These slides for clinical calculation of drugs to monitor drug therapeutic. Very helpful slides.

1. TDM and Drug Dose
Calculation

2. Body Mass Index

3. Example

4. Example

6. Additional Conversions
🠶
1 cm =0.39 inches
🠶
1 inch =2.54 cm
🠶
1 kg =2.2 pound
🠶
1 feet =12 inches

8. IBWformula
🠶
Robinson formula: 49 kg +1.7 kg per every inch
over 5 feet.
🠶
Miller formula: 53.1 kg +1.36 kg per every inch
over 5 feet.
🠶
Hamwi formula: 45.5 kg +2.2 kg per every inch
over 5 feet.

9. Commonly USED IBWformula
Devine formula
🠶
Ideal body weight (IBW) (men) =50 kg +2.3 kg x
(height, in -60)
🠶Ideal body weight (IBW)(women) =45.5 kg +2.3
kg x (height, in - 60)

10. Example of IBW
🠶
Female patients HT =170 Cm, Wt 177 pound
🠶
Male patients HT=179 Cm, Wt 189 pound

11. Lean Body Weight
🠶
LBW[kg] =(0.65 *Height[cm]) - 50.74

12. Adjusted Body weight
🠶
AjBW =adjusted body weight:
AjBW =IBW+0.4( ABW - IBW)

14. Cockcroft-Gault formula for estimating
creatinine clearance (CrCl)
🠶CrCl (male) =([140-age] ×weight in kg)/(serum
creatinine ×72)
🠶
CrCl (female) =CrCl (male) ×0.85

15. mic mol to mg/dl just divide with 0.88

16. E GFR using MDRD
GFR (mL/min/1.73 m²) = 175 × (Scr)-1.154 × (Age)-0.203 × (0.742 if
female) × (1.212 if African American) (conventional units)

18. Basal Metabolic Rate

19. Example

20. Harris Benedict Formula

21. Stress/ activity factors
🠶 If you are sedentary (little or no exercise) :Calorie-Calculation =BMR x 1.2
🠶 If you are lightly active (light exercise/sports 1-3 days/week) :Calorie-
Calculation =BMR x 1.375
🠶 If you are moderatetely active (moderate exercise/sports 3-5 days/week) :
Calorie-Calculation =BMR x 1.55
🠶 If you are very active (hard exercise/sports 6-7 days a week) :Calorie-
Calculation =BMR x 1.725
🠶 If you are extra active (very hard exercise/sports & physical job or 2x
training) :Calorie-Calculation =BMR x 1.9

22. Caloric contents
T
otal volume =2400.
🠶Dextrose: 15g/100 ml *2400 ml =360 g.
🠶360 g x 3.4 kcal/gram =1224 kcals.
🠶Lipids 3 g/100 ml x 2400 ml =72 g lipids.
🠶72 x 10 kcals/gram =720 kcals.
🠶

24. Energy requirements