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Speaking Precision Medicine: Preliminary
results from the analysis of the discourses
produced in a conference on
biotechnological applications in
biomedicine
José Carlos Pinto da Costa
(CRIA/FCSH-NOVA)
EASA Medical Anthropology Network |2017 Biennial Conference Network Meeting
5-7 July, Lisbon, Portugal
Context and purpose
Conferences and debates on biomedical
applications of biotechnologies constitute relevant
sources of data for investigating the discursive
construction of Precision or Personalized Medicine
(PM), which may affect PM related policy making
in the future. This paper presents some
preliminary results arising from a discourse
analysis held in one of such events.
2
The SPEAKING model
(Hymes, 1967, pp. 21-25)
Setting, or Scene – ...time, and place, of a speech event. In addition, psychological
setting, and cultural definition of the setting as a certain type of scene...
Participants or Personnel – Schemes of components usually distinguish Speaker
and Hearer (Sender and Receiver, Addressor and Addressee)
Ends – ...two types of ends...: ends in view (goals, purposes), and ends as outcomes.
In one sense, intentions and effects; in another, manifest and latent functions
Art Characteristics – ...two closely linked aspects of acts of speech are grouped
together: the form, and the content, of what is said.
Key – This component is introduced to distinguish the tone, manner or spirit in
which an act is done.
Instrumentalities – ...Channel and Code. By choice of Channel is understood the
choice of oral, written, telegraphic, semaphore or other medium of transmission.
By choice of Code is understood a choice at the level of distinct languages. Where
the distinction is necessary, varieties within a language may be designated
subcodes.
Norms of Interaction and of Interpretation – ... specific behaviors and proprieties
that may accompany acts of...
Genres – ...categories or types of speech act and speech event: conversation, curse,
blessing, prayer, lecture, imprecation, sales pitch, etc.
3
Setting, or Scene
The conference took place during a period of four days in a
medical school facility. The event was proceeded along three
main stages: the auditorium, where speeches were essentially
formal, structured and mainly expository; the coffee break
stage, where speeches were informal and apparently chaotic;
and the lunch break stage, where speeches were mostly
informal but the behaviours showed to be more regulated
than in coffee break scenario.
All these three stages configured the core of the event as it is
expected. Although, without the social program and the final
dinner, the event remains incomplete. As it is understandable,
due to the fact that formal experts’ discursivity was largely
unattainable in its real sense and that the one-way
communication flow impedes the redundancy effect, it is
along informal settings that I have captured the most
insightful informations.
4
Participants or Personnel
Of the total of 35 speakers who were present, 12
were local students with or in the process of obtain
their doctorate degrees. A glance over the audience
suggested that the most part of the attendants were
biotechnology students as well.
Apart from such participants, the other speakers
were from several places, foreign ones included. 77%
of the speakers were from Portugal. The remaining
speakers came from Spain (4), France (1), Poland
(1), Finland (1), Holand (1), Austria (1), although
some of these were Portuguese who worked or
collaborate with abroad or international labs.
5
Ends
The event was markedly oriented to promote possible
synergies, as its is easily detected in the congress presentation
discourse. Here, we can see that the event´s explicit main goal
was to provoke “knowledge interchange” and “to build new
networks with young and senior researchers, improving the
discussion of new scientific ideas”.
In order to translate this intention in concrete functions, the
key expression is, as one of the speakers said, “translate
science into industry products” by “transferring ideas”. This
key speaker was aware about the fact that “investors have
difficulty in understanding how this transference may be
done”. In the end, this is the core of the message the event was
intended to cope with.
6
Art Characteristics
Through a brief lexemes counting, we can see that the
textual information clearly focus on newness and
discussion of ideas about biotechnology and engineering.
