This document discusses using gold nanoparticles for breast cancer gene therapy. It provides background on breast cancer, gene therapy, and nanoparticles. It describes how gold nanoparticles can be used to deliver tumor suppressor genes or siRNA to cancer cells via gene therapy to treat breast cancer. Gold nanoparticles are promising for cancer therapy due to their ability to bind drugs and proteins and target cancer cells. The document envisions future prospects for improving siRNA delivery and developing multifunctional gold nanoparticles for combined imaging and targeted drug/gene delivery to treat breast cancer.
Nanoparticles Drug Delivery in Cancer TherapyDebolina Roy
This document discusses using nanoparticles for targeted cancer drug delivery. It outlines that nanoparticles can be engineered to target cancer cells and release anti-cancer drugs directly at the tumor site with reduced side effects compared to traditional chemotherapy. The document covers an overview of cancer, how nanoparticles work as drug carriers, how they can target cancer cells specifically, the benefits and drawbacks of the nanoparticle approach, and concludes with a video example of targeting breast cancer cells with doxorubicin-loaded nanoparticles.
This document discusses the potential applications of nanotechnology for cancer diagnosis and treatment. It describes how gold nanoparticles less than 100 nanometers in size can enter cells and interact with DNA and proteins, making them useful for detecting disease at the cellular level. Gold nanoparticles are highlighted as a promising tool for targeted drug delivery for cancer therapy. They can bind cytotoxic drugs and produce heat when activated by infrared light to precisely kill cancer cells without damaging healthy tissue. While gold nanoparticles show advantages like targeted therapy and non-toxicity, challenges include potential effects on the reticuloendothelial system and higher costs.
The document describes a project to develop a nanoparticle-based molecular probe targeted to HER1-overexpressing breast cancer cells for diagnosis. The probe would use quantum dot nanoparticles conjugated to an anti-EGFR single chain antibody for multi-modal MRI and fluorescence imaging of breast cancer in mouse models. The objectives are to develop Gd3+- and 64Cu-labeled quantum dots coated with the targeting antibody, characterize their targeting ability and toxicity, and use them for MRI and fluorescence imaging of breast cancer xenografts in mice.
Nanoparticles have shown promise for cancer therapy by taking advantage of their small size to selectively target tumors. Researchers are developing nanoparticles that can carry drugs, genes, or imaging agents directly into cancer cells while avoiding healthy tissues. Some nanoparticles under study use magnetic or optical properties to heat and destroy cancer cells from the inside or help locate tumors for more effective radiation therapy.
1. Gold nanoparticles show potential for use in cancer diagnosis and treatment due to their optical and photothermal properties.
2. Gold nanoparticles can be engineered to absorb near-infrared light and convert it to heat, killing nearby cancer cells through localized hyperthermia while sparing healthy cells.
3. Various synthesis methods like the Turkevich and Brust methods allow for production of monodisperse gold nanoparticles tuned to specific light absorption properties ideal for photothermal therapy applications.
This document discusses using gold nanoparticles for breast cancer gene therapy. It provides background on breast cancer, gene therapy, and nanoparticles. It describes how gold nanoparticles can be used to deliver tumor suppressor genes or siRNA to cancer cells via gene therapy to treat breast cancer. Gold nanoparticles are promising for cancer therapy due to their ability to bind drugs and proteins and target cancer cells. The document envisions future prospects for improving siRNA delivery and developing multifunctional gold nanoparticles for combined imaging and targeted drug/gene delivery to treat breast cancer.
Nanoparticles Drug Delivery in Cancer TherapyDebolina Roy
This document discusses using nanoparticles for targeted cancer drug delivery. It outlines that nanoparticles can be engineered to target cancer cells and release anti-cancer drugs directly at the tumor site with reduced side effects compared to traditional chemotherapy. The document covers an overview of cancer, how nanoparticles work as drug carriers, how they can target cancer cells specifically, the benefits and drawbacks of the nanoparticle approach, and concludes with a video example of targeting breast cancer cells with doxorubicin-loaded nanoparticles.
