This document discusses the changing role of clusters in the region of Skåne, Sweden. It outlines how clusters in Skåne have evolved from a focus on competitiveness to acting as open innovation platforms and implementing organizations for the region's research and innovation strategy. The regional cluster development program aims to foster cross-industry collaboration. Going forward, clusters are envisioned to drive strategic initiatives and work more closely with other actors in the regional innovation system. Managing this transition will involve addressing challenges around leadership, funding, trust, and strategic collaboration between clusters and their stakeholders.