This thesis proposes using an Enterprise Engineering Paradigm to help design performant, innovative and sustainable health systems. The document outlines the research methodology, which follows a Design Science Research Methodology. A literature review covers definitions of health systems and approaches like reductionism vs. holism. The theoretical foundations section explains concepts from enterprise engineering, enterprise architecture, enterprise governance and enterprise ontology. A proposed solution applies methods from the Enterprise Engineering Paradigm to analyze and improve the Belgian health system. The demonstration section presents two case studies. The findings relate the work to enterprise engineering theory and the health domain. The conclusions state that the Enterprise Engineering Paradigm prevents failures in strategic initiatives. Future work involves expanding and repeating the approach.