This document discusses the potential applications of nanotechnology for cancer diagnosis and treatment. It describes how gold nanoparticles less than 100 nanometers in size can enter cells and interact with DNA and proteins, making them useful for detecting disease at the cellular level. Gold nanoparticles are highlighted as a promising tool for targeted drug delivery for cancer therapy. They can bind cytotoxic drugs and produce heat when activated by infrared light to precisely kill cancer cells without damaging healthy tissue. While gold nanoparticles show advantages like targeted therapy and non-toxicity, challenges include potential effects on the reticuloendothelial system and higher costs.
The document describes a project to develop a nanoparticle-based molecular probe targeted to HER1-overexpressing breast cancer cells for diagnosis. The probe would use quantum dot nanoparticles conjugated to an anti-EGFR single chain antibody for multi-modal MRI and fluorescence imaging of breast cancer in mouse models. The objectives are to develop Gd3+- and 64Cu-labeled quantum dots coated with the targeting antibody, characterize their targeting ability and toxicity, and use them for MRI and fluorescence imaging of breast cancer xenografts in mice.
Nanoparticles have shown promise for cancer therapy by taking advantage of their small size to selectively target tumors. Researchers are developing nanoparticles that can carry drugs, genes, or imaging agents directly into cancer cells while avoiding healthy tissues. Some nanoparticles under study use magnetic or optical properties to heat and destroy cancer cells from the inside or help locate tumors for more effective radiation therapy.
1. Gold nanoparticles show potential for use in cancer diagnosis and treatment due to their optical and photothermal properties.
2. Gold nanoparticles can be engineered to absorb near-infrared light and convert it to heat, killing nearby cancer cells through localized hyperthermia while sparing healthy cells.
3. Various synthesis methods like the Turkevich and Brust methods allow for production of monodisperse gold nanoparticles tuned to specific light absorption properties ideal for photothermal therapy applications.
Nanomedicine uses molecular tools and knowledge of the human body at the nanoscale to diagnose, treat and prevent disease. It involves applications of nanoparticles currently under development as well as longer term research using nano-robots to make repairs at the cellular level. Nanopharmacology uses nanotechnology to develop novel methods of delivering drugs using nanoparticles, which have one dimension of 1000nm or less. Nanomedicine offers advantages like enhanced drug stability and delivery, increased bioavailability, targeted drug delivery to specific tissues and cells, and opportunities for real-time monitoring and cellular repair. However, challenges include high costs, manufacturing defects, and lack of extensive clinical trials.
The document discusses the use of gold nanoparticles for cancer detection and treatment. It describes how gold nanoparticles can be functionalized with antibodies to detect specific cancer types by binding to protein markers on cancer cells. Laser-activated gold nanoparticles may also be used to destroy cancer cells through localized heating. The document also mentions potential applications for targeted drug delivery and angiogenesis inhibition. Overall, the document outlines how the optical and structural properties of gold nanoparticles can be exploited for cancer diagnosis and therapy.
Gold nanoparticles, also called AuNPs, are nanoparticles of gold that appear red in solution. AuNPs are very stable and have unique optical and electronic properties that make them useful for a wide range of applications. Historically, medieval artists first created AuNPs unintentionally when mixing gold into glass to produce stained glass windows with various colors. Today, AuNPs are commonly synthesized using the Turkevich method and characterized using techniques like TEM, SEM, and UV-Vis spectroscopy. Current applications of AuNPs include uses in electronics, medicine for cancer detection and therapy, and as catalysts.
Wendy Noe, education coordinator for the Central Indiana Affiliate of Susan G. Komen for the Cure® presents an overview of breast cancer information, facts and advances in treatment.
Process design.cancer treatment using nanoparticles. pptHoang Tien
Nanoparticles show promise for improving cancer detection and treatment. They are small enough to enter cells and interact with DNA and proteins. Quantum dots and nanoshells can be used to detect cancer signatures. Nanoshells coated with cancer-targeting molecules can selectively heat and destroy cancer cells when exposed to near-infrared light, protecting healthy cells. While challenges remain around toxicity and delivery, nanoparticles may enable cheaper, less toxic cancer therapies compared to chemotherapy and improve outcomes.
