NIOSOMES --Introduction Preparation Of Ketoprofen Niosomes Using Central Composite Design Ketoprofen Entrapment Efficiency Optimization Of The Formulation Ingresients Results And Discussion Preparation Of Ketoprofen Niosomes Using Central Composite Design Ketoprofen Entrapment Efficiency In Vitro Release Of Ketoprofen Statistical Analysis Optimization Of The Formulation Ingredients Effect Of X1, X2, And X3 On Y1 (Entrapment Efficiency) Formulation of the optimized formula Conclusion Reference Central composite design succeeded in optimization of the formulation ingredients on the entrapment efficiency and in vitro release of Ketoprofen niosomes. Response surface methodology gave a mean to understand the effect of variables for the development of Ketoprofen niosomes.