alergi jurnal.pptx

Platelet concentrate and
type II IL-1 receptor are
risk factors for allergic
transfusion reactions in
children
W E N J I N G H U , L I F E N G , M E N G L I ,
T I N G L I , Y U D O N G D A I A N D
X I A O W E I W A N G
Criticized by
Muhammad mustaqiblat
JURNAL READING
ALLERGY AND
IMMUNOLOGY
DIVISION

Purpose: Allergic transfusion reactions (ATRs) are
immunological reactions after transfusion. Interleukin-1 (IL-1)
is a critical regulator for human diseases. We performed this
study to investigate the association of type II IL-1 decoy
receptor (IL1R2) expression with ATRs in children.
Methods: Children received blood transfusions between
January and December 2019 were included. The age, sex,
number and type of blood transfusion, allergic history, and
medical history were collected and statistically analyzed. The
blood samples were collected from children with and without
ATRs for detecting the relative expression IL1R2 mRNA.
Logistics regression analysis was performed to identify the
risk factors for ATRs in children. The area under the receiver
operating characteristic (ROC) curve (AUC) was used to
evaluate the predictive performance of risk factors

Results: Totally, 28,840 transfusions in 20,230 children, with
236 ATRs (0.82%) in 117 patients (0.58%) were included. ATRs
were common in children at the hematology-oncology department,
in children received higher number of blood transfusions, and older
children. Platelet concentrate induced a higher incidence of ATRs
(3.31%) than red cell concentrate (0.22%, p < 0.0001). After the
transfusion, IL1R2 mRNA level was higher in the blood samples in
children with ATRs than those without ATRs (p < 0.0001).
Logistics regression analysis indicated that platelet concentrate
(95% CI 3.555, 293.782) and IL1R2 expression (95% CI 1.171 ×
102 , 1.494 × 104 ) were independent risk factors for ATRs in
children. IL1R2 expression had high performance in predicting
ATRs (AUC = 0.998, 100% sensitivity and 98.85% specificity).
Conclusion: High IL1R2 expression level in children who received
blood transfusions may predict the morbidity of ATR.

Allergic
transfusion
reactions
(ATRs)
the most common
complications of blood
transfusions, especially
for the platelet transfusion
ATRs are
immunological
reactions mediated by
the allergen-
dependent and -
independent pathways
IL-6 and IL-8 with ATRs and
febrile nonhemolytic
transfusion reactions
(FNHTR) in pediatric patients
had been confirmed
(PAF
)
IL - 1
TNF
α
Mono
sit
this study to investigate the
difference in IL1R2
expression in pediatric
patients with and without
ATRs after transfusio
IL-1 polypeptides, including IL-1α
and IL-1β
IL-1 and
IL-1
receptor
(IL1R1)
(IL1R2)

Ethical approval was obtained from
the Ethics Committees of the
Children’s Hospital of Nanjing
Medical University, Nanjing, China.
This study included children
(aged ≤18) who received
blood transfusion therapy
during January and
December 2019 at hospital.
FNHTR and
ATR
classified and grouped according to
age (< 3 years, 3–6 years, 6–12
years and 12–18 years), sex, the
number of transfusions received (1,
2–5 times, 6–10 times and > 11
times)
Blood collection and real-
time RT-PCR analysis
statistical analysis
platelet
concen
trate
suspended
leukocyte-
reduced red
blood cells
(SLRBC),
fresh-
frozen
plasma
(FFP), and
cryoprecip
itate

No significant
No significant
significant
significant
significant

LITERATURE
REVIEW
Neptune is the farthest planet in our Solar
System. It’s the fourth-largest by diameter
and the densest
03
Theory
01
Theory
02
Theory
Mercury is the closest planet to the Sun and
the smallest one in the Solar System—it’s
only a bit larger than our Moon
04
Theory
Despite being red, Mars is a cold place, not
hot. It’s full of iron oxide dust, which gives
the planet its reddish cast
Venus has a beautiful name and is the second
planet from the Sun. It’s terribly hot, even
hotter than Mercury

SCHEDULE
27 29 30 31 1
3 4 5 6 7 8
10 11 12 13 14 15
17 18 19 20 21 22
24 25 26 27 28 29
28
26
2
9
16
23
WEEK 2
WEEK 1
WEEK 3
WEEK 4
WEEK 5

Venus has a beautiful name and is the
second planet from the Sun. It’s terribly hot
Jupiter is the biggest planet in our Solar System and
also the fourth-brightest object in the sky
Saturn is a gas giant, composed mostly of
hydrogen and helium
VENUS
JUPITER
SATURN
METHODOLOGY

Describe here your metrics 1
TEST
TEST 1 TEST 2 TEST 3 TEST 4 TEST 5

If you want to modify this graph, click on it, follow the link,
change the data and replace it
2,000
30,000
Cases that need further research
Sample size
RESULTS
ANALYSIS
If you want to modify this graph, click on it, follow the link,
change the data and replace it

RESULTS
ANALYSIS
Saturn is a gas giant, composed
mostly of hydrogen and helium
1,520
Jupiter is the biggest planet in
our Solar System
5,000
Neptune is the farthest planet
from the Sun
3,250

CONCLUSIONS
01
CONCLUSION
Jupiter is a gas giant and the biggest
planet in our Solar System. It’s also
the fourth-brightest object in the sky,
and its name comes from the Roman
god of the sky and lightning
02
CONCLUSION
Mercury is the closest planet to the
Sun and the smallest one in the Solar
System—it’s only a bit larger than our
Moon. The planet’s name has nothing
to do with the liquid metal

CONCLUSIONS
03
CONCLUSION
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AUTHOR Year Title of the publication. Publisher
BIBLIOGRAPHY

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