SSPE 5 min presentation

1. Subacute
sclerosing
panencephalitis
A 5 minute review

2. What is SSPE? Epidemiology
Pathophysiology Management
01 02 How rare is the disease?
03 How does the virus cause
disease?
04 How to diagnose and treat
the disease?
Table of contents
What is it?

3. Objectives
01
You can enter a subtitle here if you need it

4. 1.
2.
3.
OBJECTIVES
Define what is SSPE.
Enumerate the diagnostics test to confirm SSPE.
List the possible management
SPPE.

5. What is SSPE?
• Chronic complication of measles with a delayed
onset.
• Usually, after 7-10 years, the Measles virus regains
virulence
• Nearly always fatal.
• Results from a persistent infection with an altered
measles virus that is harbored intracellularly in the
central nervous.
Kliegman R. Stanton B. St Geme J. W. Schor N. F. Behrman R. E. & Nelson W. E. (2016). Nelson textbook of pediatrics (20th ed.).
Elsevier. Retrieved January 16 2024 from https://www.clinicalkey.com/dura/browse/bookChapter/3-s2.0-C20120035867.

6. Epidemiology
• Evidence was provided that the true incidence of
SSPE is approximately 4–11 cases per 100 000
cases of measles
• Measles infection acquired very early in life the
risk may be higher (18 per 100 000 cases).
https://www.who.int/groups/global-advisory-committee-on-vaccine-safety/topics/measles-vaccines; Extract from report of GACVS
meeting of 1-2 December 2005, published in the WHO Weekly epidemiological Record on 13 January 2006

7. Pathophysiology
Kliegman R. Stanton B. St Geme J. W. Schor N. F. Behrman R. E. & Nelson W. E. (2016). Nelson textbook of pediatrics (20th ed.).
Elsevier. Retrieved January 16 2024 from https://www.clinicalkey.com/dura/browse/bookChapter/3-s2.0-C20120035867.
A defective measles virus interacts
with
immature immune system
virus resides and
propagates, within neuronal cells for
long periods
the intracerllular
location of the virus sequesters it
from the immune system, especially
from humoral immunity.

8. Stages of SSPE
Nasirian, A., Ashrafi, M.R., & Nasrabady, S.E. (2008). Use of Α-Interferon, Amantadin and Isoprinosine in Subacute Sclerosing
Panencephalitis (Sspe): Comparing the Effectiveness. Iranian journal of child neurology, 2, 27-32.

9. Diagnostics
● The diagnosis of SSPE can be established through documentation
of:
○ measles antibody detected in cerebrospinal fluid.
■ elevated IgG and IgM antibody titers in dilutions >1 : 8
○ characteristic electroencephalographic findings
○ typical histologic findings in and/or isolation of virus or viral antigen
from brain tissue obtained by biopsy or postmortem examination.
Kliegman R. Stanton B. St Geme J. W. Schor N. F. Behrman R. E. & Nelson W. E. (2016). Nelson textbook of pediatrics (20th ed.).
Elsevier. Retrieved January 16 2024 from https://www.clinicalkey.com/dura/browse/bookChapter/3-s2.0-C20120035867.

10. Management
● Management of SSPE is primarily supportive and similar to care provided
to patients with other neurodegenerative diseases.
● Clinical trials using isoprinosine with or without interferon suggest
significant benefit (30-34% remission rate) compared to patients without
treatment (5-10% with spontaneous remissions).
Kliegman R. Stanton B. St Geme J. W. Schor N. F. Behrman R. E. & Nelson W. E. (2016). Nelson textbook of pediatrics (20th ed.).
Elsevier. Retrieved January 16 2024 from https://www.clinicalkey.com/dura/browse/bookChapter/3-s2.0-C20120035867.

11. CREDITS: This presentation template was created by Slidesgo, and
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12. EEG in SSPE
Almost all the patients of SSPE showed periodic high-amplitude
delta waves that usually occurred in patients with a disease
duration of more than four months.
Ali S, Kumar H, Ullah S, Haq MAU, Gul NG, Kumar J. Electroencephalography Patterns of Subacute Sclerosing Panencephalitis.
Cureus. 2021 Jun 17;13(6):e15728. doi: 10.7759/cureus.15728. PMID: 34285840; PMCID: PMC8286205.

