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Emilia Ambrosini, MS; Simona Ferrante, PhD;
                  Alessandra Pedrocchi, PhD;
Giancarlo Ferrigno, PhD; Franco Molteni, MD
is a partial loss of motor
                       function
mainly caused     of one side of the
                          body

hemorrhagic strokes

ischemic strokes

                      severe and
                       long-term
                        disability
Neurologicaltypically improve first
  deficits                  weeks
                      beca         after
                      use         injury
   brain plasticity
   mechanisms of neuronal
   reorganization pathways functionally
   recruitment of
   homologous
   synaptogenesis
   dendritic arborization
   functionally silent synaptic
The understanding of the
  mechanisms that improve
              is
          recovery
            cruci
              al
    design of optimized
    therapies


motor activity sensory feedback
         fundamental
Several studies

                         afferent
                     stimulation with
                        beneficial
                         changes
                     in brain activity
    repetition
    functional goal-
    directed activity
    functional electrical
    stimulation (FES)
Clinical evidence therapy
                FES-

                  reduces motor
                  impairment
                      persons with
                      hemiparesis


                           poststroke
estoration of walking goal lower limb
                   main
                          rehabilitation
Since the 1990s
                FES   increasingly used
                              in
                            evide
                       poststroke gait
                            nce
                        rehabilitation
                 improving motor and walk

  FES-induced gait training

    use of FES synchronized to the
    cycling movement
    entails a coordinated activation of the
    lower limb muscles
    approximating the cyclic movements
    of locomotion Hui-Chan CW et al.2005 SM et a
              Yan T,             Robbins
similarities between cycling and wa


           hypothes
           ized

 FES-induced cycling applied in the
 postacute phase
could play a crucial role in
promoting motor recovery and
improving locomotion.
The aim of
        our study


investigate whether FES-
induced cycling was a more
effective intervention for
postacute
Thirty-five patients, inpatients

All patients received an information sheet
    and provided their written informed
   consent. The research protocol was
approved by the medical ethics committee
          of the Valduce Hospital.
35 patients inpatients

                    Inclusion-stroke or TBI
                               -hemiparesis
                      criteria
                                -able to sit up to 30
   Exclusion                    minutes
    criteria                    -joint mobility ranges
                                that would
-cardiac pacemakers
                                 not preclude pedaling
-allergy to electrodes
                                -low spasticity in the LE
-inability to tolerate
                                m. (MAS 2)
stimulation


                     Treatment
A current-controlled -
channel stimulator
  surface electrodes: bipolar techni

    Quadriceps
    Hamstrings          of both le
    Gluteus
   maximus
    Tibialis
   anterior
current
                • Rectangular
                biphasic pulses
  pulse
  width     •           s

frequency   •      Hz
            • set on each muscle at a
intensi       tolerated value
   ty       • visibly good muscle
              contractions
whereas subjects
in the placebo group
 received stimuli of
    zero intensity.
To promote a similar mental set

participants were informed
before treatment


  might feel         might not feel
the stimulation      the stimulation
-minute      warm-up of passive cyclin

 1 -         FES group: training of
minute       FES cycling
             Placebo group: placebo
-minute      FES cyclingof passive cyc
             cool-down


 constant speed of    rpm
  throughout the training
primary outcome


the leg subscale of the
Motricity Index (MI)
gait speed was measured by timing a
walk of 50 meters
the leg subscale of the
Motricity Index (MI)
    evaluates motor power of
            the paretic
   lower extremity and ranges
          from 0 as 100
     was chosen   to a
    primary outcome
    measure related to body
    functions
gait speed    activity dom


measured by timing a walk of 50 meters
with a stopwatch
          using walking aids if necessary


    chosen         is representative of
   because          the typical indoor
  a 50-meter         walking need of
Secondary outcome

Upright Motor Control Test (UMCT)

Trunk Control Test (TCT)
The mean work produced by the paretic
and healthy legs
The pedaling unbalance
Upright Motor Control Test (U

         scored from 0 to 6

 assesses functional abilities
               of
the impaired leg during single-
        limb standing
Trunk Control Test (TCT
The mean work
            produced
        by the paretic and
           healthy legs
   the work produced by each side
 Was computed as the integral of the
                active
torque profiles mapped as function of
           the crank angle.
The pedaling unbalanc




U could range from 0% (identical work
       produced by both legs)
to 100% (WPL negative or equal to 0)
t test

compared between
    groups
repeated-measures ANOVA


   Comparisons of Outcome
        Measures Before
  Training, After Training, and
        During Follow-Up
       (post hoc Scheffè).
repeated-measures AN