7
In addition to the lexemes, which are the discourse’s minimal
meaningful units, we may now focus on maximal units, such as
meaningful categories. In this regard, the conference focused in
nine main topics (showed as scheduled): cell biology and genetic
engineeering (3 presentations), omics (4 presentations),
regenerative medicine and biomaterials (2 presentations),
pharmaceutical biotechnology (8 presentations), other
biomedical applications (2 presentations), nanobiotechnology (1
presentation), health entrepreneurship (3 presentations),
bioinformatics and biosensors (4 presentations), and bioprocess
engineering (8 presentations).
In decreasing order by number of participants, we find that the
discourse was especially varied in pharmaceutical biotechnology
and bioprocess engineering themes and individualized in the
nanobiotechnology theme. Eventually, this outcome is an
important one, as it reflects the number of participants
interested in each of the themes (or, instead, both the most and
the least explored research areas).
8
Key
Though the strong structuring of discourses, during
the presentations, “the tone, manners or spirit in
which” acts were done differed greatly. Some of the
participants were more enthusiastic than others.
This difference was more sharply detected when the
speakers were representatives of companies or of
research centers.
Generally, young students or newly graduates were
frequently rigid, as if they were expecting to meet
their function without disruptions and through a
way as straight as possible.
9
Instrumentalities
All the presentations were made in English, as well all
the interactions after the presentations. This is the main
sign of the qualifier “International” that follows the
“Congress”. Apart from this, I noted that almost all the
presentations were illegible from the place where I was
seated. Problems were many and several, since the size
and the colour of lettering, the lack of contrast due to the
colour saturation, or the cluttered powerpoint slides,
with lots of disordered graphics, images and figures.
Some of these presentations were really confusing and
the communication of the ideas toward the audience,
specially toward non-experts attendees, like me, was
definitely hindered.
10
Norms of Interaction and of
Interpretation
Communication process was hampered by both
technical and arquitectural issues. Some of the
attendees were sometimes noisy and relatively
distracted. Despite this, such issue has not
prevented communication. In fact, at no time
has the flow of expositions been interrupted.
11
Genres
As has been said, the type of discourse was
structured accordingly to a common code shared
with similar speech events. The strong
structuration of speech and the various agents
awareness of the protocol and the interaction
and interpretation norms ensure a regular
functioning during all the conference.
12
A critical glance: some notes on the
biotechnology’s deep play and two (main)
derived ethical plateaus
As Deborah Cameron points out, in order to be
complete, an ethnography of communication must
address the way how a certain discourse fits a whole
social set of significant networks, such as modernity’s
underlying rationality premises, or the deep play of
modernity (Fischer, 2004), or, even, a particular
communicative pattern, as is the case of particular
disciplines’ vocabulary repertories that constitute
professional based ideologies (Wright Mills, 1943),
such as biotechnicians’. In other terms, in order to
acquire meaning, to a given form of discourse must be
associated a given social function (Cameron, 2001).
13
That said, questions as “Why the biotechnology congress
has occurred, and why with such particular
characteristics?”, “What is the function of the resultant
discourses?” must be addressed through a discourse
analysis. My opinion is that, in order to develop such
questions, we must also develop a kind of a parallax
view, i.e., we must dislocate the focus from the formal
auditorium fieldsite to the informal social interactions,
adopting a collaborative approach, which implies
shifting the speakers’ status away from the informant
and bring it closer to that of the interlocutor. This
collaborative technique in anthropology provides
significant insights that enable us to study how
biotechnicians understand and live our world, as
Holmes & Marcus (2008) allude. After all, this is the
very goal of social anthropology, isn’t it?
14
Two ethical plateaus
1) The opacity of biotechnological discourse
The opacity of biotechnicians and bioengineers discourses
enlarges the social-technical divide, and, such “technicality of
talk” (Rachel & Woolgar, 1995:267), forces us to engage in a
negotiation to cross a boundary to a “foreign culture” (Rachel
& Woolgar, 1995:269). This may perhaps be the biggest cause
for the public be distrustful of the science and technology
discourses (Bazerman, 1983). Indeed, as Chris Toumey
reminds, the “process of building public understanding must
not be a one-way communication from active experts to
passive laypersons. On the contrary, it must include ways for
laypersons to express their questions, their concerns, and
their values, and for them to receive responses from experts”
(Toumey, 2006:29).
