This document discusses substance abuse and addiction, defining alcoholism as continued alcohol consumption despite health and social consequences. It notes that around 140 million people worldwide suffer from alcohol dependence. Genetic, cultural, and psychological factors can contribute to substance abuse. Clinical features of alcoholism include frequent drinking, changes in behavior, lack of control over drinking, and withdrawal symptoms without alcohol. Tobacco dependence occurs through nicotine addiction, with over 7 million deaths annually resulting from direct tobacco use. Treatment for substance abuse and deaddiction includes medication, counseling, rehabilitation programs, and preventing relapse.