The effect of group was
      determined
RESULTS
Participant Baseline
Characteristics




                          No
                       significa
                           nt
                       different
Comparisons of Outcome Measures
Before Training After Training, and
        During Follow-Up
Changes Between
       Groups
After Training and at
     Follow-Up




           Significant
Discussion
International Classification
 of Functioning, Disability
      and Health (ICF)
http://circ.ahajournals.org/content/124/19/21
The results of this study
        demonstrated that 20 sessions

         FES-induced cycling training

              significantly

        impairments TCT, U
                  MI,
reduc             MCT
        activity       pedaling
ed      limitations walki
                      unbalance
Motricity
             Index (MI)
impairments
          Trunk Control Test (TCT


           Upright Motor Control Tes
significant
differences between groups

  after training in favor of FES-
    treated subjects and were
      maintained at follow-up
  significant improvement of the
whole kinetic chain, involving both
leg and trunk, as demonstrated by
   MI and TCT and confirmed by
Trunk control

  important prerequisite for
the control of more complex
       limb activities

 early rehabilitatio
significant
 differences between groups


        pedaling unbalance

FES cycling treatment may help in
  “re- minding” subjects how to
 perform a symmetrical pedaling
A strength of
            the study

was the participants’ blindness to
treatment group

   ensuring that all patients
           received
the same extent of attention by
        the therapists
A possible limitation of the stu

    heterogeneous population
    of participants
   Although the optimal solution
               would be
    the definition of rehabilitative
                methods
     specific for each brain lesion
neurological
                       but affected by
         etiology and location
   patients                similar
with different      motor impairments
                       often undergo
results confirmed
                hypothes
                ized
     FES-induced cycling applied in the
     postacute phase
          could play a crucial role in
        promoting motor recovery and
            improving locomotion.

facilitating and accelerating motor recovery in
effect from FES
           t
cycling training
          o
  overground locomoti
4-week treatment of FES-
      induced cycling
                   impro
                    ves

         motor recovery
                      walking ability


     Improvements are maintained for at
ast 3 to 5 months after the end of the treatm
These improvements could be
explained by

     increased sensorial
            input
       provided to the
        brain by FES
   help in relearning how
              to
    execute movements
Neurologicaltypically improve first
  deficits                  weeks
                      beca         after
                      use         injury
   brain plasticity
   mechanisms of neuronal
   reorganization pathways functionally
   recruitment of
   homologous
   synaptogenesis
   dendritic arborization
   functionally silent synaptic
mechanisms of neuronal
    reorganization
dendritic
arborization