Nanoparticles for drug delivery by shreyaShreya Modi
This document discusses the advancement of nanotechnology and nanoparticles for cancer diagnosis and drug delivery. It outlines several challenges in developing effective nanoscale drug delivery systems, as well as properties of nanomaterials that make them suitable for drug delivery. Various nanodevices are described that could be used for targeted drug delivery, including liposomes, nanoshells, dendrimers, micelles, nanowires, nanotubes, quantum dots, and potential future nanorobots. Advantages of nanoparticle drug delivery systems include smaller size, higher bioavailability, and ability to target drugs directly to cells and nuclei. The only disadvantage mentioned is difficulty determining proper dosages.
These slides use concepts from my (Jeff Funk) course entitled analyzing hi-tech opportunities to show how nanotechnology for drug deliver is becoming economically feasible.
This document discusses various drug delivery systems including oral, injection-based, transdermal, carrier-based, and targeted delivery systems. It provides details on properties of responsive drug delivery devices and how they can provide controlled release profiles for sensitive drugs through long-lived, biocompatible designs. Specific examples covered include oral tablets and films, injection methods like dermojet pellets and insulin pens, inhalers, transdermal patches, monoclonal antibodies, liposomes, nanoparticles, and genetic transfer systems. The goal is to improve individualized therapy through controlled release and targeted delivery to increase drug efficacy while reducing side effects.
Cancer is caused by abnormal cell growth that spreads uncontrollably. It develops through a complex interaction between genes, environment, and chance. Cancer cells do not die like normal cells and continue growing and dividing in a disorderly fashion. The media needs to accurately report on cancer research studies and not oversimplify results or mislead the public. The UK has higher cancer death rates than some other countries, which may be partly due to lower spending on cancer medications.
1. Breast cancer develops from mutations in genes controlling cell growth and health. Abnormal cells divide uncontrollably, forming tumors that can be benign or malignant.
2. Malignant tumors are cancerous and can spread via the lymphatic system to other parts of the body. Breast cancer refers specifically to malignant tumors in the breast.
3. Treatment plans consider cancer type, stage, hormone sensitivity, and patient history. Early detection through education and screening as well as primary and adjuvant therapies can help improve outcomes for breast cancer.
This document provides an overview of breast cancer, including risk factors, signs and symptoms, causes, diagnosis, treatment options and prevention strategies. It notes that breast cancer is the second leading cause of cancer deaths in women. While the chances of developing breast cancer increase with age, early detection through screening and awareness of changes to the breasts can help lead to successful treatment if cancer is found early. A variety of treatment options exist depending on the type and stage of cancer diagnosed. Lifestyle factors may also impact risk.
Breast cancer is the most common cancer in women. In 2008, there were 211,000 new cases and 40,500 deaths in the US. Risk factors include family history, personal history of breast disease, older age, early menarche or late first birth. Non-invasive cancers like DCIS have increased incidence and require surgery with or without radiation. Invasive cancers are staged and treated with surgery, radiation, and systemic therapies like chemotherapy and hormonal therapy based on tumor size, lymph node involvement, and biomarkers.
Breast cancer is the second leading cause of death and second most common cancer in women. It occurs when abnormal cells in the breast grow in an uncontrolled way and form tumors. The breasts contain lobes and lobules which produce milk, connected by ducts. The two main types are ductal carcinoma, originating in the ducts, and lobular carcinoma, originating in the lobules. Risk factors include gender, age, family history, obesity, lack of exercise, alcohol consumption, and hormone therapy. Screening methods include breast self-exams, clinical exams by a doctor, and mammography. Treatment options depend on cancer stage and may involve surgery, radiation, chemotherapy, and hormone therapy. With early detection and treatment, the
Nanomedicine uses molecular tools and knowledge of the human body at the nanoscale to diagnose, treat and prevent disease. It involves applications of nanoparticles currently under development as well as longer term research using nano-robots to make repairs at the cellular level. Nanopharmacology uses nanotechnology to develop novel methods of delivering drugs using nanoparticles, which have one dimension of 1000nm or less. Nanomedicine offers advantages like enhanced drug stability and delivery, increased bioavailability, targeted drug delivery to specific tissues and cells, and opportunities for real-time monitoring and cellular repair. However, challenges include high costs, manufacturing defects, and lack of extensive clinical trials.
