Stephen Hawking was a renowned physicist and author born in 1942 in Oxford, England who lived with amyotrophic lateral sclerosis. Despite being given two years to live after his diagnosis at age 21, Hawking went on to spend his life researching cosmology, general relativity, and quantum gravity. He authored numerous popular science books explaining his work and theories to the public. Hawking died in 2018 at his home in Cambridge at the age of 76, having revolutionized scientific understanding of black holes and the origins of the universe through his work developing theories to unify general relativity and quantum mechanics.
Prezentare in limba engleza realizata de elevii cls. IXG Fekete Raluca-Maria, Mulea Bianca , Plămadă Ana-Maria,Vlad Anca
Prezentare multimedia realizata in cadrul Concursului Stiintific National de Astronomie- editia 2015
"Nicolaus Copernic"
Colegiul National "Horea, Closca si Crisan " Alba Iulia, Jud. Alba
Stephen #Hawking, one of the greatest living scientists, is wheelchair bound by a crippling disease, is also without a voice box. He embodies the importance of taking obstacles in one’s stride.
Prezentare in limba engleza realizata de elevii cls. IXG Fekete Raluca-Maria, Mulea Bianca , Plămadă Ana-Maria,Vlad Anca
Prezentare multimedia realizata in cadrul Concursului Stiintific National de Astronomie- editia 2015
"Nicolaus Copernic"
Colegiul National "Horea, Closca si Crisan " Alba Iulia, Jud. Alba
Stephen #Hawking, one of the greatest living scientists, is wheelchair bound by a crippling disease, is also without a voice box. He embodies the importance of taking obstacles in one’s stride.
This powerpoint presentation is created by Gyanbikash.com for the students of class nine to ten from their English first part NCTB textbook for multimedia class.
Albert Einstein
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This powerpoint presentation is created by Gyanbikash.com for the students of class nine to ten from their English first part NCTB textbook for multimedia class.
Albert Einstein
If you liked it don't forget to follow me-
SlideShare-www.slideshare.net/gauravyadav65
Instagram-yadavgaurav251
Facebook-www.facebook.com/yadavgaurav251
This really motivates me too help you guys more :D
LIFE OF STEPHEN HAWKING
about his life
about his education
about his study
about his early life
about his career
notable theories and achievements
famous Hawking wagers
and at last
miscellaneous facts
Powerpoint presentation by a group of 2nd ESO Students. The aim of the task was doing a collaborative project about a famous person who had meant a change in human history.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
2. FAMILY
Family:
Spouse/Ex-: Elaine Manson (1995–2006)
Father: Frank Hawking
Mother: Isobel Hawking
Siblings: Edward Hawking, Mary Hawking, Philippa Hawking
Children: Lucy Hawking, Robert Hawking, Timothy Hawking
3. EARLY LIFE OF STEPHEN HAWKING.
Hawking was born on 8 January 1942 in Oxford to Frank and Isobel Eileen Hawking (née Walker).
Hawking's mother was born into a family of doctors in Glasgow, Scotland. His wealthy paternal great-
grandfather, from Yorkshire, over-extended himself buying farm land and then went bankrupt in the
great agricultural depression during the early 20th century. His paternal great-grandmother saved the
family from financial ruin by opening a school in their home.
In St Albans, the eight-year-old Hawking attended St Albans High School for Girls for a few months. At
that time, younger boys could attend one of the houses
In 1950, when Hawking's father became head of the division of parasitology at the National Institute
for Medical Research, the family moved to St Albans, Hertfordshire.[32][33] In St Albans, the family
was considered highly intelligent and somewhat eccentricmeals were often spent with each person
silently reading a book.[32] They lived a frugal existence in a large, cluttered, and poorly maintained
house and travelled in a converted London taxicab
4.
5. DISABILITY OF HAWKING
Hawking had a rare early-onset, slow-progressing form of motor neurone disease (MND; also known
as amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease), a fatal neurodegenerative disease
that affects the motor neurones in the brain and spinal cord, which gradually paralysed him over
decades.
Hawking had experienced increasing clumsiness during his final year at Oxford, including a fall on
some stairs and difficulties when rowing.The problems worsened, and his speech became slightly
slurred. His family noticed the changes when he returned home for Christmas, and medical
investigations were begun. The MND diagnosis came when Hawking was 21, in 1963. At the time,
doctors gave him a life expectancy of two years.
In the late 1960s, Hawking's physical abilities declined: he began to use crutches and could no
longer give lectures regularly. As he slowly lost the ability to write, he developed compensatory visual
methods, including seeing equations in terms of geometry. The physicist Werner Israel later
compared the achievements to Mozart composing an entire symphony in his head. Hawking was
fiercely independent and unwilling to accept help or make concessions for his disabilities. He
preferred to be regarded as "a scientist first, popular science writer second, and, in all the ways that
6. DEATH OF STEPHEN HAWKING
Hawking died at his home in Cambridge on 14 March 2018, at the age of 76. His family stated that
he "died peacefully". He was eulogised by figures in science, entertainment, politics, and other
areas. The Gonville and Caius College flag flew at half-mast and a book of condolences was
signed by students and visitors.A tribute was made to Hawking in the closing speech by IPC
President Andrew Parsons at the closing ceremony of the 2018 Paralympic Winter Games in
Pyeongchang, South Korea.
His private funeral took place on 31 March 2018, at Great St Mary's Church, Cambridge.Guests at
the funeral included The Theory of Everything actors Eddie Redmayne and Felicity Jones, Queen
guitarist and astrophysicist Brian May, and model Lily Cole. In addition, actor Benedict
Cumberbatch, who played Stephen Hawking in Hawking, astronaut Tim Peake, Astronomer Royal
Martin Rees and physicist Kip Thorne provided readings at the service.
7. STEPHEN HAWKING
GREATEST ACHEIVEMENT
Professor Stephen Hawking had researched his whole life the basic laws governing the universe.
In fact, he was the first to elaborate an equation to try to unify general relativity and quantum
physics, a 'theory of everything'. This equation is called the temperature formula of a black hole.
His main contribution to science lies in the so-called 'theory of everything', words that give name,
by the way, to his biographical film released in 2014. That is, he was the first scientist to attempt
to unify Einstein’s Theory of General Relativity with the laws of Quantum Physics.