Sucralose is an artificial sweetener that is 600 times sweeter than sugar but contains no calories. It was discovered in 1976 by researchers in the UK. Sucralose is made by replacing parts of sugar molecules with chlorine atoms. Numerous safety studies have found sucralose does not affect blood sugar or insulin levels and passes through the body undigested. Sucralose can provide a sweet taste without calories and thus may have a role in weight management.

2. Sucralose is a no-calorie sweetener 600 times sweeter
than table sugar (sucrose). It was discovered in 1976 by
researchers at Queen Elizabeth College, University of
London, during a collaborative research program with the
sugar producer Tate & Lyle, PLC.
Sucralose is made by replacing three hydrogen-oxygen
groups on a sucrose molecule with three chlorine atoms.
Sucralose is used as an ingredient in a broad range of
foods and beverages and as a tabletop sweetener .
Sucralose

3. Sucralose adds sweetness to foods and beverages without adding calories or
carbohydrates. As an alternative to sugar and other calorie-containing
sweeteners, it can play a role in weight management programs that combine
sensible nutrition and physical activity.
While the process to make sucralose begins with sucrose, or table sugar, the
final product is different from sugar. Sucralose is made by replacing three
select hydrogen-oxygen groups on the sugar molecule with three chlorine
atoms, resulting in an intensely sweet, no-calorie sweetener.
Unlike sugar, the body does not break down sucralose into calories for energy.
Yet, both sugar and sucralose activate the same taste buds on your tongue.
Most of the sucralose people consume is not absorbed and passes through the
body. The little that is absorbed is excreted in the urine, and doesn’t
accumulate in the body.
What is sucralose?

4. Safety studies show that sucralose is a safe and essentially inert ingredient.
Conclusions from few studies include the following:
•No known side effects
•Not toxic: No adverse effects seen in test animals, even in amounts equivalent
in sweetness to 40+ pounds of sugar per day for life
•No effect on carbohydrate metabolism
•No effect on short-or long-term blood glucose control or on serum insulin
levels: Sucralose is suitable for people with diabetes
•No calories or carbohydrates: Sucralose is not recognized by the body as a
carbohydrate and is not metabolized or otherwise broken down for energy
The safety profile of sucralose

5. Numerous studies show that sucralose is not recognized by the body as a carbohydrate and thus, has
no effect on blood glucose control or insulin response. These studies included high-dose prolonged-use
studies involving people with diabetes and those without the condition.
The FDA (U.S. Food and Drug Administration) concluded that the overall data on sucralose supports its safety for the
general population, including people with diabetes.
1. J Am Diet Assoc 2003 Dec;103(12):1607-12. Lack of effect of sucralose on glucose homeostasis in subjects
with type 2 diabetes. Grotz VL, Henry RR, McGill JB, Prince MJ, Shamoon H, Trout JR, Pi-Sunyer FX .
2. Diabetes Care 1996 Sep;19(9):1004-5.Glycemic effect of a single high oral dose of the novel sweetener
sucralose in patients with diabetes. Mezitis NH, Maggio CA, Koch P, Quddoos A, Allison DB, Pi-Sunyer FX.
3. V. Lee Grotz, Ian C. Munro, An overview of the safety of sucralose, Regulatory Toxicology and Pharmacology,
Volume 55, Issue 1, October 2009, Pages 1-5, ISSN 0273-2300,
http://dx.doi.org/10.1016/j.yrtph.2009.05.011.
(http://www.sciencedirect.com/science/article/pii/S0273230009000786)
4. American Journal of Therapeutics: November/December 2003 - Volume 10 - Issue 6 - pp 438-
443Symposium: III Reunion Cientifica Terapeutica. Sweeteners and Beta-Glucans Improve Metabolic
and Anthropometrics Variables in Well Controlled Type 2 Diabetic Patients Reyna, Nadia Y. *; Cano,
Clímaco *; Bermúdez, Valmore J.1; Medina, Mayerlim T.1; Souki, Aida J.1; Ambard, Merlyn1; Nuñez,
Maryluz1; Ferrer, Mary A.2; Inglett, George E.3
The scientific studies demonstrate, and regulatory agencies agree, that sucralose is safe.
FACT: Sucralose is safe for people with diabetes

6. No-calorie sweeteners can be one tool in a healthy, balanced weight reduction plan. The US
Department of Agriculture Dietary Guidelines recommend consumers choose foods and beverages
that moderate their intake of sugars. Products sweetened with sucralose can help consumers achieve
this goal. People who want to lose weight must consider many factors, including exercise, overall
diet and psychological, cultural and emotional factors.
1.Nutr Res. 2011 Dec;31(12):882-8. doi: 10.1016/j.nutres.2011.10.004.Short-term consumption
of sucralose, a nonnutritive sweetener, is similar to water with regard to select markers of
hunger signaling and short-term glucose homeostasis in women.Brown AW, Bohan Brown MM,
Onken KL, Beitz DC
2.A Trial of Sugar-free or Sugar-Sweetened Beverages and Body Weight in Children. Janne C.
de Ruyter, M.Sc., Margreet R. Olthof, Ph.D., Jacob C. Seidell, Ph.D., and Martijn B. Katan, Ph.D.N
Engl J Med 2012; 367:1397-1406 October 11, 2012 DOI: 10.1056/NEJMoa120303
3. Inhibitors of taste receptors for use in the treatment of obesity and diabetes. European
Patent no 1802324 Shirazi-beechey, Soraya (The Elm, Torpenhow,Montgomery Hill, Wirral CH48
1NF, GB) Dyer, Jane (32 Ellerton Way, Liverpool L12 0BG, GB
Other references:
1. http://www.foodinsight.
2. US FDA Ref [Code of Federal Regulations] [Title 21, Volume 3] [Revised as of April 1, 2012]
[CITE: 21CFR172.831]
Fact: Sucralose can be helpful in a weight reduction program