The document discusses the use of gold nanoparticles for cancer detection and treatment. It describes how gold nanoparticles can be functionalized with antibodies to detect specific cancer types by binding to protein markers on cancer cells. Laser-activated gold nanoparticles may also be used to destroy cancer cells through localized heating. The document also mentions potential applications for targeted drug delivery and angiogenesis inhibition. Overall, the document outlines how the optical and structural properties of gold nanoparticles can be exploited for cancer diagnosis and therapy.
Gold nanoparticles, also called AuNPs, are nanoparticles of gold that appear red in solution. AuNPs are very stable and have unique optical and electronic properties that make them useful for a wide range of applications. Historically, medieval artists first created AuNPs unintentionally when mixing gold into glass to produce stained glass windows with various colors. Today, AuNPs are commonly synthesized using the Turkevich method and characterized using techniques like TEM, SEM, and UV-Vis spectroscopy. Current applications of AuNPs include uses in electronics, medicine for cancer detection and therapy, and as catalysts.
Wendy Noe, education coordinator for the Central Indiana Affiliate of Susan G. Komen for the Cure® presents an overview of breast cancer information, facts and advances in treatment.
Process design.cancer treatment using nanoparticles. pptHoang Tien
Nanoparticles show promise for improving cancer detection and treatment. They are small enough to enter cells and interact with DNA and proteins. Quantum dots and nanoshells can be used to detect cancer signatures. Nanoshells coated with cancer-targeting molecules can selectively heat and destroy cancer cells when exposed to near-infrared light, protecting healthy cells. While challenges remain around toxicity and delivery, nanoparticles may enable cheaper, less toxic cancer therapies compared to chemotherapy and improve outcomes.
Nanoparticles for drug delivery by shreyaShreya Modi
This document discusses the advancement of nanotechnology and nanoparticles for cancer diagnosis and drug delivery. It outlines several challenges in developing effective nanoscale drug delivery systems, as well as properties of nanomaterials that make them suitable for drug delivery. Various nanodevices are described that could be used for targeted drug delivery, including liposomes, nanoshells, dendrimers, micelles, nanowires, nanotubes, quantum dots, and potential future nanorobots. Advantages of nanoparticle drug delivery systems include smaller size, higher bioavailability, and ability to target drugs directly to cells and nuclei. The only disadvantage mentioned is difficulty determining proper dosages.
These slides use concepts from my (Jeff Funk) course entitled analyzing hi-tech opportunities to show how nanotechnology for drug deliver is becoming economically feasible.
This document discusses various drug delivery systems including oral, injection-based, transdermal, carrier-based, and targeted delivery systems. It provides details on properties of responsive drug delivery devices and how they can provide controlled release profiles for sensitive drugs through long-lived, biocompatible designs. Specific examples covered include oral tablets and films, injection methods like dermojet pellets and insulin pens, inhalers, transdermal patches, monoclonal antibodies, liposomes, nanoparticles, and genetic transfer systems. The goal is to improve individualized therapy through controlled release and targeted delivery to increase drug efficacy while reducing side effects.
Cancer is caused by abnormal cell growth that spreads uncontrollably. It develops through a complex interaction between genes, environment, and chance. Cancer cells do not die like normal cells and continue growing and dividing in a disorderly fashion. The media needs to accurately report on cancer research studies and not oversimplify results or mislead the public. The UK has higher cancer death rates than some other countries, which may be partly due to lower spending on cancer medications.
1. Breast cancer develops from mutations in genes controlling cell growth and health. Abnormal cells divide uncontrollably, forming tumors that can be benign or malignant.
2. Malignant tumors are cancerous and can spread via the lymphatic system to other parts of the body. Breast cancer refers specifically to malignant tumors in the breast.
3. Treatment plans consider cancer type, stage, hormone sensitivity, and patient history. Early detection through education and screening as well as primary and adjuvant therapies can help improve outcomes for breast cancer.