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พรีเซน

  • 1. Emilia Ambrosini, MS; Simona Ferrante, PhD; Alessandra Pedrocchi, PhD; Giancarlo Ferrigno, PhD; Franco Molteni, MD
  • 2.
  • 3. is a partial loss of motor function mainly caused of one side of the body hemorrhagic strokes ischemic strokes severe and long-term disability
  • 4. Neurologicaltypically improve first deficits weeks beca after use injury brain plasticity mechanisms of neuronal reorganization pathways functionally recruitment of homologous synaptogenesis dendritic arborization functionally silent synaptic
  • 5. The understanding of the mechanisms that improve is recovery cruci al design of optimized therapies motor activity sensory feedback fundamental
  • 6. Several studies afferent stimulation with beneficial changes in brain activity repetition functional goal- directed activity functional electrical stimulation (FES)
  • 7. Clinical evidence therapy FES- reduces motor impairment persons with hemiparesis poststroke estoration of walking goal lower limb main rehabilitation
  • 8. Since the 1990s FES increasingly used in evide poststroke gait nce rehabilitation improving motor and walk FES-induced gait training use of FES synchronized to the cycling movement entails a coordinated activation of the lower limb muscles approximating the cyclic movements of locomotion Hui-Chan CW et al.2005 SM et a Yan T, Robbins
  • 9. similarities between cycling and wa hypothes ized FES-induced cycling applied in the postacute phase could play a crucial role in promoting motor recovery and improving locomotion.
  • 10. The aim of our study investigate whether FES- induced cycling was a more effective intervention for postacute
  • 11.
  • 12. Thirty-five patients, inpatients All patients received an information sheet and provided their written informed consent. The research protocol was approved by the medical ethics committee of the Valduce Hospital.
  • 13. 35 patients inpatients Inclusion-stroke or TBI -hemiparesis criteria -able to sit up to 30 Exclusion minutes criteria -joint mobility ranges that would -cardiac pacemakers not preclude pedaling -allergy to electrodes -low spasticity in the LE -inability to tolerate m. (MAS 2) stimulation Treatment
  • 14.
  • 15.
  • 16. A current-controlled - channel stimulator surface electrodes: bipolar techni  Quadriceps  Hamstrings of both le  Gluteus maximus  Tibialis anterior
  • 17.
  • 18. current • Rectangular biphasic pulses pulse width • s frequency • Hz • set on each muscle at a intensi tolerated value ty • visibly good muscle contractions
  • 19. whereas subjects in the placebo group received stimuli of zero intensity.
  • 20. To promote a similar mental set participants were informed before treatment might feel might not feel the stimulation the stimulation
  • 21. -minute warm-up of passive cyclin 1 - FES group: training of minute FES cycling Placebo group: placebo -minute FES cyclingof passive cyc cool-down constant speed of rpm throughout the training
  • 22.
  • 23. primary outcome the leg subscale of the Motricity Index (MI) gait speed was measured by timing a walk of 50 meters
  • 24. the leg subscale of the Motricity Index (MI) evaluates motor power of the paretic lower extremity and ranges from 0 as 100 was chosen to a primary outcome measure related to body functions
  • 25.
  • 26.
  • 27. gait speed activity dom measured by timing a walk of 50 meters with a stopwatch using walking aids if necessary chosen is representative of because the typical indoor a 50-meter walking need of
  • 28. Secondary outcome Upright Motor Control Test (UMCT) Trunk Control Test (TCT) The mean work produced by the paretic and healthy legs The pedaling unbalance
  • 29. Upright Motor Control Test (U scored from 0 to 6 assesses functional abilities of the impaired leg during single- limb standing
  • 31. The mean work produced by the paretic and healthy legs the work produced by each side Was computed as the integral of the active torque profiles mapped as function of the crank angle.
  • 32. The pedaling unbalanc U could range from 0% (identical work produced by both legs) to 100% (WPL negative or equal to 0)
  • 33.
  • 35. repeated-measures ANOVA Comparisons of Outcome Measures Before Training, After Training, and During Follow-Up (post hoc Scheffè).
  • 36. repeated-measures AN The effect of group was determined
  • 38. Participant Baseline Characteristics No significa nt different
  • 39. Comparisons of Outcome Measures Before Training After Training, and During Follow-Up
  • 40. Changes Between Groups After Training and at Follow-Up Significant
  • 42. International Classification of Functioning, Disability and Health (ICF)
  • 44. The results of this study demonstrated that 20 sessions FES-induced cycling training significantly impairments TCT, U MI, reduc MCT activity pedaling ed limitations walki unbalance
  • 45. Motricity Index (MI) impairments Trunk Control Test (TCT Upright Motor Control Tes
  • 46. significant differences between groups after training in favor of FES- treated subjects and were maintained at follow-up significant improvement of the whole kinetic chain, involving both leg and trunk, as demonstrated by MI and TCT and confirmed by
  • 47. Trunk control important prerequisite for the control of more complex limb activities early rehabilitatio
  • 48. significant differences between groups pedaling unbalance FES cycling treatment may help in “re- minding” subjects how to perform a symmetrical pedaling
  • 49. A strength of the study was the participants’ blindness to treatment group ensuring that all patients received the same extent of attention by the therapists
  • 50. A possible limitation of the stu heterogeneous population of participants Although the optimal solution would be the definition of rehabilitative methods specific for each brain lesion neurological but affected by etiology and location patients similar with different motor impairments often undergo
  • 51. results confirmed hypothes ized FES-induced cycling applied in the postacute phase could play a crucial role in promoting motor recovery and improving locomotion. facilitating and accelerating motor recovery in
  • 52.
  • 53. effect from FES t cycling training o overground locomoti
  • 54. 4-week treatment of FES- induced cycling impro ves motor recovery walking ability Improvements are maintained for at ast 3 to 5 months after the end of the treatm
  • 55. These improvements could be explained by increased sensorial input provided to the brain by FES help in relearning how to execute movements
  • 56.
  • 57. Neurologicaltypically improve first deficits weeks beca after use injury brain plasticity mechanisms of neuronal reorganization pathways functionally recruitment of homologous synaptogenesis dendritic arborization functionally silent synaptic
  • 58. mechanisms of neuronal reorganization