15
2) Naïve realism, encore, or the illusion of existence of
pure objects
As Charles Bazerman (1983:292-3) puts it, “when we look to the
formulations created by science as reflected in symposia (...), we
certainly see a very specialized development of language, distinct
from our everyday conversation and newspaper reading. [T]his
specialized language of science seems constantly filled with
evidence, numbers, observations, pictures, to ensure that the
formulations correspond to real things”.
Since science and technology are socially constructed (Pinch &
Bijker, 1984; Bijker et al., 2012), they are, like human societies,
discursively and epistemologically produced facts (Knorr-Cetina,
1999) and thus “naturally artificial forms of life. [Consequently] it
remains obvious that the empirical sciences cannot be ontologically
neutral” (Luckmann, 2005:4). As communicative constructs
(Luckmann, 2005:5), data are actually socially constructed facta, as
Vico would say, since, apart from being discursively accessed, their
capture is instrumentally mediated.
16
Final remarks
The previous presented insights suggest that the non-
neutral nature of scientific discourse, as the
biotechnological, hence PM’s, one must address
questions such as: “How and why someone decides to
organize a Biotech Congress?”; “What are the intentions
and motivations of this “someone”?”; “To whom were the
discourses addressed?”; “Who will hear and interpret the
messages and what would him/her/them do with the
resulting information?”. All these questions were already
addressed (e.g., Gilbert & Mulkay, 1984), but the
demands of the day (Rabinow & Stavrianakis, 2013)
keep this as a central quest in discourse analyses. We
dare to look forward in order to enter such an
endeavour.
17
...Thank You!
Vocabula sunt notae rerum*
Cícero, quoted by Johann Gottfried Herder
* Words are characteristics of things
18

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Speaking precision medicine preliminary results from the analysis of the discourses produced in a conference on biotechnological applications in biomedicine

  • 1. Speaking Precision Medicine: Preliminary results from the analysis of the discourses produced in a conference on biotechnological applications in biomedicine José Carlos Pinto da Costa (CRIA/FCSH-NOVA) EASA Medical Anthropology Network |2017 Biennial Conference Network Meeting 5-7 July, Lisbon, Portugal
  • 2. Context and purpose Conferences and debates on biomedical applications of biotechnologies constitute relevant sources of data for investigating the discursive construction of Precision or Personalized Medicine (PM), which may affect PM related policy making in the future. This paper presents some preliminary results arising from a discourse analysis held in one of such events. 2
  • 3. The SPEAKING model (Hymes, 1967, pp. 21-25) Setting, or Scene – ...time, and place, of a speech event. In addition, psychological setting, and cultural definition of the setting as a certain type of scene... Participants or Personnel – Schemes of components usually distinguish Speaker and Hearer (Sender and Receiver, Addressor and Addressee) Ends – ...two types of ends...: ends in view (goals, purposes), and ends as outcomes. In one sense, intentions and effects; in another, manifest and latent functions Art Characteristics – ...two closely linked aspects of acts of speech are grouped together: the form, and the content, of what is said. Key – This component is introduced to distinguish the tone, manner or spirit in which an act is done. Instrumentalities – ...Channel and Code. By choice of Channel is understood the choice of oral, written, telegraphic, semaphore or other medium of transmission. By choice of Code is understood a choice at the level of distinct languages. Where the distinction is necessary, varieties within a language may be designated subcodes. Norms of Interaction and of Interpretation – ... specific behaviors and proprieties that may accompany acts of... Genres – ...categories or types of speech act and speech event: conversation, curse, blessing, prayer, lecture, imprecation, sales pitch, etc. 3
  • 4. Setting, or Scene The conference took place during a period of four days in a medical school facility. The event was proceeded along three main stages: the auditorium, where speeches were essentially formal, structured and mainly expository; the coffee break stage, where speeches were informal and apparently chaotic; and the lunch break stage, where speeches were mostly informal but the behaviours showed to be more regulated than in coffee break scenario. All these three stages configured the core of the event as it is expected. Although, without the social program and the final dinner, the event remains incomplete. As it is understandable, due to the fact that formal experts’ discursivity was largely unattainable in its real sense and that the one-way communication flow impedes the redundancy effect, it is along informal settings that I have captured the most insightful informations. 4