This document provides an overview of breast cancer, including risk factors, signs and symptoms, causes, diagnosis, treatment options and prevention strategies. It notes that breast cancer is the second leading cause of cancer deaths in women. While the chances of developing breast cancer increase with age, early detection through screening and awareness of changes to the breasts can help lead to successful treatment if cancer is found early. A variety of treatment options exist depending on the type and stage of cancer diagnosed. Lifestyle factors may also impact risk.
Breast cancer is the most common cancer in women. In 2008, there were 211,000 new cases and 40,500 deaths in the US. Risk factors include family history, personal history of breast disease, older age, early menarche or late first birth. Non-invasive cancers like DCIS have increased incidence and require surgery with or without radiation. Invasive cancers are staged and treated with surgery, radiation, and systemic therapies like chemotherapy and hormonal therapy based on tumor size, lymph node involvement, and biomarkers.
Breast cancer is the second leading cause of death and second most common cancer in women. It occurs when abnormal cells in the breast grow in an uncontrolled way and form tumors. The breasts contain lobes and lobules which produce milk, connected by ducts. The two main types are ductal carcinoma, originating in the ducts, and lobular carcinoma, originating in the lobules. Risk factors include gender, age, family history, obesity, lack of exercise, alcohol consumption, and hormone therapy. Screening methods include breast self-exams, clinical exams by a doctor, and mammography. Treatment options depend on cancer stage and may involve surgery, radiation, chemotherapy, and hormone therapy. With early detection and treatment, the
Ten cancer fighting foods that are essential in our daily life. These foods are available and affordable. It only needs slight behavior change so that we try to buy it.
Lifestyle modifications in pharmacy practice نقشهای نوین داروساز در ارتقا سلا...Amirhossein Hajimiri
Lifestyle modifications in pharmacy practice, a pharmacist guide
To open new paradigms of responsibility.
اصلاح الگوی زندگی، راهنمای داروسازان برای ارتقا سلامت عمومی جامعه
کازمتیک - فرآورده های ضد عرق و بو بر و سرطان پستانMohammad Baghaei
در مقالات یا خبرهای متعدد میخوانیم یا میشنویم که محصولات ضد عرق Antiperspirant زیر بغل )که موجب کاهش تعریق می
گردند( یا محصولات ضد بوی بد Deodorant )که موجب از بین بردن یا پوشاندن بوی بد زیر بغل میشوند( سبب بروز کانسر
پستان می گردند .
سرطان پستان تهدید بزرگي بر سلامت زنان است. سالانه حدود 000111 مورد سرطان پستان در زنان امریكایي تشخیص داده شده
و حدود 00111 زن مبتلا به سرطان پستان مي میرند.این سرطان شایعترین سرطان در زنان است كه 03 % از موارد سرطان زنان
را شامل مي شود. همچنین پس از سرطان ریه، شایعترین علت مرگ و میر ناشي از سرطان در زنان محسوب مي شود كه عامل
%01 از مرگ و میرهاي وابسته به سرطان در زنان مي باشد.
1. سلامت زنان تهیه کننده : احسان موسی فرخانی - کارشناس بهداشت عمومی مرکز بهداشت شهرستان فریمان Email:farkhanye1@mums.ac.ir
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7. cervical cancer تا چه اندازه در معرض خطر قرار دارید؟ ◄ سن کمتر از 16 سالگی در اولین مقاربت جنسی ◄ سیگار کشیدن ◄ زگیل تناسلی ◄ ابتلا به بیماریهای مقاربتی ◄ داشتن بچه زیاد ◄ استفاده طولانی از O.C.P ◄ تغذیه نامناسب ( کمبود ویتامین C,A ◄ شرکاء جنسی متعدد
8. cervical cancer چند نکته : 1 – برآورد شده است با استفاده کامل از پاپ اسمیر از 37 تا 60 درصد مرگ و میر سرطان دهانه رحم پیشگیری گردد . 2 – با وجود در دسترس بودن و استفاده فراوان از آزمون پاپ زیر گروههای زنان پر خطر کمتر غربال می شوند .