14. 150,000
Big numbers catch your audience’s attention

15. Challenge Results Solution
Goals
Despite being red, Mars
is actually a cold place.
It's full of iron oxide dust,
which gives the planet its
beautiful reddish cast
Saturn is a gas giant and
has several rings. It's
composed mostly of
hydrogen and helium. It
was named after a god
Neptune is the farthest
planet from the Sun. It's
also the fourth-largest
planet by diameter in the
Solar System

16. Mercury Venus Mars Jupiter
Mercury is the
closest planet to
the Sun and the
smallest one in
the Solar System
Mars is actually a
cold place. It's
full of iron oxide
dust, which gives
its reddish cast
Venus is the
second-brightest
natural object in
the night sky
after the Moon
Jupiter is a gas
giant and the
biggest planet in
the Solar
System. It is a
gas giant
Methods

17. By Mercury By Venus
Mercury is the closest planet
to the Sun and the smallest
one in the entire Solar
System. This planet's name
has nothing to do with the
liquid metal, since Mercury
was named after the Roman
messenger god. It is closer
to the Sun than Venus
Research and publications
Venus has a beautiful name
and is the second planet
from the Sun. It’s terribly hot,
even hotter than Mercury,
and its atmosphere is
extremely poisonous. It’s the
second-brightest natural
object in the dark night sky
after the Moon

18. Research resources
● You can list your reference websites
or publications here
● You can list your reference websites
or publications here
● You can list your reference websites
or publications here
● You can list your reference websites
or publications here
● You can list your reference websites
or publications here
● You can list your reference websites
or publications here
● You can list your reference websites
or publications here

19. Awesome
words

20. A picture is worth a thousand words

21. Factors to consider
Mercury
Mars
Mercury is the closest
planet to the Sun
Mars is a cold place. It's
full of iron oxide dust
Venus
Venus is the second
planet from the Sun

22. Clinical trial
First studies
Preclinical
Human safety
Phase 01
Expanded safety
Phase 02
Efficacy & safety
Phase 03
Earth is the place
where we all live
Result
Jupiter is the
biggest planet
Result
Mars is full of iron
oxide dust
Result
20%
90%
60%
40%
90%
10%

23. 01 02 03 04
Trial timeline
Research
Venus is the second
planet from the Sun
Preclinical
Mercury is the closest
planet to the Sun
Results
Saturn is a gas giant and
has several rings
Conclusions
Jupiter is the biggest
planet of them all

24. Phase 01
Sample
● Healthy people
● 225 - 407 patients
● 3 years follow up
Results
What data have we
collected in the study?
Goal
Check the effectiveness
of the treatment
Time: 1 year
Approximate
experimentation time
70% Success rate
Saturn is a gas giant
Side effects
Mars is a cold place
30%

25. Tendency
Follow the link in the graph to modify its data and then paste the new one here. For more info, click here
20,000
15,000
Mercury
Mars
Mercury is the closest
planet to the Sun
Mars is a cold place. It's
full of iron oxide dust

26. Results
Group Test 1 Test 2 Test 3
A 95/100 55/100 80/100
B 80/100 25/100 66/100
C 72/100 70/100 45/100
D 60/100 60/100 86/100
E 40/100 10/100 90/100
Outcome
Venus has a beautiful
name and is the second
planet from the Sun. It’s
terribly hot, even hotter
than Mercury, and its
atmosphere is extremely
poisonous. It’s the
second-brightest natural
object in the night sky
after the Moon

27. Results analysis
60%
30%
10%
Symptom A
Mercury is the closest
planet to the Sun
Symptom B
Earth is the beautiful
planet we all live on
Symptom C
Neptune is the farthest
planet from the Sun
Solution
Venus is the second
planet from the Sun

28. Success rate
50,000
This is the number of total visitors we had last month
20,000
This is the number of patients we had last month

29. “This is a quote, words full of
wisdom that someone
important said and can make
the reader get inspired.”
—Someone Famous

30. Conclusions
Mercury is the closest planet to the Sun
and the smallest one in the Solar
System—it’s only a bit larger than the
Moon. The planet’s name has nothing to
do with the liquid metal, since Mercury
was named after a Roman god

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yourwebsite.com
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“Despite being red,
Mars is actually a
very cold place”
“Mercury is the
smallest planet in
the Solar System”
“Neptune is the
farthest planet from
the Sun”
“Saturn is a gas
giant and has
several rings”
“Venus is the
second planet from
the Sun and is
terribly hot”
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53. “Despite being red,
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very cold place”
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biggest planet in the
entire Solar System”
“Saturn is a gas
giant and has
several rings”
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smallest planet in the
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