  • 5. Participants or Personnel Of the total of 35 speakers who were present, 12 were local students with or in the process of obtain their doctorate degrees. A glance over the audience suggested that the most part of the attendants were biotechnology students as well. Apart from such participants, the other speakers were from several places, foreign ones included. 77% of the speakers were from Portugal. The remaining speakers came from Spain (4), France (1), Poland (1), Finland (1), Holand (1), Austria (1), although some of these were Portuguese who worked or collaborate with abroad or international labs. 5
  • 6. Ends The event was markedly oriented to promote possible synergies, as its is easily detected in the congress presentation discourse. Here, we can see that the event´s explicit main goal was to provoke “knowledge interchange” and “to build new networks with young and senior researchers, improving the discussion of new scientific ideas”. In order to translate this intention in concrete functions, the key expression is, as one of the speakers said, “translate science into industry products” by “transferring ideas”. This key speaker was aware about the fact that “investors have difficulty in understanding how this transference may be done”. In the end, this is the core of the message the event was intended to cope with. 6
  • 7. Art Characteristics Through a brief lexemes counting, we can see that the textual information clearly focus on newness and discussion of ideas about biotechnology and engineering. 7
  • 8. In addition to the lexemes, which are the discourse’s minimal meaningful units, we may now focus on maximal units, such as meaningful categories. In this regard, the conference focused in nine main topics (showed as scheduled): cell biology and genetic engineeering (3 presentations), omics (4 presentations), regenerative medicine and biomaterials (2 presentations), pharmaceutical biotechnology (8 presentations), other biomedical applications (2 presentations), nanobiotechnology (1 presentation), health entrepreneurship (3 presentations), bioinformatics and biosensors (4 presentations), and bioprocess engineering (8 presentations). In decreasing order by number of participants, we find that the discourse was especially varied in pharmaceutical biotechnology and bioprocess engineering themes and individualized in the nanobiotechnology theme. Eventually, this outcome is an important one, as it reflects the number of participants interested in each of the themes (or, instead, both the most and the least explored research areas). 8
  • 9. Key Though the strong structuring of discourses, during the presentations, “the tone, manners or spirit in which” acts were done differed greatly. Some of the participants were more enthusiastic than others. This difference was more sharply detected when the speakers were representatives of companies or of research centers. Generally, young students or newly graduates were frequently rigid, as if they were expecting to meet their function without disruptions and through a way as straight as possible. 9
  • 10. Instrumentalities All the presentations were made in English, as well all the interactions after the presentations. This is the main sign of the qualifier “International” that follows the “Congress”. Apart from this, I noted that almost all the presentations were illegible from the place where I was seated. Problems were many and several, since the size and the colour of lettering, the lack of contrast due to the colour saturation, or the cluttered powerpoint slides, with lots of disordered graphics, images and figures. Some of these presentations were really confusing and the communication of the ideas toward the audience, specially toward non-experts attendees, like me, was definitely hindered. 10
  • 11. Norms of Interaction and of Interpretation Communication process was hampered by both technical and arquitectural issues. Some of the attendees were sometimes noisy and relatively distracted. Despite this, such issue has not prevented communication. In fact, at no time has the flow of expositions been interrupted. 11