9. Cardiovascular disease چرا زنان بیشتر در معرض خطر هستند؟ قبل از یائسگی زنان کمتر به بیماریهای قلبی دچار می شوند . از هر 1000 زن 35 تا 46 ساله یک نفر و 45 تا 54 ساله 4 نفر به بیماریهای قلبی دچار میشوند . قبل از یائسگی هورمونهایی مثل استروژن بیشترین مقدار خود را دارا هستند که شاید نقش حفاظتی در برابر بیماری قلبی مربوط به هورمونها باشد . ولی با کاهش استروژن ، خطر ابتلا به بیمارهای قلبی و سکته مغزی در زنان افزایش می یابد تا جایی که هم سطح مردان می شود . - تاثیر داروها در زنان خیلی موثر نیست . - تاثیر اعمال جراحی در زنان ضعیف تر است . - زنان نسبت به مردان زودتر همسر خود را از دست می دهند و از حمایت لازم برخوردار نبوده و به مراکز درمانی مراجعه نمی کنند . - پس از ابتلا به بیماریهای قلبی زنان بیشتر از مردان دچار اضطراب و افسردگی می شوند . .
10. Cardiovascular disease تا چه اندازه در معرض خطر قرار دارید؟ ◄ فشار خون بالا ◄ سیگار کشیدن ◄ کلسترول بالا ◄ دیابت ◄ سابقه خانوادگی ◄ چاقی ◄ بی تحرکی ◄ یائسگی
11. Cardiovascular disease چند نکته : 1- احتمال ابتلا به بیماریهای قلبی در زنانی که پس از یائسگی از درمان جایگزین استفاده می کنند نصف زنانی است که از این روش استفاده نمی کنند . 2 – سکته مغزی در مردان 2 برابر زنان اتفاق می افتد . اما اگر زنی دچار سکته مغزی شود احتمال فوت او دو برابر یک مرد است . 3 – با استفاده از یک متر دور کمر خود را اندازه بگیرید . عدد اول را بر عدد دوم تقسیم کنید در افرادی که نسبت دور کمر به باسن بیشتر از 88% باشد احتمال ابتلا به بیماری قلبی 3 برابر افرادی است که این عدد کمتر است .
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13. osteoporosis تا چه اندازه در معرض خطر هستید؟ ◄ سابقه خانوادگی پوکی استخوان ◄ مشکلات تیروئید ◄ جثه لاغر یا کوچک ◄ نژاد ( اسیایی و قفقازی ) ◄ مصرف سیگار ◄ الکل ◄ کم تحرکی ◄ مصرف ناکافی لسیم در طول زندگی ◄ یائسگی قبل از 45 سالگی ◄ سابقه شکستگی استخوان ◄ مصرف کورتون یا داروهای ضد تشنج ◄ عدم وجود قائدگی که بیش از سه ماه بطول بکشد ◄ کمبود وزن ◄ اختلالات تغذیه ای ( بی اشتهایی عصبی یا پر اشتهایی عصبی )
14. osteoporosis چند نکته : 1- احتمال شکستگی مفصل ران در یک زن برابر مجموع احتمالات ابتلا به سرطان پستان ، رحم و تخمدان است .
15. osteoporosis خود آزمایی پوکی استخوان : 1 – آیا شما اسکلت لاغر و کوچک دارید و یا نژاد شما آسیایی یا قفقازی است؟ 2 – آیا یکی از اعضای خانواده تان در بزرگسالی دچار شکستگی استخوان شده است ؟ 3 – آیا شما یائسه شده اید ؟ 4 – آیا شما به مقدار زیاد از داروهای تیروئید استفاده می کنید و یا شما از داروهای گلوکوکورتیکوئید برای بیش از 3 ماه استفاده می کنید؟ 5- آیا شما از داروهای کاهنده سیستم ایمنی استفاده می کنید و یا تحت شیمی درمانی هستید؟ 6 – آیا رژیم غذایی شما از حاوی لبنیات و کلسیم اندکی است؟ 7 – شما شما فعالیت بدنی مناسبی ندارید؟ 8 – آیا شما سیگار می کشید ویا الکل می نوشید؟ اگر تعداد جوابهای بله شما زیاد می باشد احتمال خطر پوکی استخوان در شما زیادتر است؟