  • 12. Genres As has been said, the type of discourse was structured accordingly to a common code shared with similar speech events. The strong structuration of speech and the various agents awareness of the protocol and the interaction and interpretation norms ensure a regular functioning during all the conference. 12
  • 13. A critical glance: some notes on the biotechnology’s deep play and two (main) derived ethical plateaus As Deborah Cameron points out, in order to be complete, an ethnography of communication must address the way how a certain discourse fits a whole social set of significant networks, such as modernity’s underlying rationality premises, or the deep play of modernity (Fischer, 2004), or, even, a particular communicative pattern, as is the case of particular disciplines’ vocabulary repertories that constitute professional based ideologies (Wright Mills, 1943), such as biotechnicians’. In other terms, in order to acquire meaning, to a given form of discourse must be associated a given social function (Cameron, 2001). 13
  • 14. That said, questions as “Why the biotechnology congress has occurred, and why with such particular characteristics?”, “What is the function of the resultant discourses?” must be addressed through a discourse analysis. My opinion is that, in order to develop such questions, we must also develop a kind of a parallax view, i.e., we must dislocate the focus from the formal auditorium fieldsite to the informal social interactions, adopting a collaborative approach, which implies shifting the speakers’ status away from the informant and bring it closer to that of the interlocutor. This collaborative technique in anthropology provides significant insights that enable us to study how biotechnicians understand and live our world, as Holmes & Marcus (2008) allude. After all, this is the very goal of social anthropology, isn’t it? 14
  • 15. Two ethical plateaus 1) The opacity of biotechnological discourse The opacity of biotechnicians and bioengineers discourses enlarges the social-technical divide, and, such “technicality of talk” (Rachel & Woolgar, 1995:267), forces us to engage in a negotiation to cross a boundary to a “foreign culture” (Rachel & Woolgar, 1995:269). This may perhaps be the biggest cause for the public be distrustful of the science and technology discourses (Bazerman, 1983). Indeed, as Chris Toumey reminds, the “process of building public understanding must not be a one-way communication from active experts to passive laypersons. On the contrary, it must include ways for laypersons to express their questions, their concerns, and their values, and for them to receive responses from experts” (Toumey, 2006:29). 15
  • 16. 2) Naïve realism, encore, or the illusion of existence of pure objects As Charles Bazerman (1983:292-3) puts it, “when we look to the formulations created by science as reflected in symposia (...), we certainly see a very specialized development of language, distinct from our everyday conversation and newspaper reading. [T]his specialized language of science seems constantly filled with evidence, numbers, observations, pictures, to ensure that the formulations correspond to real things”. Since science and technology are socially constructed (Pinch & Bijker, 1984; Bijker et al., 2012), they are, like human societies, discursively and epistemologically produced facts (Knorr-Cetina, 1999) and thus “naturally artificial forms of life. [Consequently] it remains obvious that the empirical sciences cannot be ontologically neutral” (Luckmann, 2005:4). As communicative constructs (Luckmann, 2005:5), data are actually socially constructed facta, as Vico would say, since, apart from being discursively accessed, their capture is instrumentally mediated. 16
  • 17. Final remarks The previous presented insights suggest that the non- neutral nature of scientific discourse, as the biotechnological, hence PM’s, one must address questions such as: “How and why someone decides to organize a Biotech Congress?”; “What are the intentions and motivations of this “someone”?”; “To whom were the discourses addressed?”; “Who will hear and interpret the messages and what would him/her/them do with the resulting information?”. All these questions were already addressed (e.g., Gilbert & Mulkay, 1984), but the demands of the day (Rabinow & Stavrianakis, 2013) keep this as a central quest in discourse analyses. We dare to look forward in order to enter such an endeavour. 17
  • 18. ...Thank You! Vocabula sunt notae rerum* Cícero, quoted by Johann Gottfried Herder * Words are characteristics of things 18